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Items: 1 to 50 of 151

1.

Higher C-Peptide Level During Glucose Clamp Is Associated With Muscle Insulin Resistance in Nonobese Japanese Men.

Kaga H, Tamura Y, Takeno K, Kakehi S, Someya Y, Funayama T, Furukawa Y, Suzuki R, Sugimoto D, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Kanazawa A, Kawamori R, Watada H.

J Endocr Soc. 2019 Jul 23;3(10):1847-1857. doi: 10.1210/js.2019-00167. eCollection 2019 Oct 1.

2.

The Distribution of Fatty Acid Biomarkers of Dairy Intake across Serum Lipid Fractions: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) Cohort.

Santaren ID, Bazinet RP, Liu Z, Johnston LW, Sievenpiper JL, Giacca A, Retnakaran R, Harris SB, Zinman B, Hanley AJ.

Lipids. 2019 Oct;54(10):617-627. doi: 10.1002/lipd.12185. Epub 2019 Aug 19.

PMID:
31429083
3.

Glucose-Responsive Composite Microneedle Patch for Hypoglycemia-Triggered Delivery of Native Glucagon.

GhavamiNejad A, Li J, Lu B, Zhou L, Lam L, Giacca A, Wu XY.

Adv Mater. 2019 Jul;31(30):e1901051. doi: 10.1002/adma.201901051. Epub 2019 Jun 5.

PMID:
31165524
4.

Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels - a non-hormonal strategy for the potential treatment of hyperglycemia.

GhavamiNejad A, Lu B, Giacca A, Wu XY.

Nanoscale. 2019 May 30;11(21):10167-10171. doi: 10.1039/c9nr01687b.

PMID:
31112182
5.

Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo.

Desai T, Koulajian K, Ivovic A, Breen DM, Luu L, Tsiani EL, Wheeler MB, Giacca A.

Nutr Diabetes. 2019 Mar 19;9(1):11. doi: 10.1038/s41387-019-0075-z.

6.

NOD1: An Interface Between Innate Immunity and Insulin Resistance.

Rivers SL, Klip A, Giacca A.

Endocrinology. 2019 May 1;160(5):1021-1030. doi: 10.1210/en.2018-01061.

PMID:
30807635
7.

Glucose-Induced β-Cell Dysfunction In Vivo: Evidence for a Causal Role of C-jun N-terminal Kinase Pathway.

Tang C, Yeung LSN, Koulajian K, Zhang L, Tai K, Volchuk A, Giacca A.

Endocrinology. 2018 Nov 1;159(11):3643-3654. doi: 10.1210/en.2018-00566.

8.

Effects of acute olanzapine exposure on central insulin-mediated regulation of whole body fuel selection and feeding.

Castellani LN, Wilkin J, Abela AR, Benarroch L, Ahasan Z, Teo C, Wilson V, Kowalchuk C, Giacca A, Remington GJ, Hahn MK.

Psychoneuroendocrinology. 2018 Dec;98:127-130. doi: 10.1016/j.psyneuen.2018.07.028. Epub 2018 Jul 30.

PMID:
30142549
9.

Clusters of fatty acids in the serum triacylglyceride fraction associate with the disorders of type 2 diabetes.

Johnston LW, Liu Z, Retnakaran R, Zinman B, Giacca A, Harris SB, Bazinet RP, Hanley AJ.

J Lipid Res. 2018 Sep;59(9):1751-1762. doi: 10.1194/jlr.P084970. Epub 2018 Jul 9.

10.

Antipsychotics and glucose metabolism: how brain and body collide.

Kowalchuk C, Castellani LN, Chintoh A, Remington G, Giacca A, Hahn MK.

Am J Physiol Endocrinol Metab. 2019 Jan 1;316(1):E1-E15. doi: 10.1152/ajpendo.00164.2018. Epub 2018 Jul 3.

PMID:
29969315
11.

Effects of insulin and analogues on carcinogen-induced mammary tumours in high-fat-fed rats.

Mori Y, Ko E, Furrer R, Qu LC, Wiber SC, Fantus IG, Thevis M, Medline A, Giacca A.

Endocr Connect. 2018 May;7(5):739-748. doi: 10.1530/EC-17-0358. Epub 2018 Apr 24.

12.

Combined Hyperglycemia- and Hyperinsulinemia-Induced Insulin Resistance in Adipocytes Is Associated With Dual Signaling Defects Mediated by PKC-ζ.

Lu H, Bogdanovic E, Yu Z, Cho C, Liu L, Ho K, Guo J, Yeung LSN, Lehmann R, Hundal HS, Giacca A, Fantus IG.

Endocrinology. 2018 Apr 1;159(4):1658-1677. doi: 10.1210/en.2017-00312.

13.

Association of NEFA composition with insulin sensitivity and beta cell function in the Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort.

Johnston LW, Harris SB, Retnakaran R, Giacca A, Liu Z, Bazinet RP, Hanley AJ.

Diabetologia. 2018 Apr;61(4):821-830. doi: 10.1007/s00125-017-4534-6. Epub 2017 Dec 24.

PMID:
29275428
14.

In male rats, the ability of central insulin to suppress glucose production is impaired by olanzapine, whereas glucose uptake is left intact.

Kowalchuk C, Teo C, Wilson V, Chintoh A, Lam L, Agarwal SM, Giacca A, Remington GJ, Hahn MK.

J Psychiatry Neurosci. 2017 Nov;42(6):424-431.

15.

In male rats, the ability of central insulin to suppress glucose production is impaired by olanzapine, whereas glucose uptake is left intact.

Kowalchuk C, Teo C, Wilson V, Chintoh A, Lam L, Agarwal SM, Giacca A, Remington GJ, Hahn MK.

J Psychiatry Neurosci. 2017 Nov;42(6):170092. doi: 10.1503/jpn.170092. Epub 2017 Oct 16.

16.

Evaluation of the specific effects of intranasal glucagon on glucose production and lipid concentration in healthy men during a pancreatic clamp.

Dash S, Xiao C, Stahel P, Koulajian K, Giacca A, Lewis GF.

Diabetes Obes Metab. 2018 Feb;20(2):328-334. doi: 10.1111/dom.13069. Epub 2017 Sep 14.

PMID:
28730676
17.

IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents.

Ivovic A, Oprescu AI, Koulajian K, Mori Y, Eversley JA, Zhang L, Nino-Fong R, Lewis GF, Donath MY, Karin M, Wheeler MB, Ehses J, Volchuk A, Chan CB, Giacca A.

Diabetologia. 2017 Oct;60(10):2021-2032. doi: 10.1007/s00125-017-4345-9. Epub 2017 Jul 20.

PMID:
28725915
18.

Correlates of insulin clearance in apparently healthy non-obese Japanese men.

Kaga H, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Kanazawa A, Kawamori R, Watada H.

Sci Rep. 2017 May 3;7(1):1462. doi: 10.1038/s41598-017-01469-x.

19.

Enhancing thermal stability of a highly concentrated insulin formulation with Pluronic F-127 for long-term use in microfabricated implantable devices.

Li J, Chu MK, Lu B, Mirzaie S, Chen K, Gordijo CR, Plettenburg O, Giacca A, Wu XY.

Drug Deliv Transl Res. 2017 Aug;7(4):529-543. doi: 10.1007/s13346-017-0381-8.

PMID:
28429276
20.

High-dose metformin (420mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis.

Guo J, Pereira TJ, Dalvi P, Yeung LSN, Swain N, Breen DM, Lam L, Dolinsky VW, Giacca A.

Metabolism. 2017 Mar;68:108-118. doi: 10.1016/j.metabol.2016.12.002. Epub 2016 Dec 10.

PMID:
28183442
21.

Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23-25 kg/m2.

Takeno K, Tamura Y, Kawaguchi M, Kakehi S, Watanabe T, Funayama T, Furukawa Y, Kaga H, Yamamoto R, Kim M, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Taka H, Fujimura T, Sawada SS, Giacca A, Kanazawa A, Fujitani Y, Kawamori R, Watada H.

J Clin Endocrinol Metab. 2016 Oct;101(10):3676-3684. Epub 2016 Jul 6.

PMID:
27383116
22.

Insulin decreases atherosclerotic plaque burden and increases plaque stability via nitric oxide synthase in apolipoprotein E-null mice.

Mori Y, Chiang S, Bendeck MP, Giacca A.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E335-45. doi: 10.1152/ajpendo.00320.2015. Epub 2016 May 24.

23.

Longitudinal Associations of Phospholipid and Cholesteryl Ester Fatty Acids With Disorders Underlying Diabetes.

Johnston LW, Harris SB, Retnakaran R, Zinman B, Giacca A, Liu Z, Bazinet RP, Hanley AJ.

J Clin Endocrinol Metab. 2016 Jun;101(6):2536-44. doi: 10.1210/jc.2015-4267. Epub 2016 May 4.

PMID:
27144932
24.

Effect of a p38 MAPK inhibitor on FFA-induced hepatic insulin resistance in vivo.

Pereira S, Yu WQ, Moore J, Mori Y, Tsiani E, Giacca A.

Nutr Diabetes. 2016 May 2;6:e210. doi: 10.1038/nutd.2016.11.

25.

Risk factors for colorectal cancer in man induce aberrant crypt foci in rats: Preliminary findings.

Yang K, Fard S, Furrer R, Archer MC, Bruce WR, Lip H, Mehta R, O'Brien PJ, Giacca A, Ward WE, Femia AP, Caderni G, Medline A, Banks K.

Nutr Cancer. 2016;68(1):94-104. doi: 10.1080/01635581.2016.1115098. Epub 2015 Dec 28.

26.

Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo.

Pereira S, Park E, Moore J, Faubert B, Breen DM, Oprescu AI, Nahle A, Kwan D, Giacca A, Tsiani E.

Appl Physiol Nutr Metab. 2015 Nov;40(11):1129-36. doi: 10.1139/apnm-2015-0075. Epub 2015 Jul 10.

PMID:
26455923
27.

Metformin attenuates olanzapine-induced hepatic, but not peripheral insulin resistance.

Remington GJ, Teo C, Wilson V, Chintoh A, Guenette M, Ahsan Z, Giacca A, Hahn MK.

J Endocrinol. 2015 Nov;227(2):71-81. doi: 10.1530/JOE-15-0074. Epub 2015 Sep 1.

PMID:
26330531
28.

A low-protein diet combined with low-dose endotoxin leads to changes in glucose homeostasis in weanling rats.

Bandsma RH, Ackerley C, Koulajian K, Zhang L, van Zutphen T, van Dijk TH, Xiao C, Giacca A, Lewis GF.

Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E466-73. doi: 10.1152/ajpendo.00090.2015. Epub 2015 Jul 7.

29.

The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent.

Guo J, Breen DM, Pereira TJ, Dalvi PS, Zhang H, Mori Y, Ghanim H, Tumiati L, Fantus IG, Bendeck MP, Dandona P, Rao V, Dolinsky VW, Heximer SP, Giacca A.

Atherosclerosis. 2015 Jul;241(1):111-20. doi: 10.1016/j.atherosclerosis.2015.04.799. Epub 2015 Apr 25.

PMID:
25974101
30.

Microfabricated microporous membranes reduce the host immune response and prolong the functional lifetime of a closed-loop insulin delivery implant in a type 1 diabetic rat model.

Li J, Chu MK, Gordijo CR, Abbasi AZ, Chen K, Adissu HA, Löhn M, Giacca A, Plettenburg O, Wu XY.

Biomaterials. 2015 Apr;47:51-61. doi: 10.1016/j.biomaterials.2015.01.005. Epub 2015 Feb 4.

PMID:
25682160
31.

In vivo performance and biocompatibility of a subcutaneous implant for real-time glucose-responsive insulin delivery.

Chu MK, Gordijo CR, Li J, Abbasi AZ, Giacca A, Plettenburg O, Wu XY.

Diabetes Technol Ther. 2015 Apr;17(4):255-67. doi: 10.1089/dia.2014.0229. Epub 2015 Feb 11.

PMID:
25671341
32.

Effect of N-acetyl-l-cysteine on insulin resistance caused by prolonged free fatty acid elevation.

Pereira S, Shah A, George Fantus I, Joseph JW, Giacca A.

J Endocrinol. 2015 Apr;225(1):1-7. doi: 10.1530/JOE-14-0676. Epub 2015 Jan 21.

PMID:
25609734
33.

In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity.

Pereira S, Breen DM, Naassan AE, Wang PY, Uchino H, Fantus IG, Carpentier AC, Gutierrez-Juarez R, Brindley DN, Lam TK, Giacca A.

Metabolism. 2015 Feb;64(2):315-22. doi: 10.1016/j.metabol.2014.10.019. Epub 2014 Oct 25.

PMID:
25467844
34.

FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress.

Pereira S, Park E, Mori Y, Haber CA, Han P, Uchida T, Stavar L, Oprescu AI, Koulajian K, Ivovic A, Yu Z, Li D, Bowman TA, Dewald J, El-Benna J, Brindley DN, Gutierrez-Juarez R, Lam TK, Najjar SM, McKay RA, Bhanot S, Fantus IG, Giacca A.

Am J Physiol Endocrinol Metab. 2014 Jul 1;307(1):E34-46. doi: 10.1152/ajpendo.00436.2013. Epub 2014 May 13.

35.

Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality.

Maheandiran M, Mylvaganam S, Wu C, El-Hayek Y, Sugumar S, Hazrati L, del Campo M, Giacca A, Zhang L, Carlen PL.

PLoS One. 2013 Dec 30;8(12):e83168. doi: 10.1371/journal.pone.0083168. eCollection 2013.

36.

Local insulin application on the carotid artery inhibits neointima formation.

Chiang S, Breen DM, Guo J, Mori Y, Giacca A.

Can J Physiol Pharmacol. 2013 Dec;91(12):1086-94. doi: 10.1139/cjpp-2013-0038. Epub 2013 Sep 12.

PMID:
24289080
37.

Deficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistance.

Turnbull J, Tiberia E, Pereira S, Zhao X, Pencea N, Wheeler AL, Yu WQ, Ivovic A, Naranian T, Israelian N, Draginov A, Piliguian M, Frankland PW, Wang P, Ackerley CA, Giacca A, Minassian BA.

J Biol Chem. 2013 Nov 29;288(48):34627-37. doi: 10.1074/jbc.M113.483198. Epub 2013 Oct 18.

38.

Acute effects of single-dose olanzapine on metabolic, endocrine, and inflammatory markers in healthy controls.

Hahn MK, Wolever TM, Arenovich T, Teo C, Giacca A, Powell V, Clarke L, Fletcher P, Cohn T, McIntyre RS, Gomes S, Chintoh A, Remington GJ.

J Clin Psychopharmacol. 2013 Dec;33(6):740-6. doi: 10.1097/JCP.0b013e31829e8333.

PMID:
24100786
39.

Effects of intracerebroventricular (ICV) olanzapine on insulin sensitivity and secretion in vivo: an animal model.

Hahn MK, Chintoh A, Remington G, Teo C, Mann S, Arenovich T, Fletcher P, Lam L, Nobrega J, Guenette M, Cohn T, Giacca A.

Eur Neuropsychopharmacol. 2014 Mar;24(3):448-58. doi: 10.1016/j.euroneuro.2013.07.011. Epub 2013 Aug 13.

PMID:
24001874
40.

In vivo effect of insulin to decrease matrix metalloproteinase-2 and -9 activity after arterial injury.

Guo J, Dhaliwall JK, Chan KK, Ghanim H, Al Koudsi N, Lam L, Madadi G, Dandona P, Giacca A, Bendeck MP.

J Vasc Res. 2013;50(4):279-88. doi: 10.1159/000351611. Epub 2013 Jul 9.

PMID:
23988659
41.

Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo.

Koulajian K, Ivovic A, Ye K, Desai T, Shah A, Fantus IG, Ran Q, Giacca A.

Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E254-62. doi: 10.1152/ajpendo.00481.2012. Epub 2013 May 21.

42.

Maternal taurine supplementation in rats partially prevents the adverse effects of early-life protein deprivation on β-cell function and insulin sensitivity.

Tang C, Marchand K, Lam L, Lux-Lantos V, Thyssen SM, Guo J, Giacca A, Arany E.

Reproduction. 2013 May 21;145(6):609-20. doi: 10.1530/REP-12-0388. Print 2013 Jun.

PMID:
23613616
43.

Atypical antipsychotics and effects of adrenergic and serotonergic receptor binding on insulin secretion in-vivo: an animal model.

Guenette MD, Giacca A, Hahn M, Teo C, Lam L, Chintoh A, Arenovich T, Remington G.

Schizophr Res. 2013 May;146(1-3):162-9. doi: 10.1016/j.schres.2013.02.023. Epub 2013 Mar 15.

PMID:
23499243
44.

NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents.

Koulajian K, Desai T, Liu GC, Ivovic A, Patterson JN, Tang C, El-Benna J, Joseph JW, Scholey JW, Giacca A.

Diabetologia. 2013 May;56(5):1078-87. doi: 10.1007/s00125-013-2858-4. Epub 2013 Feb 21.

45.

Duration of rise in free fatty acids determines salicylate's effect on hepatic insulin sensitivity.

Pereira S, Yu WQ, Frigolet ME, Beaudry JL, Shpilberg Y, Park E, Dirlea C, Nyomba BL, Riddell MC, Fantus IG, Giacca A.

J Endocrinol. 2013 Mar 15;217(1):31-43. doi: 10.1530/JOE-12-0214. Print 2013 Apr.

46.

Chronic olanzapine administration in rats: effect of route of administration on weight, food intake and body composition.

Mann S, Chintoh A, Giacca A, Fletcher P, Nobrega J, Hahn M, Remington G.

Pharmacol Biochem Behav. 2013 Feb;103(4):717-22. doi: 10.1016/j.pbb.2012.12.002. Epub 2012 Dec 9.

PMID:
23234835
47.

Susceptibility to fatty acid-induced β-cell dysfunction is enhanced in prediabetic diabetes-prone biobreeding rats: a potential link between β-cell lipotoxicity and islet inflammation.

Tang C, Naassan AE, Chamson-Reig A, Koulajian K, Goh TT, Yoon F, Oprescu AI, Ghanim H, Lewis GF, Dandona P, Donath MY, Ehses JA, Arany E, Giacca A.

Endocrinology. 2013 Jan;154(1):89-101. doi: 10.1210/en.2012-1720. Epub 2012 Nov 13.

PMID:
23150493
48.

Deletion of p47phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse.

Liu GC, Fang F, Zhou J, Koulajian K, Yang S, Lam L, Reich HN, John R, Herzenberg AM, Giacca A, Oudit GY, Scholey JW.

Diabetologia. 2012 Sep;55(9):2522-32. doi: 10.1007/s00125-012-2586-1. Epub 2012 Jun 1.

PMID:
22653270
49.

In vitro and in vivo testing of glucose-responsive insulin-delivery microdevices in diabetic rats.

Chu MK, Chen J, Gordijo CR, Chiang S, Ivovic A, Koulajian K, Giacca A, Wu XY, Sun Y.

Lab Chip. 2012 Jul 21;12(14):2533-9. doi: 10.1039/c2lc40139h. Epub 2012 May 8.

PMID:
22565220
50.

Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism.

Breen DM, Dolinsky VW, Zhang H, Ghanim H, Guo J, Mroziewicz M, Tsiani EL, Bendeck MP, Dandona P, Dyck JR, Heximer SP, Giacca A.

Atherosclerosis. 2012 Jun;222(2):375-81. doi: 10.1016/j.atherosclerosis.2012.03.021. Epub 2012 Mar 27.

PMID:
22552115

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