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Items: 14


TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.

Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, von Hoesslin M, Cullen JG, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen CJ, Thimme R, Youngblood B, Zehn D.

Nature. 2019 Jul;571(7764):265-269. doi: 10.1038/s41586-019-1326-9. Epub 2019 Jun 17.


Effector CD8 T cells dedifferentiate into long-lived memory cells.

Youngblood B, Hale JS, Kissick HT, Ahn E, Xu X, Wieland A, Araki K, West EE, Ghoneim HE, Fan Y, Dogra P, Davis CW, Konieczny BT, Antia R, Cheng X, Ahmed R.

Nature. 2017 Dec 21;552(7685):404-409. doi: 10.1038/nature25144. Epub 2017 Dec 13.


De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation.

Ghoneim HE, Fan Y, Moustaki A, Abdelsamed HA, Dash P, Dogra P, Carter R, Awad W, Neale G, Thomas PG, Youngblood B.

Cell. 2017 Jun 29;170(1):142-157.e19. doi: 10.1016/j.cell.2017.06.007. Epub 2017 Jun 22.


Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis.

Abdelsamed HA, Moustaki A, Fan Y, Dogra P, Ghoneim HE, Zebley CC, Triplett BM, Sekaly RP, Youngblood B.

J Exp Med. 2017 Jun 5;214(6):1593-1606. doi: 10.1084/jem.20161760. Epub 2017 May 10.


Cell-Intrinsic Barriers of T Cell-Based Immunotherapy.

Ghoneim HE, Zamora AE, Thomas PG, Youngblood BA.

Trends Mol Med. 2016 Dec;22(12):1000-1011. doi: 10.1016/j.molmed.2016.10.002. Epub 2016 Nov 4. Review.


Generating long-lived CD8(+) T-cell memory: Insights from epigenetic programs.

Dogra P, Ghoneim HE, Abdelsamed HA, Youngblood B.

Eur J Immunol. 2016 Jul;46(7):1548-62. doi: 10.1002/eji.201545550. Review.


NY-BR-1 Antigen Expression and anti-NY-BR-1 IgG in Egyptian Breast Cancer Patients: Clinicopathological and Prognostic Significance.

Abu El-Nazar SY, Ghazy AA, Ghoneim HE, Zoheir M, Ahmed AS, Sorour SS, Abouelella AM.

Egypt J Immunol. 2015;22(1):1-8.


Effect of murine exposure to gamma rays on the interplay between Th1 and Th2 lymphocytes.

Ghazy AA, Abu El-Nazar SY, Ghoneim HE, Taha AR, Abouelella AM.

Front Pharmacol. 2015 Apr 9;6:74. doi: 10.3389/fphar.2015.00074. eCollection 2015.


Effect of ultra violet irradiation on the interplay between Th1 and Th2 lymphocytes.

Abo Elnazar SY, Ghazy AA, Ghoneim HE, Taha AR, Abouelella AM.

Front Pharmacol. 2015 Mar 24;6:56. doi: 10.3389/fphar.2015.00056. eCollection 2015.


Adjunctive corticosteroid therapy improves lung immunopathology and survival during severe secondary pneumococcal pneumonia in mice.

Ghoneim HE, McCullers JA.

J Infect Dis. 2014 May 1;209(9):1459-68. doi: 10.1093/infdis/jit653. Epub 2013 Nov 23.


Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections.

Ghoneim HE, Thomas PG, McCullers JA.

J Immunol. 2013 Aug 1;191(3):1250-9. doi: 10.4049/jimmunol.1300014. Epub 2013 Jun 26.


Immunopathogenic and antibacterial effects of H3N2 influenza A virus PB1-F2 map to amino acid residues 62, 75, 79, and 82.

Alymova IV, Green AM, van de Velde N, McAuley JL, Boyd KL, Ghoneim HE, McCullers JA.

J Virol. 2011 Dec;85(23):12324-33. doi: 10.1128/JVI.05872-11. Epub 2011 Sep 21.


Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice.

Marcelin G, Aldridge JR, Duan S, Ghoneim HE, Rehg J, Marjuki H, Boon AC, McCullers JA, Webby RJ.

J Virol. 2011 Nov;85(21):11208-19. doi: 10.1128/JVI.00654-11. Epub 2011 Aug 24.


Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59.

Ellebedy AH, Lupfer C, Ghoneim HE, DeBeauchamp J, Kanneganti TD, Webby RJ.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2927-32. doi: 10.1073/pnas.1012455108. Epub 2011 Jan 26. Erratum in: Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4429.

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