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Items: 26


Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific Coq6 Knockout Mice.

Widmeier E, Airik M, Hugo H, Schapiro D, Wedel J, Ghosh CC, Nakayama M, Schneider R, Awad AM, Nag A, Cho J, Schueler M, Clarke CF, Airik R, Hildebrandt F.

J Am Soc Nephrol. 2019 Feb 8. pii: ASN.2018060625. doi: 10.1681/ASN.2018060625. [Epub ahead of print]


Multiplexed, high-throughput measurements of cell contraction and endothelial barrier function.

Rokhzan R, Ghosh CC, Schaible N, Notbohm J, Yoshie H, Ehrlicher AJ, Higgins SJ, Zhang R, Haller H, Hardin CC, David S, Parikh SM, Krishnan R.

Lab Invest. 2019 Jan;99(1):138-145. doi: 10.1038/s41374-018-0136-2. Epub 2018 Oct 11.


Molecular Regulation of Acute Tie2 Suppression in Sepsis.

Thamm K, Schrimpf C, Retzlaff J, Idowu TO, van Meurs M, Zijlstra JG, Ghosh CC, Zeitvogel J, Werfel TA, Haller H, Parikh SM, David S.

Crit Care Med. 2018 Sep;46(9):e928-e936. doi: 10.1097/CCM.0000000000003269.


Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis.

Retzlaff J, Thamm K, Ghosh CC, Ziegler W, Haller H, Parikh SM, David S.

Sci Rep. 2017 Mar 9;7:44113. doi: 10.1038/srep44113.


KLF2 and KLF4 control endothelial identity and vascular integrity.

Sangwung P, Zhou G, Nayak L, Chan ER, Kumar S, Kang DW, Zhang R, Liao X, Lu Y, Sugi K, Fujioka H, Shi H, Lapping SD, Ghosh CC, Higgins SJ, Parikh SM, Jo H, Jain MK.

JCI Insight. 2017 Feb 23;2(4):e91700. doi: 10.1172/jci.insight.91700.


A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.

Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z.

Nat Med. 2016 Apr;22(4):421-6. doi: 10.1038/nm.4057. Epub 2016 Mar 7.


Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.

Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2472-7. doi: 10.1073/pnas.1519467113. Epub 2016 Feb 16.


Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis.

Ghosh CC, Thamm K, Berghelli AV, Schrimpf C, Maski MR, Abid T, Milam KE, Rajakumar A, Santel A, Kielstein JT, Ahmed A, Thickett D, Wang K, Chase M, Donnino MW, Aird WC, Haller H, David S, Parikh SM.

Crit Care Med. 2015 Jul;43(7):e230-40. doi: 10.1097/CCM.0000000000000993.


Angiopoietin-1 requires oxidant signaling through p47phox to promote endothelial barrier defense.

Ghosh CC, Mukherjee A, David S, Milam KE, Hunter JT, Parikh SM.

PLoS One. 2015 Mar 11;10(3):e0119577. doi: 10.1371/journal.pone.0119577. eCollection 2015.


Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar.

Aisiku O, Peters CG, De Ceunynck K, Ghosh CC, Dilks JR, Fustolo-Gunnink SF, Huang M, Dockendorff C, Parikh SM, Flaumenhaft R.

Blood. 2015 Mar 19;125(12):1976-85. doi: 10.1182/blood-2014-09-599910. Epub 2015 Jan 13.


Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease).

Xie Z, Chan E, Yin Y, Ghosh CC, Wisch L, Nelson C, Young M, Parikh SM, Druey KM.

J Clin Cell Immunol. 2014;5:1000213.


Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis.

Stiehl T, Thamm K, Kaufmann J, Schaeper U, Kirsch T, Haller H, Santel A, Ghosh CC, Parikh SM, David S.

Crit Care Med. 2014 Oct;42(10):e654-62. doi: 10.1097/CCM.0000000000000524.


Detecting Tie2, an endothelial growth factor receptor, by using immunohistochemistry in mouse lungs.

Guha PP, David SA, Ghosh CC.

Methods Mol Biol. 2014;1172:201-8. doi: 10.1007/978-1-4939-0928-5_18.


Mechanistic classification of the systemic capillary leak syndrome: Clarkson disease.

Xie Z, Ghosh CC, Parikh SM, Druey KM.

Am J Respir Crit Care Med. 2014 May 1;189(9):1145-7. doi: 10.1164/rccm.201310-1746LE. No abstract available.


Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*.

David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM.

Crit Care Med. 2012 Nov;40(11):3034-41. doi: 10.1097/CCM.0b013e31825fdc31.


Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.

Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10024-9. doi: 10.1073/pnas.1120755109. Epub 2012 Jun 4. Erratum in: Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18625.


Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome).

Xie Z, Ghosh CC, Patel R, Iwaki S, Gaskins D, Nelson C, Jones N, Greipp PR, Parikh SM, Druey KM.

Blood. 2012 May 3;119(18):4321-32. doi: 10.1182/blood-2011-08-375816. Epub 2012 Mar 12.


Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense.

David S, Ghosh CC, Mukherjee A, Parikh SM.

Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2643-52. doi: 10.1161/ATVBAHA.111.233189.


Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality.

David S, Ghosh CC, Kümpers P, Shushakova N, Van Slyke P, Khankin EV, Karumanchi SA, Dumont D, Parikh SM.

Am J Physiol Lung Cell Mol Physiol. 2011 Jun;300(6):L851-62. doi: 10.1152/ajplung.00459.2010. Epub 2011 Mar 18.


Bortezomib induces nuclear translocation of IκBα resulting in gene-specific suppression of NF-κB--dependent transcription and induction of apoptosis in CTCL.

Juvekar A, Manna S, Ramaswami S, Chang TP, Vu HY, Ghosh CC, Celiker MY, Vancurova I.

Mol Cancer Res. 2011 Feb;9(2):183-94. doi: 10.1158/1541-7786.MCR-10-0368. Epub 2011 Jan 11.


Gene-specific repression of proinflammatory cytokines in stimulated human macrophages by nuclear IκBα.

Ghosh CC, Ramaswami S, Juvekar A, Vu HY, Galdieri L, Davidson D, Vancurova I.

J Immunol. 2010 Sep 15;185(6):3685-93. doi: 10.4049/jimmunol.0902230. Epub 2010 Aug 9.


Analysis of nucleocytoplasmic shuttling of NF kappa B proteins in human leukocytes.

Ghosh CC, Vu HY, Mujo T, Vancurova I.

Methods Mol Biol. 2008;457:279-92.


Saccharomyces cerevisiae phospholipase C regulates transcription of Msn2p-dependent stress-responsive genes.

Demczuk A, Guha N, Nguyen PH, Desai P, Chang J, Guzinska K, Rollins J, Ghosh CC, Goodwin L, Vancura A.

Eukaryot Cell. 2008 Jun;7(6):967-79. doi: 10.1128/EC.00438-07. Epub 2008 Mar 28.


NFkappaB is persistently activated in continuously stimulated human neutrophils.

Miskolci V, Rollins J, Vu HY, Ghosh CC, Davidson D, Vancurova I.

Mol Med. 2007 Mar-Apr;13(3-4):134-42.


TNFalpha release from peripheral blood leukocytes depends on a CRM1-mediated nuclear export.

Miskolci V, Ghosh CC, Rollins J, Romero C, Vu HY, Robinson S, Davidson D, Vancurova I.

Biochem Biophys Res Commun. 2006 Dec 15;351(2):354-60. Epub 2006 Oct 16.


Terminalia arjuna (Roxb.) protects rabbit heart against ischemic-reperfusion injury: role of antioxidant enzymes and heat shock protein.

Gauthaman K, Banerjee SK, Dinda AK, Ghosh CC, Maulik SK.

J Ethnopharmacol. 2005 Jan 15;96(3):403-9. Epub 2004 Nov 21.


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