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Evaluation of the effects of rTMS on self-reported quality of life and disability in treatment-resistant depression: A THREE-D study.

Giacobbe P, Mithani K, Meng Y, Vila-Rodriguez F, Daskalakis ZJ, Downar J, Blumberger DM.

J Affect Disord. 2020 May 1;268:127-133. doi: 10.1016/j.jad.2020.03.002. Epub 2020 Mar 3.


A low-mass planet candidate orbiting Proxima Centauri at a distance of 1.5 AU.

Damasso M, Del Sordo F, Anglada-Escudé G, Giacobbe P, Sozzetti A, Morbidelli A, Pojmanski G, Barbato D, Butler RP, Jones HRA, Hambsch FJ, Jenkins JS, López-González MJ, Morales N, Peña Rojas PA, Rodríguez-López C, Rodríguez E, Amado PJ, Anglada G, Feng F, Gómez JF.

Sci Adv. 2020 Jan 15;6(3):eaax7467. doi: 10.1126/sciadv.aax7467. eCollection 2020 Jan.


Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers.

Daniels S, Horman T, Lapointe T, Melanson B, Storace A, Kennedy SH, Frey BN, Rizvi SJ, Hassel S, Mueller DJ, Parikh SV, Lam RW, Blier P, Farzan F, Giacobbe P, Milev R, Placenza F, Soares CN, Turecki G, Uher R, Leri F.

J Affect Disord. 2020 Feb 15;263:353-366. doi: 10.1016/j.jad.2019.11.108. Epub 2019 Nov 23. Review.


Endocannabinoid modulating drugs improve anxiety but not the expression of conditioned fear in a rodent model of post-traumatic stress disorder.

Vimalanathan A, Gidyk DC, Diwan M, Gouveia FV, Lipsman N, Giacobbe P, Nobrega JN, Hamani C.

Neuropharmacology. 2020 Apr;166:107965. doi: 10.1016/j.neuropharm.2020.107965. Epub 2020 Jan 13.


Use of Machine Learning for Predicting Escitalopram Treatment Outcome From Electroencephalography Recordings in Adult Patients With Depression.

Zhdanov A, Atluri S, Wong W, Vaghei Y, Daskalakis ZJ, Blumberger DM, Frey BN, Giacobbe P, Lam RW, Milev R, Mueller DJ, Turecki G, Parikh SV, Rotzinger S, Soares CN, Brenner CA, Vila-Rodriguez F, McAndrews MP, Kleffner K, Alonso-Prieto E, Arnott SR, Foster JA, Strother SC, Uher R, Kennedy SH, Farzan F.

JAMA Netw Open. 2020 Jan 3;3(1):e1918377. doi: 10.1001/jamanetworkopen.2019.18377.


Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation for treatment-refractory major depressive disorder: A three-arm, blinded, randomized controlled trial.

Dunlop K, Sheen J, Schulze L, Fettes P, Mansouri F, Feffer K, Blumberger DM, Daskalakis ZJ, Kennedy SH, Giacobbe P, Woodside B, Downar J.

Brain Stimul. 2020 Mar - Apr;13(2):337-340. doi: 10.1016/j.brs.2019.10.020. Epub 2019 Oct 31.


Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants.

Ju C, Fiori LM, Belzeaux R, Theroux JF, Chen GG, Aouabed Z, Blier P, Farzan F, Frey BN, Giacobbe P, Lam RW, Leri F, MacQueen GM, Milev R, Müller DJ, Parikh SV, Rotzinger S, Soares CN, Uher R, Li Q, Foster JA, Kennedy SH, Turecki G.

Transl Psychiatry. 2019 Oct 8;9(1):254. doi: 10.1038/s41398-019-0589-0.


Probing the circuitry of panic with deep brain stimulation: Connectomic analysis and review of the literature.

Elias GJB, Giacobbe P, Boutet A, Germann J, Beyn ME, Gramer RM, Pancholi A, Joel SE, Lozano AM.

Brain Stimul. 2020 Jan - Feb;13(1):10-14. doi: 10.1016/j.brs.2019.09.010. Epub 2019 Sep 25.


Neuroanatomical predictors of response to subcallosal cingulate deep brain stimulation for treatment-resistant depression

Sankar T, Chakravarty MM, Jawa N, Li SX, Giacobbe P, Kennedy SH, Rizvi SJ, Mayberg HS, Hamani C, Lozano AM.

J Psychiatry Neurosci. 2020 Jan 1;45(1):45-54. doi: 10.1503/jpn.180207.


Network Basis of Seizures Induced by Deep Brain Stimulation: Literature Review and Connectivity Analysis.

Boutet A, Jain M, Elias GJB, Gramer R, Germann J, Davidson B, Coblentz A, Giacobbe P, Kucharczyk W, Wennberg RA, Ibrahim GM, Lozano AM.

World Neurosurg. 2019 Dec;132:314-320. doi: 10.1016/j.wneu.2019.08.094. Epub 2019 Aug 23. Review.


Electroencephalography in Psychiatric Surgery: Past Use and Future Directions.

Mithani K, Meng Y, Abrahao A, Mikhail M, Hamani C, Giacobbe P, Lipsman N.

Stereotact Funct Neurosurg. 2019;97(3):141-152. doi: 10.1159/000500994. Epub 2019 Aug 14. Review.


Safety, tolerability and effectiveness of a novel 20 Hz rTMS protocol targeting dorsomedial prefrontal cortex in major depression: An open-label case series.

Miron JP, Feffer K, Cash RFH, Derakhshan D, Kim JMS, Fettes P, Giacobbe P, Blumberger DM, Daskalakis ZJ, Downar J.

Brain Stimul. 2019 Sep - Oct;12(5):1319-1321. doi: 10.1016/j.brs.2019.06.020. Epub 2019 Jun 20. No abstract available.


Magnetic Resonance-Guided Focused Ultrasound for Psychiatric Disorders.

Davidson B, Meng Y, Giacobbe P, Hamani C, Lipsman N.

Clin Pharmacol Ther. 2019 Oct;106(4):720-722. doi: 10.1002/cpt.1467. Epub 2019 May 24. No abstract available.


Predicting Worsening Suicidal Ideation With Clinical Features and Peripheral Expression of Messenger RNA and MicroRNA During Antidepressant Treatment.

Belzeaux R, Fiori LM, Lopez JP, Boucekine M, Boyer L, Blier P, Farzan F, Frey BN, Giacobbe P, Lam RW, Leri F, MacQueen GM, Milev R, Müller DJ, Parikh SV, Rotzinger S, Soares CN, Uher R, Foster JA, Kennedy SH, Turecki G.

J Clin Psychiatry. 2019 May 7;80(3). pii: 18m12556. doi: 10.4088/JCP.18m12556.


Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report.

Kennedy SH, Lam RW, Rotzinger S, Milev RV, Blier P, Downar J, Evans KR, Farzan F, Foster JA, Frey BN, Giacobbe P, Hall GB, Harkness KL, Hassel S, Ismail Z, Leri F, McInerney S, MacQueen GM, Minuzzi L, Müller DJ, Parikh SV, Placenza FM, Quilty LC, Ravindran AV, Sassi RB, Soares CN, Strother SC, Turecki G, Vaccarino AL, Vila-Rodriguez F, Yu J, Uher R; CAN-BIND Investigator Team.

J Clin Psychiatry. 2019 Feb 5;80(2). pii: 18m12202. doi: 10.4088/JCP.18m12202.


Neuromodulation Strategies in Post-Traumatic Stress Disorder: From Preclinical Models to Clinical Applications.

Gouveia FV, Gidyk DC, Giacobbe P, Ng E, Meng Y, Davidson B, Abrahao A, Lipsman N, Hamani C.

Brain Sci. 2019 Feb 19;9(2). pii: E45. doi: 10.3390/brainsci9020045. Review.


Trajectories of Response to Dorsolateral Prefrontal rTMS in Major Depression: A THREE-D Study.

Kaster TS, Downar J, Vila-Rodriguez F, Thorpe KE, Feffer K, Noda Y, Giacobbe P, Knyahnytska Y, Kennedy SH, Lam RW, Daskalakis ZJ, Blumberger DM.

Am J Psychiatry. 2019 May 1;176(5):367-375. doi: 10.1176/appi.ajp.2018.18091096. Epub 2019 Feb 15.


A Real-Time Phase-Locking System for Non-invasive Brain Stimulation.

Mansouri F, Fettes P, Schulze L, Giacobbe P, Zariffa J, Downar J.

Front Neurosci. 2018 Dec 3;12:877. doi: 10.3389/fnins.2018.00877. eCollection 2018.


Inferior thalamic peduncle deep brain stimulation for treatment-refractory obsessive-compulsive disorder: A phase 1 pilot trial.

Lee DJ, Dallapiazza RF, De Vloo P, Elias GJB, Fomenko A, Boutet A, Giacobbe P, Lozano AM.

Brain Stimul. 2019 Mar - Apr;12(2):344-352. doi: 10.1016/j.brs.2018.11.012. Epub 2018 Nov 27.


Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia (the ADvance Trial): A Two Year Follow-up Including Results of Delayed Activation.

Leoutsakos JS, Yan H, Anderson WS, Asaad WF, Baltuch G, Burke A, Chakravarty MM, Drake KE, Foote KD, Fosdick L, Giacobbe P, Mari Z, McAndrews MP, Munro CA, Oh ES, Okun MS, Pendergrass JC, Ponce FA, Rosenberg PB, Sabbagh MN, Salloway S, Tang-Wai DF, Targum SD, Wolk D, Lozano AM, Smith GS, Lyketsos CG.

J Alzheimers Dis. 2018;64(2):597-606. doi: 10.3233/JAD-180121.


Development and validation of a 3D-printed neuronavigation headset for therapeutic brain stimulation.

Mansouri F, Mir-Moghtadaei A, Niranjan V, Wu JS, Akhmedjanov D, Nuh M, Cairo T, Giacobbe P, Zariffa J, Downar J.

J Neural Eng. 2018 Aug;15(4):046034. doi: 10.1088/1741-2552/aacb96. Epub 2018 Jun 11.


Diagnosis and Management of Anxiety Disorders.

Giacobbe P, Flint A.

Continuum (Minneap Minn). 2018 Jun;24(3, BEHAVIORAL NEUROLOGY AND PSYCHIATRY):893-919. doi: 10.1212/CON.0000000000000607. Review.


Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial.

Blumberger DM, Vila-Rodriguez F, Thorpe KE, Feffer K, Noda Y, Giacobbe P, Knyahnytska Y, Kennedy SH, Lam RW, Daskalakis ZJ, Downar J.

Lancet. 2018 Apr 28;391(10131):1683-1692. doi: 10.1016/S0140-6736(18)30295-2. Epub 2018 Apr 26. Erratum in: Lancet. 2018 Jun 23;391(10139):e24.


Abnormal Functional Connectivity of Frontopolar Subregions in Treatment-Nonresponsive Major Depressive Disorder.

Fettes PW, Moayedi M, Dunlop K, Mansouri F, Vila-Rodriguez F, Giacobbe P, Davis KD, Lam RW, Kennedy SH, Daskalakis ZJ, Blumberger DM, Downar J.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Apr;3(4):337-347. doi: 10.1016/j.bpsc.2017.12.003. Epub 2017 Dec 27.


Conflict monitoring mechanism at the single-neuron level in the human ventral anterior cingulate cortex.

Shapira-Lichter I, Strauss I, Oren N, Gazit T, Sammartino F, Giacobbe P, Kennedy S, Hutchison WD, Fried I, Hendler T, Lozano AM.

Neuroimage. 2018 Jul 15;175:45-55. doi: 10.1016/j.neuroimage.2018.03.028. Epub 2018 Mar 15.


Improvements in Health-Related Quality of Life With Electroconvulsive Therapy: A Meta-analysis.

Giacobbe P, Rakita U, Penner-Goeke K, Feffer K, Flint AJ, Kennedy SH, Downar J.

J ECT. 2018 Jun;34(2):87-94. doi: 10.1097/YCT.0000000000000486. Review.


The comparative effectiveness of electroencephalographic indices in predicting response to escitalopram therapy in depression: A pilot study.

Baskaran A, Farzan F, Milev R, Brenner CA, Alturi S, Pat McAndrews M, Blier P, Evans K, Foster JA, Frey BN, Giacobbe P, Lam RW, Leri F, MacQueen GM, Müller DJ, Parikh SV, Rotzinger S, Soares CN, Strother SC, Turecki G, Kennedy SH; CAN-BIND Investigators Team.

J Affect Disord. 2018 Feb;227:542-549. doi: 10.1016/j.jad.2017.10.028. Epub 2017 Nov 3.


1Hz rTMS of the right orbitofrontal cortex for major depression: Safety, tolerability and clinical outcomes.

Feffer K, Fettes P, Giacobbe P, Daskalakis ZJ, Blumberger DM, Downar J.

Eur Neuropsychopharmacol. 2018 Jan;28(1):109-117. doi: 10.1016/j.euroneuro.2017.11.011. Epub 2017 Nov 17.


Number of pulses or number of sessions? An open-label study of trajectories of improvement for once-vs. twice-daily dorsomedial prefrontal rTMS in major depression.

Schulze L, Feffer K, Lozano C, Giacobbe P, Daskalakis ZJ, Blumberger DM, Downar J.

Brain Stimul. 2018 Mar - Apr;11(2):327-336. doi: 10.1016/j.brs.2017.11.002. Epub 2017 Nov 7.


Early symptom improvement at 10 sessions as a predictor of rTMS treatment outcome in major depression.

Feffer K, Lee HH, Mansouri F, Giacobbe P, Vila-Rodriguez F, Kennedy SH, Daskalakis ZJ, Blumberger DM, Downar J.

Brain Stimul. 2018 Jan - Feb;11(1):181-189. doi: 10.1016/j.brs.2017.10.010. Epub 2017 Oct 19.


Epilepsy as a Network Disorder (1): What can we learn from other network disorders such as autistic spectrum disorder and mood disorders?

Kanner AM, Scharfman H, Jette N, Anagnostou E, Bernard C, Camfield C, Camfield P, Legg K, Dinstein I, Giacobbe P, Friedman A, Pohlmann-Eden B.

Epilepsy Behav. 2017 Dec;77:106-113. doi: 10.1016/j.yebeh.2017.09.014. Epub 2017 Oct 26.


Efficacy and tolerability of lisdexamfetamine as an antidepressant augmentation strategy: A meta-analysis of randomized controlled trials.

Giacobbe P, Rakita U, Lam R, Milev R, Kennedy SH, McIntyre RS.

J Affect Disord. 2018 Jan 15;226:294-300. doi: 10.1016/j.jad.2017.09.041. Epub 2017 Oct 3.


A Fast EEG Forecasting Algorithm for Phase-Locked Transcranial Electrical Stimulation of the Human Brain.

Mansouri F, Dunlop K, Giacobbe P, Downar J, Zariffa J.

Front Neurosci. 2017 Jul 20;11:401. doi: 10.3389/fnins.2017.00401. eCollection 2017.


The History and Future of Ablative Neurosurgery for Major Depressive Disorder.

Volpini M, Giacobbe P, Cosgrove GR, Levitt A, Lozano AM, Lipsman N.

Stereotact Funct Neurosurg. 2017;95(4):216-228. doi: 10.1159/000478025. Epub 2017 Jul 20. Review.


Factors Associated With Global Variability in Electroconvulsive Therapy Utilization.

Rakita U, Bingham K, Fung K, Giacobbe P.

J ECT. 2017 Dec;33(4):253-259. doi: 10.1097/YCT.0000000000000405.


MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.

Lopez JP, Fiori LM, Cruceanu C, Lin R, Labonte B, Cates HM, Heller EA, Vialou V, Ku SM, Gerald C, Han MH, Foster J, Frey BN, Soares CN, Müller DJ, Farzan F, Leri F, MacQueen GM, Feilotter H, Tyryshkin K, Evans KR, Giacobbe P, Blier P, Lam RW, Milev R, Parikh SV, Rotzinger S, Strother SC, Lewis CM, Aitchison KJ, Wittenberg GM, Mechawar N, Nestler EJ, Uher R, Kennedy SH, Turecki G.

Nat Commun. 2017 May 22;8:15497. doi: 10.1038/ncomms15497.


Neurocognitive Predictors of Response in Treatment Resistant Depression to Subcallosal Cingulate Gyrus Deep Brain Stimulation.

McInerney SJ, McNeely HE, Geraci J, Giacobbe P, Rizvi SJ, Ceniti AK, Cyriac A, Mayberg HS, Lozano AM, Kennedy SH.

Front Hum Neurosci. 2017 Feb 24;11:74. doi: 10.3389/fnhum.2017.00074. eCollection 2017.


Deep brain stimulation of the subcallosal cingulate for treatment-refractory anorexia nervosa: 1 year follow-up of an open-label trial.

Lipsman N, Lam E, Volpini M, Sutandar K, Twose R, Giacobbe P, Sodums DJ, Smith GS, Woodside DB, Lozano AM.

Lancet Psychiatry. 2017 Apr;4(4):285-294. doi: 10.1016/S2215-0366(17)30076-7. Epub 2017 Feb 24.


Successful dorsomedial prefrontal rTMS for major depression in borderline personality disorder: Three cases.

Feffer K, Peters SK, Bhui K, Downar J, Giacobbe P.

Brain Stimul. 2017 May - Jun;10(3):716-717. doi: 10.1016/j.brs.2017.01.583. Epub 2017 Feb 2. No abstract available.


Neural correlates of successful orbitofrontal 1 Hz rTMS following unsuccessful dorsolateral and dorsomedial prefrontal rTMS in major depression: A case report.

Fettes P, Peters S, Giacobbe P, Blumberger DM, Downar J.

Brain Stimul. 2017 Jan - Feb;10(1):165-167. doi: 10.1016/j.brs.2016.11.008. Epub 2016 Nov 16. No abstract available.


Effect of antipsychotic pharmacotherapy on clinical outcomes of intermittent theta-burst stimulation for refractory depression.

Schulze L, Remington G, Giacobbe P, Kennedy SH, Blumberger DM, Daskalakis ZJ, Downar J.

J Psychopharmacol. 2017 Mar;31(3):312-319. doi: 10.1177/0269881116675516. Epub 2016 Nov 11.


Opioid use disorder patients' perceptions of healthcare delivery platforms.

Rakita U, Giacobbe P, Cavacuiti C.

SAGE Open Med. 2016 Sep 23;4:2050312116670405. eCollection 2016.


A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer's Disease.

Lozano AM, Fosdick L, Chakravarty MM, Leoutsakos JM, Munro C, Oh E, Drake KE, Lyman CH, Rosenberg PB, Anderson WS, Tang-Wai DF, Pendergrass JC, Salloway S, Asaad WF, Ponce FA, Burke A, Sabbagh M, Wolk DA, Baltuch G, Okun MS, Foote KD, McAndrews MP, Giacobbe P, Targum SD, Lyketsos CG, Smith GS.

J Alzheimers Dis. 2016 Sep 6;54(2):777-87. doi: 10.3233/JAD-160017.


Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 4. Neurostimulation Treatments.

Milev RV, Giacobbe P, Kennedy SH, Blumberger DM, Daskalakis ZJ, Downar J, Modirrousta M, Patry S, Vila-Rodriguez F, Lam RW, MacQueen GM, Parikh SV, Ravindran AV; CANMAT Depression Work Group.

Can J Psychiatry. 2016 Sep;61(9):561-75. doi: 10.1177/0706743716660033. Epub 2016 Aug 2. Review.


Validation of a 25% Nasion-Inion Heuristic for Locating the Dorsomedial Prefrontal Cortex for Repetitive Transcranial Magnetic Stimulation.

Mir-Moghtadaei A, Giacobbe P, Daskalakis ZJ, Blumberger DM, Downar J.

Brain Stimul. 2016 Sep-Oct;9(5):793-795. doi: 10.1016/j.brs.2016.05.010. Epub 2016 May 24. No abstract available.


Cognitive safety of dorsomedial prefrontal repetitive transcranial magnetic stimulation in major depression.

Schulze L, Wheeler S, McAndrews MP, Solomon CJ, Giacobbe P, Downar J.

Eur Neuropsychopharmacol. 2016 Jul;26(7):1213-26. doi: 10.1016/j.euroneuro.2016.04.004. Epub 2016 May 3.


Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort.

Lam RW, Milev R, Rotzinger S, Andreazza AC, Blier P, Brenner C, Daskalakis ZJ, Dharsee M, Downar J, Evans KR, Farzan F, Foster JA, Frey BN, Geraci J, Giacobbe P, Feilotter HE, Hall GB, Harkness KL, Hassel S, Ismail Z, Leri F, Liotti M, MacQueen GM, McAndrews MP, Minuzzi L, Müller DJ, Parikh SV, Placenza FM, Quilty LC, Ravindran AV, Salomons TV, Soares CN, Strother SC, Turecki G, Vaccarino AL, Vila-Rodriguez F, Kennedy SH; CAN-BIND Investigator Team.

BMC Psychiatry. 2016 Apr 16;16:105. doi: 10.1186/s12888-016-0785-x.


Reductions in Cortico-Striatal Hyperconnectivity Accompany Successful Treatment of Obsessive-Compulsive Disorder with Dorsomedial Prefrontal rTMS.

Dunlop K, Woodside B, Olmsted M, Colton P, Giacobbe P, Downar J.

Neuropsychopharmacology. 2016 Apr;41(5):1395-403. doi: 10.1038/npp.2015.292. Epub 2015 Oct 6.


MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder.

Dunlop K, Gaprielian P, Blumberger D, Daskalakis ZJ, Kennedy SH, Giacobbe P, Downar J.

J Vis Exp. 2015 Aug 11;(102):e53129. doi: 10.3791/53129.


Increases in frontostriatal connectivity are associated with response to dorsomedial repetitive transcranial magnetic stimulation in refractory binge/purge behaviors.

Dunlop K, Woodside B, Lam E, Olmsted M, Colton P, Giacobbe P, Downar J.

Neuroimage Clin. 2015 Jul 2;8:611-8. doi: 10.1016/j.nicl.2015.06.008. eCollection 2015.

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