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Items: 1 to 50 of 126

1.

Network dynamics of the yeast methyltransferome.

Giaever G, Lissina E, Nislow C.

Microb Cell. 2019 Jul 9;6(8):356-369. doi: 10.15698/mic2019.08.687.

2.

Publisher Correction: PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling.

Nawrotek A, Benabdi S, Niyomchon S, Kryszke MH, Ginestier C, Cañeque T, Tepshi L, Mariani A, St Onge RP, Giaever G, Nislow C, Charafe-Jauffret E, Rodriguez R, Zeghouf M, Cherfils J.

Nat Chem Biol. 2019 May;15(5):549. doi: 10.1038/s41589-019-0255-0.

PMID:
30833779
3.

PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling.

Nawrotek A, Benabdi S, Niyomchon S, Kryszke MH, Ginestier C, Cañeque T, Tepshi L, Mariani A, St Onge RP, Giaever G, Nislow C, Charafe-Jauffret E, Rodriguez R, Zeghouf M, Cherfils J.

Nat Chem Biol. 2019 Apr;15(4):358-366. doi: 10.1038/s41589-019-0228-3. Epub 2019 Feb 11. Erratum in: Nat Chem Biol. 2019 Mar 4;:.

PMID:
30742123
4.

Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids".

Mor V, Rella A, Farnoud AM, Singh A, Munshi M, Bryan A, Naseem S, Konopka JB, Ojima I, Bullesbach E, Ashbaugh A, Linke MJ, Cushion M, Collins M, Ananthula HK, Sallans L, Desai PB, Wiederhold NP, Fothergill AW, Kirkpatrick WR, Patterson T, Wong LH, Sinha S, Giaever G, Nislow C, Flaherty P, Pan X, Cesar GV, de Melo Tavares P, Frases S, Miranda K, Rodrigues ML, Luberto C, Nimrichter L, Del Poeta M.

MBio. 2018 Mar 13;9(2). pii: e00188-18. doi: 10.1128/mBio.00188-18. No abstract available.

5.

Physical Forces Modulate Oxidative Status and Stress Defense Meditated Metabolic Adaptation of Yeast Colonies: Spaceflight and Microgravity Simulations.

Hammond TG, Allen PL, Gunter MA, Chiang J, Giaever G, Nislow C, Birdsall HH.

Microgravity Sci Technol. 2018;30(3):195-208. doi: 10.1007/s12217-017-9588-z. Epub 2017 Dec 29.

6.

Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress.

Acton E, Lee AH, Zhao PJ, Flibotte S, Neira M, Sinha S, Chiang J, Flaherty P, Nislow C, Giaever G.

Open Biol. 2017 Jun;7(6). pii: 160330. doi: 10.1098/rsob.160330.

7.

Genome-Wide Screen Reveals sec21 Mutants of Saccharomyces cerevisiae Are Methotrexate-Resistant.

Wong LH, Flibotte S, Sinha S, Chiang J, Giaever G, Nislow C.

G3 (Bethesda). 2017 Apr 3;7(4):1251-1257. doi: 10.1534/g3.116.038117.

8.

A chemogenomic approach to understand the antifungal action of Lichen-derived vulpinic acid.

Kwon Y, Cha J, Chiang J, Tran G, Giaever G, Nislow C, Hur JS, Kwak YS.

J Appl Microbiol. 2016 Dec;121(6):1580-1591. doi: 10.1111/jam.13300. Epub 2016 Nov 3.

PMID:
27660105
9.

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.

Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, Debbert SL, Delves M, Dennis AS, Deroose F, Duffy S, Fletcher S, Giaever G, Hallyburton I, Gamo FJ, Gebbia M, Guy RK, Hungerford Z, Kirk K, Lafuente-Monasterio MJ, Lee A, Meister S, Nislow C, Overington JP, Papadatos G, Patiny L, Pham J, Ralph SA, Ruecker A, Ryan E, Southan C, Srivastava K, Swain C, Tarnowski MJ, Thomson P, Turner P, Wallace IM, Wells TN, White K, White L, Willis P, Winzeler EA, Wittlin S, Todd MH.

ACS Cent Sci. 2016 Oct 26;2(10):687-701. Epub 2016 Sep 14.

10.

Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity.

Mathew MD, Mathew ND, Miller A, Simpson M, Au V, Garland S, Gestin M, Edgley ML, Flibotte S, Balgi A, Chiang J, Giaever G, Dean P, Tung A, Roberge M, Roskelley C, Forge T, Nislow C, Moerman D.

PLoS Negl Trop Dis. 2016 Oct 18;10(10):e0005058. doi: 10.1371/journal.pntd.0005058. eCollection 2016 Oct.

11.

Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions.

Wong LH, Sinha S, Bergeron JR, Mellor JC, Giaever G, Flaherty P, Nislow C.

PLoS Genet. 2016 Sep 2;12(9):e1006275. doi: 10.1371/journal.pgen.1006275. eCollection 2016 Sep.

12.

Functional Genomics Using the Saccharomyces cerevisiae Yeast Deletion Collections.

Nislow C, Wong LH, Lee AH, Giaever G.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.top080945.

PMID:
27587784
13.

Systematic Mapping of Chemical-Genetic Interactions in Saccharomyces cerevisiae.

Suresh S, Schlecht U, Xu W, Bray W, Miranda M, Davis RW, Nislow C, Giaever G, Lokey RS, St Onge RP.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.top077701.

PMID:
27587783
14.

Identification of Chemical-Genetic Interactions via Parallel Analysis of Barcoded Yeast Strains.

Suresh S, Schlecht U, Xu W, Miranda M, Davis RW, Nislow C, Giaever G, St Onge RP.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot088054.

PMID:
27587778
15.

Functional Profiling Using the Saccharomyces Genome Deletion Project Collections.

Nislow C, Wong LH, Lee AH, Giaever G.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot088039.

PMID:
27587776
16.

Signaling pathways coordinating the alkaline pH response confer resistance to the hevein-type plant antimicrobial peptide Pn-AMP1 in Saccharomyces cerevisiae.

Kwon Y, Chiang J, Tran G, Giaever G, Nislow C, Hahn BS, Kwak YS, Koo JC.

Planta. 2016 Dec;244(6):1229-1240. Epub 2016 Aug 10.

PMID:
27510723
17.

A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia.

Jeyaraju DV, Hurren R, Wang X, MacLean N, Gronda M, Shamas-Din A, Minden MD, Giaever G, Schimmer AD.

Oncotarget. 2016 Aug 2;7(31):49777-49785. doi: 10.18632/oncotarget.10446.

18.

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

Kennedy MA, Moffat TC, Gable K, Ganesan S, Niewola-Staszkowska K, Johnston A, Nislow C, Giaever G, Harris LJ, Loewith R, Zaremberg V, Harper ME, Dunn T, Bennett SAL, Baetz K.

Sci Rep. 2016 Jan 13;6:19332. doi: 10.1038/srep19332.

19.

Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.

Simoneau A, Ricard É, Weber S, Hammond-Martel I, Wong LH, Sellam A, Giaever G, Nislow C, Raymond M, Wurtele H.

Nucleic Acids Res. 2016 Apr 7;44(6):2706-26. doi: 10.1093/nar/gkv1537. Epub 2016 Jan 8.

20.

Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants.

Hamza A, Tammpere E, Kofoed M, Keong C, Chiang J, Giaever G, Nislow C, Hieter P.

Genetics. 2015 Nov;201(3):1263-74. doi: 10.1534/genetics.115.181099. Epub 2015 Sep 9.

21.

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

Pandyra AA, Mullen PJ, Goard CA, Ericson E, Sharma P, Kalkat M, Yu R, Pong JT, Brown KR, Hart T, Gebbia M, Lang KS, Giaever G, Nislow C, Moffat J, Penn LZ.

Oncotarget. 2015 Sep 29;6(29):26909-21. doi: 10.18632/oncotarget.4817.

22.

An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes.

Kofoed M, Milbury KL, Chiang JH, Sinha S, Ben-Aroya S, Giaever G, Nislow C, Hieter P, Stirling PC.

G3 (Bethesda). 2015 Jul 14;5(9):1879-87. doi: 10.1534/g3.115.019174.

23.

Caenorhabditis elegans is a useful model for anthelmintic discovery.

Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ.

Nat Commun. 2015 Jun 25;6:7485. doi: 10.1038/ncomms8485.

24.

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids.

Mor V, Rella A, Farnoud AM, Singh A, Munshi M, Bryan A, Naseem S, Konopka JB, Ojima I, Bullesbach E, Ashbaugh A, Linke MJ, Cushion M, Collins M, Ananthula HK, Sallans L, Desai PB, Wiederhold NP, Fothergill AW, Kirkpatrick WR, Patterson T, Wong LH, Sinha S, Giaever G, Nislow C, Flaherty P, Pan X, Cesar GV, de Melo Tavares P, Frases S, Miranda K, Rodrigues ML, Luberto C, Nimrichter L, Del Poeta M.

MBio. 2015 Jun 23;6(3):e00647. doi: 10.1128/mBio.00647-15. Erratum in: MBio. 2018 Mar 13;9(2):.

25.

Microbial and biochemical basis of a Fusarium wilt-suppressive soil.

Cha JY, Han S, Hong HJ, Cho H, Kim D, Kwon Y, Kwon SK, Crüsemann M, Bok Lee Y, Kim JF, Giaever G, Nislow C, Moore BS, Thomashow LS, Weller DM, Kwak YS.

ISME J. 2016 Jan;10(1):119-29. doi: 10.1038/ismej.2015.95. Epub 2015 Jun 9.

26.

Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.

Bernard D, Gebbia M, Prabha S, Gronda M, MacLean N, Wang X, Hurren R, Sukhai MA, Cho EE, Manolson MF, Datti A, Wrana J, Minden MD, Al-Awar R, Aman A, Nislow C, Giaever G, Schimmer AD.

Apoptosis. 2015 Jul;20(7):948-59. doi: 10.1007/s10495-015-1123-3.

PMID:
25832785
27.

Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight.

Nislow C, Lee AY, Allen PL, Giaever G, Smith A, Gebbia M, Stodieck LS, Hammond JS, Birdsall HH, Hammond TG.

Biomed Res Int. 2015;2015:976458. doi: 10.1155/2015/976458. Epub 2015 Jan 13.

28.

A genome scale overexpression screen to reveal drug activity in human cells.

Arnoldo A, Kittanakom S, Heisler LE, Mak AB, Shukalyuk AI, Torti D, Moffat J, Giaever G, Nislow C.

Genome Med. 2014 Apr 29;6(4):32. doi: 10.1186/gm549. eCollection 2014.

29.

The yeast deletion collection: a decade of functional genomics.

Giaever G, Nislow C.

Genetics. 2014 Jun;197(2):451-65. doi: 10.1534/genetics.114.161620. Epub 2014 Jun 17. Review.

30.

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, Suresh S, Duby G, Heisler LE, Surendra A, Fung E, Urbanus ML, Gebbia M, Lissina E, Miranda M, Chiang JH, Aparicio AM, Zeghouf M, Davis RW, Cherfils J, Boutry M, Kaiser CA, Cummins CL, Trimble WS, Brown GW, Schimmer AD, Bankaitis VA, Nislow C, Bader GD, Giaever G.

Science. 2014 Apr 11;344(6180):208-11. doi: 10.1126/science.1250217. Erratum in: Science. 2014 May 23;344(6186):1255771.

31.

Large-scale identification and analysis of suppressive drug interactions.

Cokol M, Weinstein ZB, Yilancioglu K, Tasan M, Doak A, Cansever D, Mutlu B, Li S, Rodriguez-Esteban R, Akhmedov M, Guvenek A, Cokol M, Cetiner S, Giaever G, Iossifov I, Nislow C, Shoichet B, Roth FP.

Chem Biol. 2014 Apr 24;21(4):541-551. doi: 10.1016/j.chembiol.2014.02.012. Epub 2014 Apr 3.

32.

PITPs as targets for selectively interfering with phosphoinositide signaling in cells.

Nile AH, Tripathi A, Yuan P, Mousley CJ, Suresh S, Wallace IM, Shah SD, Pohlhaus DT, Temple B, Nislow C, Giaever G, Tropsha A, Davis RW, St Onge RP, Bankaitis VA.

Nat Chem Biol. 2014 Jan;10(1):76-84. doi: 10.1038/nchembio.1389. Epub 2013 Nov 24.

33.

A novel small molecule methyltransferase is important for virulence in Candida albicans.

Lissina E, Weiss D, Young B, Rella A, Cheung-Ong K, Del Poeta M, Clarke SG, Giaever G, Nislow C.

ACS Chem Biol. 2013 Dec 20;8(12):2785-93. doi: 10.1021/cb400607h. Epub 2013 Oct 16.

34.

Miniature short hairpin RNA screens to characterize antiproliferative drugs.

Kittanakom S, Arnoldo A, Brown KR, Wallace I, Kunavisarut T, Torti D, Heisler LE, Surendra A, Moffat J, Giaever G, Nislow C.

G3 (Bethesda). 2013 Aug 7;3(8):1375-87. doi: 10.1534/g3.113.006437.

35.

A high-throughput yeast assay identifies synergistic drug combinations.

Torres NP, Lee AY, Giaever G, Nislow C, Brown GW.

Assay Drug Dev Technol. 2013 Jun;11(5):299-307. doi: 10.1089/adt.2012.503.

PMID:
23772551
36.

DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology.

Cheung-Ong K, Giaever G, Nislow C.

Chem Biol. 2013 May 23;20(5):648-59. doi: 10.1016/j.chembiol.2013.04.007. Review.

37.

Global analysis of SUMO chain function reveals multiple roles in chromatin regulation.

Srikumar T, Lewicki MC, Costanzo M, Tkach JM, van Bakel H, Tsui K, Johnson ES, Brown GW, Andrews BJ, Boone C, Giaever G, Nislow C, Raught B.

J Cell Biol. 2013 Apr 1;201(1):145-63. doi: 10.1083/jcb.201210019.

38.

Chromatin is an ancient innovation conserved between Archaea and Eukarya.

Ammar R, Torti D, Tsui K, Gebbia M, Durbic T, Bader GD, Giaever G, Nislow C.

Elife. 2012 Dec 13;1:e00078. doi: 10.7554/eLife.00078.

39.

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors.

Sukhai MA, Prabha S, Hurren R, Rutledge AC, Lee AY, Sriskanthadevan S, Sun H, Wang X, Skrtic M, Seneviratne A, Cusimano M, Jhas B, Gronda M, MacLean N, Cho EE, Spagnuolo PA, Sharmeen S, Gebbia M, Urbanus M, Eppert K, Dissanayake D, Jonet A, Dassonville-Klimpt A, Li X, Datti A, Ohashi PS, Wrana J, Rogers I, Sonnet P, Ellis WY, Corey SJ, Eaves C, Minden MD, Wang JC, Dick JE, Nislow C, Giaever G, Schimmer AD.

J Clin Invest. 2013 Jan;123(1):315-28. doi: 10.1172/JCI64180. Epub 2012 Dec 3.

40.

A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis.

Alfred SE, Surendra A, Le C, Lin K, Mok A, Wallace IM, Proctor M, Urbanus ML, Giaever G, Nislow C.

Genome Biol. 2012 Nov 18;13(11):R105. doi: 10.1186/gb-2012-13-11-r105.

41.

Functional analysis with a barcoder yeast gene overexpression system.

Douglas AC, Smith AM, Sharifpoor S, Yan Z, Durbic T, Heisler LE, Lee AY, Ryan O, Göttert H, Surendra A, van Dyk D, Giaever G, Boone C, Nislow C, Andrews BJ.

G3 (Bethesda). 2012 Oct;2(10):1279-89. doi: 10.1534/g3.112.003400. Epub 2012 Oct 1.

42.

Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae.

Orij R, Urbanus ML, Vizeacoumar FJ, Giaever G, Boone C, Nislow C, Brul S, Smits GJ.

Genome Biol. 2012 Sep 10;13(9):R80. doi: 10.1186/gb-2012-13-9-r80.

43.

An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations.

Shabtai D, Giaever G, Nislow C.

BMC Bioinformatics. 2012 Sep 25;13:245. doi: 10.1186/1471-2105-13-245.

44.

Global gene deletion analysis exploring yeast filamentous growth.

Ryan O, Shapiro RS, Kurat CF, Mayhew D, Baryshnikova A, Chin B, Lin ZY, Cox MJ, Vizeacoumar F, Cheung D, Bahr S, Tsui K, Tebbji F, Sellam A, Istel F, Schwarzmüller T, Reynolds TB, Kuchler K, Gifford DK, Whiteway M, Giaever G, Nislow C, Costanzo M, Gingras AC, Mitra RD, Andrews B, Fink GR, Cowen LE, Boone C.

Science. 2012 Sep 14;337(6100):1353-6. doi: 10.1126/science.1224339.

45.

Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents.

Cheung-Ong K, Song KT, Ma Z, Shabtai D, Lee AY, Gallo D, Heisler LE, Brown GW, Bierbach U, Giaever G, Nislow C.

ACS Chem Biol. 2012 Nov 16;7(11):1892-901. doi: 10.1021/cb300320d. Epub 2012 Sep 5.

46.

Barcode sequencing for understanding drug-gene interactions.

Smith AM, Durbic T, Kittanakom S, Giaever G, Nislow C.

Methods Mol Biol. 2012;910:55-69. doi: 10.1007/978-1-61779-965-5_4.

PMID:
22821592
47.

A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae.

Singh-Babak SD, Shekhar T, Smith AM, Giaever G, Nislow C, Cowen LE.

Mol Biosyst. 2012 Oct;8(10):2575-84. doi: 10.1039/c2mb25107h.

PMID:
22751784
48.

Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics.

Jaime MD, Lopez-Llorca LV, Conesa A, Lee AY, Proctor M, Heisler LE, Gebbia M, Giaever G, Westwood JT, Nislow C.

BMC Genomics. 2012 Jun 22;13:267. doi: 10.1186/1471-2164-13-267.

49.

A global perspective of the genetic basis for carbonyl stress resistance.

Hoon S, Gebbia M, Costanzo M, Davis RW, Giaever G, Nislow C.

G3 (Bethesda). 2011 Aug;1(3):219-31. doi: 10.1534/g3.111.000505. Epub 2011 Aug 1.

50.

Mitochondrial electron transport is the cellular target of the oncology drug elesclomol.

Blackman RK, Cheung-Ong K, Gebbia M, Proia DA, He S, Kepros J, Jonneaux A, Marchetti P, Kluza J, Rao PE, Wada Y, Giaever G, Nislow C.

PLoS One. 2012;7(1):e29798. doi: 10.1371/journal.pone.0029798. Epub 2012 Jan 11.

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