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Items: 41

1.

Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens.

Grillová L, Oppelt J, Mikalová L, Nováková M, Giacani L, Niesnerová A, Noda AA, Mechaly AE, Pospíšilová P, Čejková D, Grange PA, Dupin N, Strnadel R, Chen M, Denham I, Arora N, Picardeau M, Weston C, Forsyth RA, Šmajs D.

Front Microbiol. 2019 Jul 31;10:1691. doi: 10.3389/fmicb.2019.01691. eCollection 2019.

2.

Author Correction: The wide utility of rabbits as models of human diseases.

Esteves PJ, Abrantes J, Baldauf HM, BenMohamed L, Chen Y, Christensen N, González-Gallego J, Giacani L, Hu J, Kaplan G, Keppler OT, Knight KL, Kong XP, Lanning DK, Le Pendu J, de Matos AL, Liu J, Liu S, Lopes AM, Lu S, Lukehart S, Manabe YC, Neves F, McFadden G, Pan R, Peng X, de Sousa-Pereira P, Pinheiro A, Rahman M, Ruvoën-Clouet N, Subbian S, Tuñón MJ, van der Loo W, Vaine M, Via LE, Wang S, Mage R.

Exp Mol Med. 2019 Jul 4;51(7):71. doi: 10.1038/s12276-019-0252-0.

PMID:
31270317
3.

Evaluation of the Protective Ability of the Treponema pallidum subsp. pallidum Tp0126 OmpW Homolog in the Rabbit Model of Syphilis.

Haynes AM, Godornes C, Ke W, Giacani L.

Infect Immun. 2019 Jul 23;87(8). pii: e00323-19. doi: 10.1128/IAI.00323-19. Print 2019 Aug.

PMID:
31182617
4.

Treponema pallidum subsp. pallidum DNA and RNA in Semen of a Syphilis Patient Without Genital or Anal Lesions.

Godornes C, Ciccarese G, Drago F, Giacani L.

Sex Transm Dis. 2019 Jun;46(6):e62-e64. doi: 10.1097/OLQ.0000000000000956.

PMID:
31095105
5.

Analysis of host cell binding specificity mediated by the Tp0136 adhesin of the syphilis agent Treponema pallidum subsp. pallidum.

Djokic V, Giacani L, Parveen N.

PLoS Negl Trop Dis. 2019 May 9;13(5):e0007401. doi: 10.1371/journal.pntd.0007401. eCollection 2019 May.

6.

Non-pathogenic Borrelia burgdorferi expressing Treponema pallidum TprK and Tp0435 antigens as a novel approach to evaluate syphilis vaccine candidates.

Parveen N, Fernandez MC, Haynes AM, Zhang RL, Godornes BC, Centurion-Lara A, Giacani L.

Vaccine. 2019 Mar 22;37(13):1807-1818. doi: 10.1016/j.vaccine.2019.02.022. Epub 2019 Feb 20.

PMID:
30797635
7.

Topical treatment with gallium maltolate reduces Treponema pallidum subsp. pertenue burden in primary experimental lesions in a rabbit model of yaws.

Giacani L, Bernstein LR, Haynes AM, Godornes BC, Ciccarese G, Drago F, Parodi A, Valdevit S, Anselmi L, Tomasini CF, Baca AM.

PLoS Negl Trop Dis. 2019 Jan 2;13(1):e0007076. doi: 10.1371/journal.pntd.0007076. eCollection 2019 Jan.

8.

Treponema pallidum subsp. pallidum DNA and RNA in semen of a syphilis patient without genital or anal lesions. Possible implications for disease transmissibility.

Godornes C, Ciccarese G, Drago F, Giacani L.

Sex Transm Dis. 2018 Dec 3. doi: 10.1097/OLQ.0000000000000956. [Epub ahead of print]

PMID:
30516728
9.

Sequencing of Treponema pallidum subsp. pallidum from isolate UZ1974 using Anti-Treponemal Antibodies Enrichment: First complete whole genome sequence obtained directly from human clinical material.

Grillová L, Giacani L, Mikalová L, Strouhal M, Strnadel R, Marra C, Centurion-Lara A, Poveda L, Russo G, Čejková D, Vašků V, Oppelt J, Šmajs D.

PLoS One. 2018 Aug 21;13(8):e0202619. doi: 10.1371/journal.pone.0202619. eCollection 2018.

10.

The wide utility of rabbits as models of human diseases.

Esteves PJ, Abrantes J, Baldauf HM, BenMohamed L, Chen Y, Christensen N, González-Gallego J, Giacani L, Hu J, Kaplan G, Keppler OT, Knight KL, Kong XP, Lanning DK, Le Pendu J, de Matos AL, Liu J, Liu S, Lopes AM, Lu S, Lukehart S, Manabe YC, Neves F, McFadden G, Pan R, Peng X, de Sousa-Pereira P, Pinheiro A, Rahman M, Ruvoën-Clouet N, Subbian S, Tuñón MJ, van der Loo W, Vaine M, Via LE, Wang S, Mage R.

Exp Mol Med. 2018 May 22;50(5):66. doi: 10.1038/s12276-018-0094-1. Review. Erratum in: Exp Mol Med. 2019 Jul 4;51(7):71.

11.

Enhanced Molecular Typing of Treponema pallidum subspecies pallidum Strains From 4 Italian Hospitals Shows Geographical Differences in Strain Type Heterogeneity, Widespread Resistance to Macrolides, and Lack of Mutations Associated With Doxycycline Resistance.

Giacani L, Ciccarese G, Puga-Salazar C, Dal Conte I, Colli L, Cusini M, Ramoni S, Delmonte S, DʼAntuono A, Gaspari V, Drago F.

Sex Transm Dis. 2018 Apr;45(4):237-242. doi: 10.1097/OLQ.0000000000000741.

12.

Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea.

Godornes C, Giacani L, Barry AE, Mitja O, Lukehart SA.

PLoS Negl Trop Dis. 2017 Dec 27;11(12):e0006113. doi: 10.1371/journal.pntd.0006113. eCollection 2017 Dec.

13.

Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster.

Arora N, Schuenemann VJ, Jäger G, Peltzer A, Seitz A, Herbig A, Strouhal M, Grillová L, Sánchez-Busó L, Kühnert D, Bos KI, Davis LR, Mikalová L, Bruisten S, Komericki P, French P, Grant PR, Pando MA, Vaulet LG, Fermepin MR, Martinez A, Centurion Lara A, Giacani L, Norris SJ, Šmajs D, Bosshard PP, González-Candelas F, Nieselt K, Krause J, Bagheri HC.

Nat Microbiol. 2016 Dec 5;2:16245. doi: 10.1038/nmicrobiol.2016.245.

14.

Treponema pallidum Lipoprotein TP0435 Expressed in Borrelia burgdorferi Produces Multiple Surface/Periplasmic Isoforms and mediates Adherence.

Chan K, Nasereddin T, Alter L, Centurion-Lara A, Giacani L, Parveen N.

Sci Rep. 2016 May 10;6:25593. doi: 10.1038/srep25593.

15.

Fluorescence in situ hybridization for the identification of Treponema pallidum in tissue sections.

Petrich A, Rojas P, Schulze J, Loddenkemper C, Giacani L, Schneider T, Hertel M, Kikhney J, Moter A.

Int J Med Microbiol. 2015 Oct;305(7):709-18. doi: 10.1016/j.ijmm.2015.08.022. Epub 2015 Aug 28.

PMID:
26365167
16.

The molecular epidemiology of Treponema pallidum subspecies pallidum.

Ma DY, Giacani L, Centurión-Lara A.

Sex Health. 2015 Apr;12(2):141-7. doi: 10.1071/SH14197.

17.

Transcription of TP0126, Treponema pallidum putative OmpW homolog, is regulated by the length of a homopolymeric guanosine repeat.

Giacani L, Brandt SL, Ke W, Reid TB, Molini BJ, Iverson-Cabral S, Ciccarese G, Drago F, Lukehart SA, Centurion-Lara A.

Infect Immun. 2015 Jun;83(6):2275-89. doi: 10.1128/IAI.00360-15. Epub 2015 Mar 23.

18.

Treponema pallidum subsp. pallidum TP0136 protein is heterogeneous among isolates and binds cellular and plasma fibronectin via its NH2-terminal end.

Ke W, Molini BJ, Lukehart SA, Giacani L.

PLoS Negl Trop Dis. 2015 Mar 20;9(3):e0003662. doi: 10.1371/journal.pntd.0003662. eCollection 2015 Mar.

19.

Whole genome sequence of the Treponema pallidum subsp. endemicum strain Bosnia A: the genome is related to yaws treponemes but contains few loci similar to syphilis treponemes.

Staudová B, Strouhal M, Zobaníková M, Cejková D, Fulton LL, Chen L, Giacani L, Centurion-Lara A, Bruisten SM, Sodergren E, Weinstock GM, Smajs D.

PLoS Negl Trop Dis. 2014 Nov 6;8(11):e3261. doi: 10.1371/journal.pntd.0003261. eCollection 2014.

20.

When is syphilis not syphilis? Or is it?

Lukehart SA, Giacani L.

Sex Transm Dis. 2014 Sep;41(9):554-5. doi: 10.1097/OLQ.0000000000000179. No abstract available.

21.

Complete Genome Sequence of the Treponema pallidum subsp. pallidum Sea81-4 Strain.

Giacani L, Iverson-Cabral SL, King JC, Molini BJ, Lukehart SA, Centurion-Lara A.

Genome Announc. 2014 Apr 17;2(2). pii: e00333-14. doi: 10.1128/genomeA.00333-14.

22.

The endemic treponematoses.

Giacani L, Lukehart SA.

Clin Microbiol Rev. 2014 Jan;27(1):89-115. doi: 10.1128/CMR.00070-13. Review.

23.

Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains.

Centurion-Lara A, Giacani L, Godornes C, Molini BJ, Brinck Reid T, Lukehart SA.

PLoS Negl Trop Dis. 2013 May 16;7(5):e2222. doi: 10.1371/journal.pntd.0002222. Print 2013.

24.

A case of congenital syphilis.

Mannelli L, Perez FA, Parisi MT, Giacani L.

Emerg Radiol. 2013 Aug;20(4):337-9. doi: 10.1007/s10140-013-1112-1. Epub 2013 Feb 27.

PMID:
23443516
25.

Identification of the Treponema pallidum subsp. pallidum TP0092 (RpoE) regulon and its implications for pathogen persistence in the host and syphilis pathogenesis.

Giacani L, Denisenko O, Tompa M, Centurion-Lara A.

J Bacteriol. 2013 Feb;195(4):896-907. doi: 10.1128/JB.01973-12. Epub 2012 Dec 14.

26.

Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen.

Giacani L, Chattopadhyay S, Centurion-Lara A, Jeffrey BM, Le HT, Molini BJ, Lukehart SA, Sokurenko EV, Rockey DD.

PLoS Negl Trop Dis. 2012;6(6):e1698. doi: 10.1371/journal.pntd.0001698. Epub 2012 Jun 12.

27.

Comparative investigation of the genomic regions involved in antigenic variation of the TprK antigen among treponemal species, subspecies, and strains.

Giacani L, Brandt SL, Puray-Chavez M, Reid TB, Godornes C, Molini BJ, Benzler M, Hartig JS, Lukehart SA, Centurion-Lara A.

J Bacteriol. 2012 Aug;194(16):4208-25. doi: 10.1128/JB.00863-12. Epub 2012 Jun 1.

28.

Complete genome sequence and annotation of the Treponema pallidum subsp. pallidum Chicago strain.

Giacani L, Jeffrey BM, Molini BJ, Le HT, Lukehart SA, Centurion-Lara A, Rockey DD.

J Bacteriol. 2010 May;192(10):2645-6. doi: 10.1128/JB.00159-10. Epub 2010 Mar 26.

29.

Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis.

Giacani L, Molini BJ, Kim EY, Godornes BC, Leader BT, Tantalo LC, Centurion-Lara A, Lukehart SA.

J Immunol. 2010 Apr 1;184(7):3822-9. doi: 10.4049/jimmunol.0902788. Epub 2010 Feb 26.

30.

TP0262 is a modulator of promoter activity of tpr Subfamily II genes of Treponema pallidum ssp. pallidum.

Giacani L, Godornes C, Puray-Chavez M, Guerra-Giraldez C, Tompa M, Lukehart SA, Centurion-Lara A.

Mol Microbiol. 2009 Jun;72(5):1087-99. doi: 10.1111/j.1365-2958.2009.06712.x. Epub 2009 Apr 30.

31.

Length of guanosine homopolymeric repeats modulates promoter activity of subfamily II tpr genes of Treponema pallidum ssp. pallidum.

Giacani L, Lukehart S, Centurion-Lara A.

FEMS Immunol Med Microbiol. 2007 Nov;51(2):289-301. Epub 2007 Aug 7.

32.

Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis.

Giacani L, Molini B, Godornes C, Barrett L, Van Voorhis W, Centurion-Lara A, Lukehart SA.

Infect Immun. 2007 Jan;75(1):104-12. Epub 2006 Oct 9.

33.

Molecular evolution of the tprC, D, I, K, G, and J genes in the pathogenic genus Treponema.

Gray RR, Mulligan CJ, Molini BJ, Sun ES, Giacani L, Godornes C, Kitchen A, Lukehart SA, Centurion-Lara A.

Mol Biol Evol. 2006 Nov;23(11):2220-33. Epub 2006 Aug 22.

PMID:
16926243
34.
35.

Immunological evaluation and cellular location analysis of the TprI antigen of Treponema pallidum subsp. pallidum.

Giacani L, Sambri V, Marangoni A, Cavrini F, Storni E, Donati M, Corona S, Lanzarini P, Cevenini R.

Infect Immun. 2005 Jun;73(6):3817-22.

36.

Tpr homologs in Treponema paraluiscuniculi Cuniculi A strain.

Giacani L, Sun ES, Hevner K, Molini BJ, Van Voorhis WC, Lukehart SA, Centurion-Lara A.

Infect Immun. 2004 Nov;72(11):6561-76.

37.

Production of tumor necrosis factor alpha by Treponema pallidum, Borrelia burgdorferi s.l., and Leptospira interrogans in isolated rat Kupffer cells.

Marangoni A, Aldini R, Sambri V, Giacani L, Di Leo K, Cevenini R.

FEMS Immunol Med Microbiol. 2004 Apr 9;40(3):187-91.

38.

Chemiluminescence detection of reactive oxygen species in isolated Kupffer cells during phagocytosis of Treponema pallidum.

Aldini R, Marangoni A, Guardigli M, Sambri V, Giacani L, Montagnani M, Roda A, Cevenini R.

Comp Hepatol. 2004 Jan 14;3 Suppl 1:S41. No abstract available.

39.

Phagocytosis of Treponema pallidum and reactive oxygen species production by isolated rat Kupffer cells.

Marangoni A, Aldini R, Guardigli M, Sambri V, Giacani L, Montagnani M, Roda A, Cevenini R.

Med Microbiol Immunol. 2003 Nov;192(4):183-8. Epub 2003 Apr 11.

PMID:
12690445
40.

DNA immunization with pgp3 gene of Chlamydia trachomatis inhibits the spread of chlamydial infection from the lower to the upper genital tract in C3H/HeN mice.

Donati M, Sambri V, Comanducci M, Di Leo K, Storni E, Giacani L, Ratti G, Cevenini R.

Vaccine. 2003 Mar 7;21(11-12):1089-93.

PMID:
12559784
41.

Comparative in vitro activity of five cathelicidin-derived synthetic peptides against Leptospira, Borrelia and Treponema pallidum.

Sambri V, Marangoni A, Giacani L, Gennaro R, Murgia R, Cevenini R, Cinco M.

J Antimicrob Chemother. 2002 Dec;50(6):895-902.

PMID:
12461010

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