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Items: 14


Setting research priorities for global respiratory medicine within the National Institute for Health Research (NIHR) Global Health Research Unit in Respiratory Health (RESPIRE).

Rudan I, Agrawal D, Hussein N, Cheong AT, Cunningham S, Dockerell D, Ghazali SS, Ghorpade D, Habib M, Hazir T, Juvekar S, Kawade A, Lee PY, Liew SM, Luz S, Khoo EM, Nair H, Norrie J, Patil R, Pinnock H, Ramdzan SN, Roy S, Salim H, Smith P, Yahya HM, Williams S, Campbell H, Sheikh A.

J Glob Health. 2018 Dec;8(2):0201314. doi: 10.7189/jogh.08.020314. Review. No abstract available.


Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance.

Ghorpade DS, Ozcan L, Zheng Z, Nicoloro SM, Shen Y, Chen E, Blüher M, Czech MP, Tabas I.

Nature. 2018 Mar 29;555(7698):673-677. doi: 10.1038/nature26138. Epub 2018 Mar 21.


Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance.

Ozcan L, Ghorpade DS, Zheng Z, de Souza JC, Chen K, Bessler M, Bagloo M, Schrope B, Pestell R, Tabas I.

Cell Rep. 2016 Jun 7;15(10):2214-2225. doi: 10.1016/j.celrep.2016.05.006. Epub 2016 May 26.


Ac2PIM-responsive miR-150 and miR-143 target receptor-interacting protein kinase 2 and transforming growth factor beta-activated kinase 1 to suppress NOD2-induced immunomodulators.

Prakhar P, Holla S, Ghorpade DS, Gilleron M, Puzo G, Udupa V, Balaji KN.

J Biol Chem. 2015 Oct 30;290(44):26576-86. doi: 10.1074/jbc.M115.662817. Epub 2015 Sep 21.


Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity.

Subramanian M, Ozcan L, Ghorpade DS, Ferrante AW Jr, Tabas I.

PLoS One. 2015 Aug 28;10(8):e0135842. doi: 10.1371/journal.pone.0135842. eCollection 2015.


Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity.

Ozcan L, Xu X, Deng SX, Ghorpade DS, Thomas T, Cremers S, Hubbard B, Serrano-Wu MH, Gaestel M, Landry DW, Tabas I.

Diabetes. 2015 Oct;64(10):3396-405. doi: 10.2337/db14-1945. Epub 2015 Jun 11.


Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice.

Fredman G, Kamaly N, Spolitu S, Milton J, Ghorpade D, Chiasson R, Kuriakose G, Perretti M, Farokzhad O, Tabas I.

Sci Transl Med. 2015 Feb 18;7(275):275ra20. doi: 10.1126/scitranslmed.aaa1065. Erratum in: Sci Transl Med. 2015 Mar 4;7(277):277er2. Farokzhad, Omid [corrected to Farokhzad, Omid].


Mycobacterium bovis BCG promotes tumor cell survival from tumor necrosis factor-α-induced apoptosis.

Holla S, Ghorpade DS, Singh V, Bansal K, Balaji KN.

Mol Cancer. 2014 Sep 11;13:210. doi: 10.1186/1476-4598-13-210.


NOD2-nitric oxide-responsive microRNA-146a activates Sonic hedgehog signaling to orchestrate inflammatory responses in murine model of inflammatory bowel disease.

Ghorpade DS, Sinha AY, Holla S, Singh V, Balaji KN.

J Biol Chem. 2013 Nov 15;288(46):33037-48. doi: 10.1074/jbc.M113.492496. Epub 2013 Oct 3.


Nitric oxide and KLF4 protein epigenetically modify class II transactivator to repress major histocompatibility complex II expression during Mycobacterium bovis bacillus Calmette-Guerin infection.

Ghorpade DS, Holla S, Sinha AY, Alagesan SK, Balaji KN.

J Biol Chem. 2013 Jul 12;288(28):20592-606. doi: 10.1074/jbc.M113.472183. Epub 2013 Jun 3.


Sonic hedgehog-dependent induction of microRNA 31 and microRNA 150 regulates Mycobacterium bovis BCG-driven toll-like receptor 2 signaling.

Ghorpade DS, Holla S, Kaveri SV, Bayry J, Patil SA, Balaji KN.

Mol Cell Biol. 2013 Feb;33(3):543-56. doi: 10.1128/MCB.01108-12. Epub 2012 Nov 19.


MicroRNA-155 is required for Mycobacterium bovis BCG-mediated apoptosis of macrophages.

Ghorpade DS, Leyland R, Kurowska-Stolarska M, Patil SA, Balaji KN.

Mol Cell Biol. 2012 Jun;32(12):2239-53. doi: 10.1128/MCB.06597-11. Epub 2012 Apr 2.


Src homology 3-interacting domain of Rv1917c of Mycobacterium tuberculosis induces selective maturation of human dendritic cells by regulating PI3K-MAPK-NF-kappaB signaling and drives Th2 immune responses.

Bansal K, Sinha AY, Ghorpade DS, Togarsimalemath SK, Patil SA, Kaveri SV, Balaji KN, Bayry J.

J Biol Chem. 2010 Nov 19;285(47):36511-22. doi: 10.1074/jbc.M110.158055. Epub 2010 Sep 13.

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