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Multicentre cross-sectional observational registry to monitor the safety of early discharge after rule-out of acute myocardial infarction by copeptin and troponin: the Pro-Core registry.

Giannitsis E, Clifford P, Slagman A, Ruedelstein R, Liebetrau C, Hamm C, Honnart D, Huber K, Vollert JO, Simonelli C, Schröder M, Wiemer JC, Mueller-Hennessen M, Schroer H, Kastner K, Möckel M.

BMJ Open. 2019 Jul 23;9(7):e028311. doi: 10.1136/bmjopen-2018-028311.


Management and outcomes of patients with unstable angina with undetectable, normal, or intermediate hsTnT levels.

Giannitsis E, Biener M, Hund H, Mueller-Hennessen M, Vafaie M, Gandowitz J, Riedle C, Löhr J, Katus HA, Stoyanov KM.

Clin Res Cardiol. 2019 Jul 19. doi: 10.1007/s00392-019-01529-4. [Epub ahead of print]


RAPID-CPU: a prospective study on implementation of the ESC 0/1-hour algorithm and safety of discharge after rule-out of myocardial infarction.

Stoyanov KM, Hund H, Biener M, Gandowitz J, Riedle C, Löhr J, Mueller-Hennessen M, Vafaie M, Katus HA, Giannitsis E.

Eur Heart J Acute Cardiovasc Care. 2019 Jul 12:2048872619861911. doi: 10.1177/2048872619861911. [Epub ahead of print]


Skeletal myopathies as a non-cardiac cause of elevations of cardiac troponin concentrations.

Giannitsis E, Mueller C, Katus HA.

Diagnosis (Berl). 2019 Aug 27;6(3):189-201. doi: 10.1515/dx-2019-0045. Review.


Application of High-Sensitivity Troponin in Suspected Myocardial Infarction.

Neumann JT, Twerenbold R, Ojeda F, Sörensen NA, Chapman AR, Shah ASV, Anand A, Boeddinghaus J, Nestelberger T, Badertscher P, Mokhtari A, Pickering JW, Troughton RW, Greenslade J, Parsonage W, Mueller-Hennessen M, Gori T, Jernberg T, Morris N, Liebetrau C, Hamm C, Katus HA, Münzel T, Landmesser U, Salomaa V, Iacoviello L, Ferrario MM, Giampaoli S, Kee F, Thorand B, Peters A, Borchini R, Jørgensen T, Söderberg S, Sans S, Tunstall-Pedoe H, Kuulasmaa K, Renné T, Lackner KJ, Worster A, Body R, Ekelund U, Kavsak PA, Keller T, Lindahl B, Wild P, Giannitsis E, Than M, Cullen LA, Mills NL, Mueller C, Zeller T, Westermann D, Blankenberg S.

N Engl J Med. 2019 Jun 27;380(26):2529-2540. doi: 10.1056/NEJMoa1803377.


[Perioperative cardiovasular morbidity and mortality in noncardiac surgical interventions : Measures for optimal anesthesiological care].

Janßen H, Dehne S, Giannitsis E, Weigand MA, Larmann J.

Anaesthesist. 2019 Jun 14. doi: 10.1007/s00101-019-0616-9. [Epub ahead of print] Review. German.


ST-segment elevation myocardial infarction.

Vogel B, Claessen BE, Arnold SV, Chan D, Cohen DJ, Giannitsis E, Gibson CM, Goto S, Katus HA, Kerneis M, Kimura T, Kunadian V, Pinto DS, Shiomi H, Spertus JA, Steg PG, Mehran R.

Nat Rev Dis Primers. 2019 Jun 6;5(1):39. doi: 10.1038/s41572-019-0090-3. Review.


Diagnosis of acute myocardial infarction in the presence of left bundle branch block.

Nestelberger T, Cullen L, Lindahl B, Reichlin T, Greenslade JH, Giannitsis E, Christ M, Morawiec B, Miro O, Martín-Sánchez FJ, Wussler DN, Koechlin L, Twerenbold R, Parsonage W, Boeddinghaus J, Rubini Gimenez M, Puelacher C, Wildi K, Buerge T, Badertscher P, DuFaydeLavallaz J, Strebel I, Croton L, Bendig G, Osswald S, Pickering JW, Than M, Mueller C; APACE, ADAPT and TRAPID-AMI Investigators.

Heart. 2019 May 29. pii: heartjnl-2018-314673. doi: 10.1136/heartjnl-2018-314673. [Epub ahead of print]


[Cardiac troponins and beyond in acute coronary syndrome].

Vafaie M, Stoyanov KM, Katus HA, Giannitsis E.

Internist (Berl). 2019 Jun;60(6):555-563. doi: 10.1007/s00108-019-0611-x. Review. German.


[Diagnosis of myocardial infarction in critically ill, ventilated patients].

Vafaie M, Stoyanov KM, Giannitsis E.

Med Klin Intensivmed Notfmed. 2019 May;114(4):290-296. doi: 10.1007/s00063-019-0572-9. Epub 2019 Mar 28. Review. German.


Long-term biological variation of high-sensitivity cardiac troponin T using minimal important differences and reference change values in stable outpatients with cardiovascular disease.

Täger T, Giannitsis E, Greve K, Fröhlich H, Müller-Hennessen M, Vafaie M, Katus HA, Frankenstein L, Biener M.

Clin Biochem. 2019 May;67:7-11. doi: 10.1016/j.clinbiochem.2019.03.003. Epub 2019 Mar 11.


Pathophysiological background and prognostic implication of systolic aortic root motion in non-ischemic dilated cardiomyopathy.

Aurich M, Niemers M, Fuchs P, Greiner S, Müller-Hennessen M, Uhlmann L, Giannitsis E, Ehlermann P, Meder B, Katus HA, Mereles D.

Sci Rep. 2019 Mar 7;9(1):3866. doi: 10.1038/s41598-019-40386-z.


High-sensitivity cardiac troponin T as an independent predictor of stroke in patients admitted to an emergency department with atrial fibrillation.

Vafaie M, Giannitsis E, Mueller-Hennessen M, Biener M, Makarenko E, Yueksel B, Katus HA, Stoyanov KM.

PLoS One. 2019 Feb 12;14(2):e0212278. doi: 10.1371/journal.pone.0212278. eCollection 2019.


Symptoms Predictive of Acute Myocardial Infarction in the Troponin Era: Analysis From the TRAPID-AMI Study.

McCord J, Aurora L, Lindahl B, Giannitsis E, Calle-Muller C, Nowak R, Body R, Christ M, deFilippi CR, Christenson RH, Jacobsen G, Alquezar A, Panteghini M, Melki D, Plebani M, Verschuren F, French J, Bendig G, Weiser S, Mueller C; TRAPID-AMI Investigators.

Crit Pathw Cardiol. 2019 Mar;18(1):10-15. doi: 10.1097/HPC.0000000000000163.


Effect of early tirofiban administration on N-terminal pro-B-type natriuretic peptide level in patients treated with primary percutaneous coronary intervention.

Fabris E, Ottervanger JP, Hermanides RS, Ten Berg JM, Sinagra G, Koopmans PC, Giannitsis E, Hamm C, van 't Hof AWJ.

Catheter Cardiovasc Interv. 2019 Apr 1;93(5):E293-E297. doi: 10.1002/ccd.28043. Epub 2018 Dec 26.


Plasma Concentrations of Myeloid-Derived Growth Factor in Healthy Individuals and Patients with Acute Myocardial Infarction as Assessed by Multiple Reaction Monitoring-Mass Spectrometry.

Polten F, Reboll MR, Widera C, Kempf T, Bethmann K, Gupta P, Miglietta J, Pekcec A, Tillmanns J, Bauersachs J, Giannitsis E, Pich A, Wollert KC.

Anal Chem. 2019 Jan 15;91(2):1302-1308. doi: 10.1021/acs.analchem.8b03041. Epub 2018 Dec 28.


Combined testing of copeptin and high-sensitivity cardiac troponin T at presentation in comparison to other algorithms for rapid rule-out of acute myocardial infarction.

Mueller-Hennessen M, Lindahl B, Giannitsis E, Vafaie M, Biener M, Haushofer AC, Seier J, Christ M, Alquézar-Arbé A, deFilippi CR, McCord J, Body R, Panteghini M, Jernberg T, Plebani M, Verschuren F, French JK, Christenson RH, Dinkel C, Katus HA, Mueller C.

Int J Cardiol. 2019 Feb 1;276:261-267. doi: 10.1016/j.ijcard.2018.10.084. Epub 2018 Oct 26.


Diagnostic and prognostic value of sex- and age-specific cutpoints for high-sensitivity Troponin T in non-ST-elevation acute coronary syndrome.

Widera C, Giannitsis E, Mueller-Hennessen M, Reimann I, Guba-Quint A, Marquardt I, Bethmann K, Meyer S.

Int J Cardiol. 2019 Jan 15;275:13-19. doi: 10.1016/j.ijcard.2018.10.027. Epub 2018 Oct 11.


Cardiovascular magnetic resonance of cardiac morphology and function: impact of different strategies of contour drawing and indexing.

Riffel JH, Schmucker K, Andre F, Ochs M, Hirschberg K, Schaub E, Fritz T, Mueller-Hennessen M, Giannitsis E, Katus HA, Friedrich MG.

Clin Res Cardiol. 2019 Apr;108(4):411-429. doi: 10.1007/s00392-018-1371-7. Epub 2018 Sep 10.


Impact of age on the performance of the ESC 0/1h-algorithms for early diagnosis of myocardial infarction.

Boeddinghaus J, Nestelberger T, Twerenbold R, Neumann JT, Lindahl B, Giannitsis E, Sörensen NA, Badertscher P, Jann JE, Wussler D, Puelacher C, Rubini Giménez M, Wildi K, Strebel I, Du Fay de Lavallaz J, Selman F, Sabti Z, Kozhuharov N, Potlukova E, Rentsch K, Miró Ò, Martin-Sanchez FJ, Morawiec B, Parenica J, Lohrmann J, Kloos W, Buser A, Geigy N, Keller DI, Osswald S, Reichlin T, Westermann D, Blankenberg S, Mueller C; APACE, BACC, and TRAPID-AMI Investigators .

Eur Heart J. 2018 Nov 7;39(42):3780-3794. doi: 10.1093/eurheartj/ehy514.


Cost analysis of early discharge using combined copeptin/cardiac troponin testing versus serial cardiac troponin testing in patients with suspected acute coronary syndrome.

Reinhold T, Giannitsis E, Möckel M, Frankenstein L, Vafaie M, Vollert JO, Slagman A.

PLoS One. 2018 Aug 23;13(8):e0202133. doi: 10.1371/journal.pone.0202133. eCollection 2018.


The German CPU registry: Comparison of smokers and nonsmokers.

Bock D, Senges J, Pohlmann C, Hochadel M, Münzel T, Giannitsis E, Schmitt C, Heusch G, Voigtländer T, Mudra H, Schumacher B, Darius H, Maier LS, Hailer B, Haude M, Gohlke H, Hink U.

Herz. 2018 Jul 27. doi: 10.1007/s00059-018-4733-z. [Epub ahead of print]


The need for dedicated advanced heart failure units to optimize heart failure care: impact of optimized advanced heart failure unit care on heart transplant outcome in high-risk patients.

Kreusser MM, Tschierschke R, Beckendorf J, Baxmann T, Frankenstein L, Dösch AO, Schultz JH, Giannitsis E, Pleger ST, Ruhparwar A, Karck M, Katus HA, Raake PW.

ESC Heart Fail. 2018 Dec;5(6):1108-1117. doi: 10.1002/ehf2.12314. Epub 2018 Jul 9.


Biomarker in cardiology : DGK welcomes ESC Munich 2018.

Katus HA, Giannitsis E.

Clin Res Cardiol. 2018 Aug;107(Suppl 2):10-15. doi: 10.1007/s00392-018-1300-9. Epub 2018 Jun 28. Review.


[Essential cardiac biomarkers in the differential diagnosis of acute chest pain : An update].

Vafaie M, Giannitsis E, Katus HA.

Herz. 2018 Aug;43(5):469-482. doi: 10.1007/s00059-018-4717-z. Review. German.


Amyloid-β (1-40) and Mortality in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome: A Cohort Study.

Stamatelopoulos K, Mueller-Hennessen M, Georgiopoulos G, Sachse M, Boeddinghaus J, Sopova K, Gatsiou A, Amrhein C, Biener M, Vafaie M, Athanasouli F, Stakos D, Pateras K, Twerenbold R, Badertscher P, Nestelberger T, Dimmeler S, Katus HA, Zeiher AM, Mueller C, Giannitsis E, Stellos K.

Ann Intern Med. 2018 Jun 19;168(12):855-865. doi: 10.7326/M17-1540. Epub 2018 May 22.


Troponins: established and novel indications in the management of cardiovascular disease.

Giannitsis E, Katus HA.

Heart. 2018 Oct;104(20):1714-1722. doi: 10.1136/heartjnl-2017-311387. Epub 2018 May 3. Review. No abstract available.


Risk prediction in stable cardiovascular disease using a high-sensitivity cardiac troponin T single biomarker strategy compared to the ESC-SCORE.

Biener M, Giannitsis E, Kuhner M, Zelniker T, Mueller-Hennessen M, Vafaie M, Stoyanov KM, Neumann FJ, Katus HA, Hochholzer W, Valina CM.

Open Heart. 2018 Apr 25;5(1):e000710. doi: 10.1136/openhrt-2017-000710. eCollection 2018.


Clinical performance of a new point-of-care cardiac troponin I test.

Christ M, Geier F, Blaschke S, Giannitsis E, Khellaf M, Mair J, Pariente D, Scharnhorst V, Semjonow V, Hausfater P.

Clin Chem Lab Med. 2018 Jul 26;56(8):1336-1344. doi: 10.1515/cclm-2017-0693.


Reg3β is associated with cardiac inflammation and provides prognostic information in patients with acute coronary syndrome.

Lörchner H, Widera C, Hou Y, Elsässer A, Warnecke H, Giannitsis E, Hulot JS, Braun T, Wollert KC, Pöling J.

Int J Cardiol. 2018 May 1;258:7-13. doi: 10.1016/j.ijcard.2018.01.043.


Guideline-adherence regarding critical time intervals in the German Chest Pain Unit registry.

Vafaie M, Hochadel M, Münzel T, Hailer B, Schumacher B, Heusch G, Voigtländer T, Mudra H, Haude M, Barth S, Schmitt C, Darius H, Maier LS, Katus HA, Senges J, Giannitsis E.

Eur Heart J Acute Cardiovasc Care. 2018 Mar 1:2048872618762639. doi: 10.1177/2048872618762639. [Epub ahead of print]


Variability of cardiovascular magnetic resonance (CMR) T1 mapping parameters in healthy volunteers during long-term follow-up.

Aus dem Siepen F, Baumgärtner C, Müller-Henessen M, André F, Messroghli D, Ochs M, Riffel J, Giannitsis E, Katus HA, Friedrich MG, Buss SJ.

Open Heart. 2018 Feb 24;5(1):e000717. doi: 10.1136/openhrt-2017-000717. eCollection 2018.


Invasive treatment of NSTEMI patients in German Chest Pain Units - Evidence for a treatment paradox.

Schmidt FP, Schmitt C, Hochadel M, Giannitsis E, Darius H, Maier LS, Schmitt C, Heusch G, Voigtländer T, Mudra H, Gori T, Senges J, Münzel T; German Chest Pain Unit Registry.

Int J Cardiol. 2018 Mar 15;255:15-19. doi: 10.1016/j.ijcard.2017.11.018.


Unidimensional Longitudinal Strain: A Simple Approach for the Assessment of Longitudinal Myocardial Deformation by Echocardiography.

Aurich M, Fuchs P, Müller-Hennessen M, Uhlmann L, Niemers M, Greiner S, Täger T, Hirschberg K, Ehlermann P, Meder B, Frankenstein L, Giannitsis E, Katus HA, Mereles D.

J Am Soc Echocardiogr. 2018 Jun;31(6):733-742. doi: 10.1016/j.echo.2017.12.010. Epub 2018 Feb 21.


Correction: Economic evaluation of the one-hour rule-out and rule-in algorithm for acute myocardial infarction using the high-sensitivity cardiac troponin T assay in the emergency department.

Ambavane A, Lindahl B, Giannitsis E, Roiz J, Mendivil J, Frankenstein L, Body R, Christ M, Bingisser R, Alquezar A, Mueller C; TRAPID-AMI investigators.

PLoS One. 2018 Jan 11;13(1):e0191348. doi: 10.1371/journal.pone.0191348. eCollection 2018.


How is cardiac troponin released from injured myocardium?

Mair J, Lindahl B, Hammarsten O, Müller C, Giannitsis E, Huber K, Möckel M, Plebani M, Thygesen K, Jaffe AS.

Eur Heart J Acute Cardiovasc Care. 2018 Sep;7(6):553-560. doi: 10.1177/2048872617748553. Epub 2017 Dec 27. Review.


Rationale and design of the IMPACT EU-trial: improve management of heart failure with procalcitonin biomarkers in cardiology (BIC)-18.

Möckel M, Slagman A, Vollert JO, Ebmeyer S, Wiemer JC, Searle J, Giannitsis E, Kellum JA, Maisel A.

Biomarkers. 2018 Feb;23(1):97-103. doi: 10.1080/1354750X.2017.1420823. Epub 2018 Jan 8.


Platelet function monitoring for stent thrombosis in critically III patients with an acute Coronary syndrome.

Tilemann L, Mohr SK, Preusch M, Chorianopoulos E, Giannitsis E, Katus HA, Müller OJ.

J Interv Cardiol. 2018 Jun;31(3):277-283. doi: 10.1111/joic.12474. Epub 2017 Dec 6.


TIMP-1: is surrogate testing for extracellular matrix remodelling ready for clinical translation or only an Icelandic phenomenon?

Giannitsis E, Katus HA.

Eur Heart J. 2017 Dec 7;38(46):3431-3433. doi: 10.1093/eurheartj/ehx632. No abstract available.


Economic evaluation of the one-hour rule-out and rule-in algorithm for acute myocardial infarction using the high-sensitivity cardiac troponin T assay in the emergency department.

Ambavane A, Lindahl B, Giannitsis E, Roiz J, Mendivil J, Frankenstein L, Body R, Christ M, Bingisser R, Alquezar A, Mueller C; TRAPID-AMI investigators.

PLoS One. 2017 Nov 9;12(11):e0187662. doi: 10.1371/journal.pone.0187662. eCollection 2017. Erratum in: PLoS One. 2018 Jan 11;13(1):e0191348.


Early diagnosis of acute coronary syndrome.

Katus H, Ziegler A, Ekinci O, Giannitsis E, Stough WG, Achenbach S, Blankenberg S, Brueckmann M, Collinson P, Comaniciu D, Crea F, Dinh W, Ducrocq G, Flachskampf FA, Fox KAA, Friedrich MG, Hebert KA, Himmelmann A, Hlatky M, Lautsch D, Lindahl B, Lindholm D, Mills NL, Minotti G, Möckel M, Omland T, Semjonow V.

Eur Heart J. 2017 Nov 1;38(41):3049-3055. doi: 10.1093/eurheartj/ehx492.


The Reply.

Biener M, Giannitsis E, Katus HA.

Am J Med. 2017 Oct;130(10):e461. doi: 10.1016/j.amjmed.2017.06.032. No abstract available.


Quantification of Renal Function and Cardiovascular Mortality in Patients Admitted to the Emergency Department with Suspected Acute Coronary Syndromes.

Bahrmann P, Bertsch T, Giannitsis E, Christ M, Hofner B, Christenson R, Lindahl B, Mueller C.

Clin Lab. 2017 Sep 1;63(9):1457-1466. doi: 10.7754/Clin.Lab.2017.170326.


[Dual Antiplatelet Therapy in the Perioperative Period - To Continue or Discontinue Treatment?]

Koscielny J, von Heymann C, Zeymer U, Cremer J, Spannagl M, Labenz J, Giannitsis E, Goss F.

Dtsch Med Wochenschr. 2017 Aug;142(16):1223-1230. doi: 10.1055/s-0043-104372. Epub 2017 Aug 15. German.


Comparative accuracy of NT-proBNP and MR-proANP for the diagnosis of acute heart failure in dyspnoeic patients.

Darche FF, Baumgärtner C, Biener M, Müller-Hennessen M, Vafaie M, Koch V, Stoyanov K, Rivinius R, Katus HA, Giannitsis E.

ESC Heart Fail. 2017 Aug;4(3):232-240. doi: 10.1002/ehf2.12150. Epub 2017 Apr 21.


Long-term mortality and prehospital tirofiban treatment in patients with ST elevation myocardial infarction.

Fabris E, Kilic S, Schellings DAAM, Ten Berg JM, Kennedy MW, van Houwelingen KG, Giannitsis E, Kolkman E, Ottervanger JP, Hamm C, Van't Hof AWJ.

Heart. 2017 Oct;103(19):1515-1520. doi: 10.1136/heartjnl-2017-311181. Epub 2017 Jul 5.


Prognostic Value of Serum Troponin T in Unstable Angina.

Katus HA, Giannitsis E.

Clin Chem. 2018 Feb;64(2):396-397. doi: 10.1373/clinchem.2017.272799. Epub 2017 Jun 23. Review. No abstract available.


Aptamer-based proteomic profiling for prognostication in pulmonary arterial hypertension.

Giannitsis E, Mueller-Hennessen M, Katus HA.

Lancet Respir Med. 2017 Sep;5(9):671-672. doi: 10.1016/S2213-2600(17)30209-6. Epub 2017 Jun 15. No abstract available.


Use of copeptin for rapid rule-out of acute myocardial infarction.

Mueller C, Möckel M, Giannitsis E, Huber K, Mair J, Plebani M, Thygesen K, Jaffe AS, Lindahl B; ESC Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association.

Eur Heart J Acute Cardiovasc Care. 2018 Sep;7(6):570-576. doi: 10.1177/2048872617710791. Epub 2017 Jun 8. Review.


Concerns About the Stability of hsTnI Assay After 20 Years of Storage.

Giannitsis E, Katus HA.

J Am Coll Cardiol. 2017 Jun 6;69(22):2772-2773. doi: 10.1016/j.jacc.2017.01.077. No abstract available.

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