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PiT-2, a type III sodium-dependent phosphate transporter, protects against vascular calcification in mice with chronic kidney disease fed a high-phosphate diet.

Yamada S, Leaf EM, Chia JJ, Cox TC, Speer MY, Giachelli CM.

Kidney Int. 2018 Oct;94(4):716-727. doi: 10.1016/j.kint.2018.05.015. Epub 2018 Jul 21.


Increased Calcific Aortic Valve Disease in response to a diabetogenic, procalcific diet in the LDLr-/-ApoB100/100 mouse model.

Scatena M, Jackson MF, Speer MY, Leaf EM, Wallingford MC, Giachelli CM.

Cardiovasc Pathol. 2018 May - Jun;34:28-37. doi: 10.1016/j.carpath.2018.02.002. Epub 2018 Feb 15.


Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness.

Durham AL, Speer MY, Scatena M, Giachelli CM, Shanahan CM.

Cardiovasc Res. 2018 Mar 15;114(4):590-600. doi: 10.1093/cvr/cvy010. Review.


Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice.

Yamada S, Wallingford MC, Borgeia S, Cox TC, Giachelli CM.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):553-559. doi: 10.1016/j.bbrc.2017.11.071. Epub 2017 Nov 11.


Noncanonical Wnts at the Cusp of Fibrocalcific Signaling Processes in Human Calcific Aortic Valve Disease.

Giachelli CM, Speer MY.

Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):387-388. doi: 10.1161/ATVBAHA.116.308842. No abstract available.


Osteoclast precursors do not express CD68: results from CD68 promoter-driven RANK transgenic mice.

Jackson MF, Scatena M, Giachelli CM.

FEBS Lett. 2017 Mar;591(5):728-736. doi: 10.1002/1873-3468.12588. Epub 2017 Feb 20.


Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho.

Yamada S, Giachelli CM.

Bone. 2017 Jul;100:87-93. doi: 10.1016/j.bone.2016.11.012. Epub 2016 Nov 12. Review.


Runx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation.

Lin ME, Chen TM, Wallingford MC, Nguyen NB, Yamada S, Sawangmake C, Zhang J, Speer MY, Giachelli CM.

Cardiovasc Res. 2016 Nov 1;112(2):606-616. doi: 10.1093/cvr/cvw205.


Osteopontin protects against high phosphate-induced nephrocalcinosis and vascular calcification.

Paloian NJ, Leaf EM, Giachelli CM.

Kidney Int. 2016 May;89(5):1027-1036. doi: 10.1016/j.kint.2015.12.046. Epub 2016 Mar 9.


Slc20a2 deficiency results in fetal growth restriction and placental calcification associated with thickened basement membranes and novel CD13 and lamininα1 expressing cells.

Wallingford MC, Gammill HS, Giachelli CM.

Reprod Biol. 2016 Mar;16(1):13-26. doi: 10.1016/j.repbio.2015.12.004. Epub 2016 Jan 11.


SLC20A2 Deficiency in Mice Leads to Elevated Phosphate Levels in Cerbrospinal Fluid and Glymphatic Pathway-Associated Arteriolar Calcification, and Recapitulates Human Idiopathic Basal Ganglia Calcification.

Wallingford MC, Chia JJ, Leaf EM, Borgeia S, Chavkin NW, Sawangmake C, Marro K, Cox TC, Speer MY, Giachelli CM.

Brain Pathol. 2017 Jan;27(1):64-76. doi: 10.1111/bpa.12362. Epub 2016 May 6.


Engineering macrophages to control the inflammatory response and angiogenesis.

Eaton KV, Yang HL, Giachelli CM, Scatena M.

Exp Cell Res. 2015 Dec 10;339(2):300-9. doi: 10.1016/j.yexcr.2015.11.021. Epub 2015 Nov 21.


Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice.

Lin ME, Chen T, Leaf EM, Speer MY, Giachelli CM.

Am J Pathol. 2015 Jul;185(7):1958-69. doi: 10.1016/j.ajpath.2015.03.020. Epub 2015 May 15.


Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells.

Chavkin NW, Chia JJ, Crouthamel MH, Giachelli CM.

Exp Cell Res. 2015 Apr 10;333(1):39-48. doi: 10.1016/j.yexcr.2015.02.002. Epub 2015 Feb 13.


Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.

Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E.

Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2387-93. doi: 10.1161/ATVBAHA.114.302523. Epub 2014 Sep 4. Review.


A current understanding of vascular calcification in CKD.

Paloian NJ, Giachelli CM.

Am J Physiol Renal Physiol. 2014 Oct 15;307(8):F891-900. doi: 10.1152/ajprenal.00163.2014. Epub 2014 Aug 20. Review.


Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.

Wallingford MC, Giachelli CM.

Mech Dev. 2014 Aug;133:189-202. doi: 10.1016/j.mod.2014.08.001. Epub 2014 Aug 17.


Engineered biomaterials control differentiation and proliferation of human-embryonic-stem-cell-derived cardiomyocytes via timed Notch activation.

Tung JC, Paige SL, Ratner BD, Murry CE, Giachelli CM.

Stem Cell Reports. 2014 Feb 27;2(3):271-81. doi: 10.1016/j.stemcr.2014.01.011. eCollection 2014 Mar 11.


An inducible, ligand-independent receptor activator of NF-κB gene to control osteoclast differentiation from monocytic precursors.

Rementer CW, Wu M, Buranaphatthana W, Yang HY, Scatena M, Giachelli CM.

PLoS One. 2013 Dec 27;8(12):e84465. doi: 10.1371/journal.pone.0084465. eCollection 2013.


Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2.

Crouthamel MH, Lau WL, Leaf EM, Chavkin NW, Wallingford MC, Peterson DF, Li X, Liu Y, Chin MT, Levi M, Giachelli CM.

Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2625-32. doi: 10.1161/ATVBAHA.113.302249. Epub 2013 Aug 22.


Vascular calcification: an update on mechanisms and challenges in treatment.

Wu M, Rementer C, Giachelli CM.

Calcif Tissue Int. 2013 Oct;93(4):365-73. doi: 10.1007/s00223-013-9712-z. Epub 2013 Mar 1. Review.


Fibroblast growth factor 23 is not associated with and does not induce arterial calcification.

Scialla JJ, Lau WL, Reilly MP, Isakova T, Yang HY, Crouthamel MH, Chavkin NW, Rahman M, Wahl P, Amaral AP, Hamano T, Master SR, Nessel L, Chai B, Xie D, Kallem RR, Chen J, Lash JP, Kusek JW, Budoff MJ, Giachelli CM, Wolf M; Chronic Renal Insufficiency Cohort Study Investigators.

Kidney Int. 2013 Jun;83(6):1159-68. doi: 10.1038/ki.2013.3. Epub 2013 Feb 6.


Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B cell development.

Liu L, Sánchez-Bonilla M, Crouthamel M, Giachelli C, Keel S.

Exp Hematol. 2013 May;41(5):432-43.e7. doi: 10.1016/j.exphem.2013.01.004. Epub 2013 Jan 30.


Prevascularized microtemplated fibrin scaffolds for cardiac tissue engineering applications.

Thomson KS, Korte FS, Giachelli CM, Ratner BD, Regnier M, Scatena M.

Tissue Eng Part A. 2013 Apr;19(7-8):967-77. doi: 10.1089/ten.tea.2012.0286. Epub 2013 Jan 14.


Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin.

Lund SA, Wilson CL, Raines EW, Tang J, Giachelli CM, Scatena M.

J Cell Biochem. 2013 May;114(5):1194-202. doi: 10.1002/jcb.24462.


Smooth muscle cell plasticity: fact or fiction?

Nguyen AT, Gomez D, Bell RD, Campbell JH, Clowes AW, Gabbiani G, Giachelli CM, Parmacek MS, Raines EW, Rusch NJ, Speer MY, Sturek M, Thyberg J, Towler DA, Weiser-Evans MC, Yan C, Miano JM, Owens GK.

Circ Res. 2013 Jan 4;112(1):17-22. doi: 10.1161/CIRCRESAHA.112.281048. Epub 2012 Oct 23. No abstract available.


High phosphate feeding promotes mineral and bone abnormalities in mice with chronic kidney disease.

Lau WL, Linnes M, Chu EY, Foster BL, Bartley BA, Somerman MJ, Giachelli CM.

Nephrol Dial Transplant. 2013 Jan;28(1):62-9. doi: 10.1093/ndt/gfs333. Epub 2012 Oct 8.


RANKL enhances macrophage paracrine pro-calcific activity in high phosphate-treated smooth muscle cells: dependence on IL-6 and TNF-α.

Deuell KA, Callegari A, Giachelli CM, Rosenfeld ME, Scatena M.

J Vasc Res. 2012;49(6):510-21. doi: 10.1159/000341216. Epub 2012 Aug 30.


Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet.

Lau WL, Leaf EM, Hu MC, Takeno MM, Kuro-o M, Moe OW, Giachelli CM.

Kidney Int. 2012 Dec;82(12):1261-70. doi: 10.1038/ki.2012.322. Epub 2012 Aug 29.


Surface-bound orientated Jagged-1 enhances osteogenic differentiation of human periodontal ligament-derived mesenchymal stem cells.

Osathanon T, Ritprajak P, Nowwarote N, Manokawinchoke J, Giachelli C, Pavasant P.

J Biomed Mater Res A. 2013 Feb;101(2):358-67. doi: 10.1002/jbm.a.34332. Epub 2012 Jul 30.


Engineering biomaterials to integrate and heal: the biocompatibility paradigm shifts.

Bryers JD, Giachelli CM, Ratner BD.

Biotechnol Bioeng. 2012 Aug;109(8):1898-911. doi: 10.1002/bit.24559. Epub 2012 May 24. Review.


Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping study.

Naik V, Leaf EM, Hu JH, Yang HY, Nguyen NB, Giachelli CM, Speer MY.

Cardiovasc Res. 2012 Jun 1;94(3):545-54. doi: 10.1093/cvr/cvs126. Epub 2012 Mar 21.


Combination of Sleeping Beauty transposition and chemically induced dimerization selection for robust production of engineered cells.

Kacherovsky N, Harkey MA, Blau CA, Giachelli CM, Pun SH.

Nucleic Acids Res. 2012 Jun;40(11):e85. doi: 10.1093/nar/gks213. Epub 2012 Mar 8.


Arterial calcification in chronic kidney disease: key roles for calcium and phosphate.

Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM.

Circ Res. 2011 Sep 2;109(6):697-711. doi: 10.1161/CIRCRESAHA.110.234914. Review.


Direct effects of phosphate on vascular cell function.

Lau WL, Pai A, Moe SM, Giachelli CM.

Adv Chronic Kidney Dis. 2011 Mar;18(2):105-12. doi: 10.1053/j.ackd.2010.12.002. Review.


Matrix remodeling in vascular calcification associated with chronic kidney disease.

Pai AS, Giachelli CM.

J Am Soc Nephrol. 2010 Oct;21(10):1637-40. doi: 10.1681/ASN.2010040349. Epub 2010 Aug 26.


Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1.

Lau WL, Festing MH, Giachelli CM.

Thromb Haemost. 2010 Sep;104(3):464-70. doi: 10.1160/TH09-12-0814. Epub 2010 Jul 20. Review.


Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification.

Yao Y, Bennett BJ, Wang X, Rosenfeld ME, Giachelli C, Lusis AJ, Boström KI.

Circ Res. 2010 Aug 20;107(4):485-94. doi: 10.1161/CIRCRESAHA.110.219071. Epub 2010 Jun 24.


Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesis.

Speer MY, Li X, Hiremath PG, Giachelli CM.

J Cell Biochem. 2010 Jul 1;110(4):935-47. doi: 10.1002/jcb.22607.


Characterization of mandibular bone in a mouse model of chronic kidney disease.

Lee MM, Chu EY, El-Abbadi MM, Foster BL, Tompkins KA, Giachelli CM, Somerman MJ.

J Periodontol. 2010 Feb;81(2):300-9. doi: 10.1902/jop.2009.090379.


Vitamin D receptor activators induce an anticalcific paracrine program in macrophages: requirement of osteopontin.

Li X, Speer MY, Yang H, Bergen J, Giachelli CM.

Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):321-6. doi: 10.1161/ATVBAHA.109.196576. Epub 2009 Nov 30.


Discoidin domain receptor-1 deficiency attenuates atherosclerotic calcification and smooth muscle cell-mediated mineralization.

Ahmad PJ, Trcka D, Xue S, Franco C, Speer MY, Giachelli CM, Bendeck MP.

Am J Pathol. 2009 Dec;175(6):2686-96. doi: 10.2353/ajpath.2009.080734. Epub 2009 Nov 5.


Generation of mouse conditional and null alleles of the type III sodium-dependent phosphate cotransporter PiT-1.

Festing MH, Speer MY, Yang HY, Giachelli CM.

Genesis. 2009 Dec;47(12):858-63. doi: 10.1002/dvg.20577.


The role of osteopontin in inflammatory processes.

Lund SA, Giachelli CM, Scatena M.

J Cell Commun Signal. 2009 Dec;3(3-4):311-22. doi: 10.1007/s12079-009-0068-0. Epub 2009 Oct 2.


Immobilization of alkaline phosphatase on microporous nanofibrous fibrin scaffolds for bone tissue engineering.

Osathanon T, Giachelli CM, Somerman MJ.

Biomaterials. 2009 Sep;30(27):4513-21. doi: 10.1016/j.biomaterials.2009.05.022. Epub 2009 Jun 6.


Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin.

El-Abbadi MM, Pai AS, Leaf EM, Yang HY, Bartley BA, Quan KK, Ingalls CM, Liao HW, Giachelli CM.

Kidney Int. 2009 Jun;75(12):1297-1307. doi: 10.1038/ki.2009.83. Epub 2009 Mar 25.


Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries.

Speer MY, Yang HY, Brabb T, Leaf E, Look A, Lin WL, Frutkin A, Dichek D, Giachelli CM.

Circ Res. 2009 Mar 27;104(6):733-41. doi: 10.1161/CIRCRESAHA.108.183053. Epub 2009 Feb 5.


The emerging role of phosphate in vascular calcification.

Giachelli CM.

Kidney Int. 2009 May;75(9):890-7. doi: 10.1038/ki.2008.644. Epub 2009 Jan 14. Review.


Osteoprotegerin and RANKL differentially regulate angiogenesis and endothelial cell function.

McGonigle JS, Giachelli CM, Scatena M.

Angiogenesis. 2009;12(1):35-46. doi: 10.1007/s10456-008-9127-z. Epub 2008 Dec 23.


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