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Items: 1 to 50 of 57

1.

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.

Elliot MJ, Maini RN, Feldmann M, Long-Fox A, Charles P, Katasikis P, Brennan FM, Bijl H, Ghrayeb J, Woody JN.

Arthritis Rheum. 2008 Feb;58(2 Suppl):S92-S101. doi: 10.1002/art.23362.

2.

HCV persistence and immune evasion in the absence of memory T cell help.

Grakoui A, Shoukry NH, Woollard DJ, Han JH, Hanson HL, Ghrayeb J, Murthy KK, Rice CM, Walker CM.

Science. 2003 Oct 24;302(5645):659-62.

3.

Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection.

Shoukry NH, Grakoui A, Houghton M, Chien DY, Ghrayeb J, Reimann KA, Walker CM.

J Exp Med. 2003 Jun 16;197(12):1645-55.

4.

CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection.

Thimme R, Wieland S, Steiger C, Ghrayeb J, Reimann KA, Purcell RH, Chisari FV.

J Virol. 2003 Jan;77(1):68-76.

5.

Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment.

Lifson JD, Rossio JL, Piatak M Jr, Parks T, Li L, Kiser R, Coalter V, Fisher B, Flynn BM, Czajak S, Hirsch VM, Reimann KA, Schmitz JE, Ghrayeb J, Bischofberger N, Nowak MA, Desrosiers RC, Wodarz D.

J Virol. 2001 Nov;75(21):10187-99.

6.

A nonhuman primate model for the selective elimination of CD8+ lymphocytes using a mouse-human chimeric monoclonal antibody.

Schmitz JE, Simon MA, Kuroda MJ, Lifton MA, Ollert MW, Vogel CW, Racz P, Tenner-Racz K, Scallon BJ, Dalesandro M, Ghrayeb J, Rieber EP, Sasseville VG, Reimann KA.

Am J Pathol. 1999 Jun;154(6):1923-32.

7.

Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.

Schmitz JE, Kuroda MJ, Santra S, Sasseville VG, Simon MA, Lifton MA, Racz P, Tenner-Racz K, Dalesandro M, Scallon BJ, Ghrayeb J, Forman MA, Montefiori DC, Rieber EP, Letvin NL, Reimann KA.

Science. 1999 Feb 5;283(5403):857-60.

8.

Minimal tumor necrosis factor receptor binding protein: optimum biological activity of a truncated p55 soluble tumor necrosis factor receptor-IgG fusion protein.

Corcoran AE, Scallon BJ, Trinh H, Chernajovsky Y, Ghrayeb J, Feldmann M.

Eur Cytokine Netw. 1998 Sep;9(3):255-62.

9.

Neutralization of TNF by the antibody cA2 reveals differential regulation of adhesion molecule expression on TNF-activated endothelial cells.

Nakada MT, Tam SH, Woulfe DS, Casper KA, Swerlick RA, Ghrayeb J.

Cell Adhes Commun. 1998 Sep;5(6):491-503.

PMID:
9791729
10.

Inhibition of tumor necrosis factor activity minimizes target organ damage in experimental autoimmune uveoretinitis despite quantitatively normal activated T cell traffic to the retina.

Dick AD, McMenamin PG, Körner H, Scallon BJ, Ghrayeb J, Forrester JV, Sedgwick JD.

Eur J Immunol. 1996 May;26(5):1018-25.

PMID:
8647162
11.

Unimpaired autoreactive T-cell traffic within the central nervous system during tumor necrosis factor receptor-mediated inhibition of experimental autoimmune encephalomyelitis.

Körner H, Goodsall AL, Lemckert FA, Scallon BJ, Ghrayeb J, Ford AL, Sedgwick JD.

Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11066-70.

12.

Functional comparisons of different tumour necrosis factor receptor/IgG fusion proteins.

Scallon BJ, Trinh H, Nedelman M, Brennan FM, Feldmann M, Ghrayeb J.

Cytokine. 1995 Nov;7(8):759-70.

PMID:
8664442
13.

The immunogenicity of the 7E3 murine monoclonal Fab antibody fragment variable region is dramatically reduced in humans by substitution of human for murine constant regions.

Knight DM, Wagner C, Jordan R, McAleer MF, DeRita R, Fass DN, Coller BS, Weisman HF, Ghrayeb J.

Mol Immunol. 1995 Nov;32(16):1271-81.

PMID:
8559151
14.

Lipopolysaccharide (LPS) neutralizing peptides reveal a lipid A binding site of LPS binding protein.

Taylor AH, Heavner G, Nedelman M, Sherris D, Brunt E, Knight D, Ghrayeb J.

J Biol Chem. 1995 Jul 28;270(30):17934-8.

15.
16.
17.

The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo.

Siegel SA, Shealy DJ, Nakada MT, Le J, Woulfe DS, Probert L, Kollias G, Ghrayeb J, Vilcek J, Daddona PE.

Cytokine. 1995 Jan;7(1):15-25.

PMID:
7538333
18.

TNF receptor fusion proteins are effective inhibitors of TNF-mediated cytotoxicity on human KYM-1D4 rhabdomyosarcoma cells.

Butler DM, Scallon B, Meager A, Kissonerghis M, Corcoran A, Chernajovsky Y, Feldmann M, Ghrayeb J, Brennan FM.

Cytokine. 1994 Nov;6(6):616-23.

PMID:
7893970
19.

Expression and characterization of cM-T413, a chimeric anti-CD4 antibody with in vitro immunosuppressive activity.

Looney JE, Willinger A, Lin G, Rieber EP, Riethmuller G, Ghrayeb J.

J Immunother Emphasis Tumor Immunol. 1994 Jul;16(1):36-46.

PMID:
8081558
20.

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.

Elliott MJ, Maini RN, Feldmann M, Long-Fox A, Charles P, Katsikis P, Brennan FM, Walker J, Bijl H, Ghrayeb J, et al.

Arthritis Rheum. 1993 Dec;36(12):1681-90.

PMID:
8250987
21.

Effects of isotype and Fc region on in vitro function of a mouse/human chimeric CD4 antibody.

Dalesandro MR, Pak KY, Tam S, Wilson E, Looney JE, Knight DM, Ghrayeb J, Reiter C, Rieber EP, Riethmuller G, et al.

Int Immunol. 1993 Mar;5(3):283-91.

PMID:
8466865
22.

Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis.

Moreland LW, Bucy RP, Tilden A, Pratt PW, LoBuglio AF, Khazaeli M, Everson MP, Daddona P, Ghrayeb J, Kilgarriff C, et al.

Arthritis Rheum. 1993 Mar;36(3):307-18.

PMID:
8095785
23.

High-level expression and characterization of a mouse-human chimeric CD4 antibody with therapeutic potential.

Looney JE, Knight DM, Arevalo-Moore M, Trinh H, Pak KY, Dalesandro MR, Rieber EP, Riethmuller G, Daddona PE, Ghrayeb J.

Hum Antibodies Hybridomas. 1992 Oct;3(4):191-200.

PMID:
1477300
24.

Stable expression of cloned human antibody genes in murine myeloma cells.

Knight DM, McDonough M, Moore MA, Abercrombie D, Siegel R, Ghrayeb J.

Hum Antibodies Hybridomas. 1992 Jul;3(3):129-36.

PMID:
1391662
25.

Pharmacokinetics of a mouse/human chimeric monoclonal antibody (C-17-1A) in metastatic adenocarcinoma patients.

Trang JM, LoBuglio AF, Wheeler RH, Harvey EB, Sun L, Ghrayeb J, Khazaeli MB.

Pharm Res. 1990 Jun;7(6):587-92.

PMID:
2367327
26.

Localization of B-cell stimulatory activity of HIV-1 to the carboxyl terminus of gp41.

Chirmule N, Kalyanaraman VS, Saxinger C, Wong-Staal F, Ghrayeb J, Pahwa S.

AIDS Res Hum Retroviruses. 1990 Mar;6(3):299-305.

PMID:
2187499
27.

IL-6/IFN-beta 2 in synovial effusions of patients with rheumatoid arthritis and other arthritides. Identification of several isoforms and studies of cellular sources.

Bhardwaj N, Santhanam U, Lau LL, Tatter SB, Ghrayeb J, Rivelis M, Steinman RM, Sehgal PB, May LT.

J Immunol. 1989 Oct 1;143(7):2153-9.

PMID:
2789256
28.

Post-translational modifications of human interleukin-6.

Santhanam U, Ghrayeb J, Sehgal PB, May LT.

Arch Biochem Biophys. 1989 Oct;274(1):161-70.

PMID:
2789018
29.

Mouse/human chimeric monoclonal antibody in man: kinetics and immune response.

LoBuglio AF, Wheeler RH, Trang J, Haynes A, Rogers K, Harvey EB, Sun L, Ghrayeb J, Khazaeli MB.

Proc Natl Acad Sci U S A. 1989 Jun;86(11):4220-4.

30.

T-cell response towards HIV in infected individuals with and without zidovudine therapy, and in HIV-exposed sexual partners.

Ranki A, Mattinen S, Yarchoan R, Broder S, Ghrayeb J, Lähdevirta J, Krohn K.

AIDS. 1989 Feb;3(2):63-9.

PMID:
2496721
31.

Multiple forms of human interleukin-6. Phosphoglycoproteins secreted by many different tissues.

May LT, Santhanam U, Tatter SB, Ghrayeb J, Sehgal PB.

Ann N Y Acad Sci. 1989;557:114-9; discussion 119-21. Review. No abstract available.

PMID:
2660692
32.

Biological characterization of a chimeric mouse-human IgM antibody directed against the 17-1A antigen.

Fogler WE, Sun LK, Klinger MR, Ghrayeb J, Daddona PE.

Cancer Immunol Immunother. 1989;30(1):43-50.

PMID:
2598174
33.

Biological activity of human-mouse IgG1, IgG2, IgG3, and IgG4 chimeric monoclonal antibodies with antitumor specificity.

Steplewski Z, Sun LK, Shearman CW, Ghrayeb J, Daddona P, Koprowski H.

Proc Natl Acad Sci U S A. 1988 Jul;85(13):4852-6.

34.

The expression in Escherichia coli of recombinant human platelet factor 4, a protein with immunoregulatory activity.

Barone AD, Ghrayeb J, Hammerling U, Zucker MB, Thorbecke GJ.

J Biol Chem. 1988 Jun 25;263(18):8710-5.

35.

Synthesis and secretion of multiple forms of beta 2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes.

May LT, Ghrayeb J, Santhanam U, Tatter SB, Sthoeger Z, Helfgott DC, Chiorazzi N, Grieninger G, Sehgal PB.

J Biol Chem. 1988 Jun 5;263(16):7760-6.

37.

Phosphorylation of secreted forms of human beta 2-interferon/hepatocyte stimulating factor/interleukin-6.

May LT, Santhanam U, Tatter SB, Bhardwaj N, Ghrayeb J, Sehgal PB.

Biochem Biophys Res Commun. 1988 May 16;152(3):1144-50.

PMID:
3259872
38.

Human lymphocyte and monocyte lysis of tumor cells mediated by a mouse/human IgG1 chimeric monoclonal antibody.

Shaw DR, Harrison G, Sun LK, Shearman C, Ghrayeb J, McKinney S, Daddona PE, LoBuglio AF.

J Biol Response Mod. 1988 Apr;7(2):204-11.

PMID:
3361351
39.
41.

Characterization of a mouse/human chimeric monoclonal antibody (17-1A) to a colon cancer tumor-associated antigen.

Shaw DR, Khazaeli MB, Sun LK, Ghrayeb J, Daddona PE, McKinney S, LoBuglio AF.

J Immunol. 1987 Jun 15;138(12):4534-8.

PMID:
3584980
42.

Expression of the art/trs protein of HIV and study of its role in viral envelope synthesis.

Knight DM, Flomerfelt FA, Ghrayeb J.

Science. 1987 May 15;236(4803):837-40.

PMID:
3033827
43.

Rapid, easy, and economical screening test for antibodies to human immunodeficiency virus.

Carlson JR, Mertens SC, Yee JL, Gardner MB, Watson-Williams EJ, Ghrayeb J, Jennings MB, Biggar RJ.

Lancet. 1987 Feb 14;1(8529):361-2.

PMID:
2880165
44.

Human immunodeficiency virus: the eighth gene.

Wong-Staal F, Chanda PK, Ghrayeb J.

AIDS Res Hum Retroviruses. 1987 Spring;3(1):33-9.

PMID:
3476127
45.

Chimeric antibody with human constant regions and mouse variable regions directed against carcinoma-associated antigen 17-1A.

Sun LK, Curtis P, Rakowicz-Szulczynska E, Ghrayeb J, Chang N, Morrison SL, Koprowski H.

Proc Natl Acad Sci U S A. 1987 Jan;84(1):214-8.

46.

HTLV-III/LAV-neutralizing antibodies to an E. coli-produced fragment of the virus envelope.

Putney SD, Matthews TJ, Robey WG, Lynn DL, Robert-Guroff M, Mueller WT, Langlois AJ, Ghrayeb J, Petteway SR Jr, Weinhold KJ, et al.

Science. 1986 Dec 12;234(4782):1392-5.

PMID:
2431482
47.

Cytoplasmic localization of the HTLV-III 3' orf protein in cultured T cells.

Franchini G, Robert-Guroff M, Ghrayeb J, Chang NT, Wong-Staal F.

Virology. 1986 Dec;155(2):593-9.

PMID:
3538645
48.

Chimeric antibodies with 17-1A-derived variable and human constant regions.

Sun LK, Curtis P, Rakowicz-Szulczynska E, Ghrayeb J, Morrison SL, Chang N, Koprowski H.

Hybridoma. 1986 Jul;5 Suppl 1:S17-20. No abstract available.

PMID:
3744381
49.

Expression of the protein encoded by the 3' open reading frame of human T-cell lymphotropic virus type III in bacteria: demonstration of its immunoreactivity with human sera.

Franchini G, Robert-Guroff M, Wong-Staal F, Ghrayeb J, Kato I, Chang TW, Chang NT.

Proc Natl Acad Sci U S A. 1986 Jul;83(14):5282-5.

50.

Human T-cell lymphotropic virus type III (HTLV-III) core antigens: synthesis in Escherichia coli and immunoreactivity with human sera.

Ghrayeb J, Kato I, McKinney S, Huang JJ, Chanda PK, Ho DD, Sarangadharan MG, Chang TW, Chang NT.

DNA. 1986 Apr;5(2):93-9.

PMID:
3011373

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