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Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling.

El Zein RM, Soria AH, Golib Dzib JF, Rickard AJ, Fernandes-Rosa FL, Samson-Couterie B, Giscos-Douriez I, Rocha A, Poglitsch M, Gomez-Sanchez CE, Amar L, Ghyselinck NB, Benecke A, Zennaro MC, Boulkroun S.

Sci Rep. 2019 Oct 11;9(1):14677. doi: 10.1038/s41598-019-50988-2.


Retinoic acid signaling pathways.

Ghyselinck NB, Duester G.

Development. 2019 Jul 4;146(13). pii: dev167502. doi: 10.1242/dev.167502. Review.


Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium.

Teletin M, Vernet N, Yu J, Klopfenstein M, Jones JW, Féret B, Kane MA, Ghyselinck NB, Mark M.

Development. 2019 Jan 4;146(1). pii: dev170225. doi: 10.1242/dev.170225.


Retinoic acid improves nephrotoxic serum-induced glomerulonephritis through activation of podocyte retinoic acid receptor α.

Dai Y, Chen A, Liu R, Gu L, Sharma S, Cai W, Salem F, Salant DJ, Pippin JW, Shankland SJ, Moeller MJ, Ghyselinck NB, Ding X, Chuang PY, Lee K, He JC.

Kidney Int. 2017 Dec;92(6):1444-1457. doi: 10.1016/j.kint.2017.04.026. Epub 2017 Jul 27.


Roles of Retinoic Acid in Germ Cell Differentiation.

Teletin M, Vernet N, Ghyselinck NB, Mark M.

Curr Top Dev Biol. 2017;125:191-225. doi: 10.1016/bs.ctdb.2016.11.013. Epub 2017 Jan 16. Review.


Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion.

Chassot AA, Le Rolle M, Jourden M, Taketo MM, Ghyselinck NB, Chaboissier MC.

Dev Biol. 2017 Jun 1;426(1):17-27. doi: 10.1016/j.ydbio.2017.04.010. Epub 2017 Apr 26.


Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary.

Minkina A, Lindeman RE, Gearhart MD, Chassot AA, Chaboissier MC, Ghyselinck NB, Bardwell VJ, Zarkower D.

Dev Biol. 2017 Apr 15;424(2):208-220. doi: 10.1016/j.ydbio.2017.02.015. Epub 2017 Mar 6.


Endogenous retinoic acid signaling is required for maintenance and regeneration of cornea.

Kumar S, Dollé P, Ghyselinck NB, Duester G.

Exp Eye Res. 2017 Jan;154:190-195. doi: 10.1016/j.exer.2016.11.009. Epub 2016 Nov 10. Review.


Hepatocytes Are the Principal Source of Circulating RBP4 in Mice.

Thompson SJ, Sargsyan A, Lee SA, Yuen JJ, Cai J, Smalling R, Ghyselinck N, Mark M, Blaner WS, Graham TE.

Diabetes. 2017 Jan;66(1):58-63. doi: 10.2337/db16-0286. Epub 2016 Oct 19.


Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor.

Gely-Pernot A, Raverdeau M, Teletin M, Vernet N, Féret B, Klopfenstein M, Dennefeld C, Davidson I, Benoit G, Mark M, Ghyselinck NB.

PLoS Genet. 2015 Oct 1;11(10):e1005501. doi: 10.1371/journal.pgen.1005501. eCollection 2015 Oct.


MEI4 – a central player in the regulation of meiotic DNA double-strand break formation in the mouse.

Kumar R, Ghyselinck N, Ishiguro K, Watanabe Y, Kouznetsova A, Höög C, Strong E, Schimenti J, Daniel K, Toth A, de Massy B.

J Cell Sci. 2015 May 1;128(9):1800-11. doi: 10.1242/jcs.165464. Epub 2015 Mar 20.


Role of retinoic acid receptor (RAR) signaling in post-natal male germ cell differentiation.

Mark M, Teletin M, Vernet N, Ghyselinck NB.

Biochim Biophys Acta. 2015 Feb;1849(2):84-93. doi: 10.1016/j.bbagrm.2014.05.019. Epub 2014 May 27. Review.


DMRT1 protects male gonadal cells from retinoid-dependent sexual transdifferentiation.

Minkina A, Matson CK, Lindeman RE, Ghyselinck NB, Bardwell VJ, Zarkower D.

Dev Cell. 2014 Jun 9;29(5):511-520. doi: 10.1016/j.devcel.2014.04.017. Epub 2014 May 22.


FOXL2 is a female sex-determining gene in the goat.

Boulanger L, Pannetier M, Gall L, Allais-Bonnet A, Elzaiat M, Le Bourhis D, Daniel N, Richard C, Cotinot C, Ghyselinck NB, Pailhoux E.

Curr Biol. 2014 Feb 17;24(4):404-8. doi: 10.1016/j.cub.2013.12.039. Epub 2014 Jan 30.


The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye.

Berry DC, Jacobs H, Marwarha G, Gely-Pernot A, O'Byrne SM, DeSantis D, Klopfenstein M, Feret B, Dennefeld C, Blaner WS, Croniger CM, Mark M, Noy N, Ghyselinck NB.

J Biol Chem. 2013 Aug 23;288(34):24528-39. doi: 10.1074/jbc.M113.484014. Epub 2013 Jul 9.


Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals.

Lavery R, Chassot AA, Pauper E, Gregoire EP, Klopfenstein M, de Rooij DG, Mark M, Schedl A, Ghyselinck NB, Chaboissier MC.

PLoS Genet. 2012;8(12):e1003170. doi: 10.1371/journal.pgen.1003170. Epub 2012 Dec 27.


Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.

Raverdeau M, Gely-Pernot A, Féret B, Dennefeld C, Benoit G, Davidson I, Chambon P, Mark M, Ghyselinck NB.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16582-7. doi: 10.1073/pnas.1214936109. Epub 2012 Sep 24.


Transthyretin blocks retinol uptake and cell signaling by the holo-retinol-binding protein receptor STRA6.

Berry DC, Croniger CM, Ghyselinck NB, Noy N.

Mol Cell Biol. 2012 Oct;32(19):3851-9. doi: 10.1128/MCB.00775-12. Epub 2012 Jul 23.


Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6.

Ruiz A, Mark M, Jacobs H, Klopfenstein M, Hu J, Lloyd M, Habib S, Tosha C, Radu RA, Ghyselinck NB, Nusinowitz S, Bok D.

Invest Ophthalmol Vis Sci. 2012 May 17;53(6):3027-39. doi: 10.1167/iovs.11-8476.


Spermatogonia differentiation requires retinoic acid receptor γ.

Gely-Pernot A, Raverdeau M, Célébi C, Dennefeld C, Feret B, Klopfenstein M, Yoshida S, Ghyselinck NB, Mark M.

Endocrinology. 2012 Jan;153(1):438-49. doi: 10.1210/en.2011-1102. Epub 2011 Nov 1.


Retinoic acid drives aryl hydrocarbon receptor expression and is instrumental to dioxin-induced toxicity during palate development.

Jacobs H, Dennefeld C, Féret B, Viluksela M, Håkansson H, Mark M, Ghyselinck NB.

Environ Health Perspect. 2011 Nov;119(11):1590-5. doi: 10.1289/ehp.1003075. Epub 2011 Aug 1.


RA-RAR-β counteracts myelin-dependent inhibition of neurite outgrowth via Lingo-1 repression.

Puttagunta R, Schmandke A, Floriddia E, Gaub P, Fomin N, Ghyselinck NB, Di Giovanni S.

J Cell Biol. 2011 Jun 27;193(7):1147-56. doi: 10.1083/jcb.201102066. Epub 2011 Jun 20.


Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development.

Fernández-Miranda G, Trakala M, Martín J, Escobar B, González A, Ghyselinck NB, Ortega S, Cañamero M, Pérez de Castro I, Malumbres M.

Development. 2011 Jul;138(13):2661-72. doi: 10.1242/dev.066381. Epub 2011 May 25.


Retinoids enhance glucocorticoid-induced apoptosis of T cells by facilitating glucocorticoid receptor-mediated transcription.

Tóth K, Sarang Z, Scholtz B, Brázda P, Ghyselinck N, Chambon P, Fésüs L, Szondy Z.

Cell Death Differ. 2011 May;18(5):783-92. doi: 10.1038/cdd.2010.136. Epub 2010 Nov 12.


Retinoic acid receptor (RAR)-alpha is not critically required for mediating retinoic acid effects in the developing mouse retina.

Cammas L, Trensz F, Jellali A, Ghyselinck NB, Roux MJ, Dollé P.

Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3281-90. doi: 10.1167/iovs.09-3769. Epub 2010 Jan 27.


Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction.

Leclerc EA, Huchenq A, Mattiuzzo NR, Metzger D, Chambon P, Ghyselinck NB, Serre G, Jonca N, Guerrin M.

J Cell Sci. 2009 Aug 1;122(Pt 15):2699-709. doi: 10.1242/jcs.050302. Epub 2009 Jul 13.


Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

Williams JA, Kondo N, Okabe T, Takeshita N, Pilchak DM, Koyama E, Ochiai T, Jensen D, Chu ML, Kane MA, Napoli JL, Enomoto-Iwamoto M, Ghyselinck N, Chambon P, Pacifici M, Iwamoto M.

Dev Biol. 2009 Apr 15;328(2):315-27. doi: 10.1016/j.ydbio.2009.01.031. Epub 2009 Feb 3.


Function of retinoic acid receptors during embryonic development.

Mark M, Ghyselinck NB, Chambon P.

Nucl Recept Signal. 2009;7:e002. doi: 10.1621/nrs.07002. Epub 2009 Apr 3. Review.


A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development.

Mascrez B, Ghyselinck NB, Chambon P, Mark M.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4272-7. doi: 10.1073/pnas.0813143106. Epub 2009 Mar 2.


Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.

Hill JA, Hall JA, Sun CM, Cai Q, Ghyselinck N, Chambon P, Belkaid Y, Mathis D, Benoist C.

Immunity. 2008 Nov 14;29(5):758-70. doi: 10.1016/j.immuni.2008.09.018.


STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation.

Mark M, Jacobs H, Oulad-Abdelghani M, Dennefeld C, Féret B, Vernet N, Codreanu CA, Chambon P, Ghyselinck NB.

J Cell Sci. 2008 Oct 1;121(Pt 19):3233-42. doi: 10.1242/jcs.035071.


Retinoid X receptor beta (RXRB) expression in Sertoli cells controls cholesterol homeostasis and spermiation.

Vernet N, Dennefeld C, Klopfenstein M, Ruiz A, Bok D, Ghyselinck NB, Mark M.

Reproduction. 2008 Nov;136(5):619-26. doi: 10.1530/REP-08-0235. Epub 2008 Aug 19.


Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis.

Matt N, Ghyselinck NB, Pellerin I, Dupé V.

Dev Biol. 2008 Aug 1;320(1):140-8. doi: 10.1016/j.ydbio.2008.04.039. Epub 2008 May 11.


Modular patterning of structure and function of the striatum by retinoid receptor signaling.

Liao WL, Tsai HC, Wang HF, Chang J, Lu KM, Wu HL, Lee YC, Tsai TF, Takahashi H, Wagner M, Ghyselinck NB, Chambon P, Liu FC.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6765-70. doi: 10.1073/pnas.0802109105. Epub 2008 Apr 28.


Functional implication of the vitamin A signaling pathway in the brain.

Tafti M, Ghyselinck NB.

Arch Neurol. 2007 Dec;64(12):1706-11. Review.


Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage.

Ruiz A, Ghyselinck NB, Mata N, Nusinowitz S, Lloyd M, Dennefeld C, Chambon P, Bok D.

Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5377-87.


Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism.

Vauclair S, Majo F, Durham AD, Ghyselinck NB, Barrandon Y, Radtke F.

Dev Cell. 2007 Aug;13(2):242-53.


Adopting the good reFLEXes when generating conditional alterations in the mouse genome.

Schnütgen F, Ghyselinck NB.

Transgenic Res. 2007 Aug;16(4):405-13. Epub 2007 Apr 6. Review.


Retinoids control anterior and dorsal properties in the developing forebrain.

Halilagic A, Ribes V, Ghyselinck NB, Zile MH, Dollé P, Studer M.

Dev Biol. 2007 Mar 1;303(1):362-75. Epub 2006 Nov 17.


Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells.

Vernet N, Dennefeld C, Guillou F, Chambon P, Ghyselinck NB, Mark M.

EMBO J. 2006 Dec 13;25(24):5816-25. Epub 2006 Nov 23.


Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.

Calléja C, Messaddeq N, Chapellier B, Yang H, Krezel W, Li M, Metzger D, Mascrez B, Ohta K, Kagechika H, Endo Y, Mark M, Ghyselinck NB, Chambon P.

Genes Dev. 2006 Jun 1;20(11):1525-38.


Retinoids and spermatogenesis: lessons from mutant mice lacking the plasma retinol binding protein.

Ghyselinck NB, Vernet N, Dennefeld C, Giese N, Nau H, Chambon P, Viville S, Mark M.

Dev Dyn. 2006 Jun;235(6):1608-22.


Retinoic acid signaling affects cortical synchrony during sleep.

Maret S, Franken P, Dauvilliers Y, Ghyselinck NB, Chambon P, Tafti M.

Science. 2005 Oct 7;310(5745):111-3.


Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis.

Vernet N, Dennefeld C, Rochette-Egly C, Oulad-Abdelghani M, Chambon P, Ghyselinck NB, Mark M.

Endocrinology. 2006 Jan;147(1):96-110. Epub 2005 Oct 6.


Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells.

Matt N, Dupé V, Garnier JM, Dennefeld C, Chambon P, Mark M, Ghyselinck NB.

Development. 2005 Nov;132(21):4789-800. Epub 2005 Oct 5.


Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms.

Hoegberg P, Schmidt CK, Fletcher N, Nilsson CB, Trossvik C, Gerlienke Schuur A, Brouwer A, Nau H, Ghyselinck NB, Chambon P, Håkansson H.

Chem Biol Interact. 2005 Sep 10;156(1):25-39.


Working memory deficits in retinoid X receptor gamma-deficient mice.

Wietrzych M, Meziane H, Sutter A, Ghyselinck N, Chapman PF, Chambon P, Krezel W.

Learn Mem. 2005 May-Jun;12(3):318-26. Epub 2005 May 16.


Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.

Schnütgen F, De-Zolt S, Van Sloun P, Hollatz M, Floss T, Hansen J, Altschmied J, Seisenberger C, Ghyselinck NB, Ruiz P, Chambon P, Wurst W, von Melchner H.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7221-6. Epub 2005 May 3.


Cellular retinol-binding protein type III is needed for retinoid incorporation into milk.

Piantedosi R, Ghyselinck N, Blaner WS, Vogel S.

J Biol Chem. 2005 Jun 24;280(25):24286-92. Epub 2005 May 3.

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