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R180T variant of δ-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features.

Montioli R, Paiardini A, Giardina G, Zanzoni S, Cutruzzola F, Cellini B, Borri Voltattorni C.

FEBS J. 2019 Apr 8. doi: 10.1111/febs.14843. [Epub ahead of print]


The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.

Guiducci G, Paone A, Tramonti A, Giardina G, Rinaldo S, Bouzidi A, Magnifico MC, Marani M, Menendez JA, Fatica A, Macone A, Armaos A, Tartaglia GG, Contestabile R, Paiardini A, Cutruzzolà F.

Nucleic Acids Res. 2019 Feb 27. pii: gkz129. doi: 10.1093/nar/gkz129. [Epub ahead of print]


Non-invAsive VentIlation for early General wArd respiraTory failurE (NAVIGATE): A multicenter randomized controlled study. Protocol and statistical analysis plan.

Cabrini L, Brusasco C, Roasio A, Corradi F, Nardelli P, Filippini M, Cotticelli V, Belletti A, Ferrera L, Antonucci E, Baiardo Redaelli M, Lattuada M, Colombo S, Olper L, Ponzetta G, Ananiadou S, Monti G, Severi L, Maj G, Giardina G, Biondi-Zoccai G, Benedetto U, Gemma M, Cavallero SSM, Hajjar LA, Zangrillo A, Bellomo R, Landoni G.

Contemp Clin Trials. 2019 Mar;78:126-132. doi: 10.1016/j.cct.2019.02.001. Epub 2019 Feb 7.


Seizures and recurrence of Takotsubo syndrome: One clinical presentation and trigger, but two different anatomical variants in the same patient. A case to meditate on.

Binaghi G, Congia D, Cossa S, Ganga R, Giardina G, Matta G, Merella W, Melis M, Pasqualucci D, Serra E, Porcu M.

Seizure. 2018 Dec;63:37-39. doi: 10.1016/j.seizure.2018.10.014. Epub 2018 Oct 26. No abstract available.


When Intimate Partner Violence Meets Same Sex Couples: A Review of Same Sex Intimate Partner Violence.

Rollè L, Giardina G, Caldarera AM, Gerino E, Brustia P.

Front Psychol. 2018 Aug 21;9:1506. doi: 10.3389/fpsyg.2018.01506. eCollection 2018. Review.


Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa.

Mantoni F, Paiardini A, Brunotti P, D'Angelo C, Cervoni L, Paone A, Cappellacci L, Petrelli R, Ricciutelli M, Leoni L, Rampioni G, Arcovito A, Rinaldo S, Cutruzzolà F, Giardina G.

FEBS J. 2018 Oct;285(20):3815-3834. doi: 10.1111/febs.14634. Epub 2018 Sep 7.


A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa.

Paiardini A, Mantoni F, Giardina G, Paone A, Janson G, Leoni L, Rampioni G, Cutruzzolà F, Rinaldo S.

Proteins. 2018 Oct;86(10):1088-1096. doi: 10.1002/prot.25587. Epub 2018 Sep 8.


The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.

Giardina G, Paone A, Tramonti A, Lucchi R, Marani M, Magnifico MC, Bouzidi A, Pontecorvi V, Guiducci G, Zamparelli C, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.

FEBS J. 2018 Sep;285(17):3238-3253. doi: 10.1111/febs.14610. Epub 2018 Aug 7.


Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.

Tramonti A, Paiardini A, Paone A, Bouzidi A, Giardina G, Guiducci G, Magnifico MC, Rinaldo S, McDermott L, Menendez JA, Contestabile R, Cutruzzolà F.

Arch Biochem Biophys. 2018 Sep 1;653:71-79. doi: 10.1016/ Epub 2018 Jul 4.


Beyond nitrogen metabolism: nitric oxide, cyclic-di-GMP and bacterial biofilms.

Rinaldo S, Giardina G, Mantoni F, Paone A, Cutruzzolà F.

FEMS Microbiol Lett. 2018 Mar 1;365(6). doi: 10.1093/femsle/fny029.


Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.

Giardina G, Paiardini A, Montioli R, Cellini B, Voltattorni CB, Cutruzzolà F.

Sci Rep. 2017 Sep 15;7(1):11704. doi: 10.1038/s41598-017-11948-w.


Discovering Selective Diguanylate Cyclase Inhibitors: From PleD to Discrimination of the Active Site of Cyclic-di-GMP Phosphodiesterases.

Rinaldo S, Giardina G, Mantoni F, Paiardini A, Paone A, Cutruzzolà F.

Methods Mol Biol. 2017;1657:431-453. doi: 10.1007/978-1-4939-7240-1_32.


Glucose Metabolism in the Progression of Prostate Cancer.

Cutruzzolà F, Giardina G, Marani M, Macone A, Paiardini A, Rinaldo S, Paone A.

Front Physiol. 2017 Feb 21;8:97. doi: 10.3389/fphys.2017.00097. eCollection 2017. Review.


New Insights Emerging from Recent Investigations on Human Group II Pyridoxal 5'-Phosphate Decarboxylases.

Paiardini A, Giardina G, Rossignoli G, Voltattorni CB, Bertoldi M.

Curr Med Chem. 2017;24(3):226-244. doi: 10.2174/0929867324666161123093339. Review.


A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.

Marani M, Paone A, Fiascarelli A, Macone A, Gargano M, Rinaldo S, Giardina G, Pontecorvi V, Koes D, McDermott L, Yang T, Paiardini A, Contestabile R, Cutruzzolà F.

Oncotarget. 2016 Jan 26;7(4):4570-83. doi: 10.18632/oncotarget.6726.


Invariant NKT cells are expanded in peripheral blood but are undetectable in salivary glands of patients with primary Sjögren's syndrome.

Guggino G, Ciccia F, Raimondo S, Giardina G, Alessandro R, Dieli F, Sireci G, Triolo G.

Clin Exp Rheumatol. 2016 Jan-Feb;34(1):25-31. Epub 2015 Dec 1.


Synthesis of Triazole-Linked Analogues of c-di-GMP and Their Interactions with Diguanylate Cyclase.

Fernicola S, Torquati I, Paiardini A, Giardina G, Rampioni G, Messina M, Leoni L, Del Bello F, Petrelli R, Rinaldo S, Cappellacci L, Cutruzzolà F.

J Med Chem. 2015 Oct 22;58(20):8269-84. doi: 10.1021/acs.jmedchem.5b01184. Epub 2015 Oct 12.


In Silico Discovery and In Vitro Validation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD.

Fernicola S, Paiardini A, Giardina G, Rampioni G, Leoni L, Cutruzzolà F, Rinaldo S.

J Bacteriol. 2015 Sep 28;198(1):147-56. doi: 10.1128/JB.00742-15. Print 2016 Jan 1.


Chest and breast MRI: the added value of a fast imaging for a new diagnostic approach in the planning of augmentation surgery in patients with thoracic asymmetries.

Rinaldi P, Parapatt GK, Giuliani M, Borelli C, Giardina GG, Fubelli R, Buccheri C, Tambasco D, Belli P, Salgarello M, Bonomo L.

Eur Rev Med Pharmacol Sci. 2015 Jul;19(13):2359-67.


Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis.

Ciccia F, Guggino G, Rizzo A, Manzo A, Vitolo B, La Manna MP, Giardina G, Sireci G, Dieli F, Montecucco CM, Alessandro R, Triolo G.

Rheumatology (Oxford). 2015 Dec;54(12):2264-72. doi: 10.1093/rheumatology/kev252. Epub 2015 Jul 15.


Structural basis of functional diversification of the HD-GYP domain revealed by the Pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site.

Rinaldo S, Paiardini A, Stelitano V, Brunotti P, Cervoni L, Fernicola S, Protano C, Vitali M, Cutruzzolà F, Giardina G.

J Bacteriol. 2015 Apr;197(8):1525-35. doi: 10.1128/JB.02606-14. Epub 2015 Feb 17.


Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.

Paiardini A, Fiascarelli A, Rinaldo S, Daidone F, Giardina G, Koes DR, Parroni A, Montini G, Marani M, Paone A, McDermott LA, Contestabile R, Cutruzzolà F.

ChemMedChem. 2015 Mar;10(3):490-7. doi: 10.1002/cmdc.201500028. Epub 2015 Feb 10.


How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.

Giardina G, Brunotti P, Fiascarelli A, Cicalini A, Costa MG, Buckle AM, di Salvo ML, Giorgi A, Marani M, Paone A, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.

FEBS J. 2015 Apr;282(7):1225-41. doi: 10.1111/febs.13211. Epub 2015 Feb 13.


Airway fistula closure after stem-cell infusion.

Petrella F, Spaggiari L, Acocella F, Barberis M, Bellomi M, Brizzola S, Donghi S, Giardina G, Giordano R, Guarize J, Lazzari L, Montemurro T, Pastano R, Rizzo S, Toffalorio F, Tosoni A, Zanotti M.

N Engl J Med. 2015 Jan 1;372(1):96-7. doi: 10.1056/NEJMc1411374. No abstract available.


SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.

Paone A, Marani M, Fiascarelli A, Rinaldo S, Giardina G, Contestabile R, Paiardini A, Cutruzzolà F.

Cell Death Dis. 2014 Nov 20;5:e1525. doi: 10.1038/cddis.2014.482.


Nitrosylation of c heme in cd(1)-nitrite reductase is enhanced during catalysis.

Rinaldo S, Giardina G, Cutruzzolà F.

Biochem Biophys Res Commun. 2014 Aug 29;451(3):449-54. doi: 10.1016/j.bbrc.2014.08.020. Epub 2014 Aug 10.


Diffusion magnetic resonance imaging in breast cancer characterisation: correlations between the apparent diffusion coefficient and major prognostic factors.

Belli P, Costantini M, Bufi E, Giardina GG, Rinaldi P, Franceschini G, Bonomo L.

Radiol Med. 2015 Mar;120(3):268-76. doi: 10.1007/s11547-014-0442-8. Epub 2014 Aug 6.


Distal-proximal crosstalk in the heme binding pocket of the NO sensor DNR.

Cutruzzolà F, Arcovito A, Giardina G, della Longa S, D'Angelo P, Rinaldo S.

Biometals. 2014 Aug;27(4):763-73. doi: 10.1007/s10534-014-9770-3. Epub 2014 Jul 10.


The in vitro addition of methotrexate and/or methylprednisolone determines peripheral reduction in Th17 and expansion of conventional Treg and of IL-10 producing Th17 lymphocytes in patients with early rheumatoid arthritis.

Guggino G, Giardina A, Ferrante A, Giardina G, Schinocca C, Sireci G, Dieli F, Ciccia F, Triolo G.

Rheumatol Int. 2015 Jan;35(1):171-5. doi: 10.1007/s00296-014-3030-2. Epub 2014 May 3.


Targeting IL-6 signalling in early rheumatoid arthritis is followed by Th1 and Th17 suppression and Th2 expansion.

Guggino G, Giardina AR, Raimondo S, Giardina G, Sireci G, Dieli F, Peralta M, Alessandro R, Triolo G, Ciccia F.

Clin Exp Rheumatol. 2014 Jan-Feb;32(1):77-81. Epub 2014 Jan 14.


Neuroendocrine breast cancer: retrospective analysis of 96 patients and review of literature.

Rovera F, Lavazza M, La Rosa S, Fachinetti A, Chiappa C, Marelli M, Sessa F, Giardina G, Gueli R, Dionigi G, Rausei S, Boni L, Dionigi R.

Int J Surg. 2013;11 Suppl 1:S79-83. doi: 10.1016/S1743-9191(13)60023-0.


Investigating the allosteric regulation of YfiN from Pseudomonas aeruginosa: clues from the structure of the catalytic domain.

Giardina G, Paiardini A, Fernicola S, Franceschini S, Rinaldo S, Stelitano V, Cutruzzolà F.

PLoS One. 2013 Nov 22;8(11):e81324. doi: 10.1371/journal.pone.0081324. eCollection 2013.


C-di-GMP hydrolysis by Pseudomonas aeruginosa HD-GYP phosphodiesterases: analysis of the reaction mechanism and novel roles for pGpG.

Stelitano V, Giardina G, Paiardini A, Castiglione N, Cutruzzolà F, Rinaldo S.

PLoS One. 2013 Sep 16;8(9):e74920. doi: 10.1371/journal.pone.0074920. eCollection 2013.


Probing the activity of diguanylate cyclases and c-di-GMP phosphodiesterases in real-time by CD spectroscopy.

Stelitano V, Brandt A, Fernicola S, Franceschini S, Giardina G, Pica A, Rinaldo S, Sica F, Cutruzzolà F.

Nucleic Acids Res. 2013 Apr;41(7):e79. doi: 10.1093/nar/gkt028. Epub 2013 Jan 28.


Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target.

Boumis G, Giardina G, Angelucci F, Bellelli A, Brunori M, Dimastrogiovanni D, Saccoccia F, Miele AE.

Biochem Biophys Res Commun. 2012 Sep 7;425(4):806-11. doi: 10.1016/j.bbrc.2012.07.156. Epub 2012 Aug 6.


IP issues facing researchers by Gino D'Oca.

Almarsson O, Angiolini M, Baell J, Giardina G, Ingham A, Hughes A, Pevarello P, Sindelar R.

Pharm Pat Anal. 2012 May;1(2):129-35. doi: 10.4155/ppa.12.15.


Preoperative chemotherapy plus trastuzumab, lapatinib, or both in human epidermal growth factor receptor 2-positive operable breast cancer: results of the randomized phase II CHER-LOB study.

Guarneri V, Frassoldati A, Bottini A, Cagossi K, Bisagni G, Sarti S, Ravaioli A, Cavanna L, Giardina G, Musolino A, Untch M, Orlando L, Artioli F, Boni C, Generali DG, Serra P, Bagnalasta M, Marini L, Piacentini F, D'Amico R, Conte P.

J Clin Oncol. 2012 Jun 1;30(16):1989-95. doi: 10.1200/JCO.2011.39.0823. Epub 2012 Apr 9.


Unusual heme binding properties of the dissimilative nitrate respiration regulator, a bacterial nitric oxide sensor.

Rinaldo S, Castiglione N, Giardina G, Caruso M, Arcovito A, Longa SD, D'Angelo P, Cutruzzolà F.

Antioxid Redox Signal. 2012 Nov 1;17(9):1178-89. doi: 10.1089/ars.2011.4226. Epub 2012 Apr 27.


Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors.

Daidone F, Montioli R, Paiardini A, Cellini B, Macchiarulo A, Giardina G, Bossa F, Borri Voltattorni C.

PLoS One. 2012;7(2):e31610. doi: 10.1371/journal.pone.0031610. Epub 2012 Feb 23.


Nitrite and nitrite reductases: from molecular mechanisms to significance in human health and disease.

Castiglione N, Rinaldo S, Giardina G, Stelitano V, Cutruzzolà F.

Antioxid Redox Signal. 2012 Aug 15;17(4):684-716. doi: 10.1089/ars.2011.4196. Epub 2012 Mar 16. Review.


Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.

Giardina G, Montioli R, Gianni S, Cellini B, Paiardini A, Voltattorni CB, Cutruzzolà F.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20514-9. doi: 10.1073/pnas.1111456108. Epub 2011 Dec 5.


Pirin inhibits cellular senescence in melanocytic cells.

Licciulli S, Luise C, Scafetta G, Capra M, Giardina G, Nuciforo P, Bosari S, Viale G, Mazzarol G, Tonelli C, Lanfrancone L, Alcalay M.

Am J Pathol. 2011 May;178(5):2397-406. doi: 10.1016/j.ajpath.2011.01.019.


γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes.

Imbimbo BP, Giardina GA.

Curr Top Med Chem. 2011;11(12):1555-70. Review.


The Pseudomonas aeruginosa DNR transcription factor: light and shade of nitric oxide-sensing mechanisms.

Giardina G, Castiglione N, Caruso M, Cutruzzolà F, Rinaldo S.

Biochem Soc Trans. 2011 Jan;39(1):294-8. doi: 10.1042/BST0390294.


The catalytic mechanism of Pseudomonas aeruginosa cd1 nitrite reductase.

Rinaldo S, Giardina G, Castiglione N, Stelitano V, Cutruzzolà F.

Biochem Soc Trans. 2011 Jan;39(1):195-200. doi: 10.1042/BST0390195.


Diffusion-weighted imaging in breast cancer: relationship between apparent diffusion coefficient and tumour aggressiveness.

Costantini M, Belli P, Rinaldi P, Bufi E, Giardina G, Franceschini G, Petrone G, Bonomo L.

Clin Radiol. 2010 Dec;65(12):1005-12. doi: 10.1016/j.crad.2010.07.008. Epub 2010 Sep 24.


Spirocerca lupi isolated from gastric lesions in foxes (Vulpes vulpes) in Sicily (Italy).

Ferrantelli V, Riili S, Vicari D, Percipalle M, Chetta M, Monteverde V, Gaglio G, Giardina G, Usai F, Poglayen G.

Pol J Vet Sci. 2010;13(3):465-71.


Limits on light-speed anisotropies from Compton scattering of high-energy electrons.

Bocquet JP, Moricciani D, Bellini V, Beretta M, Casano L, D'Angelo A, Di Salvo R, Fantini A, Franco D, Gervino G, Ghio F, Giardina G, Girolami B, Giusa A, Gurzadyan VG, Kashin A, Knyazyan S, Lapik A, Lehnert R, Levi Sandri P, Lleres A, Mammoliti F, Mandaglio G, Manganaro M, Margarian A, Mehrabyan S, Messi R, Nedorezov V, Perrin C, Randieri C, Rebreyend D, Rudnev N, Russo G, Schaerf C, Sperduto ML, Sutera MC, Turinge A, Vegna V.

Phys Rev Lett. 2010 Jun 18;104(24):241601. Epub 2010 Jun 17.


Salmonella infection in illegally imported spur-thighed tortoises (Testudo graeca).

Percipalle M, Giardina G, Lipari L, Piraino C, Macrì D, Ferrantelli V.

Zoonoses Public Health. 2011 Jun;58(4):262-9. doi: 10.1111/j.1863-2378.2010.01345.x. Epub 2010 Jul 5.


Accelerating the drug-discovery process: new tools and technologies available to medicinal chemists.

Raveglia LF, Giardina GA.

Future Med Chem. 2009 Sep;1(6):1019-23. doi: 10.4155/fmc.09.79. No abstract available.

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