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Items: 1 to 50 of 110


Lentiviral-based reporter constructs for profiling chondrogenic activity in primary equine cell populations.

Martin-Pena A, Porter RM, Plumton G, McCarrel TM, Morton AJ, Guijarro MV, Ghivizzani SC, Sharma B, Palmer GD.

Eur Cell Mater. 2018 Oct 12;36:156-170. doi: 10.22203/eCM.v036a12.


Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model.

Watson Levings RS, Broome TA, Smith AD, Rice BL, Gibbs EP, Myara DA, Hyddmark EV, Nasri E, Zarezadeh A, Levings PP, Lu Y, White ME, Dacanay EA, Foremny GB, Evans CH, Morton AJ, Winter M, Dark MJ, Nickerson DM, Colahan PT, Ghivizzani SC.

Hum Gene Ther Clin Dev. 2018 Jun;29(2):90-100. doi: 10.1089/humc.2017.142.


Self-Complementary Adeno-Associated Virus-Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model.

Watson Levings RS, Smith AD, Broome TA, Rice BL, Gibbs EP, Myara DA, Hyddmark EV, Nasri E, Zarezadeh A, Levings PP, Lu Y, White ME, Dacanay EA, Foremny GB, Evans CH, Morton AJ, Winter M, Dark MJ, Nickerson DM, Colahan PT, Ghivizzani SC.

Hum Gene Ther Clin Dev. 2018 Jun;29(2):101-112. doi: 10.1089/humc.2017.143.


Arthritis gene therapy is becoming a reality.

Evans CH, Ghivizzani SC, Robbins PD.

Nat Rev Rheumatol. 2018 Jul;14(7):381-382. doi: 10.1038/s41584-018-0009-5. No abstract available.


Gene Therapy to Enhance Bone and Cartilage Repair in Orthopaedic Surgery.

Bougioukli S, Evans CH, Alluri RK, Ghivizzani SC, Lieberman JR.

Curr Gene Ther. 2018;18(3):154-170. doi: 10.2174/1566523218666180410152842.


Arthritis Gene Therapy Approved in Korea.

Evans CH, Ghivizzani SC, Robbins PD.

J Am Acad Orthop Surg. 2018 Jan 15;26(2):e36-e38. doi: 10.5435/JAAOS-D-17-00695. No abstract available.


Gene Delivery to Joints by Intra-Articular Injection.

Evans CH, Ghivizzani SC, Robbins PD.

Hum Gene Ther. 2018 Jan;29(1):2-14. doi: 10.1089/hum.2017.181. Review.


Animal models in osteosarcoma.

Guijarro MV, Ghivizzani SC, Gibbs CP.

Front Oncol. 2014 Jul 18;4:189. doi: 10.3389/fonc.2014.00189. eCollection 2014. Review. Erratum in: Front Genet. 2014;5:475.


Arthritis gene therapy and its tortuous path into the clinic.

Evans CH, Ghivizzani SC, Robbins PD.

Transl Res. 2013 Apr;161(4):205-16. doi: 10.1016/j.trsl.2013.01.002. Epub 2013 Jan 29. Review.


scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints.

Watson RS, Broome TA, Levings PP, Rice BL, Kay JD, Smith AD, Gouze E, Gouze JN, Dacanay EA, Hauswirth WW, Nickerson DM, Dark MJ, Colahan PT, Ghivizzani SC.

Gene Ther. 2013 Jun;20(6):670-7. doi: 10.1038/gt.2012.81. Epub 2012 Nov 15.


Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells.

Steinert AF, Weissenberger M, Kunz M, Gilbert F, Ghivizzani SC, Göbel S, Jakob F, Nöth U, Rudert M.

Arthritis Res Ther. 2012 Jul 20;14(4):R168. doi: 10.1186/ar3921.


An acidic oligopeptide displayed on AAV2 improves axial muscle tropism after systemic delivery.

Lee NC, Falk DJ, Byrne BJ, Conlon TJ, Clement N, Porvasnik S, Jorgensen ML, Potter M, Erger KE, Watson R, Ghivizzani SC, Chiu HC, Chien YH, Hwu WL.

Genet Vaccines Ther. 2012 Jun 18;10(1):3. doi: 10.1186/1479-0556-10-3.


Orthopedic gene therapy--lost in translation?

Evans CH, Ghivizzani SC, Robbins PD.

J Cell Physiol. 2012 Feb;227(2):416-20. doi: 10.1002/jcp.23031.


Evidence for the osteosarcoma stem cell.

Gibbs CP Jr, Levings PP, Ghivizzani SC.

Curr Orthop Pract. 2011 Jul;22(4):322-326.


Getting arthritis gene therapy into the clinic.

Evans CH, Ghivizzani SC, Robbins PD.

Nat Rev Rheumatol. 2011 Apr;7(4):244-9. doi: 10.1038/nrrheum.2010.193. Epub 2010 Dec 7. Review.


Gene delivery of TGF-β1 induces arthrofibrosis and chondrometaplasia of synovium in vivo.

Watson RS, Gouze E, Levings PP, Bush ML, Kay JD, Jorgensen MS, Dacanay EA, Reith JW, Wright TW, Ghivizzani SC.

Lab Invest. 2010 Nov;90(11):1615-27. doi: 10.1038/labinvest.2010.145. Epub 2010 Aug 9.


Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer.

Steinert AF, Proffen B, Kunz M, Hendrich C, Ghivizzani SC, Nöth U, Rethwilm A, Eulert J, Evans CH.

Arthritis Res Ther. 2009;11(5):R148. doi: 10.1186/ar2822. Epub 2009 Oct 2.


Progress and Prospects: genetic treatments for disorders of bones and joints.

Evans CH, Ghivizzani SC, Robbins PD.

Gene Ther. 2009 Aug;16(8):944-52. doi: 10.1038/gt.2009.73. Review.


Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma.

Levings PP, McGarry SV, Currie TP, Nickerson DM, McClellan S, Ghivizzani SC, Steindler DA, Gibbs CP.

Cancer Res. 2009 Jul 15;69(14):5648-55. doi: 10.1158/0008-5472.CAN-08-3580. Epub 2009 Jul 7.


Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus.

Kay JD, Gouze E, Oligino TJ, Gouze JN, Watson RS, Levings PP, Bush ML, Dacanay A, Nickerson DM, Robbins PD, Evans CH, Ghivizzani SC.

J Gene Med. 2009 Jul;11(7):605-14. doi: 10.1002/jgm.1334.


Gene therapy of the rheumatic diseases: 1998 to 2008.

Evans CH, Ghivizzani SC, Robbins PD.

Arthritis Res Ther. 2009;11(1):209. doi: 10.1186/ar2563. Epub 2009 Jan 30. Review.


Orthopedic gene therapy in 2008.

Evans CH, Ghivizzani SC, Robbins PD.

Mol Ther. 2009 Feb;17(2):231-44. doi: 10.1038/mt.2008.265. Epub 2008 Dec 9. Review.


Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis.

Wehling P, Reinecke J, Baltzer AW, Granrath M, Schulitz KP, Schultz C, Krauspe R, Whiteside TW, Elder E, Ghivizzani SC, Robbins PD, Evans CH.

Hum Gene Ther. 2009 Feb;20(2):97-101. doi: 10.1089/hum.2008.075.


Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer.

Steinert AF, Palmer GD, Pilapil C, Nöth U, Evans CH, Ghivizzani SC.

Tissue Eng Part A. 2009 May;15(5):1127-39. doi: 10.1089/ten.tea.2007.0252.


Perspectives on the use of gene therapy for chronic joint diseases.

Ghivizzani SC, Gouze E, Gouze JN, Kay JD, Bush ML, Watson RS, Levings PP, Nickerson DM, Colahan PT, Robbins PD, Evans CH.

Curr Gene Ther. 2008 Aug;8(4):273-86. Review.


Arthritis gene therapy's first death.

Evans CH, Ghivizzani SC, Robbins PD.

Arthritis Res Ther. 2008;10(3):110. doi: 10.1186/ar2411. Epub 2008 May 27.


Reduction in severity of a herpes simplex virus type 1 murine infection by treatment with a ribozyme targeting the UL20 gene RNA.

Liu J, Lewin AS, Tuli SS, Ghivizzani SC, Schultz GS, Bloom DC.

J Virol. 2008 Aug;82(15):7467-74. doi: 10.1128/JVI.02720-07. Epub 2008 May 28.


A simple, lanthanide-based method to enhance the transduction efficiency of adenovirus vectors.

Palmer GD, Stoddart MJ, Gouze E, Gouze JN, Ghivizzani SC, Porter RM, Evans CH.

Gene Ther. 2008 Mar;15(5):357-63. doi: 10.1038/ Epub 2008 Jan 24.


Major biological obstacles for persistent cell-based regeneration of articular cartilage.

Steinert AF, Ghivizzani SC, Rethwilm A, Tuan RS, Evans CH, Nöth U.

Arthritis Res Ther. 2007;9(3):213. Review.


Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid.

Steinert AF, Palmer GD, Capito R, Hofstaetter JG, Pilapil C, Ghivizzani SC, Spector M, Evans CH.

Tissue Eng. 2007 Sep;13(9):2227-37.


Facilitated endogenous repair: making tissue engineering simple, practical, and economical.

Evans CH, Palmer GD, Pascher A, Porter R, Kwong FN, Gouze E, Gouze JN, Liu F, Steinert A, Betz O, Betz V, Vrahas M, Ghivizzani SC.

Tissue Eng. 2007 Aug;13(8):1987-93. Review.


Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases.

Gouze E, Gouze JN, Palmer GD, Pilapil C, Evans CH, Ghivizzani SC.

Mol Ther. 2007 Jun;15(6):1114-20. Epub 2007 Apr 17.


[Gene therapy for osteoarticular disorders].

Gouze JN, Evans CH, Ghivizzani SC, Gouze E.

Med Sci (Paris). 2007 Mar;23(3):303-9. Review. French.


Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta.

Gouze JN, Gouze E, Popp MP, Bush ML, Dacanay EA, Kay JD, Levings PP, Patel KR, Saran JP, Watson RS, Ghivizzani SC.

Arthritis Res Ther. 2006;8(6):R173.


Will arthritis gene therapy become a clinical reality?

Evans CH, Ghivizzani SC, Robbins PD.

Nat Clin Pract Rheumatol. 2006 Jul;2(7):344-5. Review. No abstract available.


Gene therapy for arthritis: what next?

Evans CH, Ghivizzani SC, Robbins PD.

Arthritis Rheum. 2006 Jun;54(6):1714-29. Review. No abstract available.


Gene therapeutic approaches-transfer in vivo.

Evans CH, Gouze E, Gouze JN, Robbins PD, Ghivizzani SC.

Adv Drug Deliv Rev. 2006 May 20;58(2):243-58. Epub 2006 Feb 28. Review.


Stem-like cells in bone sarcomas: implications for tumorigenesis.

Gibbs CP, Kukekov VG, Reith JD, Tchigrinova O, Suslov ON, Scott EW, Ghivizzani SC, Ignatova TN, Steindler DA.

Neoplasia. 2005 Nov;7(11):967-76.


The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics.

Evans CH, Ghivizzani SC, Gouze E, Rediske JJ, Schwarz EM, Robbins PD.

Arthritis Res Ther. 2005;7(6):273-8. Epub 2005 Oct 28.


Gene therapy for the treatment of musculoskeletal diseases.

Evans CH, Ghivizzani SC, Herndon JH, Robbins PD.

J Am Acad Orthop Surg. 2005 Jul-Aug;13(4):230-42. Review.


Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro.

Palmer GD, Steinert A, Pascher A, Gouze E, Gouze JN, Betz O, Johnstone B, Evans CH, Ghivizzani SC.

Mol Ther. 2005 Aug;12(2):219-28.


Gene transfer to human joints: progress toward a gene therapy of arthritis.

Evans CH, Robbins PD, Ghivizzani SC, Wasko MC, Tomaino MM, Kang R, Muzzonigro TA, Vogt M, Elder EM, Whiteside TL, Watkins SC, Herndon JH.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8698-703. Epub 2005 Jun 6.


The 2003 Nicolas Andry Award. Orthopaedic gene therapy.

Evans CH, Ghivizzani SC, Robbins PD.

Clin Orthop Relat Res. 2004 Dec;(429):316-29. Review.


Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model.

Pascher A, Steinert AF, Palmer GD, Betz O, Gouze JN, Gouze E, Pilapil C, Ghivizzani SC, Evans CH, Murray MM.

Mol Ther. 2004 Aug;10(2):327-36.


In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors.

Gouze JN, Stoddart MJ, Gouze E, Palmer GD, Ghivizzani SC, Grodzinsky AJ, Evans CH.

Methods Mol Med. 2004;100:147-64.


Adenovirus-mediated gene transfer of glutamine: fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1beta on rat chondrocytes.

Gouze JN, Gouze E, Palmer GD, Kaneto H, Ghivizzani SC, Grodzinsky AJ, Evans CH.

Osteoarthritis Cartilage. 2004 Mar;12(3):217-24.


Osteoarthritis gene therapy.

Evans CH, Gouze JN, Gouze E, Robbins PD, Ghivizzani SC.

Gene Ther. 2004 Feb;11(4):379-89. Review.


Gene-based approaches for the repair of articular cartilage.

Trippel SB, Ghivizzani SC, Nixon AJ.

Gene Ther. 2004 Feb;11(4):351-9. Review.


Gene delivery to cartilage defects using coagulated bone marrow aspirate.

Pascher A, Palmer GD, Steinert A, Oligino T, Gouze E, Gouze JN, Betz O, Spector M, Robbins PD, Evans CH, Ghivizzani SC.

Gene Ther. 2004 Jan;11(2):133-41.


Evaluation of Ad-BMP-2 for enhancing fracture healing in an infected defect fracture rabbit model.

Southwood LL, Frisbie DD, Kawcak CE, Ghivizzani SC, Evans CH, McIlwraith CW.

J Orthop Res. 2004 Jan;22(1):66-72.

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