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Initial Results from the Survey of Organizational Research Climates (SOuRCe) in the U.S. Department of Veterans Affairs Healthcare System.

Martinson BC, Nelson D, Hagel-Campbell E, Mohr D, Charns MP, Bangerter A, Thrush CR, Ghilardi JR, Bloomfield H, Owen R, Wells JA.

PLoS One. 2016 Mar 11;11(3):e0151571. doi: 10.1371/journal.pone.0151571. eCollection 2016.


Pathophysiology and medical treatment of pain in fibrous dysplasia of bone.

Chapurlat RD, Gensburger D, Jimenez-Andrade JM, Ghilardi JR, Kelly M, Mantyh P.

Orphanet J Rare Dis. 2012 May 24;7 Suppl 1:S3. doi: 10.1186/1750-1172-7-S1-S3. Epub 2012 May 24. Review.


Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature.

Reilly RM, McDonald HA, Puttfarcken PS, Joshi SK, Lewis L, Pai M, Franklin PH, Segreti JA, Neelands TR, Han P, Chen J, Mantyh PW, Ghilardi JR, Turner TM, Voight EA, Daanen JF, Schmidt RG, Gomtsyan A, Kort ME, Faltynek CR, Kym PR.

J Pharmacol Exp Ther. 2012 Aug;342(2):416-28. doi: 10.1124/jpet.111.190314. Epub 2012 May 8.


Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint.

Ghilardi JR, Freeman KT, Jimenez-Andrade JM, Coughlin KA, Kaczmarska MJ, Castaneda-Corral G, Bloom AP, Kuskowski MA, Mantyh PW.

Arthritis Rheum. 2012 Jul;64(7):2223-32. doi: 10.1002/art.34385.


Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain.

Jimenez-Andrade JM, Ghilardi JR, Castañeda-Corral G, Kuskowski MA, Mantyh PW.

Pain. 2011 Nov;152(11):2564-74. doi: 10.1016/j.pain.2011.07.020. Epub 2011 Sep 9.


Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers.

Bloom AP, Jimenez-Andrade JM, Taylor RN, Castañeda-Corral G, Kaczmarska MJ, Freeman KT, Coughlin KA, Ghilardi JR, Kuskowski MA, Mantyh PW.

J Pain. 2011 Jun;12(6):698-711. doi: 10.1016/j.jpain.2010.12.016. Epub 2011 Apr 15.


The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A.

Castañeda-Corral G, Jimenez-Andrade JM, Bloom AP, Taylor RN, Mantyh WG, Kaczmarska MJ, Ghilardi JR, Mantyh PW.

Neuroscience. 2011 Mar 31;178:196-207. doi: 10.1016/j.neuroscience.2011.01.039. Epub 2011 Jan 26.


Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain.

Ghilardi JR, Freeman KT, Jimenez-Andrade JM, Mantyh WG, Bloom AP, Kuskowski MA, Mantyh PW.

Mol Pain. 2010 Dec 7;6:87. doi: 10.1186/1744-8069-6-87.


Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain.

Jimenez-Andrade JM, Bloom AP, Stake JI, Mantyh WG, Taylor RN, Freeman KT, Ghilardi JR, Kuskowski MA, Mantyh PW.

J Neurosci. 2010 Nov 3;30(44):14649-56. doi: 10.1523/JNEUROSCI.3300-10.2010.


The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain.

Jimenez-Andrade JM, Mantyh WG, Bloom AP, Freeman KT, Ghilardi JR, Kuskowski MA, Mantyh PW.

Neurobiol Aging. 2012 May;33(5):921-32. doi: 10.1016/j.neurobiolaging.2010.08.008. Epub 2010 Oct 13.


Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers.

Ghilardi JR, Freeman KT, Jimenez-Andrade JM, Mantyh WG, Bloom AP, Bouhana KS, Trollinger D, Winkler J, Lee P, Andrews SW, Kuskowski MA, Mantyh PW.

Bone. 2011 Feb;48(2):389-98. doi: 10.1016/j.bone.2010.09.019. Epub 2010 Sep 18.


Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain.

Mantyh WG, Jimenez-Andrade JM, Stake JI, Bloom AP, Kaczmarska MJ, Taylor RN, Freeman KT, Ghilardi JR, Kuskowski MA, Mantyh PW.

Neuroscience. 2010 Dec 1;171(2):588-98. doi: 10.1016/j.neuroscience.2010.08.056. Epub 2010 Sep 20.


Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain.

Jimenez-Andrade JM, Bloom AP, Mantyh WG, Koewler NJ, Freeman KT, Delong D, Ghilardi JR, Kuskowski MA, Mantyh PW.

Neuroscience. 2009 Sep 15;162(4):1244-54. doi: 10.1016/j.neuroscience.2009.05.065. Epub 2009 May 29.


Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia.

Honore P, Chandran P, Hernandez G, Gauvin DM, Mikusa JP, Zhong C, Joshi SK, Ghilardi JR, Sevcik MA, Fryer RM, Segreti JA, Banfor PN, Marsh K, Neelands T, Bayburt E, Daanen JF, Gomtsyan A, Lee CH, Kort ME, Reilly RM, Surowy CS, Kym PR, Mantyh PW, Sullivan JP, Jarvis MF, Faltynek CR.

Pain. 2009 Mar;142(1-2):27-35. doi: 10.1016/j.pain.2008.11.004. Epub 2009 Jan 9.


Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer.

Halvorson KG, Sevcik MA, Ghilardi JR, Sullivan LJ, Koewler NJ, Bauss F, Mantyh PW.

J Pain Symptom Manage. 2008 Sep;36(3):289-303. doi: 10.1016/j.jpainsymman.2007.10.005. Epub 2008 Apr 14.


Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: implications for chemical-induced peripheral sensory neuropathies.

Jimenez-Andrade JM, Herrera MB, Ghilardi JR, Vardanyan M, Melemedjian OK, Mantyh PW.

Mol Pain. 2008 Mar 19;4:10. doi: 10.1186/1744-8069-4-10.


A fracture pain model in the rat: adaptation of a closed femur fracture model to study skeletal pain.

Freeman KT, Koewler NJ, Jimenez-Andrade JM, Buus RJ, Herrera MB, Martin CD, Ghilardi JR, Kuskowski MA, Mantyh PW.

Anesthesiology. 2008 Mar;108(3):473-83. doi: 10.1097/ALN.0b013e3181649351.


An evolving cellular pathology occurs in dorsal root ganglia, peripheral nerve and spinal cord following intravenous administration of paclitaxel in the rat.

Peters CM, Jimenez-Andrade JM, Kuskowski MA, Ghilardi JR, Mantyh PW.

Brain Res. 2007 Sep 7;1168:46-59. Epub 2007 Jul 17.


Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture.

Jimenez-Andrade JM, Martin CD, Koewler NJ, Freeman KT, Sullivan LJ, Halvorson KG, Barthold CM, Peters CM, Buus RJ, Ghilardi JR, Lewis JL, Kuskowski MA, Mantyh PW.

Pain. 2007 Dec 15;133(1-3):183-96. Epub 2007 Aug 10.


Effects of a monoclonal antibody raised against nerve growth factor on skeletal pain and bone healing after fracture of the C57BL/6J mouse femur.

Koewler NJ, Freeman KT, Buus RJ, Herrera MB, Jimenez-Andrade JM, Ghilardi JR, Peters CM, Sullivan LJ, Kuskowski MA, Lewis JL, Mantyh PW.

J Bone Miner Res. 2007 Nov;22(11):1732-42.


Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells.

Peters CM, Jimenez-Andrade JM, Jonas BM, Sevcik MA, Koewler NJ, Ghilardi JR, Wong GY, Mantyh PW.

Exp Neurol. 2007 Jan;203(1):42-54. Epub 2006 Sep 26.


Endogenous opioids inhibit early-stage pancreatic pain in a mouse model of pancreatic cancer.

Sevcik MA, Jonas BM, Lindsay TH, Halvorson KG, Ghilardi JR, Kuskowski MA, Mukherjee P, Maggio JE, Mantyh PW.

Gastroenterology. 2006 Sep;131(3):900-10.


Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer.

Halvorson KG, Sevcik MA, Ghilardi JR, Rosol TJ, Mantyh PW.

Clin J Pain. 2006 Sep;22(7):587-600. Review.


Sensory neurons and their supporting cells located in the trigeminal, thoracic and lumbar ganglia differentially express markers of injury following intravenous administration of paclitaxel in the rat.

Jimenez-Andrade JM, Peters CM, Mejia NA, Ghilardi JR, Kuskowski MA, Mantyh PW.

Neurosci Lett. 2006 Sep 11;405(1-2):62-7. Epub 2006 Jul 18.


Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs.

Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL.

Toxicol Sci. 2006 May;91(1):286-98. Epub 2006 Feb 24.


A quantitative analysis of the sensory and sympathetic innervation of the mouse pancreas.

Lindsay TH, Halvorson KG, Peters CM, Ghilardi JR, Kuskowski MA, Wong GY, Mantyh PW.

Neuroscience. 2006;137(4):1417-26. Epub 2006 Jan 4.


Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression.

Lindsay TH, Jonas BM, Sevcik MA, Kubota K, Halvorson KG, Ghilardi JR, Kuskowski MA, Stelow EB, Mukherjee P, Gendler SJ, Wong GY, Mantyh PW.

Pain. 2005 Dec 15;119(1-3):233-46. Epub 2005 Nov 18.


Analgesic efficacy of bradykinin B1 antagonists in a murine bone cancer pain model.

Sevcik MA, Ghilardi JR, Halvorson KG, Lindsay TH, Kubota K, Mantyh PW.

J Pain. 2005 Nov;6(11):771-5.


A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone.

Halvorson KG, Kubota K, Sevcik MA, Lindsay TH, Sotillo JE, Ghilardi JR, Rosol TJ, Boustany L, Shelton DL, Mantyh PW.

Cancer Res. 2005 Oct 15;65(20):9426-35.


Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization.

Sevcik MA, Ghilardi JR, Peters CM, Lindsay TH, Halvorson KG, Jonas BM, Kubota K, Kuskowski MA, Boustany L, Shelton DL, Mantyh PW.

Pain. 2005 May;115(1-2):128-41.


Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain.

Peters CM, Ghilardi JR, Keyser CP, Kubota K, Lindsay TH, Luger NM, Mach DB, Schwei MJ, Sevcik MA, Mantyh PW.

Exp Neurol. 2005 May;193(1):85-100.


Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.

Ghilardi JR, Röhrich H, Lindsay TH, Sevcik MA, Schwei MJ, Kubota K, Halvorson KG, Poblete J, Chaplan SR, Dubin AE, Carruthers NI, Swanson D, Kuskowski M, Flores CM, Julius D, Mantyh PW.

J Neurosci. 2005 Mar 23;25(12):3126-31.


The involvement of prostaglandins in tumorigenesis, tumor-induced osteolysis and bone cancer pain.

Sabino MC, Ghilardi JR, Feia KJ, Jongen JL, Keyser CP, Luger NM, Mach DB, Peters CM, Rogers SD, Schwei MJ, De Filipe C, Mantyh PW.

J Musculoskelet Neuronal Interact. 2002 Dec;2(6):561-2. No abstract available.


Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus.

Khasabov SG, Ghilardi JR, Mantyh PW, Simone DA.

J Neurophysiol. 2005 Feb;93(2):998-1006. Epub 2004 Sep 29.


Bone cancer pain: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis.

Sevcik MA, Luger NM, Mach DB, Sabino MA, Peters CM, Ghilardi JR, Schwei MJ, Röhrich H, De Felipe C, Kuskowski MA, Mantyh PW.

Pain. 2004 Sep;111(1-2):169-80.


Endothelin and the tumorigenic component of bone cancer pain.

Peters CM, Lindsay TH, Pomonis JD, Luger NM, Ghilardi JR, Sevcik MA, Mantyh PW.

Neuroscience. 2004;126(4):1043-52.


Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia.

Ghilardi JR, Svensson CI, Rogers SD, Yaksh TL, Mantyh PW.

J Neurosci. 2004 Mar 17;24(11):2727-32.


Proteomic analysis of the reactive phenotype of astrocytes following endothelin-1 exposure.

Egnaczyk GF, Pomonis JD, Schmidt JA, Rogers SD, Peters C, Ghilardi JR, Mantyh PW, Maggio JE.

Proteomics. 2003 May;3(5):689-98.


Endothelin receptor expression in the normal and injured spinal cord: potential involvement in injury-induced ischemia and gliosis.

Peters CM, Rogers SD, Pomonis JD, Egnaczyk GF, Keyser CP, Schmidt JA, Ghilardi JR, Maggio JE, Mantyh PW.

Exp Neurol. 2003 Mar;180(1):1-13. Erratum in: Exp Neurol. 2003 Aug;182(2):518. Egnazyck, Gregory F [corrected to Egnaczyk, Gregory F].


Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS.

Rogers SD, Peters CM, Pomonis JD, Hagiwara H, Ghilardi JR, Mantyh PW.

Glia. 2003 Jan 15;41(2):180-90.


Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2.

Sabino MA, Ghilardi JR, Jongen JL, Keyser CP, Luger NM, Mach DB, Peters CM, Rogers SD, Schwei MJ, de Felipe C, Mantyh PW.

Cancer Res. 2002 Dec 15;62(24):7343-9.


Spinal neurons that possess the substance P receptor are required for the development of central sensitization.

Khasabov SG, Rogers SD, Ghilardi JR, Peters CM, Mantyh PW, Simone DA.

J Neurosci. 2002 Oct 15;22(20):9086-98.


Apolipoprotein E affects amyloid formation but not amyloid growth in vitro: mechanistic implications for apoE4 enhanced amyloid burden and risk for Alzheimer's disease.

Esler WP, Marshall JR, Stimson ER, Ghilardi JR, Vinters HV, Mantyh PW, Maggio JE.

Amyloid. 2002 Mar;9(1):1-12.


Noninvasive imaging of peripherally injected Alzheimer's disease type synthetic A beta amyloid in vivo.

Marshall JR, Stimson ER, Ghilardi JR, Vinters HV, Mantyh PW, Maggio JE.

Bioconjug Chem. 2002 Mar-Apr;13(2):276-84.


Expression and localization of endothelin receptors: implications for the involvement of peripheral glia in nociception.

Pomonis JD, Rogers SD, Peters CM, Ghilardi JR, Mantyh PW.

J Neurosci. 2001 Feb 1;21(3):999-1006.


Activation barriers to structural transition determine deposition rates of Alzheimer's disease a beta amyloid.

Esler WP, Felix AM, Stimson ER, Lachenmann MJ, Ghilardi JR, Lu YA, Vinters HV, Mantyh PW, Lee JP, Maggio JE.

J Struct Biol. 2000 Jun;130(2-3):174-83.


Alzheimer's disease amyloid propagation by a template-dependent dock-lock mechanism.

Esler WP, Stimson ER, Jennings JM, Vinters HV, Ghilardi JR, Lee JP, Mantyh PW, Maggio JE.

Biochemistry. 2000 May 30;39(21):6288-95.


Transmission of chronic nociception by spinal neurons expressing the substance P receptor.

Nichols ML, Allen BJ, Rogers SD, Ghilardi JR, Honore P, Luger NM, Finke MP, Li J, Lappi DA, Simone DA, Mantyh PW.

Science. 1999 Nov 19;286(5444):1558-61.


Deposition of monomeric, not oligomeric, Abeta mediates growth of Alzheimer's disease amyloid plaques in human brain preparations.

Tseng BP, Esler WP, Clish CB, Stimson ER, Ghilardi JR, Vinters HV, Mantyh PW, Lee JP, Maggio JE.

Biochemistry. 1999 Aug 10;38(32):10424-31.


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