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30 Immunotherapy in advanced NSCLC-from the 'tsunami' of therapeutic knowledge to a clinical practice algorithm: results from an international expert panel meeting of the Italian Association of Thoracic Oncology (AIOT).

de Marinis F, Ciardiello F, Baas P, Crinò L, Giaccone G, Grossi F, Hellmann MD, Mok TSK, Lena H, Paz-Ares L, Rodriguez-Abreu D, Von Pavel J, Gridelli C.

ESMO Open. 2018 May 31;3(4):e000298. doi: 10.1136/esmoopen-2017-000298. eCollection 2018. Review.


Dasatinib sensitises KRAS-mutant cancer cells to mitogen-activated protein kinase kinase inhibitor via inhibition of TAZ activity.

Rao G, Kim IK, Conforti F, Liu J, Zhang YW, Giaccone G.

Eur J Cancer. 2018 Aug;99:37-48. doi: 10.1016/j.ejca.2018.05.013. Epub 2018 Jun 11.


Tau Mutations Serve as a Novel Risk Factor for Cancer.

Rossi G, Redaelli V, Contiero P, Fabiano S, Tagliabue G, Perego P, Benussi L, Bruni AC, Filippini G, Farinotti M, Giaccone G, Buiatiotis S, Manzoni C, Ferrari R, Tagliavini F.

Cancer Res. 2018 Jul 1;78(13):3731-3739. doi: 10.1158/0008-5472.CAN-17-3175. Epub 2018 May 24.


Randomized phase 2 study of gemcitabine and cisplatin with or without vitamin supplementation in patients with advanced esophagogastric cancer.

van Zweeden AA, van Groeningen CJ, Honeywell RJ, Giovannetti E, Ruijter R, Smorenburg CH, Giaccone G, Verheul HMW, Peters GJ, van der Vliet HJ.

Cancer Chemother Pharmacol. 2018 Jul;82(1):39-48. doi: 10.1007/s00280-018-3588-6. Epub 2018 Apr 25.


A Placebo-Controlled Phase II Study of Ruxolitinib in Combination With Pemetrexed and Cisplatin for First-Line Treatment of Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer and Systemic Inflammation.

Giaccone G, Sanborn RE, Waqar SN, Martinez-Marti A, Ponce S, Zhen H, Kennealey G, Erickson-Viitanen S, Schaefer E.

Clin Lung Cancer. 2018 Mar 23. pii: S1525-7304(18)30058-5. doi: 10.1016/j.cllc.2018.03.016. [Epub ahead of print]


Effects of peptidyl-prolyl isomerase 1 depletion in animal models of prion diseases.

Legname G, Virgilio T, Bistaffa E, De Luca CMG, Catania M, Zago P, Isopi E, Campagnani I, Tagliavini F, Giaccone G, Moda F.

Prion. 2018 Mar 4;12(2):127-137. doi: 10.1080/19336896.2018.1464367. Epub 2018 May 18.


The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer.

Fernandez HR, Gadre SM, Tan M, Graham GT, Mosaoa R, Ongkeko MS, Kim KA, Riggins RB, Parasido E, Petrini I, Pacini S, Cheema A, Varghese R, Ressom HW, Zhang Y, Albanese C, Üren A, Paige M, Giaccone G, Avantaggiati ML.

Cell Death Differ. 2018 Jul;25(7):1239-1258. doi: 10.1038/s41418-018-0101-z. Epub 2018 Apr 12.


Palliative thoracic radiation therapy for non-small cell lung cancer: 2018 Update of an American Society for Radiation Oncology (ASTRO) Evidence-Based Guideline.

Moeller B, Balagamwala EH, Chen A, Creach KM, Giaccone G, Koshy M, Zaky S, Rodrigues G.

Pract Radiat Oncol. 2018 Jul - Aug;8(4):245-250. doi: 10.1016/j.prro.2018.02.009. Epub 2018 Apr 4.


C-MET inhibitors for advanced non-small cell lung cancer.

Pasquini G, Giaccone G.

Expert Opin Investig Drugs. 2018 Apr;27(4):363-375. doi: 10.1080/13543784.2018.1462336. Epub 2018 Apr 11. Review.


Precision oncology in non-small-cell lung cancer: opportunities and challenges.

Kim C, Giaccone G.

Nat Rev Clin Oncol. 2018 Jun;15(6):348-349. doi: 10.1038/s41571-018-0008-0. No abstract available.


A Phase Ib/II Study of Ganetespib With Doxorubicin in Advanced Solid Tumors Including Relapsed-Refractory Small Cell Lung Cancer.

Subramaniam DS, Liu SV, Crawford J, Kramer J, Thompson J, Wang H, Giaccone G.

Front Oncol. 2018 Mar 12;8:64. doi: 10.3389/fonc.2018.00064. eCollection 2018.


Frontotemporal Dementia and Chorea Associated with a Compound Heterozygous TREM2 Mutation.

Redaelli V, Salsano E, Colleoni L, Corbetta P, Tringali G, Del Sole A, Giaccone G, Rossi G.

J Alzheimers Dis. 2018;63(1):195-201. doi: 10.3233/JAD-180018.


Molecular subtypes of Alzheimer's disease.

Di Fede G, Catania M, Maderna E, Ghidoni R, Benussi L, Tonoli E, Giaccone G, Moda F, Paterlini A, Campagnani I, Sorrentino S, Colombo L, Kubis A, Bistaffa E, Ghetti B, Tagliavini F.

Sci Rep. 2018 Feb 19;8(1):3269. doi: 10.1038/s41598-018-21641-1.


The Integrated Genomic Landscape of Thymic Epithelial Tumors.

Radovich M, Pickering CR, Felau I, Ha G, Zhang H, Jo H, Hoadley KA, Anur P, Zhang J, McLellan M, Bowlby R, Matthew T, Danilova L, Hegde AM, Kim J, Leiserson MDM, Sethi G, Lu C, Ryan M, Su X, Cherniack AD, Robertson G, Akbani R, Spellman P, Weinstein JN, Hayes DN, Raphael B, Lichtenberg T, Leraas K, Zenklusen JC; Cancer Genome Atlas Network, Fujimoto J, Scapulatempo-Neto C, Moreira AL, Hwang D, Huang J, Marino M, Korst R, Giaccone G, Gokmen-Polar Y, Badve S, Rajan A, Ströbel P, Girard N, Tsao MS, Marx A, Tsao AS, Loehrer PJ.

Cancer Cell. 2018 Feb 12;33(2):244-258.e10. doi: 10.1016/j.ccell.2018.01.003.


Phase I trial of belinostat with cisplatin and etoposide in advanced solid tumors, with a focus on neuroendocrine and small cell cancers of the lung.

Balasubramaniam S, Redon CE, Peer CJ, Bryla C, Lee MJ, Trepel JB, Tomita Y, Rajan A, Giaccone G, Bonner WM, Figg WD, Fojo T, Piekarz RL, Bates SE.

Anticancer Drugs. 2018 Jun;29(5):457-465. doi: 10.1097/CAD.0000000000000596.


High cripto-1 and low miR-205 expression levels as prognostic markers in early stage non-small cell lung cancer.

Park KS, Moon YW, Raffeld M, Lee DH, Wang Y, Giaccone G.

Lung Cancer. 2018 Feb;116:38-45. doi: 10.1016/j.lungcan.2017.12.010. Epub 2017 Dec 15.


Hemoglobin mRNA Changes in the Frontal Cortex of Patients with Neurodegenerative Diseases.

Vanni S, Zattoni M, Moda F, Giaccone G, Tagliavini F, Haïk S, Deslys JP, Zanusso G, Ironside JW, Carmona M, Ferrer I, Kovacs GG, Legname G.

Front Neurosci. 2018 Jan 22;12:8. doi: 10.3389/fnins.2018.00008. eCollection 2018.


Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study.

Giaccone G, Kim C, Thompson J, McGuire C, Kallakury B, Chahine JJ, Manning M, Mogg R, Blumenschein WM, Tan MT, Subramaniam DS, Liu SV, Kaplan IM, McCutcheon JN.

Lancet Oncol. 2018 Mar;19(3):347-355. doi: 10.1016/S1470-2045(18)30062-7. Epub 2018 Jan 26.


A phase I study of intravenous artesunate in patients with advanced solid tumor malignancies.

Deeken JF, Wang H, Hartley M, Cheema AK, Smaglo B, Hwang JJ, He AR, Weiner LM, Marshall JL, Giaccone G, Liu S, Luecht J, Spiegel JY, Pishvaian MJ.

Cancer Chemother Pharmacol. 2018 Mar;81(3):587-596. doi: 10.1007/s00280-018-3533-8. Epub 2018 Feb 1.


In Situ Tissue Labeling of Cerebral Amyloid Using HIV-Related Tat Peptide.

Maderna E, Colombo L, Cagnotto A, Di Fede G, Indaco A, Tagliavini F, Salmona M, Giaccone G.

Mol Neurobiol. 2018 Jan 19. doi: 10.1007/s12035-018-0870-x. [Epub ahead of print]


Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study.

Cali I, Cohen ML, Haik S, Parchi P, Giaccone G, Collins SJ, Kofskey D, Wang H, McLean CA, Brandel JP, Privat N, Sazdovitch V, Duyckaerts C, Kitamoto T, Belay ED, Maddox RA, Tagliavini F, Pocchiari M, Leschek E, Appleby BS, Safar JG, Schonberger LB, Gambetti P.

Acta Neuropathol Commun. 2018 Jan 8;6(1):5. doi: 10.1186/s40478-017-0503-z.


MEK inhibitors under development for treatment of non-small-cell lung cancer.

Kim C, Giaccone G.

Expert Opin Investig Drugs. 2018 Jan;27(1):17-30. doi: 10.1080/13543784.2018.1415324. Epub 2017 Dec 13. Review.


Phase 2 study of intermittent pulse dacomitinib in patients with advanced non-small cell lung cancers.

Yu HA, Ahn MJ, Cho BC, Gerber DE, Natale RB, Socinski MA, Giri N, Quinn S, Sbar E, Zhang H, Giaccone G.

Lung Cancer. 2017 Oct;112:195-199. doi: 10.1016/j.lungcan.2017.08.017. Epub 2017 Aug 23.


Translational Research in Alzheimer's and Prion Diseases.

Di Fede G, Giaccone G, Salmona M, Tagliavini F.

J Alzheimers Dis. 2018;62(3):1247-1259. doi: 10.3233/JAD-170770.


Circulating cell-free DNA mutation patterns in early and late stage colon and pancreatic cancer.

Vietsch EE, Graham GT, McCutcheon JN, Javaid A, Giaccone G, Marshall JL, Wellstein A.

Cancer Genet. 2017 Dec;218-219:39-50. doi: 10.1016/j.cancergen.2017.08.006. Epub 2017 Sep 14.


Differential overexpression of SERPINA3 in human prion diseases.

Vanni S, Moda F, Zattoni M, Bistaffa E, De Cecco E, Rossi M, Giaccone G, Tagliavini F, Haïk S, Deslys JP, Zanusso G, Ironside JW, Ferrer I, Kovacs GG, Legname G.

Sci Rep. 2017 Nov 15;7(1):15637. doi: 10.1038/s41598-017-15778-8.


Combined Small Cell Carcinoma of the Lung: Is It a Single Entity?

Zhao X, McCutcheon JN, Kallakury B, Chahine JJ, Pratt D, Raffeld M, Chen Y, Wang C, Giaccone G.

J Thorac Oncol. 2018 Feb;13(2):237-245. doi: 10.1016/j.jtho.2017.10.010. Epub 2017 Oct 31.


Case for Stopping Targeted Therapy When Lung Cancer Progresses on Treatment in Hospice-Eligible Patients.

Smith TJ, Hanna N, Johnson D, Baker S Jr, Biermann WA, Brahmer J, Ellis PM, Giaccone G, Hesketh PJ, Jaiyesimi I, Leighl NB, Riely GJ, Schiller JH, Schneider BJ, Tashbar J, Temin S, Masters G.

J Oncol Pract. 2017 Dec;13(12):780-783. doi: 10.1200/JOP.2017.027367. Epub 2017 Oct 5. No abstract available.


A Phase I, Dose Escalation Study of Oral ASP8273 in Patients with Non-small Cell Lung Cancers with Epidermal Growth Factor Receptor Mutations.

Yu HA, Spira A, Horn L, Weiss J, West H, Giaccone G, Evans T, Kelly RJ, Desai B, Krivoshik A, Moran D, Poondru S, Jie F, Aoyama K, Keating A, Oxnard GR.

Clin Cancer Res. 2017 Dec 15;23(24):7467-7473. doi: 10.1158/1078-0432.CCR-17-1447. Epub 2017 Sep 27.


High diagnostic value of second generation CSF RT-QuIC across the wide spectrum of CJD prions.

Franceschini A, Baiardi S, Hughson AG, McKenzie N, Moda F, Rossi M, Capellari S, Green A, Giaccone G, Caughey B, Parchi P.

Sci Rep. 2017 Sep 6;7(1):10655. doi: 10.1038/s41598-017-10922-w.


Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors.

Conforti F, Zhang X, Rao G, De Pas T, Yonemori Y, Rodriguez JA, McCutcheon JN, Rahhal R, Alberobello AT, Wang Y, Zhang YW, Guha U, Giaccone G.

Cancer Res. 2017 Oct 15;77(20):5614-5627. doi: 10.1158/0008-5472.CAN-17-1323. Epub 2017 Aug 17.


Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update.

Hanna N, Johnson D, Temin S, Baker S Jr, Brahmer J, Ellis PM, Giaccone G, Hesketh PJ, Jaiyesimi I, Leighl NB, Riely GJ, Schiller JH, Schneider BJ, Smith TJ, Tashbar J, Biermann WA, Masters G.

J Clin Oncol. 2017 Oct 20;35(30):3484-3515. doi: 10.1200/JCO.2017.74.6065. Epub 2017 Aug 14.


Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations.

Rao G, Pierobon M, Kim IK, Hsu WH, Deng J, Moon YW, Petricoin EF, Zhang YW, Wang Y, Giaccone G.

Sci Rep. 2017 Aug 1;7(1):7066. doi: 10.1038/s41598-017-06128-9.


An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice.

Fu Y, Silverstein S, McCutcheon JN, Dyba M, Nath RG, Aggarwal M, Coia H, Bai A, Pan J, Jiang J, Kallakury B, Wang H, Zhang YW, Giaccone G, He AR, Chung FL.

Hepatology. 2018 Jan;67(1):159-170. doi: 10.1002/hep.29380. Epub 2017 Nov 13.


Towards an early clinical diagnosis of sporadic CJD VV2 (ataxic type).

Baiardi S, Magherini A, Capellari S, Redaelli V, Ladogana A, Rossi M, Tagliavini F, Pocchiari M, Giaccone G, Parchi P.

J Neurol Neurosurg Psychiatry. 2017 Sep;88(9):764-772. doi: 10.1136/jnnp-2017-315942. Epub 2017 Jul 1.


Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts C, Ferrer I, Forrest SL, Gelpi E, Gentleman SM, Giaccone G, Grinberg LT, Halliday GM, Hatanpaa KJ, Hof PR, Hofer M, Hortobágyi T, Ironside JW, King A, Kofler J, Kövari E, Kril JJ, Love S, Mackenzie IR, Mao Q, Matej R, McLean C, Munoz DG, Murray ME, Neltner J, Nelson PT, Ritchie D, Rodriguez RD, Rohan Z, Rozemuller A, Sakai K, Schultz C, Seilhean D, Smith V, Tacik P, Takahashi H, Takao M, Rudolf Thal D, Weis S, Wharton SB, White CL 3rd, Woulfe JM, Yamada M, Trojanowski JQ.

J Neuropathol Exp Neurol. 2017 Jul 1;76(7):605-619. doi: 10.1093/jnen/nlx041.


An In Vivo 11C-(R)-PK11195 PET and In Vitro Pathology Study of Microglia Activation in Creutzfeldt-Jakob Disease.

Iaccarino L, Moresco RM, Presotto L, Bugiani O, Iannaccone S, Giaccone G, Tagliavini F, Perani D.

Mol Neurobiol. 2018 Apr;55(4):2856-2868. doi: 10.1007/s12035-017-0522-6. Epub 2017 Apr 28.


Missense mutation in GRN gene affecting RNA splicing and plasma progranulin level in a family affected by frontotemporal lobar degeneration.

Luzzi S, Colleoni L, Corbetta P, Baldinelli S, Fiori C, Girelli F, Silvestrini M, Caroppo P, Giaccone G, Tagliavini F, Rossi G.

Neurobiol Aging. 2017 Jun;54:214.e1-214.e6. doi: 10.1016/j.neurobiolaging.2017.02.008. Epub 2017 Feb 20.


Metastatic lymphoepithelioma-like carcinoma of the lung treated with nivolumab: a case report and focused review of literature.

Kim C, Rajan A, DeBrito PA, Giaccone G.

Transl Lung Cancer Res. 2016 Dec;5(6):720-726. doi: 10.21037/tlcr.2016.11.06.


Effects of Multiple Genetic Loci on Age at Onset in Frontotemporal Dementia.

Ferrari R, Grassi M, Graziano F, Palluzzi F, Archetti S, Bonomi E, Bruni AC, Maletta RG, Bernardi L, Cupidi C, Colao R, Rainero I, Rubino E, Pinessi L, Galimberti D, Scarpini E, Serpente M, Nacmias B, Piaceri I, Bagnoli S, Rossi G, Giaccone G, Tagliavini F, Benussi L, Binetti G, Ghidoni R, Singleton A, Hardy J, Momeni P, Padovani A, Borroni B.

J Alzheimers Dis. 2017;56(4):1271-1278. doi: 10.3233/JAD-160949.


First-in-human phase 1 study of margetuximab (MGAH22), an Fc-modified chimeric monoclonal antibody, in patients with HER2-positive advanced solid tumors.

Bang YJ, Giaccone G, Im SA, Oh DY, Bauer TM, Nordstrom JL, Li H, Chichili GR, Moore PA, Hong S, Stewart SJ, Baughman JE, Lechleider RJ, Burris HA.

Ann Oncol. 2017 Apr 1;28(4):855-861. doi: 10.1093/annonc/mdx002.


Lessons learned from BATTLE-2 in the war on cancer: the use of Bayesian method in clinical trial design.

Kim C, Giaccone G.

Ann Transl Med. 2016 Dec;4(23):466. doi: 10.21037/atm.2016.11.48. No abstract available.


Alzheimer neuropathology without frontotemporal lobar degeneration hallmarks (TAR DNA-binding protein 43 inclusions) in missense progranulin mutation Cys139Arg.

Redaelli V, Rossi G, Maderna E, Kovacs GG, Piccoli E, Caroppo P, Cacciatore F, Spinello S, Grisoli M, Sozzi G, Salmaggi A, Tagliavini F, Giaccone G.

Brain Pathol. 2018 Jan;28(1):72-76. doi: 10.1111/bpa.12480. Epub 2017 Feb 15.


PS01.56: IMpower110: Phase III Trial Comparing 1L Atezolizumab with Chemotherapy in PD-L1-Selected Chemotherapy-Naive NSCLC Patients: Topic: Medical Oncology.

Herbst RS, De Marinis F, Jassem J, Lam S, Mocci S, Sandler A, Lopez-Chavez A, Deng Y, Giaccone G, Spigel DR.

J Thorac Oncol. 2016 Nov;11(11S):S304-S305. doi: 10.1016/j.jtho.2016.09.091. Epub 2016 Oct 28. No abstract available.


Ganetespib for small cell lung cancer.

Subramaniam DS, Warner EA, Giaccone G.

Expert Opin Investig Drugs. 2017 Jan;26(1):103-108. doi: 10.1080/13543784.2017.1268599. Epub 2016 Dec 15. Review.


Genomic profiling of multiple sequentially acquired tumor metastatic sites from an "exceptional responder" lung adenocarcinoma patient reveals extensive genomic heterogeneity and novel somatic variants driving treatment response.

Biswas R, Gao S, Cultraro CM, Maity TK, Venugopalan A, Abdullaev Z, Shaytan AK, Carter CA, Thomas A, Rajan A, Song Y, Pitts S, Chen K, Bass S, Boland J, Hanada KI, Chen J, Meltzer PS, Panchenko AR, Yang JC, Pack S, Giaccone G, Schrump DS, Khan J, Guha U.

Cold Spring Harb Mol Case Stud. 2016 Nov;2(6):a001263.


Expression of mesothelin in thymic carcinoma and its potential therapeutic significance.

Thomas A, Chen Y, Berman A, Schrump DS, Giaccone G, Pastan I, Venzon DJ, Liewehr DJ, Steinberg SM, Miettinen M, Hassan R, Rajan A.

Lung Cancer. 2016 Nov;101:104-110. doi: 10.1016/j.lungcan.2016.09.015. Epub 2016 Sep 28.


Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation.

Testa G, Staurenghi E, Zerbinati C, Gargiulo S, Iuliano L, Giaccone G, Fantò F, Poli G, Leonarduzzi G, Gamba P.

Redox Biol. 2016 Dec;10:24-33. doi: 10.1016/j.redox.2016.09.001. Epub 2016 Sep 16.


Lung cancer: First-line immunotherapy in lung cancer - taking the first step.

Liu SV, Giaccone G.

Nat Rev Clin Oncol. 2016 Oct;13(10):595-6. doi: 10.1038/nrclinonc.2016.148. Epub 2016 Sep 13. No abstract available.


Novel approaches in cancer immunotherapy.

Subramaniam DS, Liu SV, Giaccone G.

Discov Med. 2016 Apr;21(116):267-74.

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