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The TCR/CD3 complex in leukemogenesis and as a therapeutic target in T-cell acute lymphoblastic leukemia.

Dos Santos NR, Ghysdael J, Tran Quang C.

Adv Biol Regul. 2019 Jul 27:100638. doi: 10.1016/j.jbior.2019.100638. [Epub ahead of print] Review.


Novel Intergenically Spliced Chimera, NFATC3-PLA2G15, Is Associated with Aggressive T-ALL Biology and Outcome.

Bond J, Tran Quang C, Hypolite G, Belhocine M, Bergon A, Cordonnier G, Ghysdael J, Macintyre E, Boissel N, Spicuglia S, Asnafi V.

Mol Cancer Res. 2018 Mar;16(3):470-475. doi: 10.1158/1541-7786.MCR-17-0442. Epub 2018 Jan 12.


A TCR-switchable cell death pathway in T-ALL.

Quang CT, Zaniboni B, Ghysdael J.

Oncoscience. 2017 Mar 31;4(3-4):17-18. doi: 10.18632/oncoscience.342. eCollection 2017 Mar. No abstract available.


The calcineurin protein phosphatase is dispensable for BCR-ABL-induced B-ALL maintenance, propagation and response to dasatinib.

Rocchetti F, Tran Quang C, Maragno AL, Nguyen J, Lasgi C, Ghysdael J.

Leukemia. 2017 Jan;31(1):248-251. doi: 10.1038/leu.2016.269. Epub 2016 Oct 3. No abstract available.


Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia.

Trinquand A, Dos Santos NR, Tran Quang C, Rocchetti F, Zaniboni B, Belhocine M, Da Costa de Jesus C, Lhermitte L, Tesio M, Dussiot M, Cosset FL, Verhoeyen E, Pflumio F, Ifrah N, Dombret H, Spicuglia S, Chatenoud L, Gross DA, Hermine O, Macintyre E, Ghysdael J, Asnafi V.

Cancer Discov. 2016 Sep;6(9):972-85. doi: 10.1158/2159-8290.CD-15-0675. Epub 2016 Jun 28.


Microenvironmental cues for T-cell acute lymphoblastic leukemia development.

Passaro D, Quang CT, Ghysdael J.

Immunol Rev. 2016 May;271(1):156-72. doi: 10.1111/imr.12402. Review.


Calcineurin/CXCR4 in T-ALL.

Passaro D, Quang CT, Ghysdael J.

Oncoscience. 2015 Sep 12;2(10):781-2. eCollection 2015. No abstract available.


Lymphotoxin-β receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype.

Fernandes MT, Ghezzo MN, Silveira AB, Kalathur RK, Póvoa V, Ribeiro AR, Brandalise SR, Dejardin E, Alves NL, Ghysdael J, Barata JT, Yunes JA, dos Santos NR.

Br J Haematol. 2015 Dec;171(5):736-51. doi: 10.1111/bjh.13760. Epub 2015 Oct 12. Erratum in: Br J Haematol. 2016 Jun;173(5):804.


CXCR4 Is Required for Leukemia-Initiating Cell Activity in T Cell Acute Lymphoblastic Leukemia.

Passaro D, Irigoyen M, Catherinet C, Gachet S, Da Costa De Jesus C, Lasgi C, Tran Quang C, Ghysdael J.

Cancer Cell. 2015 Jun 8;27(6):769-79. doi: 10.1016/j.ccell.2015.05.003.


Control of CD8 T cell proliferation and terminal differentiation by active STAT5 and CDKN2A/CDKN2B.

Grange M, Giordano M, Mas A, Roncagalli R, Firaguay G, Nunes JA, Ghysdael J, Schmitt-Verhulst AM, Auphan-Anezin N.

Immunology. 2015 Aug;145(4):543-57. doi: 10.1111/imm.12471. Epub 2015 Jun 15.


The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells.

Quang CT, Leboucher S, Passaro D, Fuhrmann L, Nourieh M, Vincent-Salomon A, Ghysdael J.

Cell Death Dis. 2015 Feb 26;6:e1658. doi: 10.1038/cddis.2015.14.


Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression.

Uzan B, Poglio S, Gerby B, Wu CL, Gross J, Armstrong F, Calvo J, Cahu X, Deswarte C, Dumont F, Passaro D, Besnard-Guérin C, Leblanc T, Baruchel A, Landman-Parker J, Ballerini P, Baud V, Ghysdael J, Baleydier F, Porteu F, Pflumio F.

EMBO Mol Med. 2014 Jun;6(6):821-34. doi: 10.1002/emmm.201303286. Epub 2014 Apr 6.


Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia.

Hawkins ED, Oliaro J, Ramsbottom KM, Ting SB, Sacirbegovic F, Harvey M, Kinwell T, Ghysdael J, Johnstone RW, Humbert PO, Russell SM.

PLoS One. 2014 Jan 27;9(1):e87376. doi: 10.1371/journal.pone.0087376. eCollection 2014.


Deregulation of AhR function by the human acute leukemia TEL-ARNT fusion protein.

Nguyen-Khac F, Della Valle V, Lopez RG, Ghysdael J, Bernard OA.

Am J Hematol. 2014 May;89(5):566-7. doi: 10.1002/ajh.23680. Epub 2014 Feb 28. No abstract available.


Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.

Waibel M, Solomon VS, Knight DA, Ralli RA, Kim SK, Banks KM, Vidacs E, Virely C, Sia KC, Bracken LS, Collins-Underwood R, Drenberg C, Ramsey LB, Meyer SC, Takiguchi M, Dickins RA, Levine R, Ghysdael J, Dawson MA, Lock RB, Mullighan CG, Johnstone RW.

Cell Rep. 2013 Nov 27;5(4):1047-59. doi: 10.1016/j.celrep.2013.10.038. Epub 2013 Nov 21.


Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia.

Bellanger D, Jacquemin V, Chopin M, Pierron G, Bernard OA, Ghysdael J, Stern MH.

Leukemia. 2014 Feb;28(2):417-9. doi: 10.1038/leu.2013.271. Epub 2013 Sep 19. No abstract available.


Leukemia-initiating cell activity requires calcineurin in T-cell acute lymphoblastic leukemia.

Gachet S, Genescà E, Passaro D, Irigoyen M, Alcalde H, Clémenson C, Poglio S, Pflumio F, Janin A, Lasgi C, Dodier S, Soyer M, Duménil G, Ghysdael J.

Leukemia. 2013 Dec;27(12):2289-300. doi: 10.1038/leu.2013.156. Epub 2013 May 21.


ISG15 modulates development of the erythroid lineage.

Maragno AL, Pironin M, Alcalde H, Cong X, Knobeloch KP, Tangy F, Zhang DE, Ghysdael J, Quang CT.

PLoS One. 2011;6(10):e26068. doi: 10.1371/journal.pone.0026068. Epub 2011 Oct 12.


Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

Jeannet R, Mastio J, Macias-Garcia A, Oravecz A, Ashworth T, Geimer Le Lay AS, Jost B, Le Gras S, Ghysdael J, Gridley T, Honjo T, Radtke F, Aster JC, Chan S, Kastner P.

Blood. 2010 Dec 16;116(25):5443-54. doi: 10.1182/blood-2010-05-286658. Epub 2010 Sep 9.


Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia.

Virely C, Moulin S, Cobaleda C, Lasgi C, Alberdi A, Soulier J, Sigaux F, Chan S, Kastner P, Ghysdael J.

Leukemia. 2010 Jun;24(6):1200-4. doi: 10.1038/leu.2010.63. Epub 2010 Apr 15. No abstract available.


Calcineurin/NFAT signaling in lymphoid malignancies.

Gachet S, Ghysdael J.

Gen Physiol Biophys. 2009;28 Spec No Focus:F47-54. Review.


RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.

Hewitt SL, Yin B, Ji Y, Chaumeil J, Marszalek K, Tenthorey J, Salvagiotto G, Steinel N, Ramsey LB, Ghysdael J, Farrar MA, Sleckman BP, Schatz DG, Busslinger M, Bassing CH, Skok JA.

Nat Immunol. 2009 Jun;10(6):655-64. doi: 10.1038/ni.1735. Erratum in: Nat Immunol. 2009 Jun;10(6). doi: 10.1038/ni.1735. Nat Immunol. 2009 Sep;10(9):1034. Nat Immunol. 2010 Mar;11(4):355-6.


RelB-dependent stromal cells promote T-cell leukemogenesis.

dos Santos NR, Williame M, Gachet S, Cormier F, Janin A, Weih D, Weih F, Ghysdael J.

PLoS One. 2008 Jul 2;3(7):e2555. doi: 10.1371/journal.pone.0002555.


The calcineurin/NFAT signaling pathway: a novel therapeutic target in leukemia and solid tumors.

Medyouf H, Ghysdael J.

Cell Cycle. 2008 Feb 1;7(3):297-303. Epub 2007 Nov 23. Review.


Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia.

Medyouf H, Alcalde H, Berthier C, Guillemin MC, dos Santos NR, Janin A, Decaudin D, de Thé H, Ghysdael J.

Nat Med. 2007 Jun;13(6):736-41. Epub 2007 May 21.


Pre-TCR expression cooperates with TEL-JAK2 to transform immature thymocytes and induce T-cell leukemia.

dos Santos NR, Rickman DS, de Reynies A, Cormier F, Williame M, Blanchard C, Stern MH, Ghysdael J.

Blood. 2007 May 1;109(9):3972-81. Epub 2006 Dec 27.


Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation.

Nguyen-Khac F, Della Valle V, Lopez RG, Ravet E, Mauchauffé M, Friedman AD, Huang LE, Fichelson S, Ghysdael J, Bernard OA.

Oncogene. 2006 Aug 10;25(35):4840-7. Epub 2006 Mar 20.


Constitutive STAT5 activation specifically cooperates with the loss of p53 function in B-cell lymphomagenesis.

Joliot V, Cormier F, Medyouf H, Alcalde H, Ghysdael J.

Oncogene. 2006 Aug 3;25(33):4573-84. Epub 2006 Mar 13.


Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice.

Dumortier A, Jeannet R, Kirstetter P, Kleinmann E, Sellars M, dos Santos NR, Thibault C, Barths J, Ghysdael J, Punt JA, Kastner P, Chan S.

Mol Cell Biol. 2006 Jan;26(1):209-20.


A transgenic mouse model for TEL-JAK2-induced B-cell lymphoma/leukemia.

dos Santos NR, Ghysdael J.

Leukemia. 2006 Jan;20(1):182-5. No abstract available.


FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family.

van den Akker E, Ano S, Shih HM, Wang LC, Pironin M, Palvimo JJ, Kotaja N, Kirsh O, Dejean A, Ghysdael J.

J Biol Chem. 2005 Nov 11;280(45):38035-46. Epub 2005 Sep 7.


TYK2 is a key regulator of the surveillance of B lymphoid tumors.

Stoiber D, Kovacic B, Schuster C, Schellack C, Karaghiosoff M, Kreibich R, Weisz E, Artwohl M, Kleine OC, Muller M, Baumgartner-Parzer S, Ghysdael J, Freissmuth M, Sexl V.

J Clin Invest. 2004 Dec;114(11):1650-8.


Erythroblast transformation by FLI-1 depends upon its specific DNA binding and transcriptional activation properties.

Ano S, Pereira R, Pironin M, Lesault I, Milley C, Lebigot I, Quang CT, Ghysdael J.

J Biol Chem. 2004 Jan 23;279(4):2993-3002. Epub 2003 Oct 21.


Up-regulation of SLAP in FLI-1-transformed erythroblasts interferes with EpoR signaling.

Lebigot I, Gardellin P, Lefebvre L, Beug H, Ghysdael J, Quang CT.

Blood. 2003 Dec 15;102(13):4555-62. Epub 2003 Aug 28.


v-SRC specifically regulates the nucleo-cytoplasmic delocalization of the major isoform of TEL (ETV6).

Lopez RG, Carron C, Ghysdael J.

J Biol Chem. 2003 Oct 17;278(42):41316-25. Epub 2003 Jul 31.


Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5.

Ohtani N, Brennan P, Gaubatz S, Sanij E, Hertzog P, Wolvetang E, Ghysdael J, Rowe M, Hara E.

J Cell Biol. 2003 Jul 21;162(2):173-83. Epub 2003 Jul 14.


Identification and characterization of a PU.1/Spi-B binding site in the bovine leukemia virus long terminal repeat.

Dekoninck A, Calomme C, Nizet S, de Launoit Y, Burny A, Ghysdael J, Van Lint C.

Oncogene. 2003 May 15;22(19):2882-96.


Direct regulation of BCL-2 by FLI-1 is involved in the survival of FLI-1-transformed erythroblasts.

Lesault I, Quang CT, Frampton J, Ghysdael J.

EMBO J. 2002 Feb 15;21(4):694-703.


A non-classical ISRE/ISGF3 pathway mediates induction of RANTES gene transcription by type I IFNs.

Cremer I, Ghysdael J, Vieillard V.

FEBS Lett. 2002 Jan 30;511(1-3):41-5.


The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells.

Monni R, Santos SC, Mauchauffe M, Berger R, Ghysdael J, Gouilleux F, Gisselbrecht S, Bernard O, Penard-Lacronique V.

Oncogene. 2001 Feb 15;20(7):849-58.


Proteins of the ETS family with transcriptional repressor activity.

Mavrothalassitis G, Ghysdael J.

Oncogene. 2000 Dec 18;19(55):6524-32. Review.


SPI-1 transforming properties depend upon specifically activated forms of the EPOR.

Pereira R, Raingeaud J, Pironin M, Ghysdael J, Quang CT.

Oncogene. 2000 Oct 19;19(44):5106-10.


Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL.

Poirel H, Lopez RG, Lacronique V, Della Valle V, Mauchauffé M, Berger R, Ghysdael J, Bernard OA.

Oncogene. 2000 Sep 28;19(41):4802-6.


Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoprotein.

Guidez F, Petrie K, Ford AM, Lu H, Bennett CA, MacGregor A, Hannemann J, Ito Y, Ghysdael J, Greaves M, Wiedemann LM, Zelent A.

Blood. 2000 Oct 1;96(7):2557-61.


Erythroid cell development and leukemic transformation: interplay between signal transduction, cell cycle control and oncogenes.

Ghysdael J, Tran Quang C, Deiner EM, Dolznig H, Müllner EW, Beug H.

Pathol Biol (Paris). 2000 Apr;48(3):211-26. Review.


TEL-JAK2 transgenic mice develop T-cell leukemia.

Carron C, Cormier F, Janin A, Lacronique V, Giovannini M, Daniel MT, Bernard O, Ghysdael J.

Blood. 2000 Jun 15;95(12):3891-9.


The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion.

Salomon-Nguyen F, Della-Valle V, Mauchauffe M, Busson-Le Coniat M, Ghysdael J, Berger R, Bernard OA.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6757-62.


IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells.

Rameil P, Lécine P, Ghysdael J, Gouilleux F, Kahn-Perlès B, Imbert J.

Oncogene. 2000 Apr 20;19(17):2086-97.


Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells.

Lacronique V, Boureux A, Monni R, Dumon S, Mauchauffé M, Mayeux P, Gouilleux F, Berger R, Gisselbrecht S, Ghysdael J, Bernard OA.

Blood. 2000 Mar 15;95(6):2076-83.


Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF beta R fusion protein.

Sjöblom T, Boureux A, Rönnstrand L, Heldin CH, Ghysdael J, Ostman A.

Oncogene. 1999 Nov 25;18(50):7055-62.

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