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Items: 50


A C-Terminal Fragment of Chlorotoxin Retains Bioactivity and Inhibits Cell Migration.

Dastpeyman M, Giacomin P, Wilson D, Nolan MJ, Bansal PS, Daly NL.

Front Pharmacol. 2019 Mar 20;10:250. doi: 10.3389/fphar.2019.00250. eCollection 2019.


Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes.

Wangchuk P, Shepherd C, Constantinoiu C, Ryan RYM, Kouremenos KA, Becker L, Jones L, Buitrago G, Giacomin P, Wilson D, Daly N, McConville MJ, Miles JJ, Loukas A.

Infect Immun. 2019 Mar 25;87(4). pii: e00851-18. doi: 10.1128/IAI.00851-18. Print 2019 Apr.


Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites.

Filbey KJ, Camberis M, Chandler J, Turner R, Kettle AJ, Eichenberger RM, Giacomin P, Le Gros G.

Mucosal Immunol. 2019 Mar;12(2):352-362. doi: 10.1038/s41385-018-0102-8. Epub 2018 Nov 6.


Helminth-induced regulatory T cells and suppression of allergic responses.

Logan J, Navarro S, Loukas A, Giacomin P.

Curr Opin Immunol. 2018 Oct;54:1-6. doi: 10.1016/j.coi.2018.05.007. Epub 2018 May 29. Review.


Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice.

Eichenberger RM, Ryan S, Jones L, Buitrago G, Polster R, Montes de Oca M, Zuvelek J, Giacomin PR, Dent LA, Engwerda CR, Field MA, Sotillo J, Loukas A.

Front Immunol. 2018 Apr 30;9:850. doi: 10.3389/fimmu.2018.00850. eCollection 2018.


The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection.

Alhallaf R, Agha Z, Miller CM, Robertson AAB, Sotillo J, Croese J, Cooper MA, Masters SL, Kupz A, Smith NC, Loukas A, Giacomin PR.

Cell Rep. 2018 Apr 24;23(4):1085-1098. doi: 10.1016/j.celrep.2018.03.097.


A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development.

Bouchery T, Filbey K, Shepherd A, Chandler J, Patel D, Schmidt A, Camberis M, Peignier A, Smith AAT, Johnston K, Painter G, Pearson M, Giacomin P, Loukas A, Bottazzi ME, Hotez P, LeGros G.

PLoS Pathog. 2018 Mar 22;14(3):e1006931. doi: 10.1371/journal.ppat.1006931. eCollection 2018 Mar.


Chronic Helminth Infection Perturbs the Gut-Brain Axis, Promotes Neuropathology, and Alters Behavior.

Giacomin PR, Kraeuter AK, Albornoz EA, Jin S, Bengtsson M, Gordon R, Woodruff TM, Urich T, Sarnyai Z, Soares Magalhães RJ.

J Infect Dis. 2018 Sep 22;218(9):1511-1516. doi: 10.1093/infdis/jiy092.


Characterization of Trichuris muris secreted proteins and extracellular vesicles provides new insights into host-parasite communication.

Eichenberger RM, Talukder MH, Field MA, Wangchuk P, Giacomin P, Loukas A, Sotillo J.

J Extracell Vesicles. 2018 Jan 21;7(1):1428004. doi: 10.1080/20013078.2018.1428004. eCollection 2018.


Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases.

Sundaraneedi M, Eichenberger RM, Al-Hallaf R, Yang D, Sotillo J, Rajan S, Wangchuk P, Giacomin PR, Keene FR, Loukas A, Collins JG, Pearson MS.

Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):1-7. doi: 10.1016/j.ijpddr.2017.11.005. Epub 2017 Nov 29.


The relationship between treatment for Strongyloides stercoralis infection and type 2 diabetes mellitus in an Australian Aboriginal population: A three-year cohort study.

Hays R, Giacomin P, Olma L, Esterman A, McDermott R.

Diabetes Res Clin Pract. 2017 Dec;134:8-16. doi: 10.1016/j.diabres.2017.09.012. Epub 2017 Sep 23.


A medicinal plant compound, capnoidine, prevents the onset of inflammation in a mouse model of colitis.

Shepherd C, Giacomin P, Navarro S, Miller C, Loukas A, Wangchuk P.

J Ethnopharmacol. 2018 Jan 30;211:17-28. doi: 10.1016/j.jep.2017.09.024. Epub 2017 Sep 21.


Ectonucleotidase and adenosine deaminase as inflammatory marker in dairy cows naturally infected by Dictyocaulus viviparus.

da Silva AS, Baldissera MD, Bottari NB, Doleski PH, Carmo GM, Schwertz CI, Lucca NJ, Henker LC, Piva MM, Giacomin P, Stefani LM, Leal DBR, Machado G, Mendes RE.

Comp Immunol Microbiol Infect Dis. 2017 Apr;51:9-13. doi: 10.1016/j.cimid.2017.01.001. Epub 2017 Feb 7.


Helminth Immunomodulation in Autoimmune Disease.

Smallwood TB, Giacomin PR, Loukas A, Mulvenna JP, Clark RJ, Miles JJ.

Front Immunol. 2017 Apr 24;8:453. doi: 10.3389/fimmu.2017.00453. eCollection 2017. Review.


An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease.

Cobos Caceres C, Bansal PS, Navarro S, Wilson D, Don L, Giacomin P, Loukas A, Daly NL.

J Biol Chem. 2017 Jun 16;292(24):10288-10294. doi: 10.1074/jbc.M117.779215. Epub 2017 May 4.


Quantitative evaluation of root canal surface roughness after filing with adaptive reciprocating and continuous rotary instruments.

Sakhaei Manesh V, Giacomin P, Stoll R.

Microsc Res Tech. 2017 Jun;80(6):657-661. doi: 10.1002/jemt.22845. Epub 2017 Jan 31.


Dictyocaulosis in dairy cows in Brazil: an epidemiological, clinical-pathological and therapeutic approach.

Henker LC, Schwertz CI, Lucca NJ, Piva MM, Giacomin P, Gris A, Rhoden LA, Norbury LJ, da Silva AS, da Rosa RA, Mendes RE.

Acta Parasitol. 2017 Mar 1;62(1):129-132. doi: 10.1515/ap-2017-0015.


Changes in duodenal tissue-associated microbiota following hookworm infection and consecutive gluten challenges in humans with coeliac disease.

Giacomin P, Zakrzewski M, Jenkins TP, Su X, Al-Hallaf R, Croese J, de Vries S, Grant A, Mitreva M, Loukas A, Krause L, Cantacessi C.

Sci Rep. 2016 Nov 9;6:36797. doi: 10.1038/srep36797.


Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma.

Navarro S, Pickering DA, Ferreira IB, Jones L, Ryan S, Troy S, Leech A, Hotez PJ, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda CR, Upham JW, Julia V, Giacomin PR, Loukas A.

Sci Transl Med. 2016 Oct 26;8(362):362ra143.


Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms.

Wangchuk P, Giacomin PR, Pearson MS, Smout MJ, Loukas A.

Sci Rep. 2016 Aug 30;6:32101. doi: 10.1038/srep32101.


Compounds Derived from the Bhutanese Daisy, Ajania nubigena, Demonstrate Dual Anthelmintic Activity against Schistosoma mansoni and Trichuris muris.

Wangchuk P, Pearson MS, Giacomin PR, Becker L, Sotillo J, Pickering D, Smout MJ, Loukas A.

PLoS Negl Trop Dis. 2016 Aug 4;10(8):e0004908. doi: 10.1371/journal.pntd.0004908. eCollection 2016 Aug.


Oxidative stress in dairy cows naturally infected with the lungworm Dictyocaulus viviparus (Nematoda: Trichostrongyloidea).

da Silva AD, da Silva AS, Baldissera MD, Schwertz CI, Bottari NB, Carmo GM, Machado G, Lucca NJ, Henker LC, Piva MM, Giacomin P, Morsch VM, Schetinger MRC, da Rosa RA, Mendes RE.

J Helminthol. 2017 Jul;91(4):462-469. doi: 10.1017/S0022149X16000456. Epub 2016 Jul 27.


Helminths and Intestinal Flora Team Up to Improve Gut Health.

Giacomin P, Agha Z, Loukas A.

Trends Parasitol. 2016 Sep;32(9):664-666. doi: 10.1016/ Epub 2016 May 24.


The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.

Zaiss MM, Rapin A, Lebon L, Dubey LK, Mosconi I, Sarter K, Piersigilli A, Menin L, Walker AW, Rougemont J, Paerewijck O, Geldhof P, McCoy KD, Macpherson AJ, Croese J, Giacomin PR, Loukas A, Junt T, Marsland BJ, Harris NL.

Immunity. 2015 Nov 17;43(5):998-1010. doi: 10.1016/j.immuni.2015.09.012. Epub 2015 Oct 27.


Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia.

Smout MJ, Sotillo J, Laha T, Papatpremsiri A, Rinaldi G, Pimenta RN, Chan LY, Johnson MS, Turnbull L, Whitchurch CB, Giacomin PR, Moran CS, Golledge J, Daly N, Sripa B, Mulvenna JP, Brindley PJ, Loukas A.

PLoS Pathog. 2015 Oct 20;11(10):e1005209. doi: 10.1371/journal.ppat.1005209. eCollection 2015 Oct.


Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects.

Giacomin P, Zakrzewski M, Croese J, Su X, Sotillo J, McCann L, Navarro S, Mitreva M, Krause L, Loukas A, Cantacessi C.

Sci Rep. 2015 Sep 18;5:13797. doi: 10.1038/srep13797.


Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.

Giacomin PR, Moy RH, Noti M, Osborne LC, Siracusa MC, Alenghat T, Liu B, McCorkell KA, Troy AE, Rak GD, Hu Y, May MJ, Ma HL, Fouser LA, Sonnenberg GF, Artis D.

J Exp Med. 2015 Sep 21;212(10):1513-28. doi: 10.1084/jem.20141831. Epub 2015 Sep 14.


Suppression of inflammation by helminths: a role for the gut microbiota?

Giacomin P, Croese J, Krause L, Loukas A, Cantacessi C.

Philos Trans R Soc Lond B Biol Sci. 2015 Aug 19;370(1675). pii: 20140296. doi: 10.1098/rstb.2014.0296. Review.


Does Strongyloides stercoralis infection protect against type 2 diabetes in humans? Evidence from Australian Aboriginal adults.

Hays R, Esterman A, Giacomin P, Loukas A, McDermott R.

Diabetes Res Clin Pract. 2015 Mar;107(3):355-61. doi: 10.1016/j.diabres.2015.01.012. Epub 2015 Jan 21.


Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease.

Croese J, Giacomin P, Navarro S, Clouston A, McCann L, Dougall A, Ferreira I, Susianto A, O'Rourke P, Howlett M, McCarthy J, Engwerda C, Jones D, Loukas A.

J Allergy Clin Immunol. 2015 Feb;135(2):508-16. doi: 10.1016/j.jaci.2014.07.022. Epub 2014 Sep 20.


Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling.

Tribolet L, Cantacessi C, Pickering DA, Navarro S, Doolan DL, Trieu A, Fei H, Chao Y, Hofmann A, Gasser RB, Giacomin PR, Loukas A.

J Infect Dis. 2015 Feb 1;211(3):416-25. doi: 10.1093/infdis/jiu451. Epub 2014 Aug 19.


Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis.

Sotillo J, Sanchez-Flores A, Cantacessi C, Harcus Y, Pickering D, Bouchery T, Camberis M, Tang SC, Giacomin P, Mulvenna J, Mitreva M, Berriman M, LeGros G, Maizels RM, Loukas A.

Mol Cell Proteomics. 2014 Oct;13(10):2736-51. doi: 10.1074/mcp.M114.038950. Epub 2014 Jul 3.


Impact of experimental hookworm infection on the human gut microbiota.

Cantacessi C, Giacomin P, Croese J, Zakrzewski M, Sotillo J, McCann L, Nolan MJ, Mitreva M, Krause L, Loukas A.

J Infect Dis. 2014 Nov 1;210(9):1431-4. doi: 10.1093/infdis/jiu256. Epub 2014 May 3.


Regulatory T cells limit induction of protective immunity and promote immune pathology following intestinal helminth infection.

Sawant DV, Gravano DM, Vogel P, Giacomin P, Artis D, Vignali DA.

J Immunol. 2014 Mar 15;192(6):2904-12. doi: 10.4049/jimmunol.1202502. Epub 2014 Feb 14.


Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis.

Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CG, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M, Snyder A, Giacomin PR, Joyce KL, Hoang TB, Bewtra M, Brodsky IE, Sonnenberg GF, Bushman FD, Won KJ, Lazar MA, Artis D.

Nature. 2013 Dec 5;504(7478):153-7. doi: 10.1038/nature12687. Epub 2013 Nov 3.


In vivo assessment of caries excavation with a fluorescence camera compared to direct bacteriological sampling and quantitative analysis using flow cytometry.

Stoll R, Urban-Klein B, Giacomin P, Loukas A, Jablonski-Momeni A.

Lasers Med Sci. 2015 Feb;30(2):843-9. doi: 10.1007/s10103-013-1459-2. Epub 2013 Oct 19.


Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.

Noti M, Wojno ED, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR, Muir AB, Hill DA, Chikwava KR, Moghaddam AE, Sattentau QJ, Alex A, Zhou C, Yearley JH, Menard-Katcher P, Kubo M, Obata-Ninomiya K, Karasuyama H, Comeau MR, Brown-Whitehorn T, de Waal Malefyt R, Sleiman PM, Hakonarson H, Cianferoni A, Falk GW, Wang ML, Spergel JM, Artis D.

Nat Med. 2013 Aug;19(8):1005-13. doi: 10.1038/nm.3281. Epub 2013 Jul 21.


Hookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitis.

Ferreira I, Smyth D, Gaze S, Aziz A, Giacomin P, Ruyssers N, Artis D, Laha T, Navarro S, Loukas A, McSorley HJ.

Infect Immun. 2013 Jun;81(6):2104-11. doi: 10.1128/IAI.00563-12. Epub 2013 Apr 1.


Resistin-like molecule α promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation.

Osborne LC, Joyce KL, Alenghat T, Sonnenberg GF, Giacomin PR, Du Y, Bergstrom KS, Vallance BA, Nair MG.

J Immunol. 2013 Mar 1;190(5):2292-300. doi: 10.4049/jimmunol.1200706. Epub 2013 Jan 25.


Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection.

Giacomin PR, Siracusa MC, Walsh KP, Grencis RK, Kubo M, Comeau MR, Artis D.

J Immunol. 2012 Nov 1;189(9):4371-8. doi: 10.4049/jimmunol.1200691. Epub 2012 Sep 28.


Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation.

Mullican SE, Gaddis CA, Alenghat T, Nair MG, Giacomin PR, Everett LJ, Feng D, Steger DJ, Schug J, Artis D, Lazar MA.

Genes Dev. 2011 Dec 1;25(23):2480-8. doi: 10.1101/gad.175950.111.


IL-35-mediated induction of a potent regulatory T cell population.

Collison LW, Chaturvedi V, Henderson AL, Giacomin PR, Guy C, Bankoti J, Finkelstein D, Forbes K, Workman CJ, Brown SA, Rehg JE, Jones ML, Ni HT, Artis D, Turk MJ, Vignali DA.

Nat Immunol. 2010 Dec;11(12):1093-101. doi: 10.1038/ni.1952. Epub 2010 Oct 17.


MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.

Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y, Zaph C, van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, Artis D.

Nat Immunol. 2009 Jul;10(7):697-705. doi: 10.1038/ni.1740. Epub 2009 May 24.


Toxocara canis larval excretory/secretory proteins impair eosinophil-dependent resistance of mice to Nippostrongylus brasiliensis.

Giacomin PR, Cava M, Tumes DJ, Gauld AD, Iddawela DR, McColl SR, Parsons JC, Gordon DL, Dent LA.

Parasite Immunol. 2008 Aug;30(8):435-45. doi: 10.1111/j.1365-3024.2008.01040.x.


The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis.

Giacomin PR, Gordon DL, Botto M, Daha MR, Sanderson SD, Taylor SM, Dent LA.

Mol Immunol. 2008 Jan;45(2):446-55. Epub 2007 Aug 1.


Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis.

Knott ML, Matthaei KI, Giacomin PR, Wang H, Foster PS, Dent LA.

Int J Parasitol. 2007 Oct;37(12):1367-78. Epub 2007 May 4.


Loss of complement activation and leukocyte adherence as Nippostrongylus brasiliensis develops within the murine host.

Giacomin PR, Wang H, Gordon DL, Botto M, Dent LA.

Infect Immun. 2005 Nov;73(11):7442-9.


Oxygen-sensing pathway for SK channels in the ovine adrenal medulla.

Keating DJ, Rychkov GY, Giacomin P, Roberts ML.

Clin Exp Pharmacol Physiol. 2005 Oct;32(10):882-7.


Quantitation of complement and leukocyte binding to a parasitic helminth species.

Giacomin PR, Wang H, Gordon DL, Dent LA.

J Immunol Methods. 2004 Jun;289(1-2):201-10.


Time course of induction of increased human motor cortex excitability by nerve stimulation.

McKay D, Brooker R, Giacomin P, Ridding M, Miles T.

Neuroreport. 2002 Jul 19;13(10):1271-3.


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