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Items: 1 to 50 of 253

1.

Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence Following Radiation Therapy in Immunosuppressed Patients.

Rafat M, Aguilera TA, Vilalta M, Bronsart LL, Soto LA, von Eyben R, Golla MA, Ahrari Y, Melemenidis S, Afghahi A, Jenkins MJ, Kurian AW, Horst K, Giaccia AJ, Graves EE.

Cancer Res. 2018 Jun 7. pii: canres.3623.2017. doi: 10.1158/0008-5472.CAN-17-3623. [Epub ahead of print]

PMID:
29880480
2.

The tumour microenvironment links complement system dysregulation and hypoxic signalling.

Olcina MM, Kim RK, Melemenidis S, Graves EE, Giaccia AJ.

Br J Radiol. 2018 May 15:20180069. doi: 10.1259/bjr.20180069. [Epub ahead of print]

PMID:
29544344
3.

A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation.

Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC.

Mol Cancer Res. 2018 May;16(5):745-753. doi: 10.1158/1541-7786.MCR-17-0307. Epub 2018 Feb 9.

PMID:
29440447
4.

PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing.

Ko SH, Nauta AC, Morrison SD, Hu MS, Zimmermann AS, Chung MT, Glotzbach JP, Wong VW, Walmsley GG, Peter Lorenz H, Chan DA, Gurtner GC, Giaccia AJ, Longaker MT.

Plast Reconstr Surg. 2018 Jan;141(1):55e-67e. doi: 10.1097/PRS.0000000000003959.

PMID:
29280872
5.

Long-range hypoxia signaling in NAFLD.

LaGory EL, Giaccia AJ.

Nat Med. 2017 Nov 7;23(11):1251-1252. doi: 10.1038/nm.4436. No abstract available.

PMID:
29117167
6.

Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells.

Wu PH, Onodera Y, Ichikawa Y, Rankin EB, Giaccia AJ, Watanabe Y, Qian W, Hashimoto T, Shirato H, Nam JM.

Int J Nanomedicine. 2017 Jul 14;12:5069-5085. doi: 10.2147/IJN.S137833. eCollection 2017.

7.

BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer.

Chiou SH, Risca VI, Wang GX, Yang D, Grüner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, Castellini L, Graves EE, Kim GE, Mourrain P, Koong AC, Giaccia AJ, Winslow MM.

Cancer Discov. 2017 Oct;7(10):1184-1199. doi: 10.1158/2159-8290.CD-17-0250. Epub 2017 Aug 8.

8.

Hypoxia: Signaling the Metastatic Cascade.

Rankin EB, Nam JM, Giaccia AJ.

Trends Cancer. 2016 Jun;2(6):295-304. doi: 10.1016/j.trecan.2016.05.006. Epub 2016 Jun 2. Review.

9.

Stress-responsive HILPDA is necessary for thermoregulation during fasting.

VandeKopple MJ, Wu J, Baer LA, Bal NC, Maurya SK, Kalyanasundaram A, Periasamy M, Stanford KI, Giaccia AJ, Denko NC, Papandreou I.

J Endocrinol. 2017 Oct;235(1):27-38. doi: 10.1530/JOE-17-0289. Epub 2017 Jul 24.

PMID:
28739822
10.

Hypoxia and Bone Metastatic Disease.

Johnson RW, Sowder ME, Giaccia AJ.

Curr Osteoporos Rep. 2017 Aug;15(4):231-238. doi: 10.1007/s11914-017-0378-8. Review.

PMID:
28597139
11.

Metabolic Alterations in Cancer and Their Potential as Therapeutic Targets.

Weyandt JD, Thompson CB, Giaccia AJ, Rathmell WK.

Am Soc Clin Oncol Educ Book. 2017;37:825-832. doi: 10.14694/EDBK_175561. Review.

12.

Pre-metastatic niches: organ-specific homes for metastases.

Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D.

Nat Rev Cancer. 2017 May;17(5):302-317. doi: 10.1038/nrc.2017.6. Epub 2017 Mar 17. Review.

PMID:
28303905
13.

Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion-A New Role for the AXL Receptor Tyrosine Kinase.

Aguilera TA, Giaccia AJ.

Clin Cancer Res. 2017 Jun 15;23(12):2928-2933. doi: 10.1158/1078-0432.CCR-17-0189. Epub 2017 Mar 13. Review.

14.

KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage.

Castellini L, Moon EJ, Razorenova OV, Krieg AJ, von Eyben R, Giaccia AJ.

Nucleic Acids Res. 2017 Apr 20;45(7):3674-3692. doi: 10.1093/nar/gkw1281.

15.

Reprogramming the immunological microenvironment through radiation and targeting Axl.

Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ.

Nat Commun. 2016 Dec 23;7:13898. doi: 10.1038/ncomms13898.

16.

Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.

Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS 2nd, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ.

J Clin Invest. 2017 Jan 3;127(1):183-198. doi: 10.1172/JCI85610. Epub 2016 Nov 28.

17.

The Receptor Tyrosine Kinase AXL in Cancer Progression.

Rankin EB, Giaccia AJ.

Cancers (Basel). 2016 Nov 9;8(11). pii: E103. Review.

18.

Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy.

Chang AC, Ong SG, LaGory EL, Kraft PE, Giaccia AJ, Wu JC, Blau HM.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13120-13125. Epub 2016 Oct 31.

19.

Erratum: Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow.

Johnson RW, Finger EC, Olcina MM, Vilalta M, Aguilera T, Miao Y, Merkel AR, Johnson JR, Sterling JA, Wu JY, Giaccia AJ.

Nat Cell Biol. 2016 Oct 27;18(11):1260. doi: 10.1038/ncb3433.

PMID:
27784904
20.

Patterns of Vasculature in Mouse Models of Lung Cancer Are Dependent on Location.

Vilalta M, Hughes NP, Von Eyben R, Giaccia AJ, Graves EE.

Mol Imaging Biol. 2017 Apr;19(2):215-224. doi: 10.1007/s11307-016-1010-5.

21.

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow.

Johnson RW, Finger EC, Olcina MM, Vilalta M, Aguilera T, Miao Y, Merkel AR, Johnson JR, Sterling JA, Wu JY, Giaccia AJ.

Nat Cell Biol. 2016 Sep 19;18(10):1078-1089. doi: 10.1038/ncb3408. [Epub ahead of print] Erratum in: Nat Cell Biol. 2016 Oct 27;18(11):1260.

22.

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response.

Jiang D, Lynch C, Medeiros BC, Liedtke M, Bam R, Tam AB, Yang Z, Alagappan M, Abidi P, Le QT, Giaccia AJ, Denko NC, Niwa M, Koong AC.

Sci Rep. 2016 Sep 16;6:33353. doi: 10.1038/srep33353.

23.

Reducing radiation-induced gastrointestinal toxicity - the role of the PHD/HIF axis.

Olcina MM, Giaccia AJ.

J Clin Invest. 2016 Oct 3;126(10):3708-3715. doi: 10.1172/JCI84432. Epub 2016 Aug 22. Review.

24.

A New Chromatin-Cytoskeleton Link in Cancer.

Giaccia AJ.

Mol Cancer Res. 2016 Dec;14(12):1173-1175. Epub 2016 Aug 15.

25.

Isolation of Proteins on Nascent DNA in Hypoxia and Reoxygenation Conditions.

Olcina MM, Giaccia AJ, Hammond EM.

Adv Exp Med Biol. 2016;899:27-40. doi: 10.1007/978-3-319-26666-4_3.

PMID:
27325260
26.

Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.

Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC.

Mol Cancer Ther. 2016 Sep;15(9):2055-65. doi: 10.1158/1535-7163.MCT-15-1023. Epub 2016 Jun 15.

27.

Hypoxic control of metastasis.

Rankin EB, Giaccia AJ.

Science. 2016 Apr 8;352(6282):175-80. doi: 10.1126/science.aaf4405. Epub 2016 Apr 7. Review.

28.

The ever-expanding role of HIF in tumour and stromal biology.

LaGory EL, Giaccia AJ.

Nat Cell Biol. 2016 Apr;18(4):356-65. doi: 10.1038/ncb3330. Review.

29.

Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1.

Leszczynska KB, Göttgens EL, Biasoli D, Olcina MM, Ient J, Anbalagan S, Bernhardt S, Giaccia AJ, Hammond EM.

Sci Rep. 2016 Feb 15;6:21698. doi: 10.1038/srep21698.

30.

Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma.

Zhou L, Liu XD, Sun M, Zhang X, German P, Bai S, Ding Z, Tannir N, Wood CG, Matin SF, Karam JA, Tamboli P, Sircar K, Rao P, Rankin EB, Laird DA, Hoang AG, Walker CL, Giaccia AJ, Jonasch E.

Oncogene. 2016 May;35(21):2687-97. doi: 10.1038/onc.2015.343. Epub 2015 Sep 14.

31.

Fibrosis and hypoxia-inducible factor-1α-dependent tumors of the soft tissue on loss of von Hippel-Lindau in mesenchymal progenitors.

Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Sandusky G, Abadie J, Lyons KM, Giaccia AJ, Schipani E.

Am J Pathol. 2015 Nov;185(11):3090-101. doi: 10.1016/j.ajpath.2015.07.008. Epub 2015 Sep 6.

32.

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma.

LaGory EL, Wu C, Taniguchi CM, Ding CC, Chi JT, von Eyben R, Scott DA, Richardson AD, Giaccia AJ.

Cell Rep. 2015 Jul 7;12(1):116-127. doi: 10.1016/j.celrep.2015.06.006. Epub 2015 Jun 25. Erratum in: Cell Rep. 2015 Jul 28;12(4):717.

33.

Corrigendum: Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.

Wu C, Rankin EB, Castellini L, Alcudia JF, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ.

Genes Dev. 2015 Jun 1;29(11):1202. No abstract available.

34.

Emerging Treatment Paradigms in Radiation Oncology.

Le QT, Shirato H, Giaccia AJ, Koong AC.

Clin Cancer Res. 2015 Aug 1;21(15):3393-401. doi: 10.1158/1078-0432.CCR-14-1191. Epub 2015 May 19. Review.

35.

Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.

Wu C, Rankin EB, Castellini L, Alcudia JF, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ.

Genes Dev. 2015 Apr 15;29(8):817-31. doi: 10.1101/gad.255000.114. Epub 2015 Apr 6. Erratum in: Genes Dev. 2015 Jun 1;29(11):1202. Fernandez-Alcudia, Javier [corrected to Alcudia, Javier F].

36.

The end of the hypoxic EPOch.

Aguilera TA, Giaccia AJ.

Int J Radiat Oncol Biol Phys. 2015 Apr 1;91(5):895-7. doi: 10.1016/j.ijrobp.2015.01.041. No abstract available.

PMID:
25832683
37.

Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells.

Finger EC, Castellini L, Rankin EB, Vilalta M, Krieg AJ, Jiang D, Banh A, Zundel W, Powell MB, Giaccia AJ.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4441-6. doi: 10.1073/pnas.1418164112. Epub 2015 Mar 19.

38.

Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function.

Jiang D, LaGory EL, Kenzelmann Brož D, Bieging KT, Brady CA, Link N, Abrams JM, Giaccia AJ, Attardi LD.

Cell Rep. 2015 Feb 24;10(7):1096-109. doi: 10.1016/j.celrep.2015.01.043. Epub 2015 Feb 19.

39.

HIF targets in bone remodeling and metastatic disease.

Johnson RW, Schipani E, Giaccia AJ.

Pharmacol Ther. 2015 Jun;150:169-77. doi: 10.1016/j.pharmthera.2015.02.002. Epub 2015 Feb 12. Review.

40.

Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus.

Merceron C, Mangiavini L, Robling A, Wilson TL, Giaccia AJ, Shapiro IM, Schipani E, Risbud MV.

PLoS One. 2014 Oct 22;9(10):e110768. doi: 10.1371/journal.pone.0110768. eCollection 2014.

41.

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.

Kariolis MS, Miao YR, Jones DS 2nd, Kapur S, Mathews II, Giaccia AJ, Cochran JR.

Nat Chem Biol. 2014 Nov;10(11):977-83. doi: 10.1038/nchembio.1636. Epub 2014 Sep 21.

42.

Osteoblasts: a novel source of erythropoietin.

Wu C, Giaccia AJ, Rankin EB.

Curr Osteoporos Rep. 2014 Dec;12(4):428-32. doi: 10.1007/s11914-014-0236-x. Review.

43.

Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response.

Kuo P, Bratman SV, Shultz DB, von Eyben R, Chan C, Wang Z, Say C, Gupta A, Loo BW Jr, Giaccia AJ, Koong AC, Diehn M, Le QT.

Clin Cancer Res. 2014 Nov 1;20(21):5558-69. doi: 10.1158/1078-0432.CCR-14-1138. Epub 2014 Sep 4.

44.

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.

Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ, Giaccia AJ.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13373-8. doi: 10.1073/pnas.1404848111. Epub 2014 Sep 3.

45.

Molecular radiobiology: the state of the art.

Giaccia AJ.

J Clin Oncol. 2014 Sep 10;32(26):2871-8. doi: 10.1200/JCO.2014.57.2776. Epub 2014 Aug 11. Review.

46.

Neurotrophic factor GDNF promotes survival of salivary stem cells.

Xiao N, Lin Y, Cao H, Sirjani D, Giaccia AJ, Koong AC, Kong CS, Diehn M, Le QT.

J Clin Invest. 2014 Aug;124(8):3364-77. doi: 10.1172/JCI74096. Epub 2014 Jul 18.

47.

Recruitment of circulating breast cancer cells is stimulated by radiotherapy.

Vilalta M, Rafat M, Giaccia AJ, Graves EE.

Cell Rep. 2014 Jul 24;8(2):402-9. doi: 10.1016/j.celrep.2014.06.011. Epub 2014 Jul 10.

48.

Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.

Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E.

Dev Biol. 2014 Sep 1;393(1):124-36. doi: 10.1016/j.ydbio.2014.06.013. Epub 2014 Jun 24.

49.

PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2.

Taniguchi CM, Miao YR, Diep AN, Wu C, Rankin EB, Atwood TF, Xing L, Giaccia AJ.

Sci Transl Med. 2014 May 14;6(236):236ra64. doi: 10.1126/scitranslmed.3008523.

50.

Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury.

Zimmermann AS, Morrison SD, Hu MS, Li S, Nauta A, Sorkin M, Meyer NP, Walmsley GG, Maan ZN, Chan DA, Gurtner GC, Giaccia AJ, Longaker MT.

PLoS One. 2014 Apr 2;9(4):e93373. doi: 10.1371/journal.pone.0093373. eCollection 2014.

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