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Menin Associates With the Mitotic Spindle and Is Important for Cell Division.

Sawicki MP, Gholkar AA, Torres JZ.

Endocrinology. 2019 Aug 1;160(8):1926-1936. doi: 10.1210/en.2019-00274.


Leukemia Cell Cycle Chemical Profiling Identifies the G2-Phase Leukemia Specific Inhibitor Leusin-1.

Xia X, Lo YC, Gholkar AA, Senese S, Ong JY, Velasquez EF, Damoiseaux R, Torres JZ.

ACS Chem Biol. 2019 May 17;14(5):994-1001. doi: 10.1021/acschembio.9b00173. Epub 2019 May 8.


Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation.

Senese S, Lo YC, Gholkar AA, Li CM, Huang Y, Mottahedeh J, Kornblum HI, Damoiseaux R, Torres JZ.

Oncotarget. 2017 Oct 19;8(61):104007-104021. doi: 10.18632/oncotarget.21945. eCollection 2017 Nov 28.


A molecular cascade modulates MAP1B and confers resistance to mTOR inhibition in human glioblastoma.

Laks DR, Oses-Prieto JA, Alvarado AG, Nakashima J, Chand S, Azzam DB, Gholkar AA, Sperry J, Ludwig K, Condro MC, Nazarian S, Cardenas A, Shih MYS, Damoiseaux R, France B, Orozco N, Visnyei K, Crisman TJ, Gao F, Torres JZ, Coppola G, Burlingame AL, Kornblum HI.

Neuro Oncol. 2018 May 18;20(6):764-775. doi: 10.1093/neuonc/nox215.


Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential.

Lo YC, Senese S, France B, Gholkar AA, Damoiseaux R, Torres JZ.

Sci Rep. 2017 Sep 12;7(1):11261. doi: 10.1038/s41598-017-11508-2.


Safety results from the treatment of 109 cerebral aneurysms using the Woven EndoBridge technique: preliminary results in the United Kingdom.

Lawson A, Molyneux A, Sellar R, Lamin S, Thomas A, Gholkar A, Patankar T.

J Neurosurg. 2018 Jan;128(1):144-153. doi: 10.3171/2016.9.JNS152849. Epub 2017 Feb 3.


Inducible LAP-tagged Stable Cell Lines for Investigating Protein Function, Spatiotemporal Localization and Protein Interaction Networks.

Bradley M, Ramirez I, Cheung K, Gholkar AA, Torres JZ.

J Vis Exp. 2016 Dec 24;(118). doi: 10.3791/54870.


Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division.

Gholkar AA, Cheung K, Williams KJ, Lo YC, Hamideh SA, Nnebe C, Khuu C, Bensinger SJ, Torres JZ.

J Biol Chem. 2016 Aug 12;291(33):17001-8. doi: 10.1074/jbc.C116.737346. Epub 2016 Jul 4.


Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.

Cheung K, Senese S, Kuang J, Bui N, Ongpipattanakul C, Gholkar A, Cohn W, Capri J, Whitelegge JP, Torres JZ.

Mol Cell Proteomics. 2016 May;15(5):1658-69. doi: 10.1074/mcp.M115.056465. Epub 2016 Feb 29.


The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division.

Gholkar AA, Senese S, Lo YC, Vides E, Contreras E, Hodara E, Capri J, Whitelegge JP, Torres JZ.

Cell Rep. 2016 Jan 12;14(2):180-8. doi: 10.1016/j.celrep.2015.12.035. Epub 2015 Dec 31.


HydroCoils Are Associated with Lower Angiographic Recurrence Rates Than Are Bare Platinum Coils in Treatment of "Difficult-to-Treat" Aneurysms: A Post Hoc Subgroup Analysis of the HELPS Trial.

Brinjikji W, White PM, Nahser H, Wardlaw J, Sellar R, Gholkar A, Cloft HJ, Kallmes DF.

AJNR Am J Neuroradiol. 2015 Sep;36(9):1689-94. doi: 10.3174/ajnr.A4349. Epub 2015 Jul 30.


A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size.

Xia X, Gholkar A, Senese S, Torres JZ.

Cell Cycle. 2015;14(12):1938-47. doi: 10.1080/15384101.2015.1026487.


Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.

Gholkar AA, Senese S, Lo YC, Capri J, Deardorff WJ, Dharmarajan H, Contreras E, Hodara E, Whitelegge JP, Jackson PK, Torres JZ.

Cell Cycle. 2015;14(7):1116-25. doi: 10.4161/15384101.2014.985066.


A unique insertion in STARD9's motor domain regulates its stability.

Senese S, Cheung K, Lo YC, Gholkar AA, Xia X, Wohlschlegel JA, Torres JZ.

Mol Biol Cell. 2015 Feb 1;26(3):440-52. doi: 10.1091/mbc.E14-03-0829. Epub 2014 Dec 10.


Counterpoint-target aneurysm recurrence: measuring what matters.

McDougall CG, Johnston SC, Gholkar A, Turk AS.

AJNR Am J Neuroradiol. 2015 Jan;36(1):4-6. doi: 10.3174/ajnr.A4205. Epub 2014 Nov 27. No abstract available.


p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.

Veena MS, Wilken R, Zheng JY, Gholkar A, Venkatesan N, Vira D, Ahmed S, Basak SK, Dalgard CL, Ravichandran S, Batra RK, Kasahara N, Elashoff D, Fishbein MC, Whitelegge JP, Torres JZ, Wang MB, Srivatsan ES.

J Biol Chem. 2014 Dec 12;289(50):34921-37. doi: 10.1074/jbc.M114.568543. Epub 2014 Oct 20.


Chemical dissection of the cell cycle: probes for cell biology and anti-cancer drug development.

Senese S, Lo YC, Huang D, Zangle TA, Gholkar AA, Robert L, Homet B, Ribas A, Summers MK, Teitell MA, Damoiseaux R, Torres JZ.

Cell Death Dis. 2014 Oct 16;5:e1462. doi: 10.1038/cddis.2014.420.


Trigeminal neuralgia from an Arteriovenous malformation: An intra-operative diagnosis.

Jayasekera BAP, Vergani F, Gholkar A, Jenkins AJ.

Br J Neurosurg. 2015 Feb;29(1):113-114. doi: 10.3109/02688697.2014.957159. Epub 2014 Sep 15.


Minimally invasive neurosurgical access techniques to facilitate endovascular treatment of dural arteriovenous fistulae.

Cowie CJA, Pešić-Smith JD, Dambatta S, Gholkar A, Surash S, Jenkins A, Mitchell P.

Br J Neurosurg. 2015 Feb;29(1):115-117. doi: 10.3109/02688697.2014.948807. Epub 2014 Aug 18.


Treatment of poor-grade subarachnoid hemorrhage trial.

Mitra D, Gregson B, Jayakrishnan V, Gholkar A, Vincent A, White P, Mitchell P.

AJNR Am J Neuroradiol. 2015 Jan;36(1):116-20. doi: 10.3174/ajnr.A4061. Epub 2014 Jul 24.


Bioactive versus bare platinum coils in the treatment of intracranial aneurysms: the MAPS (Matrix and Platinum Science) trial.

McDougall CG, Johnston SC, Gholkar A, Barnwell SL, Vazquez Suarez JC, Massó Romero J, Chaloupka JC, Bonafe A, Wakhloo AK, Tampieri D, Dowd CF, Fox AJ, Imm SJ, Carroll K, Turk AS; MAPS Investigators.

AJNR Am J Neuroradiol. 2014 May;35(5):935-42. doi: 10.3174/ajnr.A3857. Epub 2014 Jan 30.


Stent-assisted coiling versus coiling alone in unruptured intracranial aneurysms in the matrix and platinum science trial: safety, efficacy, and mid-term outcomes.

Hetts SW, Turk A, English JD, Dowd CF, Mocco J, Prestigiacomo C, Nesbit G, Ge SG, Jin JN, Carroll K, Murayama Y, Gholkar A, Barnwell S, Lopes D, Johnston SC, McDougall C; Matrix and Platinum Science Trial Investigators.

AJNR Am J Neuroradiol. 2014 Apr;35(4):698-705. doi: 10.3174/ajnr.A3755. Epub 2013 Nov 1.


Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial.

Mendelow AD, Gregson BA, Rowan EN, Murray GD, Gholkar A, Mitchell PM; STICH II Investigators.

Lancet. 2013 Aug 3;382(9890):397-408. doi: 10.1016/S0140-6736(13)60986-1. Epub 2013 May 29. Erratum in: Lancet. 2013 Aug 3;382(9890):396.


Multimodality treatment of cerebral arteriovenous malformations.

Nataraj A, Mohamed MB, Gholkar A, Vivar R, Watkins L, Aspoas R, Gregson B, Mitchell P, Mendelow AD.

World Neurosurg. 2014 Jul-Aug;82(1-2):149-59. doi: 10.1016/j.wneu.2013.02.064. Epub 2013 Feb 20.


Update on the Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II): statistical analysis plan.

Gregson BA, Murray GD, Mitchell PM, Rowan EN, Gholkar AR, Mendelow AD.

Trials. 2012 Nov 21;13:222. doi: 10.1186/1745-6215-13-222.


The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly.

Torres JZ, Summers MK, Peterson D, Brauer MJ, Lee J, Senese S, Gholkar AA, Lo YC, Lei X, Jung K, Anderson DC, Davis DP, Belmont L, Jackson PK.

Cell. 2011 Dec 9;147(6):1309-23. doi: 10.1016/j.cell.2011.11.020.


Surgical trial in lobar intracerebral haemorrhage (STICH II) protocol.

Mendelow AD, Gregson BA, Mitchell PM, Murray GD, Rowan EN, Gholkar AR; STICH II Investigators.

Trials. 2011 May 17;12:124. doi: 10.1186/1745-6215-12-124.


Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial.

White PM, Lewis SC, Gholkar A, Sellar RJ, Nahser H, Cognard C, Forrester L, Wardlaw JM; HELPS trial collaborators.

Lancet. 2011 May 14;377(9778):1655-62. doi: 10.1016/S0140-6736(11)60408-X.


Unilateral Horner's syndrome: an unusual childhood presentation.

Sohal AP, Dasarathi M, Gholkar A, McFarland R.

J Paediatr Child Health. 2010 Nov;46(11):695, 701. doi: 10.1111/j.1440-1754.2010.01923-1.x. No abstract available.


Early migration of a self expanding intracranial stent: case report.

Lobotesis K, Gholkar A, Jayakrishnan V.

Neurosurgery. 2010 Aug;67(2):E516-7. doi: 10.1227/01.NEU.0000372094.75062.D4.


Coil embolisation of intercostal artery for operative localisation of spinal dural arterio-venous fistulae.

Barrett C, Jayakrishnan V, Gholkar A, Todd NV.

Br J Neurosurg. 2009 Jun;23(3):332-4. doi: 10.1080/02688690802464704.


Variation in outcome after subarachnoid hemorrhage: a study of neurosurgical units in UK and Ireland.

Langham J, Reeves BC, Lindsay KW, van der Meulen JH, Kirkpatrick PJ, Gholkar AR, Molyneux AJ, Shaw DM, Copley L, Browne JP; Steering Group for National Study of Subarachnoid Haemorrhage.

Stroke. 2009 Jan;40(1):111-8. doi: 10.1161/STROKEAHA.108.517805. Epub 2008 Nov 13.


Medical devices and medical training.

Todd NV, Gholkar A.

Ann R Coll Surg Engl. 2008 Nov;90(8):709-10. doi: 10.1308/003588408X321846. No abstract available.


Embolization of residual fistula following stereotactic radiosurgery in cerebral arteriovenous malformations.

Hodgson TJ, Kemeny AA, Gholkar A, Deasy N.

AJNR Am J Neuroradiol. 2009 Jan;30(1):109-10. doi: 10.3174/ajnr.A1240. Epub 2008 Aug 7.


HydroCoil Endovascular Aneurysm Occlusion and Packing Study (HELPS trial): procedural safety and operator-assessed efficacy results.

White PM, Lewis SC, Nahser H, Sellar RJ, Goddard T, Gholkar A; HELPS Trial Collaboration.

AJNR Am J Neuroradiol. 2008 Feb;29(2):217-23. doi: 10.3174/ajnr.A0936. Epub 2008 Jan 9.


Single-center experience of cerecyte coils in the treatment of intracranial aneurysms: initial experience and early follow-up results.

Butteriss D, Gholkar A, Mitra D, Birchall D, Jayakrishnan V.

AJNR Am J Neuroradiol. 2008 Jan;29(1):53-6. Epub 2007 Oct 5.


Findings of the International Subarachnoid Aneurysm Trial and the National Study of Subarachnoid Haemorrhage in context.

Reeves BC, Langham J, Lindsay KW, Molyneux AJ, Browne JP, Copley L, Shaw D, Gholkar A, Kirkpatrick PJ.

Br J Neurosurg. 2007 Aug;21(4):318-23; discussion 323-7.


Atrophy is associated with posterior cingulate white matter disruption in dementia with Lewy bodies and Alzheimer's disease.

Firbank MJ, Blamire AM, Krishnan MS, Teodorczuk A, English P, Gholkar A, Harrison R, O'Brien JT.

Neuroimage. 2007 May 15;36(1):1-7. Epub 2007 Feb 28.


Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease.

Firbank MJ, Blamire AM, Krishnan MS, Teodorczuk A, English P, Gholkar A, Harrison RM, O'Brien JT.

Psychiatry Res. 2007 Jul 15;155(2):135-45. Epub 2007 Apr 3.


Follow-up of intracranial aneurysms treated with matrix detachable coils: a single-center experience.

Mitra D, Herwadkar A, Soh C, Gholkar A.

AJNR Am J Neuroradiol. 2007 Feb;28(2):362-7.


Temporary alopecia after subarachnoid haemorrhage.

Nannapaneni R, Behari S, Mendelow D, Gholkar A.

J Clin Neurosci. 2007 Feb;14(2):157-61. Epub 2006 Nov 14.


Alexander disease: ventricular garlands and abnormalities of the medulla and spinal cord.

van der Knaap MS, Ramesh V, Schiffmann R, Blaser S, Kyllerman M, Gholkar A, Ellison DW, van der Voorn JP, van Dooren SJ, Jakobs C, Barkhof F, Salomons GS.

Neurology. 2006 Feb 28;66(4):494-8.


Comparison of image quality, diagnostic confidence and interobserver variability in contrast enhanced MR angiography and 2D time of flight angiography in evaluation of carotid stenosis.

Mitra D, Connolly D, Jenkins S, English P, Birchall D, Mandel C, Shrikanth K, Gregson B, Gholkar A.

Br J Radiol. 2006 Mar;79(939):201-7.


Intracranial aneurysms treated with endovascular coils: detection of recurrences using unenhanced and contrast-enhanced transcranial color-coded duplex sonography.

Turner CL, Higgins JN, Gholkar A, Mendelow AD, Molyneux AJ, Kerr RS, Chawda S, Kirkpatrick PJ.

Stroke. 2005 Dec;36(12):2654-9. Epub 2005 Nov 3.


Aciclovir induced posterior leucoencephalopathy.

Mahad DJ, Helldén A, Jarvis J, Mitra D, Gholkar A, Chinnery PF.

J Neurol Neurosurg Psychiatry. 2005 Sep;76(9):1308-9. No abstract available. Erratum in: J Neurol Neurosurg Psychiatry. 2005 Dec;76(12):1747. Mahad, D [corrected to Mahad, DJ].


Aneurysmal subarachnoid hemorrhage: management strategies and clinical outcomes in a regional neuroscience center.

Flett LM, Chandler CS, Giddings D, Gholkar A.

AJNR Am J Neuroradiol. 2005 Feb;26(2):367-72.


Cerebral vasculitis in a teenager with Goodpasture's syndrome.

Gittins N, Basu A, Eyre J, Gholkar A, Moghal N.

Nephrol Dial Transplant. 2004 Dec;19(12):3168-71. No abstract available.


A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects.

O'Brien JT, Lloyd A, McKeith I, Gholkar A, Ferrier N.

Am J Psychiatry. 2004 Nov;161(11):2081-90.


Reliability assessment of computerized tomography scanning measurements in intracerebral hematoma.

Bhattathiri PS, Gregson B, Prasad KS, Mitchell P, Soh C, Mitra D, Gholkar A, Mendelow AD.

Neurosurg Focus. 2003 Oct 15;15(4):E6.


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