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Mice lacking angiotensin type 2 receptor exhibit a sex-specific attenuation of insulin sensitivity.

Quiroga DT, Miquet JG, Gonzalez L, Sotelo AI, Muñoz MC, Geraldes PM, Giani JF, Dominici FP.

Mol Cell Endocrinol. 2019 Sep 17:110587. doi: 10.1016/j.mce.2019.110587. [Epub ahead of print]


ATP release drives heightened immune responses associated with hypertension.

Zhao TV, Li Y, Liu X, Xia S, Shi P, Li L, Chen Z, Yin C, Eriguchi M, Chen Y, Bernstein EA, Giani JF, Bernstein KE, Shen XZ.

Sci Immunol. 2019 Jun 28;4(36). pii: eaau6426. doi: 10.1126/sciimmunol.aau6426.


Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization.

Khan Z, Cao DY, Giani JF, Bernstein EA, Veiras LC, Fuchs S, Wang Y, Peng Z, Kalkum M, Liu GY, Bernstein KE.

J Biol Chem. 2019 Mar 22;294(12):4368-4380. doi: 10.1074/jbc.RA118.006275. Epub 2019 Jan 22.


The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease.

Eriguchi M, Bernstein EA, Veiras LC, Khan Z, Cao DY, Fuchs S, McDonough AA, Toblli JE, Gonzalez-Villalobos RA, Bernstein KE, Giani JF.

J Am Soc Nephrol. 2018 Oct;29(10):2546-2561. doi: 10.1681/ASN.2018030323. Epub 2018 Sep 5.


Chronic administration of the angiotensin type 2 receptor agonist C21 improves insulin sensitivity in C57BL/6 mice.

Quiroga DT, Muñoz MC, Gil C, Pffeifer M, Toblli JE, Steckelings UM, Giani JF, Dominici FP.

Physiol Rep. 2018 Aug;6(16):e13824. doi: 10.14814/phy2.13824.


Angiotensin-converting enzyme inhibitor works as a scar formation inhibitor by down-regulating Smad and TGF-β-activated kinase 1 (TAK1) pathways in mice.

Tan WQ, Fang QQ, Shen XZ, Giani JF, Zhao TV, Shi P, Zhang LY, Khan Z, Li Y, Li L, Xu JH, Bernstein EA, Bernstein KE.

Br J Pharmacol. 2018 Nov;175(22):4239-4252. doi: 10.1111/bph.14489. Epub 2018 Oct 8.


Angiotensin II-Induced End-Organ Damage in Mice Is Attenuated by Human Exosomes and by an Exosomal Y RNA Fragment.

Cambier L, Giani JF, Liu W, Ijichi T, Echavez AK, Valle J, Marbán E.

Hypertension. 2018 Aug;72(2):370-380. doi: 10.1161/HYPERTENSIONAHA.118.11239. Epub 2018 Jun 4.


Angiotensin-converting enzyme in innate and adaptive immunity.

Bernstein KE, Khan Z, Giani JF, Cao DY, Bernstein EA, Shen XZ.

Nat Rev Nephrol. 2018 May;14(5):325-336. doi: 10.1038/nrneph.2018.15. Epub 2018 Mar 26. Review.


Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy.

Eriguchi M, Lin M, Yamashita M, Zhao TV, Khan Z, Bernstein EA, Gurley SB, Gonzalez-Villalobos RA, Bernstein KE, Giani JF.

Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F531-F542. doi: 10.1152/ajprenal.00523.2017. Epub 2017 Nov 29.


Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways.

Hyndman KA, Mironova EV, Giani JF, Dugas C, Collins J, McDonough AA, Stockand JD, Pollock JS.

J Am Heart Assoc. 2017 Oct 24;6(10). pii: e006896. doi: 10.1161/JAHA.117.006896.


Markers of oxidative/nitrosative stress and inflammation in lung tissue of rats exposed to different intravenous iron compounds.

Toblli JE, Cao G, Giani JF, Dominici FP, Angerosa M.

Drug Des Devel Ther. 2017 Aug 1;11:2251-2263. doi: 10.2147/DDDT.S132612. eCollection 2017.


Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils.

Khan Z, Shen XZ, Bernstein EA, Giani JF, Eriguchi M, Zhao TV, Gonzalez-Villalobos RA, Fuchs S, Liu GY, Bernstein KE.

Blood. 2017 Jul 20;130(3):328-339. doi: 10.1182/blood-2016-11-752006. Epub 2017 May 17.


Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity.

Giani JF, Eriguchi M, Bernstein EA, Katsumata M, Shen XZ, Li L, McDonough AA, Fuchs S, Bernstein KE, Gonzalez-Villalobos RA.

Kidney Int. 2017 Apr;91(4):856-867. doi: 10.1016/j.kint.2016.10.007. Epub 2016 Dec 15.


Intravenous iron sucrose reverses anemia-induced cardiac remodeling, prevents myocardial fibrosis, and improves cardiac function by attenuating oxidative/nitrosative stress and inflammation.

Toblli JE, Cao G, Rivas C, Giani JF, Dominici FP.

Int J Cardiol. 2016 Jun 1;212:84-91. doi: 10.1016/j.ijcard.2016.03.039. Epub 2016 Mar 17.


Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response.

Bernstein KE, Khan Z, Giani JF, Zhao T, Eriguchi M, Bernstein EA, Gonzalez-Villalobos RA, Shen XZ.

F1000Res. 2016 Mar 23;5. pii: F1000 Faculty Rev-393. doi: 10.12688/f1000research.7508.1. eCollection 2016. Review.


Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension.

Shah KH, Shi P, Giani JF, Janjulia T, Bernstein EA, Li Y, Zhao T, Harrison DG, Bernstein KE, Shen XZ.

Circ Res. 2015 Oct 23;117(10):858-69. doi: 10.1161/CIRCRESAHA.115.306539. Epub 2015 Aug 20.


Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice.

Torrente AG, Zhang R, Zaini A, Giani JF, Kang J, Lamp ST, Philipson KD, Goldhaber JI.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9769-74. doi: 10.1073/pnas.1505670112. Epub 2015 Jul 20.


Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme.

Giani JF, Bernstein KE, Janjulia T, Han J, Toblli JE, Shen XZ, Rodriguez-Iturbe B, McDonough AA, Gonzalez-Villalobos RA.

Hypertension. 2015 Sep;66(3):534-42. doi: 10.1161/HYPERTENSIONAHA.115.05320. Epub 2015 Jul 6.


The intrarenal generation of angiotensin II is required for experimental hypertension.

Giani JF, Shah KH, Khan Z, Bernstein EA, Shen XZ, McDonough AA, Gonzalez-Villalobos RA, Bernstein KE.

Curr Opin Pharmacol. 2015 Apr;21:73-81. doi: 10.1016/j.coph.2015.01.002. Epub 2015 Jan 21. Review.


Renal generation of angiotensin II and the pathogenesis of hypertension.

Giani JF, Janjulia T, Taylor B, Bernstein EA, Shah K, Shen XZ, McDonough AA, Bernstein KE, Gonzalez-Villalobos RA.

Curr Hypertens Rep. 2014 Sep;16(9):477. doi: 10.1007/s11906-014-0477-1. Review.


Nitrosative Stress and Apoptosis by Intravenous Ferumoxytol, Iron Isomaltoside 1000, Iron Dextran, Iron Sucrose, and Ferric Carboxymaltose in a Nonclinical Model.

Toblli JE, Cao G, Giani JF, Dominici FP, Angerosa M.

Drug Res (Stuttg). 2015 Jul;65(7):354-60. doi: 10.1055/s-0034-1384534. Epub 2014 Jul 22.


Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition.

Giani JF, Janjulia T, Kamat N, Seth DM, Blackwell WL, Shah KH, Shen XZ, Fuchs S, Delpire E, Toblli JE, Bernstein KE, McDonough AA, Gonzalez-Villalobos RA.

J Am Soc Nephrol. 2014 Dec;25(12):2752-63. doi: 10.1681/ASN.2013091030. Epub 2014 Jul 10.


Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model.

Toblli JE, Rivas C, Cao G, Giani JF, Funk F, Mizzen L, Dominici FP.

Chemother Res Pract. 2014;2014:570241. doi: 10.1155/2014/570241. Epub 2014 Apr 30.


ACE overexpression in myelomonocytic cells: effect on a mouse model of Alzheimer's disease.

Koronyo-Hamaoui M, Shah K, Koronyo Y, Bernstein E, Giani JF, Janjulia T, Black KL, Shi PD, Gonzalez-Villalobos RA, Fuchs S, Shen XZ, Bernstein KE.

Curr Hypertens Rep. 2014 Jul;16(7):444. doi: 10.1007/s11906-014-0444-x. Review.


Downregulation of the ACE2/Ang-(1-7)/Mas axis in transgenic mice overexpressing GH.

Muñoz MC, Burghi V, Miquet JG, Giani JF, Banegas RD, Toblli JE, Fang Y, Wang F, Bartke A, Dominici FP.

J Endocrinol. 2014 Apr 22;221(2):215-27. doi: 10.1530/JOE-13-0497. Print 2014 May.


Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response.

Bernstein KE, Gonzalez-Villalobos RA, Giani JF, Shah K, Bernstein E, Janjulia T, Koronyo Y, Shi PD, Koronyo-Hamaoui M, Fuchs S, Shen XZ.

Biol Chem. 2014 Oct;395(10):1173-8. doi: 10.1515/hsz-2013-0295. Review.


Modulation of the action of insulin by angiotensin-(1-7).

Dominici FP, Burghi V, Muñoz MC, Giani JF.

Clin Sci (Lond). 2014 May;126(9):613-30. doi: 10.1042/CS20130333. Review.


Ischemic postconditioning reduces infarct size through the α1-adrenergic receptor pathway.

Buchholz B, D Annunzio V, Giani JF, Siachoque N, Dominici FP, Turyn D, Perez V, Donato M, Gelpi RJ.

J Cardiovasc Pharmacol. 2014 Jun;63(6):504-11. doi: 10.1097/FJC.0000000000000074.


Renal angiotensin-converting enzyme and blood pressure control.

Bernstein KE, Giani JF, Shen XZ, Gonzalez-Villalobos RA.

Curr Opin Nephrol Hypertens. 2014 Mar;23(2):106-12. doi: 10.1097/01.mnh.0000441047.13912.56. Review.


Oral administration of angiotensin-(1-7) ameliorates type 2 diabetes in rats.

Santos SH, Giani JF, Burghi V, Miquet JG, Qadri F, Braga JF, Todiras M, Kotnik K, Alenina N, Dominici FP, Santos RA, Bader M.

J Mol Med (Berl). 2014 Mar;92(3):255-65. doi: 10.1007/s00109-013-1087-0. Epub 2013 Oct 27.


Central insulin-angiotensin II interaction in blood pressure regulation in fructose overloaded rats.

Mayer MA, Höcht C, Giani JF, Muñoz MC, Carranza A, Taira CA, Dominici FP, Puyó AM, Fernández BE.

Regul Pept. 2013 Aug 10;185:37-43. doi: 10.1016/j.regpep.2013.06.001. Epub 2013 Jun 28.


Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme.

Gonzalez-Villalobos RA, Shen XZ, Bernstein EA, Janjulia T, Taylor B, Giani JF, Blackwell WL, Shah KH, Shi PD, Fuchs S, Bernstein KE.

J Mol Med (Berl). 2013 Oct;91(10):1143-54. doi: 10.1007/s00109-013-1051-z. Epub 2013 May 18. Review.


The absence of intrarenal ACE protects against hypertension.

Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, McDonough AA.

J Clin Invest. 2013 May;123(5):2011-23. doi: 10.1172/JCI65460. Epub 2013 Apr 24.


Angiotensin II type 1 receptor-associated protein: a novel modulator of angiotensin II actions in the nephron.

Giani JF, Fuchs S, Gonzalez-Villalobos RA.

Hypertension. 2013 Jun;61(6):1150-2. doi: 10.1161/HYPERTENSIONAHA.113.01150. Epub 2013 Mar 25. No abstract available.


A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme.

Bernstein KE, Ong FS, Blackwell WL, Shah KH, Giani JF, Gonzalez-Villalobos RA, Shen XZ, Fuchs S, Touyz RM.

Pharmacol Rev. 2012 Dec 20;65(1):1-46. doi: 10.1124/pr.112.006809. Print 2013 Jan. Review. Erratum in: Pharmacol Rev. 2013;65(1):544.


Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice.

Giani JF, Miquet JG, Muñoz MC, Burghi V, Toblli JE, Masternak MM, Kopchick JJ, Bartke A, Turyn D, Dominici FP.

Growth Horm IGF Res. 2012 Dec;22(6):224-33. doi: 10.1016/j.ghir.2012.08.003. Epub 2012 Sep 2.


The Mas receptor mediates modulation of insulin signaling by angiotensin-(1-7).

Muñoz MC, Giani JF, Burghi V, Mayer MA, Carranza A, Taira CA, Dominici FP.

Regul Pept. 2012 Aug 20;177(1-3):1-11. doi: 10.1016/j.regpep.2012.04.001. Epub 2012 May 1.


Angiotensin-(1-7) attenuates diabetic nephropathy in Zucker diabetic fatty rats.

Giani JF, Burghi V, Veiras LC, Tomat A, Muñoz MC, Cao G, Turyn D, Toblli JE, Dominici FP.

Am J Physiol Renal Physiol. 2012 Jun 15;302(12):F1606-15. doi: 10.1152/ajprenal.00063.2012. Epub 2012 Apr 4.


Nebivolol: impact on cardiac and endothelial function and clinical utility.

Toblli JE, DiGennaro F, Giani JF, Dominici FP.

Vasc Health Risk Manag. 2012;8:151-60. doi: 10.2147/VHRM.S20669. Epub 2012 Mar 13. Review.


Prolonged exposure to GH impairs insulin signaling in the heart.

Miquet JG, Giani JF, Martinez CS, Muñoz MC, González L, Sotelo AI, Boparai RK, Masternak MM, Bartke A, Dominici FP, Turyn D.

J Mol Endocrinol. 2011 Aug 30;47(2):167-77. doi: 10.1530/JME-11-0066. Print 2011 Oct.


Long-term treatment with nebivolol attenuates renal damage in Zucker diabetic fatty rats.

Toblli JE, Cao G, Giani JF, Muñoz MC, Angerosa M, Dominici FP.

J Hypertens. 2011 Aug;29(8):1613-23. doi: 10.1097/HJH.0b013e328349064c.


Antifibrotic effects of pioglitazone at low doses on the diabetic rat kidney are associated with the improvement of markers of cell turnover, tubular and endothelial integrity, and angiogenesis.

Toblli JE, Cao G, Giani JF, Angerosa M, Dominici FP, Gonzalez-Cadavid NF.

Kidney Blood Press Res. 2011;34(1):20-33. doi: 10.1159/000320380. Epub 2010 Nov 11.


Angiotensin-(1-7) reduces proteinuria and diminishes structural damage in renal tissue of stroke-prone spontaneously hypertensive rats.

Giani JF, Muñoz MC, Pons RA, Cao G, Toblli JE, Turyn D, Dominici FP.

Am J Physiol Renal Physiol. 2011 Jan;300(1):F272-82. doi: 10.1152/ajprenal.00278.2010. Epub 2010 Oct 20.


Centrally administered insulin potentiates the pressor response to angiotensin II.

Mayer MA, Giani JF, Höcht C, Silberman EA, Muñoz MC, Taira CA, Dominici FP, Puyó AM, Fernández BE.

Regul Pept. 2010 Aug 9;163(1-3):57-61. doi: 10.1016/j.regpep.2010.04.001. Epub 2010 Apr 28.


Angiotensin-(1-7) stimulates the phosphorylation of Akt in rat extracardiac tissues in vivo via receptor Mas.

Muñoz MC, Giani JF, Dominici FP.

Regul Pept. 2010 Apr 9;161(1-3):1-7. doi: 10.1016/j.regpep.2010.02.001. Epub 2010 Feb 25.


Angiotensin-(1-7) improves cardiac remodeling and inhibits growth-promoting pathways in the heart of fructose-fed rats.

Giani JF, Muñoz MC, Mayer MA, Veiras LC, Arranz C, Taira CA, Turyn D, Toblli JE, Dominici FP.

Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1003-13. doi: 10.1152/ajpheart.00803.2009. Epub 2010 Jan 8.


Ames dwarf (Prop1(df)/Prop1(df)) mice display increased sensitivity of the major GH-signaling pathways in liver and skeletal muscle.

Miquet JG, Muñoz MC, Giani JF, González L, Dominici FP, Bartke A, Turyn D, Sotelo AI.

Growth Horm IGF Res. 2010 Apr;20(2):118-26. doi: 10.1016/j.ghir.2009.11.003. Epub 2009 Dec 21.


Long-term treatment with an angiotensin II receptor blocker decreases adipocyte size and improves insulin signaling in obese Zucker rats.

Muñoz MC, Giani JF, Dominici FP, Turyn D, Toblli JE.

J Hypertens. 2009 Dec;27(12):2409-20. doi: 10.1097/HJH.0b013e3283310e1b.


TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance.

Muñoz MC, Giani JF, Mayer MA, Toblli JE, Turyn D, Dominici FP.

J Endocrinol. 2009 May;201(2):185-97. doi: 10.1677/JOE-08-0276. Epub 2009 Feb 27.


Chronic infusion of angiotensin-(1-7) improves insulin resistance and hypertension induced by a high-fructose diet in rats.

Giani JF, Mayer MA, Muñoz MC, Silberman EA, Höcht C, Taira CA, Gironacci MM, Turyn D, Dominici FP.

Am J Physiol Endocrinol Metab. 2009 Feb;296(2):E262-71. doi: 10.1152/ajpendo.90678.2008. Epub 2008 Nov 11.

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