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Items: 32

1.

Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage.

Collino A, Termanini A, Nicoli P, Diaferia G, Polletti S, Recordati C, Castiglioni V, Caruso D, Mitro N, Natoli G, Ghisletti S.

PLoS Genet. 2018 May 7;14(5):e1007380. doi: 10.1371/journal.pgen.1007380. eCollection 2018 May.

2.

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis.

Schauer SN, Carreira PE, Shukla R, Gerhardt DJ, Gerdes P, Sanchez-Luque FJ, Nicoli P, Kindlova M, Ghisletti S, Santos AD, Rapoud D, Samuel D, Faivre J, Ewing AD, Richardson SR, Faulkner GJ.

Genome Res. 2018 May;28(5):639-653. doi: 10.1101/gr.226993.117. Epub 2018 Apr 11.

3.

Zc3h10 is a novel mitochondrial regulator.

Audano M, Pedretti S, Cermenati G, Brioschi E, Diaferia GR, Ghisletti S, Cuomo A, Bonaldi T, Salerno F, Mora M, Grigore L, Garlaschelli K, Baragetti A, Bonacina F, Catapano AL, Norata GD, Crestani M, Caruso D, Saez E, De Fabiani E, Mitro N.

EMBO Rep. 2018 Apr;19(4). pii: e45531. doi: 10.15252/embr.201745531. Epub 2018 Mar 5.

PMID:
29507079
4.

Housekeeping and tissue-specific cis-regulatory elements: Recipes for specificity and recipes for activity.

Russo M, Natoli G, Ghisletti S.

Transcription. 2018;9(3):177-181. doi: 10.1080/21541264.2017.1378158. Epub 2017 Nov 7.

PMID:
28992423
5.

Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk.

Piccolo V, Curina A, Genua M, Ghisletti S, Simonatto M, Sabò A, Amati B, Ostuni R, Natoli G.

Nat Immunol. 2017 May;18(5):530-540. doi: 10.1038/ni.3710. Epub 2017 Mar 13.

6.

High constitutive activity of a broad panel of housekeeping and tissue-specific cis-regulatory elements depends on a subset of ETS proteins.

Curina A, Termanini A, Barozzi I, Prosperini E, Simonatto M, Polletti S, Silvola A, Soldi M, Austenaa L, Bonaldi T, Ghisletti S, Natoli G.

Genes Dev. 2017 Feb 15;31(4):399-412. doi: 10.1101/gad.293134.116. Epub 2017 Mar 8.

7.

Mutual epithelium-macrophage dependency in liver carcinogenesis mediated by ST18.

Ravà M, D'Andrea A, Doni M, Kress TR, Ostuni R, Bianchi V, Morelli MJ, Collino A, Ghisletti S, Nicoli P, Recordati C, Iascone M, Sonzogni A, D'Antiga L, Shukla R, Faulkner GJ, Natoli G, Campaner S, Amati B.

Hepatology. 2017 May;65(5):1708-1719. doi: 10.1002/hep.28942. Epub 2016 Dec 30.

8.

Transcription of Mammalian cis-Regulatory Elements Is Restrained by Actively Enforced Early Termination.

Austenaa LM, Barozzi I, Simonatto M, Masella S, Della Chiara G, Ghisletti S, Curina A, de Wit E, Bouwman BA, de Pretis S, Piccolo V, Termanini A, Prosperini E, Pelizzola M, de Laat W, Natoli G.

Mol Cell. 2015 Nov 5;60(3):460-74. doi: 10.1016/j.molcel.2015.09.018. Epub 2015 Oct 22.

9.

CAGE profiling of ncRNAs in hepatocellular carcinoma reveals widespread activation of retroviral LTR promoters in virus-induced tumors.

Hashimoto K, Suzuki AM, Dos Santos A, Desterke C, Collino A, Ghisletti S, Braun E, Bonetti A, Fort A, Qin XY, Radaelli E, Kaczkowski B, Forrest AR, Kojima S, Samuel D, Natoli G, Buendia MA, Faivre J, Carninci P.

Genome Res. 2015 Dec;25(12):1812-24. doi: 10.1101/gr.191031.115. Epub 2015 Oct 28.

10.

Corrigendum: Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency.

Iannelli F, Collino A, Sinha S, Radaelli E, Nicoli P, D'Antiga L, Sonzogni A, Faivre J, Buendia MA, Sturm E, Thompson RJ, Knisely AS, Natoli G, Ghisletti S, Ciccarelli FD.

Nat Commun. 2015 Jul 2;6:7456. doi: 10.1038/ncomms8456. No abstract available.

PMID:
26135945
11.

A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages.

Mancino A, Termanini A, Barozzi I, Ghisletti S, Ostuni R, Prosperini E, Ozato K, Natoli G.

Genes Dev. 2015 Feb 15;29(4):394-408. doi: 10.1101/gad.257592.114. Epub 2015 Jan 30.

12.

Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency.

Iannelli F, Collino A, Sinha S, Radaelli E, Nicoli P, D'Antiga L, Sonzogni A, Faivre J, Buendia MA, Sturm E, Thompson RJ, Knisely AS, Natoli G, Ghisletti S, Ciccarelli FD.

Nat Commun. 2014 May 13;5:3850. doi: 10.1038/ncomms4850. Erratum in: Nat Commun. 2015;6:7456.

PMID:
24819516
13.

Coregulation of transcription factor binding and nucleosome occupancy through DNA features of mammalian enhancers.

Barozzi I, Simonatto M, Bonifacio S, Yang L, Rohs R, Ghisletti S, Natoli G.

Mol Cell. 2014 Jun 5;54(5):844-857. doi: 10.1016/j.molcel.2014.04.006. Epub 2014 May 8.

14.

Deciphering cis-regulatory control in inflammatory cells.

Ghisletti S, Natoli G.

Philos Trans R Soc Lond B Biol Sci. 2013 May 6;368(1620):20120370. doi: 10.1098/rstb.2012.0370. Print 2013. Review.

15.

Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma.

Shukla R, Upton KR, Muñoz-Lopez M, Gerhardt DJ, Fisher ME, Nguyen T, Brennan PM, Baillie JK, Collino A, Ghisletti S, Sinha S, Iannelli F, Radaelli E, Dos Santos A, Rapoud D, Guettier C, Samuel D, Natoli G, Carninci P, Ciccarelli FD, Garcia-Perez JL, Faivre J, Faulkner GJ.

Cell. 2013 Mar 28;153(1):101-11. doi: 10.1016/j.cell.2013.02.032.

16.

Latent enhancers activated by stimulation in differentiated cells.

Ostuni R, Piccolo V, Barozzi I, Polletti S, Termanini A, Bonifacio S, Curina A, Prosperini E, Ghisletti S, Natoli G.

Cell. 2013 Jan 17;152(1-2):157-71. doi: 10.1016/j.cell.2012.12.018.

17.

Mechanisms establishing TLR4-responsive activation states of inflammatory response genes.

Escoubet-Lozach L, Benner C, Kaikkonen MU, Lozach J, Heinz S, Spann NJ, Crotti A, Stender J, Ghisletti S, Reichart D, Cheng CS, Luna R, Ludka C, Sasik R, Garcia-Bassets I, Hoffmann A, Subramaniam S, Hardiman G, Rosenfeld MG, Glass CK.

PLoS Genet. 2011 Dec;7(12):e1002401. doi: 10.1371/journal.pgen.1002401. Epub 2011 Dec 8.

18.

Coronin 2A mediates actin-dependent de-repression of inflammatory response genes.

Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK.

Nature. 2011 Feb 17;470(7334):414-8. doi: 10.1038/nature09703.

19.

The genomic landscapes of inflammation.

Natoli G, Ghisletti S, Barozzi I.

Genes Dev. 2011 Jan 15;25(2):101-6. doi: 10.1101/gad.2018811. Review.

20.

A large fraction of extragenic RNA pol II transcription sites overlap enhancers.

De Santa F, Barozzi I, Mietton F, Ghisletti S, Polletti S, Tusi BK, Muller H, Ragoussis J, Wei CL, Natoli G.

PLoS Biol. 2010 May 11;8(5):e1000384. doi: 10.1371/journal.pbio.1000384.

21.

Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages.

Ghisletti S, Barozzi I, Mietton F, Polletti S, De Santa F, Venturini E, Gregory L, Lonie L, Chew A, Wei CL, Ragoussis J, Natoli G.

Immunity. 2010 Mar 26;32(3):317-28. doi: 10.1016/j.immuni.2010.02.008. Epub 2010 Mar 4.

22.

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.

Porta C, Rimoldi M, Raes G, Brys L, Ghezzi P, Di Liberto D, Dieli F, Ghisletti S, Natoli G, De Baetselier P, Mantovani A, Sica A.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14978-83. doi: 10.1073/pnas.0809784106. Epub 2009 Aug 17.

23.

Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint.

Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK.

Mol Cell. 2009 Jul 10;35(1):48-57. doi: 10.1016/j.molcel.2009.05.023.

24.

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways.

Ghisletti S, Huang W, Jepsen K, Benner C, Hardiman G, Rosenfeld MG, Glass CK.

Genes Dev. 2009 Mar 15;23(6):681-93. doi: 10.1101/gad.1773109.

25.

Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.

Chao EY, Caravella JA, Watson MA, Campobasso N, Ghisletti S, Billin AN, Galardi C, Wang P, Laffitte BA, Iannone MA, Goodwin BJ, Nichols JA, Parks DJ, Stewart E, Wiethe RW, Williams SP, Smallwood A, Pearce KH, Glass CK, Willson TM, Zuercher WJ, Collins JL.

J Med Chem. 2008 Sep 25;51(18):5758-65. doi: 10.1021/jm800612u.

PMID:
18800767
26.

Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma.

Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass CK.

Mol Cell. 2007 Jan 12;25(1):57-70.

27.

The endogenous estrogen status regulates microglia reactivity in animal models of neuroinflammation.

Vegeto E, Belcredito S, Ghisletti S, Meda C, Etteri S, Maggi A.

Endocrinology. 2006 May;147(5):2263-72. Epub 2006 Feb 9.

PMID:
16469811
28.

17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization.

Ghisletti S, Meda C, Maggi A, Vegeto E.

Mol Cell Biol. 2005 Apr;25(8):2957-68.

29.

Regulation of the lipopolysaccharide signal transduction pathway by 17beta-estradiol in macrophage cells.

Vegeto E, Ghisletti S, Meda C, Etteri S, Belcredito S, Maggi A.

J Steroid Biochem Mol Biol. 2004 Jun;91(1-2):59-66.

PMID:
15261308
30.

Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol.

Vegeto E, Belcredito S, Etteri S, Ghisletti S, Brusadelli A, Meda C, Krust A, Dupont S, Ciana P, Chambon P, Maggi A.

Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9614-9. Epub 2003 Jul 23.

31.

Estrogen receptor alpha, a molecular switch converting transforming growth factor-alpha-mediated proliferation into differentiation in neuroblastoma cells.

Ciana P, Ghisletti S, Mussi P, Eberini I, Vegeto E, Maggi A.

J Biol Chem. 2003 Aug 22;278(34):31737-44. Epub 2003 Apr 22.

32.

Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2.

Belcredito S, Vegeto E, Brusadelli A, Ghisletti S, Mussi P, Ciana P, Maggi A.

Brain Res Brain Res Rev. 2001 Nov;37(1-3):335-42. Review.

PMID:
11744098

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