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Items: 17


Discovery of NV-5138, the first selective Brain mTORC1 activator.

Sengupta S, Giaime E, Narayan S, Hahm S, Howell J, O'Neill D, Vlasuk GP, Saiah E.

Sci Rep. 2019 Mar 11;9(1):4107. doi: 10.1038/s41598-019-40693-5.


Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.

Giaime E, Tong Y, Wagner LK, Yuan Y, Huang G, Shen J.

Neuron. 2017 Nov 15;96(4):796-807.e6. doi: 10.1016/j.neuron.2017.09.036. Epub 2017 Oct 19.


Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.

Lee SB, Kim JJ, Nam HJ, Gao B, Yin P, Qin B, Yi SY, Ham H, Evans D, Kim SH, Zhang J, Deng M, Liu T, Zhang H, Billadeau DD, Wang L, Giaime E, Shen J, Pang YP, Jen J, van Deursen JM, Lou Z.

Mol Cell. 2015 Oct 1;60(1):21-34. doi: 10.1016/j.molcel.2015.08.011. Epub 2015 Sep 17.


A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics.

Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, Shen J, Shen J, Zhou Z, Liu X.

Cell Res. 2015 Mar;25(3):394-7. doi: 10.1038/cr.2014.159. Epub 2014 Dec 5. No abstract available.


PINK1 triggers autocatalytic activation of Parkin to specify cell fate decisions.

Zhang C, Lee S, Peng Y, Bunker E, Giaime E, Shen J, Zhou Z, Liu X.

Curr Biol. 2014 Aug 18;24(16):1854-65. doi: 10.1016/j.cub.2014.07.014. Epub 2014 Jul 31.


ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.

Duplan E, Giaime E, Viotti J, Sévalle J, Corti O, Brice A, Ariga H, Qi L, Checler F, Alves da Costa C.

J Cell Sci. 2013 May 1;126(Pt 9):2124-33. doi: 10.1242/jcs.127340. Epub 2013 Feb 27.


Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening.

Giaime E, Yamaguchi H, Gautier CA, Kitada T, Shen J.

PLoS One. 2012;7(7):e40501. doi: 10.1371/journal.pone.0040501. Epub 2012 Jul 9.


Regulation of mitochondrial permeability transition pore by PINK1.

Gautier CA, Giaime E, Caballero E, Núñez L, Song Z, Chan D, Villalobos C, Shen J.

Mol Neurodegener. 2012 May 25;7:22. doi: 10.1186/1750-1326-7-22.


Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway.

Tong Y, Giaime E, Yamaguchi H, Ichimura T, Liu Y, Si H, Cai H, Bonventre JV, Shen J.

Mol Neurodegener. 2012 Jan 9;7:2. doi: 10.1186/1750-1326-7-2.


Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.

Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ 3rd, Shen J.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9879-84. doi: 10.1073/pnas.1004676107. Epub 2010 May 10.


p53-dependent control of transactivation of the Pen2 promoter by presenilins.

Dunys J, Sevalle J, Giaime E, Pardossi-Piquard R, Vitek MP, Renbaum P, Levy-Lahad E, Zhang YW, Xu H, Checler F, da Costa CA.

J Cell Sci. 2009 Nov 1;122(Pt 21):4003-8. doi: 10.1242/jcs.051169.


Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

da Costa CA, Sunyach C, Giaime E, West A, Corti O, Brice A, Safe S, Abou-Sleiman PM, Wood NW, Takahashi H, Goldberg MS, Shen J, Checler F.

Nat Cell Biol. 2009 Nov;11(11):1370-5. doi: 10.1038/ncb1981. Epub 2009 Oct 4.


Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease.

Soehn AS, Franck T, Biskup S, Giaime E, Melle C, Rott R, Cebo D, Kalbacher H, Ott E, Pahnke J, Meitinger T, Krüger R, Gasser T, Berg D, von Eggeling F, Engelender S, da Costa CA, Riess O.

Neurogenetics. 2010 May;11(2):203-15. doi: 10.1007/s10048-009-0215-z.


Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.

Giaime E, Sunyach C, Druon C, Scarzello S, Robert G, Grosso S, Auberger P, Goldberg MS, Shen J, Heutink P, Pouysségur J, Pagès G, Checler F, Alves da Costa C.

Cell Death Differ. 2010 Jan;17(1):158-69. doi: 10.1038/cdd.2009.116.


p53-dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent gamma-secretase complex.

Pardossi-Piquard R, Dunys J, Giaime E, Guillot-Sestier MV, St George-Hyslop P, Checler F, Alves da Costa C.

J Neurochem. 2009 Apr;109(1):225-37. doi: 10.1111/j.1471-4159.2009.05952.x. Epub 2009 Feb 23.


Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2.

Dunys J, Kawarai T, Giaime E, Wilk S, Herrant M, Auberger P, St George-Hyslop P, Alves da Costa C, Checler F.

Neurodegener Dis. 2007;4(2-3):156-63.


Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway.

Giaime E, Sunyach C, Herrant M, Grosso S, Auberger P, McLean PJ, Checler F, da Costa CA.

J Biol Chem. 2006 Apr 28;281(17):11515-22. Epub 2006 Feb 22.

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