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Items: 21


The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation.

Solga AC, Toonen JA, Pan Y, Cimino PJ, Ma Y, Castillon GA, Gianino SM, Ellisman MH, Lee DY, Gutmann DH.

Oncotarget. 2017 Jul 18;8(29):47206-47215. doi: 10.18632/oncotarget.17589.


NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1.

Toonen JA, Anastasaki C, Smithson LJ, Gianino SM, Li K, Kesterson RA, Gutmann DH.

Hum Mol Genet. 2016 May 1;25(9):1703-13. doi: 10.1093/hmg/ddw039. Epub 2016 Feb 16.


Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways.

Chen YH, Gianino SM, Gutmann DH.

Genes Dev. 2015 Aug 15;29(16):1677-82. doi: 10.1101/gad.261677.115. Epub 2015 Aug 13.


Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.

Kaul A, Toonen JA, Cimino PJ, Gianino SM, Gutmann DH.

Neuro Oncol. 2015 Jun;17(6):843-53. doi: 10.1093/neuonc/nou329. Epub 2014 Dec 21.


The impact of coexisting genetic mutations on murine optic glioma biology.

Kaul A, Toonen JA, Gianino SM, Gutmann DH.

Neuro Oncol. 2015 May;17(5):670-7. doi: 10.1093/neuonc/nou287. Epub 2014 Sep 21.


Reply: To PMID 24375753.

Diggs-Andrews KA, Brown JA, Gianino SM, D'Agostino McGowan L, Rubin JB, Wozniak DF, Gutmann DH.

Ann Neurol. 2014 May;75(5):800-1. doi: 10.1002/ana.24156. Epub 2014 Apr 28. No abstract available.


Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1.

Diggs-Andrews KA, Brown JA, Gianino SM, Rubin JB, Wozniak DF, Gutmann DH.

Ann Neurol. 2014 Feb;75(2):309-16. doi: 10.1002/ana.24093. Epub 2014 Feb 6.


Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects.

Kaul A, Chen YH, Emnett RJ, Gianino SM, Gutmann DH.

Genesis. 2013 Oct;51(10):708-16. doi: 10.1002/dvg.22415. Epub 2013 Aug 16.


Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation.

Pong WW, Higer SB, Gianino SM, Emnett RJ, Gutmann DH.

Ann Neurol. 2013 Feb;73(2):303-8. doi: 10.1002/ana.23813. Epub 2013 Feb 19.


NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma.

Solga AC, Gianino SM, Gutmann DH.

Oncogene. 2014 Jan 16;33(3):289-99. doi: 10.1038/onc.2012.580. Epub 2013 Jan 14.


Innate neural stem cell heterogeneity determines the patterning of glioma formation in children.

Lee DY, Gianino SM, Gutmann DH.

Cancer Cell. 2012 Jul 10;22(1):131-8. doi: 10.1016/j.ccr.2012.05.036.


Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner.

Brown JA, Diggs-Andrews KA, Gianino SM, Gutmann DH.

Mol Cell Neurosci. 2012 Jan;49(1):13-22. doi: 10.1016/j.mcn.2011.08.008. Epub 2011 Aug 26.


Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.

Banerjee S, Crouse NR, Emnett RJ, Gianino SM, Gutmann DH.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15996-6001. doi: 10.1073/pnas.1019012108. Epub 2011 Sep 6.


Interpreting mammalian target of rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes.

Banerjee S, Gianino SM, Gao F, Christians U, Gutmann DH.

Mol Cancer Ther. 2011 Feb;10(2):279-91. doi: 10.1158/1535-7163.MCT-10-0654. Epub 2011 Jan 7.


Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth.

Simmons GW, Pong WW, Emnett RJ, White CR, Gianino SM, Rodriguez FJ, Gutmann DH.

J Neuropathol Exp Neurol. 2011 Jan;70(1):51-62. doi: 10.1097/NEN.0b013e3182032d37.


CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice.

Sun T, Gianino SM, Jackson E, Piwnica-Worms D, Gutmann DH, Rubin JB.

J Neuroimmunol. 2010 Jul 27;224(1-2):108-13. doi: 10.1016/j.jneuroim.2010.05.002.


Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1.

Warrington NM, Gianino SM, Jackson E, Goldhoff P, Garbow JR, Piwnica-Worms D, Gutmann DH, Rubin JB.

Cancer Res. 2010 Jul 15;70(14):5717-27. doi: 10.1158/0008-5472.CAN-09-3769. Epub 2010 Jun 15.


Defective cAMP generation underlies the sensitivity of CNS neurons to neurofibromatosis-1 heterozygosity.

Brown JA, Gianino SM, Gutmann DH.

J Neurosci. 2010 Apr 21;30(16):5579-89. doi: 10.1523/JNEUROSCI.3994-09.2010.


The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo.

Banerjee S, Byrd JN, Gianino SM, Harpstrite SE, Rodriguez FJ, Tuskan RG, Reilly KM, Piwnica-Worms DR, Gutmann DH.

Cancer Res. 2010 Feb 15;70(4):1356-66. doi: 10.1158/0008-5472.CAN-09-2178. Epub 2010 Feb 2.


Increased c-Jun-NH2-kinase signaling in neurofibromatosis-1 heterozygous microglia drives microglia activation and promotes optic glioma proliferation.

Daginakatte GC, Gianino SM, Zhao NW, Parsadanian AS, Gutmann DH.

Cancer Res. 2008 Dec 15;68(24):10358-66. doi: 10.1158/0008-5472.CAN-08-2506.

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