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Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma.

Majumder S, Ghoshal K, Datta J, Bai S, Dong X, Quan N, Plass C, Jacob ST.

J Biol Chem. 2018 Aug 17;293(33):12948. doi: 10.1074/jbc.W118.004970. No abstract available.


Mitochondrial transcription factor A and its downstream targets are up-regulated in a rat hepatoma.

Dong X, Ghoshal K, Majumder S, Yadav SP, Jacob ST.

J Biol Chem. 2018 Aug 17;293(33):12947. doi: 10.1074/jbc.W118.004969. No abstract available.


Identification of a novel cyclic AMP-response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene.

Majumder S, Varadharaj S, Ghoshal K, Monani U, Burghes AHM, Jacob ST.

J Biol Chem. 2018 Aug 17;293(33):12946. doi: 10.1074/jbc.W118.004968. No abstract available.


Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1.

Nasser MW, Datta J, Nuovo G, Kutay H, Motiwala T, Majumder S, Wang B, Suster S, Jacob ST, Ghoshal K.

J Biol Chem. 2018 Aug 17;293(33):12945. doi: 10.1074/jbc.W118.004967. No abstract available.


Detection of HSO3-: A Rapid Colorimetric and Fluorimetric Selective Sensor for Detecting Biological SO2 in Food and Living Cells.

Paul S, Ghoshal K, Bhattacharyya M, Maiti DK.

ACS Omega. 2017 Dec 31;2(12):8633-8639. doi: 10.1021/acsomega.7b01218. Epub 2017 Dec 4.


The role of miR-122 in the dysregulation of glucose-6-phosphate dehydrogenase (G6PD) expression in hepatocellular cancer.

Barajas JM, Reyes R, Guerrero MJ, Jacob ST, Motiwala T, Ghoshal K.

Sci Rep. 2018 Jun 14;8(1):9105. doi: 10.1038/s41598-018-27358-5.


Extracellular mRNA detected by molecular beacons in tethered lipoplex nanoparticles for diagnosis of human hepatocellular carcinoma.

Wang X, Kwak KJ, Yang Z, Zhang A, Zhang X, Sullivan R, Lin D, Lee RL, Castro C, Ghoshal K, Schmidt C, Lee LJ.

PLoS One. 2018 Jun 7;13(6):e0198552. doi: 10.1371/journal.pone.0198552. eCollection 2018.


Correction for Ghoshal et al., "5-Aza-Deoxycytidine Induces Selective Degradation of DNA Methyltransferase 1 by a Proteasomal Pathway That Requires the KEN Box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal".

Ghoshal K, Datta J, Majumder S, Bai S, Kutay H, Motiwala T, Jacob ST.

Mol Cell Biol. 2018 Apr 30;38(10). pii: e00539-17. doi: 10.1128/MCB.00539-17. Print 2018 May 15. No abstract available.


A Comprehensive Analysis of Argonaute-CLIP Data Identifies Novel, Conserved and Species-Specific Targets of miR-21 in Human Liver and Hepatocellular Carcinoma.

Koenig AB, Barajas JM, Guerrero MJ, Ghoshal K.

Int J Mol Sci. 2018 Mar 14;19(3). pii: E851. doi: 10.3390/ijms19030851.


Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription.

Majumder S, Ghoshal K, Datta J, Smith DS, Bai S, Jacob ST.

J Biol Chem. 2018 Mar 9;293(10):3591. doi: 10.1074/jbc.W118.002433. No abstract available.


Treatment of PC12 cells with nerve growth factor induces proteasomal degradation of T-cadherin that requires tyrosine phosphorylation of its cadherin domain.

Bai S, Datta J, Jacob ST, Ghoshal K.

J Biol Chem. 2018 Mar 9;293(10):3590. doi: 10.1074/jbc.W118.002432. No abstract available.


PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells.

Motiwala T, Majumder S, Ghoshal K, Kutay H, Datta J, Roy S, Lucas DM, Jacob ST.

J Biol Chem. 2018 Mar 9;293(10):3589. doi: 10.1074/jbc.W118.002431. No abstract available.


Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis.

Wani NA, Zhang B, Teng KY, Barajas JM, Motiwala T, Hu P, Yu L, Brüschweiler R, Ghoshal K, Jacob ST.

Mol Cancer Res. 2018 Feb;16(2):256-268. doi: 10.1158/1541-7786.MCR-17-0304. Epub 2017 Nov 29.


Dietary fat/cholesterol-sensitive PKCβ-RB signaling: Potential role in NASH/HCC axis.

Huang W, Mehta D, Sif S, Kent LN, Jacob ST, Ghoshal K, Mehta KD.

Oncotarget. 2017 May 15;8(43):73757-73765. doi: 10.18632/oncotarget.17890. eCollection 2017 Sep 26.


Dielectric properties of plasma membrane: A signature for dyslipidemia in diabetes mellitus.

Ghoshal K, Chakraborty S, Das C, Chattopadhyay S, Chowdhury S, Bhattacharyya M.

Arch Biochem Biophys. 2017 Dec 1;635:27-36. doi: 10.1016/ Epub 2017 Oct 10.


miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 1 Subfamily A Member 2 and Family 2 Subfamily E Member 1 Expression.

Chowdhary V, Teng KY, Thakral S, Zhang B, Lin CH, Wani N, Bruschweiler-Li L, Zhang X, James L, Yang D, Junge N, Brüschweiler R, Lee WM, Ghoshal K.

Am J Pathol. 2017 Dec;187(12):2758-2774. doi: 10.1016/j.ajpath.2017.08.026. Epub 2017 Sep 28.


Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer.

Luna JM, Barajas JM, Teng KY, Sun HL, Moore MJ, Rice CM, Darnell RB, Ghoshal K.

Mol Cell. 2017 Aug 3;67(3):400-410.e7. doi: 10.1016/j.molcel.2017.06.025. Epub 2017 Jul 20.


Mouse models of acute and chronic hepacivirus infection.

Billerbeck E, Wolfisberg R, Fahnøe U, Xiao JW, Quirk C, Luna JM, Cullen JM, Hartlage AS, Chiriboga L, Ghoshal K, Lipkin WI, Bukh J, Scheel TKH, Kapoor A, Rice CM.

Science. 2017 Jul 14;357(6347):204-208. doi: 10.1126/science.aal1962.


Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model.

Teng KY, Han J, Zhang X, Hsu SH, He S, Wani NA, Barajas JM, Snyder LA, Frankel WL, Caligiuri MA, Jacob ST, Yu J, Ghoshal K.

Mol Cancer Ther. 2017 Feb;16(2):312-322. doi: 10.1158/1535-7163.MCT-16-0124. Epub 2016 Dec 15.


Sorafenib and 2-Deoxyglucose Synergistically Inhibit Proliferation of Both Sorafenib-Sensitive and -Resistant HCC Cells by Inhibiting ATP Production.

Reyes R, Wani NA, Ghoshal K, Jacob ST, Motiwala T.

Gene Expr. 2017 Feb 10;17(2):129-140. doi: 10.3727/105221616X693855. Epub 2016 Nov 16.


ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5.

Sun HL, Cui R, Zhou J, Teng KY, Hsiao YH, Nakanishi K, Fassan M, Luo Z, Shi G, Tili E, Kutay H, Lovat F, Vicentini C, Huang HL, Wang SW, Kim T, Zanesi N, Jeon YJ, Lee TJ, Guh JH, Hung MC, Ghoshal K, Teng CM, Peng Y, Croce CM.

Cancer Cell. 2016 Nov 14;30(5):723-736. doi: 10.1016/j.ccell.2016.10.001.


A novel sensor to estimate the prevalence of hypochlorous (HOCl) toxicity in individuals with type 2 diabetes and dyslipidemia.

Ghoshal K, Das S, Aich K, Goswami S, Chowdhury S, Bhattacharyya M.

Clin Chim Acta. 2016 Jul 1;458:144-53. doi: 10.1016/j.cca.2016.05.006. Epub 2016 May 11.


RNA interference-induced hepatotoxicity results from loss of the first synthesized isoform of microRNA-122 in mice.

Valdmanis PN, Gu S, Chu K, Jin L, Zhang F, Munding EM, Zhang Y, Huang Y, Kutay H, Ghoshal K, Lisowski L, Kay MA.

Nat Med. 2016 May;22(5):557-62. doi: 10.1038/nm.4079. Epub 2016 Apr 11.


MicroRNA-122 regulates polyploidization in the murine liver.

Hsu SH, Delgado ER, Otero PA, Teng KY, Kutay H, Meehan KM, Moroney JB, Monga JK, Hand NJ, Friedman JR, Ghoshal K, Duncan AW.

Hepatology. 2016 Aug;64(2):599-615. doi: 10.1002/hep.28573. Epub 2016 May 12.


Role of Noncoding RNAs as Biomarker and Therapeutic Targets for Liver Fibrosis.

Teng KY, Ghoshal K.

Gene Expr. 2015;16(4):155-62. doi: 10.3727/105221615X14399878166078. Review.


Encapsidation of Host RNAs by Cucumber Necrosis Virus Coat Protein during both Agroinfiltration and Infection.

Ghoshal K, Theilmann J, Reade R, Maghodia A, Rochon D.

J Virol. 2015 Nov;89(21):10748-61. doi: 10.1128/JVI.01466-15. Epub 2015 Aug 12.


Adiponectin: Probe of the molecular paradigm associating diabetes and obesity.

Ghoshal K, Bhattacharyya M.

World J Diabetes. 2015 Feb 15;6(1):151-66. doi: 10.4239/wjd.v6.i1.151. Review.


A triphenyl amine-based solvatofluorochromic dye for the selective and ratiometric sensing of OCl- in human blood cells.

Goswami S, Aich K, Das S, Pakhira B, Ghoshal K, Quah CK, Bhattacharyya M, Fun HK, Sarkar S.

Chem Asian J. 2015 Mar;10(3):694-700. doi: 10.1002/asia.201403234. Epub 2015 Jan 21.


Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog.

Wang X, He H, Lu Y, Ren W, Teng KY, Chiang CL, Yang Z, Yu B, Hsu S, Jacob ST, Ghoshal K, Lee LJ.

Biochim Biophys Acta. 2015 Jan;1853(1):244-53. doi: 10.1016/j.bbamcr.2014.10.017. Epub 2014 Oct 25.


mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues.

Eichhorn SW, Guo H, McGeary SE, Rodriguez-Mias RA, Shin C, Baek D, Hsu SH, Ghoshal K, Villén J, Bartel DP.

Mol Cell. 2014 Oct 2;56(1):104-15. doi: 10.1016/j.molcel.2014.08.028. Epub 2014 Sep 25.


The Cucumber leaf spot virus p25 auxiliary replicase protein binds and modifies the endoplasmic reticulum via N-terminal transmembrane domains.

Ghoshal K, Theilmann J, Reade R, Sanfacon H, Rochon D.

Virology. 2014 Nov;468-470:36-46. doi: 10.1016/j.virol.2014.07.020. Epub 2014 Aug 16.


Overview of platelet physiology: its hemostatic and nonhemostatic role in disease pathogenesis.

Ghoshal K, Bhattacharyya M.

ScientificWorldJournal. 2014 Mar 3;2014:781857. doi: 10.1155/2014/781857. eCollection 2014.


The p33 auxiliary replicase protein of Cucumber necrosis virus targets peroxisomes and infection induces de novo peroxisome formation from the endoplasmic reticulum.

Rochon D, Singh B, Reade R, Theilmann J, Ghoshal K, Alam SB, Maghodia A.

Virology. 2014 Mar;452-453:133-42. doi: 10.1016/j.virol.2013.12.035. Epub 2014 Jan 31.


Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations.

Wang X, Yu B, Ren W, Mo X, Zhou C, He H, Jia H, Wang L, Jacob ST, Lee RJ, Ghoshal K, Lee LJ.

J Control Release. 2013 Dec 28;172(3):690-8. doi: 10.1016/j.jconrel.2013.09.027. Epub 2013 Oct 8.


Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure.

Hsu SH, Wang B, Kutay H, Bid H, Shreve J, Zhang X, Costinean S, Bratasz A, Houghton P, Ghoshal K.

Am J Pathol. 2013 Dec;183(6):1719-1730. doi: 10.1016/j.ajpath.2013.08.004. Epub 2013 Oct 8.


CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma.

Chu J, Deng Y, Benson DM, He S, Hughes T, Zhang J, Peng Y, Mao H, Yi L, Ghoshal K, He X, Devine SM, Zhang X, Caligiuri MA, Hofmeister CC, Yu J.

Leukemia. 2014 Apr;28(4):917-27. doi: 10.1038/leu.2013.279. Epub 2013 Sep 26.


Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2.

Wang B, Hsu SH, Wang X, Kutay H, Bid HK, Yu J, Ganju RK, Jacob ST, Yuneva M, Ghoshal K.

Hepatology. 2014 Feb;59(2):555-66. doi: 10.1002/hep.26712. Epub 2013 Dec 20.


Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor.

Hsu SH, Yu B, Wang X, Lu Y, Schmidt CR, Lee RJ, Lee LJ, Jacob ST, Ghoshal K.

Nanomedicine. 2013 Nov;9(8):1169-80. doi: 10.1016/j.nano.2013.05.007. Epub 2013 May 30.


MicroRNAs activate natural killer cells through Toll-like receptor signaling.

He S, Chu J, Wu LC, Mao H, Peng Y, Alvarez-Breckenridge CA, Hughes T, Wei M, Zhang J, Yuan S, Sandhu S, Vasu S, Benson DM Jr, Hofmeister CC, He X, Ghoshal K, Devine SM, Caligiuri MA, Yu J.

Blood. 2013 Jun 6;121(23):4663-71. doi: 10.1182/blood-2012-07-441360. Epub 2013 Apr 11.


Lactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinoma.

Zhang M, Zhou X, Wang B, Yung BC, Lee LJ, Ghoshal K, Lee RJ.

J Control Release. 2013 Jun 28;168(3):251-61. doi: 10.1016/j.jconrel.2013.03.020. Epub 2013 Apr 6.


MicroRNAs in Liver Health and Disease.

Hsu SH, Ghoshal K.

Curr Pathobiol Rep. 2013 Mar;1(1):53-62.


Methylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate.

Hsu SH, Motiwala T, Roy S, Claus R, Mustafa M, Plass C, Freitas MA, Ghoshal K, Jacob ST.

J Cell Biochem. 2013 Aug;114(8):1810-8. doi: 10.1002/jcb.24525.


Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes.

Nagaraja T, Chen L, Balasubramanian A, Groopman JE, Ghoshal K, Jacob ST, Leask A, Brigstock DR, Anand AR, Ganju RK.

PLoS One. 2012;7(10):e46526. doi: 10.1371/journal.pone.0046526. Epub 2012 Oct 4.


Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet.

Kutay H, Klepper C, Wang B, Hsu SH, Datta J, Yu L, Zhang X, Majumder S, Motiwala T, Khan N, Belury M, McClain C, Jacob S, Ghoshal K.

PLoS One. 2012;7(8):e41949. doi: 10.1371/journal.pone.0041949. Epub 2012 Aug 8.


Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.

Hsu SH, Wang B, Kota J, Yu J, Costinean S, Kutay H, Yu L, Bai S, La Perle K, Chivukula RR, Mao H, Wei M, Clark KR, Mendell JR, Caligiuri MA, Jacob ST, Mendell JT, Ghoshal K.

J Clin Invest. 2012 Aug;122(8):2871-83. doi: 10.1172/JCI63539. Epub 2012 Jul 23.


Lipid nanoparticles for hepatic delivery of small interfering RNA.

Yu B, Hsu SH, Zhou C, Wang X, Terp MC, Wu Y, Teng L, Mao Y, Wang F, Xue W, Jacob ST, Ghoshal K, Lee RJ, Lee LJ.

Biomaterials. 2012 Sep;33(25):5924-34. doi: 10.1016/j.biomaterials.2012.05.002. Epub 2012 May 29.

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