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Items: 1 to 50 of 83

1.

Immune Mediators of Pathology in Neurobrucellosis: From Blood to Central Nervous System.

Rodríguez AM, Delpino MV, Miraglia MC, Giambartolomei GH.

Neuroscience. 2019 Jul 1;410:264-273. doi: 10.1016/j.neuroscience.2019.05.018. Epub 2019 May 23. Review.

PMID:
31128159
2.

Endocrine modulation of Brucella abortus-infected osteocytes function and osteoclastogenesis via modulation of RANKL/OPG.

Pesce Viglietti AI, Giambartolomei GH, Delpino MV.

Microbes Infect. 2019 Feb 5. pii: S1286-4579(19)30006-1. doi: 10.1016/j.micinf.2019.01.004. [Epub ahead of print]

PMID:
30735720
3.

Inhibition of antigen presentation by Brucella: many more than many ways.

Barrionuevo P, Giambartolomei GH.

Microbes Infect. 2019 Jan 21. pii: S1286-4579(19)30002-4. doi: 10.1016/j.micinf.2018.12.004. [Epub ahead of print] Review.

PMID:
30677519
4.

B. Abortus Modulates Osteoblast Function Through the Induction of Autophagy.

Pesce Viglietti AI, Gentilini MV, Arriola Benitez PC, Giambartolomei GH, Delpino MV.

Front Cell Infect Microbiol. 2018 Dec 4;8:425. doi: 10.3389/fcimb.2018.00425. eCollection 2018.

6.

Brucella abortus Traverses Brain Microvascular Endothelial Cells Using Infected Monocytes as a Trojan Horse.

Miraglia MC, Rodriguez AM, Barrionuevo P, Rodriguez J, Kim KS, Dennis VA, Delpino MV, Giambartolomei GH.

Front Cell Infect Microbiol. 2018 Jun 14;8:200. doi: 10.3389/fcimb.2018.00200. eCollection 2018.

7.

Platelets Promote Brucella abortus Monocyte Invasion by Establishing Complexes With Monocytes.

Trotta A, Velásquez LN, Milillo MA, Delpino MV, Rodríguez AM, Landoni VI, Giambartolomei GH, Pozner RG, Barrionuevo P.

Front Immunol. 2018 May 7;9:1000. doi: 10.3389/fimmu.2018.01000. eCollection 2018.

8.

Inhibition of Osteoblast Function by Brucella abortus is Reversed by Dehydroepiandrosterone and Involves ERK1/2 and Estrogen Receptor.

Gentilini MV, Pesce Viglietti AI, Arriola Benitez PC, Iglesias Molli AE, Cerrone GE, Giambartolomei GH, Delpino MV.

Front Immunol. 2018 Jan 26;9:88. doi: 10.3389/fimmu.2018.00088. eCollection 2018.

9.
10.

Brucella abortus Promotes a Fibrotic Phenotype in Hepatic Stellate Cells, with Concomitant Activation of the Autophagy Pathway.

Arriola Benitez PC, Pesce Viglietti AI, Herrmann CK, Dennis VA, Comerci DJ, Giambartolomei GH, Delpino MV.

Infect Immun. 2017 Dec 19;86(1). pii: e00522-17. doi: 10.1128/IAI.00522-17. Print 2018 Jan.

11.

B. abortus RNA is the component involved in the down-modulation of MHC-I expression on human monocytes via TLR8 and the EGFR pathway.

Milillo MA, Velásquez LN, Trotta A, Delpino MV, Marinho FV, Balboa L, Vermeulen M, Espindola SL, Rodriguez-Rodrigues N, Fernández GC, Oliveira SC, Giambartolomei GH, Barrionuevo P.

PLoS Pathog. 2017 Aug 2;13(8):e1006527. doi: 10.1371/journal.ppat.1006527. eCollection 2017 Aug.

12.

Brucella abortus-activated microglia induce neuronal death through primary phagocytosis.

Rodríguez AM, Delpino MV, Miraglia MC, Costa Franco MM, Barrionuevo P, Dennis VA, Oliveira SC, Giambartolomei GH.

Glia. 2017 Jul;65(7):1137-1151. doi: 10.1002/glia.23149. Epub 2017 Apr 11.

PMID:
28398652
13.

Brucella and Osteoarticular Cell Activation: Partners in Crime.

Giambartolomei GH, Arriola Benitez PC, Delpino MV.

Front Microbiol. 2017 Feb 20;8:256. doi: 10.3389/fmicb.2017.00256. eCollection 2017. Review.

14.

Inhibition of MHC-I by Brucella abortus is an early event during infection and involves EGFR pathway.

Velásquez LN, Milillo MA, Delpino MV, Trotta A, Mercogliano MF, Pozner RG, Schillaci R, Elizalde PV, Giambartolomei GH, Barrionuevo P.

Immunol Cell Biol. 2017 Apr;95(4):388-398. doi: 10.1038/icb.2016.111. Epub 2016 Nov 29.

PMID:
27811842
15.

Brucella abortus down-regulates MHC class II by the IL-6-dependent inhibition of CIITA through the downmodulation of IFN regulatory factor-1 (IRF-1).

Velásquez LN, Milillo MA, Delpino MV, Trotta A, Fernández P, Pozner RG, Lang R, Balboa L, Giambartolomei GH, Barrionuevo P.

J Leukoc Biol. 2017 Mar;101(3):759-773. doi: 10.1189/jlb.4A0416-196R. Epub 2016 Oct 20.

PMID:
27765819
16.

The role of NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection.

Marim FM, Franco MMC, Gomes MTR, Miraglia MC, Giambartolomei GH, Oliveira SC.

Semin Immunopathol. 2017 Feb;39(2):215-223. doi: 10.1007/s00281-016-0581-1. Epub 2016 Jul 12. Review.

17.

Brucella abortus-infected B cells induce osteoclastogenesis.

Pesce Viglietti AI, Arriola Benitez PC, Giambartolomei GH, Delpino MV.

Microbes Infect. 2016 Sep;18(9):529-35. doi: 10.1016/j.micinf.2016.04.001. Epub 2016 Apr 22.

PMID:
27109230
18.

A Brucella spp. Protease Inhibitor Limits Antigen Lysosomal Proteolysis, Increases Cross-Presentation, and Enhances CD8+ T Cell Responses.

Coria LM, Ibañez AE, Tkach M, Sabbione F, Bruno L, Carabajal MV, Berguer PM, Barrionuevo P, Schillaci R, Trevani AS, Giambartolomei GH, Pasquevich KA, Cassataro J.

J Immunol. 2016 May 15;196(10):4014-29. doi: 10.4049/jimmunol.1501188. Epub 2016 Apr 15.

19.

Glial Cell-Elicited Activation of Brain Microvasculature in Response to Brucella abortus Infection Requires ASC Inflammasome-Dependent IL-1β Production.

Miraglia MC, Costa Franco MM, Rodriguez AM, Bellozi PM, Ferrari CC, Farias MI, Dennis VA, Barrionuevo P, de Oliveira AC, Pitossi F, Kim KS, Delpino MV, Oliveira SC, Giambartolomei GH.

J Immunol. 2016 May 1;196(9):3794-805. doi: 10.4049/jimmunol.1500908. Epub 2016 Mar 16.

20.

Brucella abortus Omp19 recombinant protein subcutaneously co-delivered with an antigen enhances antigen-specific T helper 1 memory responses and induces protection against parasite challenge.

Coria LM, Ibañez AE, Pasquevich KA, Cobiello PLG, Frank FM, Giambartolomei GH, Cassataro J.

Vaccine. 2016 Jan 20;34(4):430-437. doi: 10.1016/j.vaccine.2015.12.012. Epub 2015 Dec 17.

PMID:
26707377
21.

The Effector Protein BPE005 from Brucella abortus Induces Collagen Deposition and Matrix Metalloproteinase 9 Downmodulation via Transforming Growth Factor β1 in Hepatic Stellate Cells.

Arriola Benitez PC, Rey Serantes D, Herrmann CK, Pesce Viglietti AI, Vanzulli S, Giambartolomei GH, Comerci DJ, Delpino MV.

Infect Immun. 2015 Dec 14;84(2):598-606. doi: 10.1128/IAI.01227-15. Print 2016 Feb.

22.

Brucella abortus Invasion of Osteocytes Modulates Connexin 43 and Integrin Expression and Induces Osteoclastogenesis via Receptor Activator of NF-κB Ligand and Tumor Necrosis Factor Alpha Secretion.

Pesce Viglietti AI, Arriola Benitez PC, Gentilini MV, Velásquez LN, Fossati CA, Giambartolomei GH, Delpino MV.

Infect Immun. 2015 Oct 12;84(1):11-20. doi: 10.1128/IAI.01049-15. Print 2016 Jan.

23.

A bacterial protease inhibitor protects antigens delivered in oral vaccines from digestion while triggering specific mucosal immune responses.

Ibañez AE, Coria LM, Carabajal MV, Delpino MV, Risso GS, Cobiello PG, Rinaldi J, Barrionuevo P, Bruno L, Frank F, Klinke S, Goldbaum FA, Briones G, Giambartolomei GH, Pasquevich KA, Cassataro J.

J Control Release. 2015 Dec 28;220(Pt A):18-28. doi: 10.1016/j.jconrel.2015.10.011. Epub 2015 Oct 9.

24.

CCL20 and Beta-Defensin 2 Production by Human Lung Epithelial Cells and Macrophages in Response to Brucella abortus Infection.

Hielpos MS, Ferrero MC, Fernández AG, Bonetto J, Giambartolomei GH, Fossati CA, Baldi PC.

PLoS One. 2015 Oct 8;10(10):e0140408. doi: 10.1371/journal.pone.0140408. eCollection 2015.

25.

Adrenal steroids modulate the immune response during Brucella abortus infection by a mechanism that depends on the regulation of cytokine production.

Gentilini MV, Velásquez LN, Barrionuevo P, Arriola Benitez PC, Giambartolomei GH, Delpino MV.

Infect Immun. 2015 May;83(5):1973-82. doi: 10.1128/IAI.03090-14. Epub 2015 Mar 2.

26.

Evaluation of the efficacy of outer membrane protein 31 vaccine formulations for protection against Brucella canis in BALB/c mice.

Clausse M, Díaz AG, Ibañez AE, Cassataro J, Giambartolomei GH, Estein SM.

Clin Vaccine Immunol. 2014 Dec;21(12):1689-94. doi: 10.1128/CVI.00527-14. Epub 2014 Oct 22.

27.

Brucella cyclic β-1,2-glucan plays a critical role in the induction of splenomegaly in mice.

Roset MS, Ibañez AE, de Souza Filho JA, Spera JM, Minatel L, Oliveira SC, Giambartolomei GH, Cassataro J, Briones G.

PLoS One. 2014 Jul 1;9(7):e101279. doi: 10.1371/journal.pone.0101279. eCollection 2014.

28.

Key role of Toll-like receptor 2 in the inflammatory response and major histocompatibility complex class ii downregulation in Brucella abortus-infected alveolar macrophages.

Ferrero MC, Hielpos MS, Carvalho NB, Barrionuevo P, Corsetti PP, Giambartolomei GH, Oliveira SC, Baldi PC.

Infect Immun. 2014 Feb;82(2):626-39. doi: 10.1128/IAI.01237-13. Epub 2013 Nov 25.

29.

Brucella abortus induces collagen deposition and MMP-9 down-modulation in hepatic stellate cells via TGF-β1 production.

Arriola Benitez PC, Scian R, Comerci DJ, Serantes DR, Vanzulli S, Fossati CA, Giambartolomei GH, Delpino MV.

Am J Pathol. 2013 Dec;183(6):1918-1927. doi: 10.1016/j.ajpath.2013.08.006. Epub 2013 Oct 7.

PMID:
24113459
30.

The vaccine candidate BLSOmp31 protects mice against Brucella canis infection.

Clausse M, Díaz AG, Ghersi G, Zylberman V, Cassataro J, Giambartolomei GH, Goldbaum FA, Estein SM.

Vaccine. 2013 Dec 9;31(51):6129-35. doi: 10.1016/j.vaccine.2013.07.041. Epub 2013 Jul 30.

PMID:
23906889
31.

Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins.

Ibañez AE, Smaldini P, Coria LM, Delpino MV, Pacífico LG, Oliveira SC, Risso GS, Pasquevich KA, Fossati CA, Giambartolomei GH, Docena GH, Cassataro J.

PLoS One. 2013 Jul 5;8(7):e69438. doi: 10.1371/journal.pone.0069438. Print 2013.

32.

Pathogenesis and pathobiology of zoonotic brucellosis in humans.

Baldi PC, Giambartolomei GH.

Rev Sci Tech. 2013 Apr;32(1):117-25.

33.

Brucella abortus induces TNF-α-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases.

Miraglia MC, Scian R, Samartino CG, Barrionuevo P, Rodriguez AM, Ibañez AE, Coria LM, Velásquez LN, Baldi PC, Cassataro J, Delpino MV, Giambartolomei GH.

J Neuroinflammation. 2013 Apr 12;10:47. doi: 10.1186/1742-2094-10-47.

34.

Brucella abortus invasion of synoviocytes inhibits apoptosis and induces bone resorption through RANKL expression.

Scian R, Barrionuevo P, Rodriguez AM, Arriola Benitez PC, García Samartino C, Fossati CA, Giambartolomei GH, Delpino MV.

Infect Immun. 2013 Jun;81(6):1940-51. doi: 10.1128/IAI.01366-12. Epub 2013 Mar 18.

35.

Toll-like receptor 6 plays an important role in host innate resistance to Brucella abortus infection in mice.

de Almeida LA, Macedo GC, Marinho FA, Gomes MT, Corsetti PP, Silva AM, Cassataro J, Giambartolomei GH, Oliveira SC.

Infect Immun. 2013 May;81(5):1654-62. doi: 10.1128/IAI.01356-12. Epub 2013 Mar 4.

36.

Brucella abortus induces intracellular retention of MHC-I molecules in human macrophages down-modulating cytotoxic CD8(+) T cell responses.

Barrionuevo P, Delpino MV, Pozner RG, Velásquez LN, Cassataro J, Giambartolomei GH.

Cell Microbiol. 2013 Apr;15(4):487-502. doi: 10.1111/cmi.12058. Epub 2012 Nov 21.

PMID:
23107169
37.

Brucella abortus-infected macrophages modulate T lymphocytes to promote osteoclastogenesis via IL-17.

Giambartolomei GH, Scian R, Acosta-Rodríguez E, Fossati CA, Delpino MV.

Am J Pathol. 2012 Sep;181(3):887-96. doi: 10.1016/j.ajpath.2012.05.029.

PMID:
22901753
38.

Immunopathology of Brucella infection.

Baldi PC, Giambartolomei GH.

Recent Pat Antiinfect Drug Discov. 2013 Apr;8(1):18-26. Review.

PMID:
22812614
39.

Brucella abortus invasion of osteoblasts inhibits bone formation.

Scian R, Barrionuevo P, Fossati CA, Giambartolomei GH, Delpino MV.

Infect Immun. 2012 Jul;80(7):2333-45. doi: 10.1128/IAI.00208-12. Epub 2012 Apr 30.

40.

Brucella abortus induces apoptosis of human T lymphocytes.

Velásquez LN, Delpino MV, Ibañez AE, Coria LM, Miraglia MC, Scian R, Cassataro J, Giambartolomei GH, Barrionuevo P.

Microbes Infect. 2012 Jul;14(7-8):639-50. doi: 10.1016/j.micinf.2012.02.004. Epub 2012 Feb 23.

PMID:
22387699
41.

Macrophage-elicited osteoclastogenesis in response to Brucella abortus infection requires TLR2/MyD88-dependent TNF-α production.

Delpino MV, Barrionuevo P, Macedo GC, Oliveira SC, Genaro SD, Scian R, Miraglia MC, Fossati CA, Baldi PC, Giambartolomei GH.

J Leukoc Biol. 2012 Feb;91(2):285-98. doi: 10.1189/jlb.04111185. Epub 2011 Nov 10.

PMID:
22075930
42.

Confronting the barriers to develop novel vaccines against brucellosis.

Oliveira SC, Giambartolomei GH, Cassataro J.

Expert Rev Vaccines. 2011 Sep;10(9):1291-305. doi: 10.1586/erv.11.110. Review.

PMID:
21919619
43.

Potential role of fibroblast-like synoviocytes in joint damage induced by Brucella abortus infection through production and induction of matrix metalloproteinases.

Scian R, Barrionuevo P, Giambartolomei GH, De Simone EA, Vanzulli SI, Fossati CA, Baldi PC, Delpino MV.

Infect Immun. 2011 Sep;79(9):3619-32. doi: 10.1128/IAI.05408-11. Epub 2011 Jul 5.

44.

Proinflammatory response of human endothelial cells to Brucella infection.

Ferrero MC, Bregante J, Delpino MV, Barrionuevo P, Fossati CA, Giambartolomei GH, Baldi PC.

Microbes Infect. 2011 Sep;13(10):852-61. doi: 10.1016/j.micinf.2011.04.010. Epub 2011 May 17.

PMID:
21621633
45.

An oral vaccine based on U-Omp19 induces protection against B. abortus mucosal challenge by inducing an adaptive IL-17 immune response in mice.

Pasquevich KA, Ibañez AE, Coria LM, García Samartino C, Estein SM, Zwerdling A, Barrionuevo P, Oliveira FS, Seither C, Warzecha H, Oliveira SC, Giambartolomei GH, Cassataro J.

PLoS One. 2011 Jan 14;6(1):e16203. doi: 10.1371/journal.pone.0016203.

46.

Brucella abortus inhibits IFN-γ-induced FcγRI expression and FcγRI-restricted phagocytosis via toll-like receptor 2 on human monocytes/macrophages.

Barrionuevo P, Delpino MV, Velásquez LN, García Samartino C, Coria LM, Ibañez AE, Rodríguez ME, Cassataro J, Giambartolomei GH.

Microbes Infect. 2011 Mar;13(3):239-50. doi: 10.1016/j.micinf.2010.10.020. Epub 2010 Nov 9.

PMID:
21070860
47.

Granulocyte-macrophage colony-stimulating factor- and tumor necrosis factor alpha-mediated matrix metalloproteinase production by human osteoblasts and monocytes after infection with Brucella abortus.

Scian R, Barrionuevo P, Giambartolomei GH, Fossati CA, Baldi PC, Delpino MV.

Infect Immun. 2011 Jan;79(1):192-202. doi: 10.1128/IAI.00934-10. Epub 2010 Oct 18.

48.

The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic and oral acquired brucellosis.

Pasquevich KA, García Samartino C, Coria LM, Estein SM, Zwerdling A, Ibañez AE, Barrionuevo P, Oliveira FS, Carvalho NB, Borkowski J, Oliveira SC, Warzecha H, Giambartolomei GH, Cassataro J.

J Immunol. 2010 May 1;184(9):5200-12. doi: 10.4049/jimmunol.0902209. Epub 2010 Mar 29.

49.

Brucella abortus induces the secretion of proinflammatory mediators from glial cells leading to astrocyte apoptosis.

García Samartino C, Delpino MV, Pott Godoy C, Di Genaro MS, Pasquevich KA, Zwerdling A, Barrionuevo P, Mathieu P, Cassataro J, Pitossi F, Giambartolomei GH.

Am J Pathol. 2010 Mar;176(3):1323-38. doi: 10.2353/ajpath.2010.090503. Epub 2010 Jan 21.

50.

The polymeric antigen BLSOmp31 confers protection against Brucella ovis infection in rams.

Estein SM, Fiorentino MA, Paolicchi FA, Clausse M, Manazza J, Cassataro J, Giambartolomei GH, Coria LM, Zylberman V, Fossati CA, Kjeken R, Goldbaum FA.

Vaccine. 2009 Nov 12;27(48):6704-11. doi: 10.1016/j.vaccine.2009.08.097. Epub 2009 Sep 11.

PMID:
19748579

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