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Impact of diet on irinotecan toxicity in mice.

Mallick P, Shah P, Ittmann MM, Trivedi M, Hu M, Gao S, Ghose R.

Chem Biol Interact. 2018 Aug 1;291:87-94. doi: 10.1016/j.cbi.2018.06.018. Epub 2018 Jun 18.


wwwwMethyl NMR Spectroscopy: Measurement of Dynamics in Viral RNA-directed RNA Polymerases.

Alphonse S, Ghose R.

Methods. 2018 May 29. pii: S1046-2023(18)30133-6. doi: 10.1016/j.ymeth.2018.05.021. [Epub ahead of print] Review.


Structural Dynamics of the Activation of Elongation Factor 2 Kinase by Ca2+-Calmodulin.

Will N, Lee K, Hajredini F, Giles DH, Abzalimov RR, Clarkson M, Dalby KN, Ghose R.

J Mol Biol. 2018 May 22. pii: S0022-2836(18)30486-8. doi: 10.1016/j.jmb.2018.05.033. [Epub ahead of print]


Sequential Protein Expression and Capsid Assembly in Cell: Toward the Study of Multiprotein Viral Capsids Using Solid-State Nuclear Magnetic Resonance Techniques.

Alphonse S, Itin B, Khayat R, Ghose R.

Biochemistry. 2018 Mar 13;57(10):1568-1571. doi: 10.1021/acs.biochem.8b00003. Epub 2018 Feb 23.


Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro.

Taneja G, Chu C, Maturu P, Moorthy B, Ghose R.

Drug Metab Dispos. 2018 Apr;46(4):397-404. doi: 10.1124/dmd.117.079160. Epub 2018 Feb 12.


Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number.

Katsanos D, Koneru SL, Mestek Boukhibar L, Gritti N, Ghose R, Appleford PJ, Doitsidou M, Woollard A, van Zon JS, Poole RJ, Barkoulas M.

PLoS Biol. 2017 Nov 6;15(11):e2002429. doi: 10.1371/journal.pbio.2002429. eCollection 2017 Nov.


Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review.

Myers AL, Kawedia JD, Champlin RE, Kramer MA, Nieto Y, Ghose R, Andersson BS.

Expert Opin Drug Metab Toxicol. 2017 Sep;13(9):901-923. doi: 10.1080/17425255.2017.1360277. Epub 2017 Aug 17. Review.


Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2.

Piserchio A, Warthaka M, Kaoud TS, Callaway K, Dalby KN, Ghose R.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6287-E6296. doi: 10.1073/pnas.1702973114. Epub 2017 Jul 17.


Characterization of DNA Binding by the Isolated N-Terminal Domain of Vaccinia Virus DNA Topoisomerase IB.

Reed B, Yakovleva L, Shuman S, Ghose R.

Biochemistry. 2017 Jul 5;56(26):3307-3317. doi: 10.1021/acs.biochem.7b00042. Epub 2017 Jun 19.


Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions.

Mallick P, Taneja G, Moorthy B, Ghose R.

Expert Opin Drug Metab Toxicol. 2017 Jun;13(6):605-616. doi: 10.1080/17425255.2017.1292251. Epub 2017 Feb 22. Review.


Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro.

Mallick P, Basu S, Moorthy B, Ghose R.

Toxicol In Vitro. 2017 Jun;41:75-82. doi: 10.1016/j.tiv.2017.02.019. Epub 2017 Feb 27.


Cystoviral RNA-directed RNA polymerases: Regulation of RNA synthesis on multiple time and length scales.

Alphonse S, Ghose R.

Virus Res. 2017 Apr 15;234:135-152. doi: 10.1016/j.virusres.2017.01.006. Epub 2017 Jan 16. Review.


Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION.

Tavares CD, Giles DH, Stancu G, Chitjian CA, Ferguson SB, Wellmann RM, Kaoud TS, Ghose R, Dalby KN.

J Biol Chem. 2017 Feb 3;292(5):2032-2045. doi: 10.1074/jbc.M116.753277. Epub 2016 Dec 12.


Structure of the C-Terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase.

Will N, Piserchio A, Snyder I, Ferguson SB, Giles DH, Dalby KN, Ghose R.

Biochemistry. 2016 Sep 27;55(38):5377-86. doi: 10.1021/acs.biochem.6b00711. Epub 2016 Sep 14.


Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin.

Lee K, Alphonse S, Piserchio A, Tavares CD, Giles DH, Wellmann RM, Dalby KN, Ghose R.

Structure. 2016 Sep 6;24(9):1441-51. doi: 10.1016/j.str.2016.06.015. Epub 2016 Aug 4.


In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin.

Ghose R, Mallick P, Taneja G, Chu C, Moorthy B.

Methods Mol Biol. 2016;1395:55-68. doi: 10.1007/978-1-4939-3347-1_4.


Impact of obesity on accumulation of the toxic irinotecan metabolite, SN-38, in mice.

Mallick P, Shah P, Gandhi A, Ghose R.

Life Sci. 2015 Oct 15;139:132-8. doi: 10.1016/j.lfs.2015.08.017. Epub 2015 Sep 1.


Methyl Relaxation Measurements Reveal Patterns of Fast Dynamics in a Viral RNA-Directed RNA Polymerase.

Alphonse S, Bhattacharya S, Wang H, Ghose R.

Biochemistry. 2015 Sep 29;54(38):5828-38. doi: 10.1021/acs.biochem.5b00828. Epub 2015 Sep 17.


Erratum: Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2.

Piserchio A, Ramakrishan V, Wang H, Kaoud TS, Arshava B, Dutta K, Dalby KN, Ghose R.

Sci Rep. 2015 Jul 31;5:12369. doi: 10.1038/srep12369. No abstract available.


Does the level of socioeconomic deprivation at the location of cardiac arrest in an English region influence the likelihood of receiving bystander-initiated cardiopulmonary resuscitation?

Moncur L, Ainsborough N, Ghose R, Kendal SP, Salvatori M, Wright J.

Emerg Med J. 2016 Feb;33(2):105-8. doi: 10.1136/emermed-2015-204643. Epub 2015 Jun 25.


Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2.

Piserchio A, Ramakrishan V, Wang H, Kaoud TS, Arshava B, Dutta K, Dalby KN, Ghose R.

Sci Rep. 2015 Jun 8;5:11127. doi: 10.1038/srep11127. Erratum in: Sci Rep. 2015;5:12369.


Cystoviral polymerase complex protein P7 uses its acidic C-terminal tail to regulate the RNA-directed RNA polymerase P2.

Alphonse S, Arnold JJ, Bhattacharya S, Wang H, Kloss B, Cameron CE, Ghose R.

J Mol Biol. 2014 Jul 15;426(14):2580-93. doi: 10.1016/j.jmb.2014.04.028. Epub 2014 May 9.


Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters.

Shah P, Guo T, Moore DD, Ghose R.

Drug Metab Dispos. 2014 Jan;42(1):172-81. doi: 10.1124/dmd.113.053850. Epub 2013 Nov 5.


Structure of the RNA-directed RNA polymerase from the cystovirus φ12.

Ren Z, C Franklin M, Ghose R.

Proteins. 2013 Aug;81(8):1479-84. doi: 10.1002/prot.24297. Epub 2013 Jun 1.


Regulatory interactions between a bacterial tyrosine kinase and its cognate phosphatase.

Temel DB, Dutta K, Alphonse S, Nourikyan J, Grangeasse C, Ghose R.

J Biol Chem. 2013 May 24;288(21):15212-28. doi: 10.1074/jbc.M113.457804. Epub 2013 Mar 30.


A measured approach: determining the PLCγ1 docking site on Itk using a biochemical ruler.

Ghose R.

J Mol Biol. 2013 Feb 22;425(4):679-82. doi: 10.1016/j.jmb.2012.12.013. Epub 2012 Dec 22. No abstract available.


Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice.

Gandhi A, Guo T, Shah P, Moorthy B, Ghose R.

Toxicol Appl Pharmacol. 2013 Feb 1;266(3):430-8. doi: 10.1016/j.taap.2012.11.030. Epub 2012 Dec 11.


Sequence-specific backbone ¹H, ¹³C and ¹⁵N assignments of the catalytic domain of the Escherichia coli protein tyrosine kinase, Wzc.

Temel DB, Dutta K, Ghose R.

Biomol NMR Assign. 2014 Apr;8(1):37-41. doi: 10.1007/s12104-012-9448-0. Epub 2012 Dec 8.


Docking interactions of hematopoietic tyrosine phosphatase with MAP kinases ERK2 and p38α.

Piserchio A, Francis DM, Koveal D, Dalby KN, Page R, Peti W, Ghose R.

Biochemistry. 2012 Oct 16;51(41):8047-9. doi: 10.1021/bi3012725. Epub 2012 Oct 5.


Impact of hepatic malignancy on CYP3A4 gene expression.

Fahy BN, Guo T, Ghose R.

J Surg Res. 2012 Dec;178(2):768-72. doi: 10.1016/j.jss.2012.06.008. Epub 2012 Jun 21.


Drug disposition in pathophysiological conditions.

Gandhi A, Moorthy B, Ghose R.

Curr Drug Metab. 2012 Nov;13(9):1327-44. Review.


CYP3A-dependent drug metabolism is reduced in bacterial inflammation in mice.

Gandhi AS, Guo T, Shah P, Moorthy B, Chow DS, Hu M, Ghose R.

Br J Pharmacol. 2012 Aug;166(7):2176-87. doi: 10.1111/j.1476-5381.2012.01933.x.


Contrasting behavior between dispersive seismic velocity and attenuation: advantages in subsoil characterization.

Zhubayev A, Ghose R.

J Acoust Soc Am. 2012 Feb;131(2):EL170-6. doi: 10.1121/1.3678692.


Assignment of backbone resonances in a eukaryotic protein kinase - ERK2 as a representative example.

Piserchio A, Dalby KN, Ghose R.

Methods Mol Biol. 2012;831:359-68. doi: 10.1007/978-1-61779-480-3_19.


Expression and purification of Src-family kinases for solution NMR studies.

Piserchio A, Cowburn D, Ghose R.

Methods Mol Biol. 2012;831:111-31. doi: 10.1007/978-1-61779-480-3_7.


Solution structure and DNA-binding properties of the phosphoesterase domain of DNA ligase D.

Natarajan A, Dutta K, Temel DB, Nair PA, Shuman S, Ghose R.

Nucleic Acids Res. 2012 Mar;40(5):2076-88. doi: 10.1093/nar/gkr950. Epub 2011 Nov 13.


Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters.

Ghose R, Omoluabi O, Gandhi A, Shah P, Strohacker K, Carpenter KC, McFarlin B, Guo T.

Life Sci. 2011 Jul 4;89(1-2):57-64. doi: 10.1016/j.lfs.2011.05.005. Epub 2011 May 18.


A model of a MAPK•substrate complex in an active conformation: a computational and experimental approach.

Lee S, Warthaka M, Yan C, Kaoud TS, Piserchio A, Ghose R, Ren P, Dalby KN.

PLoS One. 2011 Apr 11;6(4):e18594. doi: 10.1371/journal.pone.0018594.


Solution NMR insights into docking interactions involving inactive ERK2.

Piserchio A, Warthaka M, Devkota AK, Kaoud TS, Lee S, Abramczyk O, Ren P, Dalby KN, Ghose R.

Biochemistry. 2011 May 10;50(18):3660-72. doi: 10.1021/bi2000559. Epub 2011 Apr 19.


Slow conformational dynamics in the cystoviral RNA-directed RNA polymerase P2: influence of substrate nucleotides and template RNA.

Ren Z, Ghose R.

Biochemistry. 2011 Mar 22;50(11):1875-84. doi: 10.1021/bi101863g. Epub 2011 Feb 4. Erratum in: Biochemistry. 2011 May 3;50(17):3578.


Sequence-specific 1H, 13C and 15N assignments of the phosphoesterase (PE) domain of Pseudomonas aeruginosa DNA ligase D (LigD).

Dutta K, Natarajan A, Nair PA, Shuman S, Ghose R.

Biomol NMR Assign. 2011 Oct;5(2):151-5. doi: 10.1007/s12104-010-9289-7. Epub 2011 Jan 7.


On the measurement of ¹⁵N-{¹H} nuclear Overhauser effects. 2. Effects of the saturation scheme and water signal suppression.

Ferrage F, Reichel A, Battacharya S, Cowburn D, Ghose R.

J Magn Reson. 2010 Dec;207(2):294-303. doi: 10.1016/j.jmr.2010.09.014. Epub 2010 Sep 24.


Bystander CPR in south east Scotland increases over 16 years.

Ghose R, Lyon RM, Clegg GR, Gray AJ; Emergency Medicine Research Group Edinburgh.

Resuscitation. 2010 Nov;81(11):1488-91. doi: 10.1016/j.resuscitation.2010.06.012. Epub 2010 Jul 23.


Nuclear spin relaxation in isotropic and anisotropic media.

Nicholas MP, Eryilmaz E, Ferrage F, Cowburn D, Ghose R.

Prog Nucl Magn Reson Spectrosc. 2010 Aug;57(2):111-58. doi: 10.1016/j.pnmrs.2010.04.003. Epub 2010 Apr 29. Review. No abstract available.


Dynamics on multiple timescales in the RNA-directed RNA polymerase from the cystovirus phi6.

Ren Z, Wang H, Ghose R.

Nucleic Acids Res. 2010 Aug;38(15):5105-18. doi: 10.1093/nar/gkq210. Epub 2010 Apr 12.


Solution NMR studies of Chlorella virus DNA ligase-adenylate.

Piserchio A, Nair PA, Shuman S, Ghose R.

J Mol Biol. 2010 Jan 15;395(2):291-308. doi: 10.1016/j.jmb.2009.11.007. Epub 2009 Nov 11.


Sequence-specific 1H N, 13C, and 15N backbone resonance assignments of the 34 kDa Paramecium bursaria Chlorella virus 1 (PBCV1) DNA ligase.

Piserchio A, Nair PA, Shuman S, Ghose R.

Biomol NMR Assign. 2009 Jun;3(1):77-80. doi: 10.1007/s12104-009-9145-9. Epub 2009 Jan 13.

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