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One year in review 2019: fibromyalgia.

Atzeni F, Talotta R, Masala IF, Giacomelli C, Conversano C, Nucera V, Lucchino B, Iannuccelli C, Di Franco M, Bazzichi L.

Clin Exp Rheumatol. 2019 Jan-Feb;37 Suppl 116(1):3-10. Epub 2019 Feb 6. Review.


Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts.

Daniele S, Giacomelli C, Pietrobono D, Barresi E, Piccarducci R, La Pietra V, Taliani S, Da Settimo F, Marinelli L, Novellino E, Martini C, Trincavelli ML.

Biochim Biophys Acta Mol Cell Res. 2019 May;1866(5):737-749. doi: 10.1016/j.bbamcr.2019.01.012. Epub 2019 Jan 28.


Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes.

Barresi E, Giacomelli C, Daniele S, Tonazzini I, Robello M, Salerno S, Piano I, Cosimelli B, Greco G, Da Settimo F, Martini C, Trincavelli ML, Taliani S.

Bioorg Med Chem. 2018 Dec 1;26(22):5885-5895. doi: 10.1016/j.bmc.2018.10.039. Epub 2018 Nov 1.


Brain ageing and neurodegenerative disease: The role of cellular waste management.

Daniele S, Giacomelli C, Martini C.

Biochem Pharmacol. 2018 Dec;158:207-216. doi: 10.1016/j.bcp.2018.10.030. Epub 2018 Oct 28. Review.


Cytokine secretion responsiveness of lymphomonocytes following cortisol cell exposure: Sex differences.

Da Pozzo E, Giacomelli C, Cavallini C, Martini C.

PLoS One. 2018 Jul 26;13(7):e0200924. doi: 10.1371/journal.pone.0200924. eCollection 2018.


TGFβ1 regulates HGF-induced cell migration and hepatocyte growth factor receptor MET expression via C-ets-1 and miR-128-3p in basal-like breast cancer.

Breunig C, Erdem N, Bott A, Greiwe JF, Reinz E, Bernhardt S, Giacomelli C, Wachter A, Kanthelhardt EJ, Beißbarth T, Vetter M, Wiemann S.

Mol Oncol. 2018 Sep;12(9):1447-1463. doi: 10.1002/1878-0261.12355. Epub 2018 Jul 30.


Epigenetic Modifications of the α-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects.

Daniele S, Costa B, Pietrobono D, Giacomelli C, Iofrida C, Trincavelli ML, Fusi J, Franzoni F, Martini C.

Oxid Med Cell Longev. 2018 Apr 15;2018:3740345. doi: 10.1155/2018/3740345. eCollection 2018.


Negative effects of a high tumour necrosis factor-α concentration on human gingival mesenchymal stem cell trophism: the use of natural compounds as modulatory agents.

Giacomelli C, Natali L, Nisi M, De Leo M, Daniele S, Costa B, Graziani F, Gabriele M, Braca A, Trincavelli ML, Martini C.

Stem Cell Res Ther. 2018 May 11;9(1):135. doi: 10.1186/s13287-018-0880-7.


Putative salivary biomarkers useful to differentiate patients with fibromyalgia.

Ciregia F, Giacomelli C, Giusti L, Boldrini C, Piga I, Pepe P, Consensi A, Gori S, Lucacchini A, Mazzoni MR, Bazzichi L.

J Proteomics. 2019 Jan 6;190:44-54. doi: 10.1016/j.jprot.2018.04.012. Epub 2018 Apr 11.


Albumin biofunctionalization to minimize the Staphylococcus aureus adhesion on solid substrates.

Martín ML, Pfaffen V, Valenti LE, Giacomelli CE.

Colloids Surf B Biointerfaces. 2018 Jul 1;167:156-164. doi: 10.1016/j.colsurfb.2018.04.006. Epub 2018 Apr 3.


Relevance of protein-protein interactions on the biological identity of nanoparticles.

Vasti C, Bonnet LV, Galiano MR, Rojas R, Giacomelli CE.

Colloids Surf B Biointerfaces. 2018 Jun 1;166:330-338. doi: 10.1016/j.colsurfb.2018.03.032. Epub 2018 Mar 26.


α-Synuclein Heterocomplexes with β-Amyloid Are Increased in Red Blood Cells of Parkinson's Disease Patients and Correlate with Disease Severity.

Daniele S, Frosini D, Pietrobono D, Petrozzi L, Lo Gerfo A, Baldacci F, Fusi J, Giacomelli C, Siciliano G, Trincavelli ML, Franzoni F, Ceravolo R, Martini C, Bonuccelli U.

Front Mol Neurosci. 2018 Feb 22;11:53. doi: 10.3389/fnmol.2018.00053. eCollection 2018.


The A2B Adenosine Receptor Modulates the Epithelial- Mesenchymal Transition through the Balance of cAMP/PKA and MAPK/ERK Pathway Activation in Human Epithelial Lung Cells.

Giacomelli C, Daniele S, Romei C, Tavanti L, Neri T, Piano I, Celi A, Martini C, Trincavelli ML.

Front Pharmacol. 2018 Jan 31;9:54. doi: 10.3389/fphar.2018.00054. eCollection 2018.


α-Synuclein Aggregated with Tau and β-Amyloid in Human Platelets from Healthy Subjects: Correlation with Physical Exercise.

Daniele S, Pietrobono D, Fusi J, Lo Gerfo A, Cerri E, Chico L, Iofrida C, Petrozzi L, Baldacci F, Giacomelli C, Galetta F, Siciliano G, Bonuccelli U, Trincavelli ML, Franzoni F, Martini C.

Front Aging Neurosci. 2018 Jan 30;10:17. doi: 10.3389/fnagi.2018.00017. eCollection 2018.


Nanoparticle-Cell Interactions: Surface Chemistry Effects on the Cellular Uptake of Biocompatible Block Copolymer Assemblies.

de Castro CE, Ribeiro CAS, Alavarse AC, Albuquerque LJC, da Silva MCC, Jäger E, Surman F, Schmidt V, Giacomelli C, Giacomelli FC.

Langmuir. 2018 Feb 6;34(5):2180-2188. doi: 10.1021/acs.langmuir.7b04040. Epub 2018 Jan 29.


Carnosol controls the human glioblastoma stemness features through the epithelial-mesenchymal transition modulation and the induction of cancer stem cell apoptosis.

Giacomelli C, Daniele S, Natali L, Iofrida C, Flamini G, Braca A, Trincavelli ML, Martini C.

Sci Rep. 2017 Nov 9;7(1):15174. doi: 10.1038/s41598-017-15360-2.


Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer.

Morgillo F, Amendola G, Della Corte CM, Giacomelli C, Botta L, Di Maro S, Messere A, Ciaramella V, Taliani S, Marinelli L, Trincavelli ML, Martini C, Novellino E, Ciardiello F, Cosconati S.

J Med Chem. 2017 Sep 14;60(17):7447-7458. doi: 10.1021/acs.jmedchem.7b00794. Epub 2017 Aug 22.


Gene Transfection Mediated by Catiomers Requires Free Highly Charged Polymer Chains To Overcome Intracellular Barriers.

Albuquerque LJC, de Castro CE, Riske KA, da Silva MCC, Muraro PIR, Schmidt V, Giacomelli C, Giacomelli FC.

Biomacromolecules. 2017 Jun 12;18(6):1918-1927. doi: 10.1021/acs.biomac.7b00344. Epub 2017 May 5.


Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells.

Daniele S, Pietrobono D, Costa B, Giustiniano M, La Pietra V, Giacomelli C, La Regina G, Silvestri R, Taliani S, Trincavelli ML, Da Settimo F, Novellino E, Martini C, Marinelli L.

ACS Chem Neurosci. 2018 Jan 17;9(1):85-99. doi: 10.1021/acschemneuro.7b00023. Epub 2017 Apr 11.


Coordinated Pulses of mRNA and of Protein Translation or Degradation Produce EGF-Induced Protein Bursts.

Golan-Lavi R, Giacomelli C, Fuks G, Zeisel A, Sonntag J, Sinha S, Köstler W, Wiemann S, Korf U, Yarden Y, Domany E.

Cell Rep. 2017 Mar 28;18(13):3129-3142. doi: 10.1016/j.celrep.2017.03.014.


Effects of Antecedent Manipulations and Social Reinforcement to Increase Lateral Positioning in a Premature Infant with Obstructive Sleep Apnea.

Voulgarakis H, Forte S, Giacomelli C, Bendell-Estroff D, Krous H.

Behav Anal Pract. 2016 Aug 31;10(1):83-86. doi: 10.1007/s40617-016-0141-0. eCollection 2017 Mar.


Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization.

Nuti E, Rosalia L, Cuffaro D, Camodeca C, Giacomelli C, Da Pozzo E, Tuccinardi T, Costa B, Antoni C, Vera L, Ciccone L, Orlandini E, Nencetti S, Dive V, Martini C, Stura EA, Rossello A.

ACS Med Chem Lett. 2017 Feb 7;8(3):293-298. doi: 10.1021/acsmedchemlett.6b00446. eCollection 2017 Mar 9.


Potential biomarkers and novel pharmacological targets in protein aggregation-related neurodegenerative diseases.

Giacomelli C, Daniele S, Martini C.

Biochem Pharmacol. 2017 May 1;131:1-15. doi: 10.1016/j.bcp.2017.01.017. Epub 2017 Jan 31. Review.


Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals.

Daniele S, Natali L, Giacomelli C, Campiglia P, Novellino E, Martini C, Trincavelli ML.

Mol Cell Biol. 2017 Mar 31;37(8). pii: e00442-16. doi: 10.1128/MCB.00442-16. Print 2017 Apr 15.


Role for a water-soluble form of CoQ10 in female subjects affected by fibromyalgia. A preliminary study.

Di Pierro F, Rossi A, Consensi A, Giacomelli C, Bazzichi L.

Clin Exp Rheumatol. 2017 May-Jun;35 Suppl 105(3):20-27. Epub 2016 Dec 13.


Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells.

Daniele S, Sestito S, Pietrobono D, Giacomelli C, Chiellini G, Di Maio D, Marinelli L, Novellino E, Martini C, Rapposelli S.

ACS Chem Neurosci. 2017 Jan 18;8(1):100-114. doi: 10.1021/acschemneuro.6b00251. Epub 2016 Nov 10.


Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome.

Ciregia F, Kollipara L, Giusti L, Zahedi RP, Giacomelli C, Mazzoni MR, Giannaccini G, Scarpellini P, Urbani A, Sickmann A, Lucacchini A, Bazzichi L.

Transl Psychiatry. 2016 Sep 27;6(9):e904. doi: 10.1038/tp.2016.184.


Salivary psoriasin (S100A7) correlates with diffusion capacity of carbon monoxide in a large cohort of systemic sclerosis patients.

Giusti L, Sernissi F, Donadio E, Ciregia F, Giacomelli C, Giannaccini G, Mazzoni MR, Lucacchini A, Bazzichi L.

J Transl Med. 2016 Sep 8;14:262. doi: 10.1186/s12967-016-1023-5.


Intracellular Bioinorganic Chemistry and Cross Talk Among Different -Omics.

Mendola D, Giacomelli C, Rizzarelli E.

Curr Top Med Chem. 2016;16(27):3103-3130. Review.


TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being.

Da Pozzo E, Giacomelli C, Costa B, Cavallini C, Taliani S, Barresi E, Da Settimo F, Martini C.

Int J Mol Sci. 2016 Jun 29;17(7). pii: E1028. doi: 10.3390/ijms17071028.


4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor.

Cosimelli B, Greco G, Laneri S, Novellino E, Sacchi A, Trincavelli ML, Giacomelli C, Taliani S, Da Settimo F, Martini C.

Chem Biol Drug Des. 2016 Nov;88(5):724-729. doi: 10.1111/cbdd.12801. Epub 2016 Jul 11.


One year in review 2016: fibromyalgia.

Bazzichi L, Giacomelli C, Consensi A, Atzeni F, Batticciotto A, Di Franco M, Casale R, Sarzi-Puttini P.

Clin Exp Rheumatol. 2016 Mar-Apr;34(2 Suppl 96):S145-9. Epub 2016 Apr 22. Review.


Transdiagnostic factors across fibromyalgia and mental disorders: sleep disturbances may play a key role. A clinical review.

Palagini L, Carmassi C, Conversano C, Gesi C, Bazzichi L, Giacomelli C, Dell'Osso L.

Clin Exp Rheumatol. 2016 Mar-Apr;34(2 Suppl 96):S140-4. Epub 2016 Apr 27. Review.


Toward PET imaging of A2B adenosine receptors: a carbon-11 labeled triazinobenzimidazole tracer: Synthesis and imaging of a new A2B PET tracer.

Petroni D, Giacomelli C, Taliani S, Barresi E, Robello M, Daniele S, Bartoli A, Burchielli S, Pardini S, Salvadori PA, Da Settimo F, Martini C, Trincavelli ML, Menichetti L.

Nucl Med Biol. 2016 May;43(5):309-17. doi: 10.1016/j.nucmedbio.2016.02.005. Epub 2016 Feb 27.


New insights into the anticancer activity of carnosol: p53 reactivation in the U87MG human glioblastoma cell line.

Giacomelli C, Natali L, Trincavelli ML, Daniele S, Bertoli A, Flamini G, Braca A, Martini C.

Int J Biochem Cell Biol. 2016 May;74:95-108. doi: 10.1016/j.biocel.2016.02.019. Epub 2016 Mar 3.


Degradation dynamics of microRNAs revealed by a novel pulse-chase approach.

Marzi MJ, Ghini F, Cerruti B, de Pretis S, Bonetti P, Giacomelli C, Gorski MM, Kress T, Pelizzola M, Muller H, Amati B, Nicassio F.

Genome Res. 2016 Apr;26(4):554-65. doi: 10.1101/gr.198788.115. Epub 2016 Jan 28.


TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy.

Costa B, Da Pozzo E, Giacomelli C, Barresi E, Taliani S, Da Settimo F, Martini C.

Sci Rep. 2016 Jan 11;6:18164. doi: 10.1038/srep18164.


Efficient Condensation of DNA into Environmentally Responsive Polyplexes Produced from Block Catiomers Carrying Amine or Diamine Groups.

Albuquerque LJ, Annes K, Milazzotto MP, Mattei B, Riske KA, Jäger E, Pánek J, Štěpánek P, Kapusta P, Muraro PI, De Freitas AG, Schmidt V, Giacomelli C, Bonvent JJ, Giacomelli FC.

Langmuir. 2016 Jan 19;32(2):577-86. doi: 10.1021/acs.langmuir.5b04080. Epub 2016 Jan 4.


Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity.

La Mendola D, Arnesano F, Hansson Ö, Giacomelli C, Calò V, Mangini V, Magrì A, Bellia F, Trincavelli ML, Martini C, Natile G, Rizzarelli E.

Metallomics. 2016 Jan;8(1):118-24. doi: 10.1039/c5mt00216h.


Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection.

Da Pozzo E, Giacomelli C, Barresi E, Costa B, Taliani S, Passetti Fda S, Martini C.

Biochem Soc Trans. 2015 Aug;43(4):559-65. doi: 10.1042/BST20150028. Epub 2015 Aug 3. Review.


Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death.

Daniele S, Giacomelli C, Zappelli E, Granchi C, Trincavelli ML, Minutolo F, Martini C.

Sci Rep. 2015 Oct 23;5:15556. doi: 10.1038/srep15556.


Local Administration of Gold Nanoparticles Prevents Pivotal Pathological Changes in Murine Models of Atopic Asthma.

Barreto E, Serra MF, Dos Santos RV, Dos Santos CE, Hickmann J, Cotias AC, Pão CR, Trindade SG, Schimidt V, Giacomelli C, Carvalho VF, Rodrigues E Silva PM, Cordeiro RS, Martins MA.

J Biomed Nanotechnol. 2015 Jun;11(6):1038-50.


Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides.

Barresi E, Bruno A, Taliani S, Cosconati S, Da Pozzo E, Salerno S, Simorini F, Daniele S, Giacomelli C, Marini AM, La Motta C, Marinelli L, Cosimelli B, Novellino E, Greco G, Da Settimo F, Martini C.

J Med Chem. 2015 Aug 13;58(15):6081-92. doi: 10.1021/acs.jmedchem.5b00689. Epub 2015 Jul 28.


Unaffected features of BSA stabilized Ag nanoparticles after storage and reconstitution in biological relevant media.

Valenti LE, Giacomelli CE.

Colloids Surf B Biointerfaces. 2015 Aug 1;132:71-7. doi: 10.1016/j.colsurfb.2015.05.002. Epub 2015 May 14.


Fibromyalgia and nutrition: what news?

Rossi A, Di Lollo AC, Guzzo MP, Giacomelli C, Atzeni F, Bazzichi L, Di Franco M.

Clin Exp Rheumatol. 2015 Jan-Feb;33(1 Suppl 88):S117-25. Epub 2015 Mar 18. Review.


Algo-dysfunctional syndromes: a critical digest of the recent literature.

Talotta R, Atzeni F, Bazzichi L, Giacomelli C, Di Franco M, Salaffi F, Sarzi-Puttini P.

Clin Exp Rheumatol. 2015 Jan-Feb;33(1 Suppl 88):S102-8. Epub 2015 Mar 18. Review.


♦Copper (II) ions modulate Angiogenin activity in human endothelial cells.

Giacomelli C, Trincavelli ML, Satriano C, Hansson Ö, La Mendola D, Rizzarelli E, Martini C.

Int J Biochem Cell Biol. 2015 Mar;60:185-96. doi: 10.1016/j.biocel.2015.01.005. Epub 2015 Jan 14.


Polymer-coated palladium nanoparticle catalysts for Suzuki coupling reactions.

Bortolotto T, Facchinetto SE, Trindade SG, Ossig A, Petzhold CL, Vargas J, Rodrigues OE, Giacomelli C, Schmidt V.

J Colloid Interface Sci. 2015 Feb 1;439:154-61. doi: 10.1016/j.jcis.2014.10.037. Epub 2014 Nov 4.


Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.

Giovannoni MP, Ciciani G, Cilibrizzi A, Crocetti L, Daniele S, Di Cesare Mannelli L, Ghelardini C, Giacomelli C, Guerrini G, Martini C, Trincavelli ML, Vergelli C.

Eur J Med Chem. 2015 Jan 7;89:32-41. doi: 10.1016/j.ejmech.2014.10.020. Epub 2014 Oct 12.


TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance.

Costa B, Da Pozzo E, Giacomelli C, Taliani S, Bendinelli S, Barresi E, Da Settimo F, Martini C.

Apoptosis. 2015 Mar;20(3):383-98. doi: 10.1007/s10495-014-1063-3.


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