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Items: 1 to 50 of 72

1.

Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.

Zamboni V, Armentano M, Berto G, Ciraolo E, Ghigo A, Garzotto D, Umbach A, DiCunto F, Parmigiani E, Boido M, Vercelli A, El-Assawy N, Mauro A, Priano L, Ponzoni L, Murru L, Passafaro M, Hirsch E, Merlo GR.

Sci Rep. 2018 May 8;8(1):7254. doi: 10.1038/s41598-018-25354-3.

2.

Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting.

Wyart E, Reano S, Hsu MY, Longo DL, Li M, Hirsch E, Filigheddu N, Ghigo A, Riganti C, Porporato PE.

Oxid Med Cell Longev. 2018 Feb 26;2018:6419805. doi: 10.1155/2018/6419805. eCollection 2018.

3.

A Novel Interpretation for Arterial Pulse Pressure Amplification in Health and Disease.

Alfonso MR, Armentano RL, Cymberknop LJ, Ghigo AR, Pessana FM, Legnani WE.

J Healthc Eng. 2018 Jan 16;2018:1364185. doi: 10.1155/2018/1364185. eCollection 2018.

4.

Antineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective.

Varricchi G, Ameri P, Cadeddu C, Ghigo A, Madonna R, Marone G, Mercurio V, Monte I, Novo G, Parrella P, Pirozzi F, Pecoraro A, Spallarossa P, Zito C, Mercuro G, Pagliaro P, Tocchetti CG.

Front Physiol. 2018 Mar 7;9:167. doi: 10.3389/fphys.2018.00167. eCollection 2018. Review.

5.

PI3K signaling in chronic obstructive pulmonary disease: mechanisms, targets, and therapy.

Pirozzi F, Ren K, Murabito A, Ghigo A.

Curr Med Chem. 2018 Mar 20. doi: 10.2174/0929867325666180320120054. [Epub ahead of print]

PMID:
29557740
6.

Phosphoinositide 3-Kinase Gamma Inhibition Protects from Anthracycline Cardiotoxicity and Reduces Tumor Growth.

Li M, Sala V, De Santis MC, Cimino J, Cappello P, Pianca N, Di Bona A, Margaria JP, Martini M, Lazzarini E, Pirozzi F, Rossi L, Franco I, Bornbaum J, Heger J, Rohrbach S, Perino A, Tocchetti CG, Lima BHF, Teixeira MM, Porporato PE, Schulz R, Angelini A, Sandri M, Ameri P, Sciarretta S, Lima-Júnior RCP, Mongillo M, Zaglia T, Morello F, Novelli F, Hirsch E, Ghigo A.

Circulation. 2018 Jan 18. pii: CIRCULATIONAHA.117.030352. doi: 10.1161/CIRCULATIONAHA.117.030352. [Epub ahead of print]

PMID:
29348263
7.

Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits.

Duarte LJ, Chaves VC, Nascimento MVPDS, Calvete E, Li M, Ciraolo E, Ghigo A, Hirsch E, Simões CMO, Reginatto FH, Dalmarco EM.

Food Chem. 2018 May 1;247:56-65. doi: 10.1016/j.foodchem.2017.12.015. Epub 2017 Dec 7.

PMID:
29277228
8.

Data demonstrating the role of peroxiredoxin 2 as important anti-oxidant system in lung homeostasis.

Federti E, Matte A, Ghigo A, Andolfo I, James C, Siciliano A, Leboeuf C, Janin A, Manna F, Choi SY, Iolascon A, Beneduce E, Melisi D, Kim DW, Levi S, De Franceschi L.

Data Brief. 2017 Sep 30;15:376-381. doi: 10.1016/j.dib.2017.09.062. eCollection 2017 Dec.

9.

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function.

Gulluni F, Martini M, De Santis MC, Campa CC, Ghigo A, Margaria JP, Ciraolo E, Franco I, Ala U, Annaratone L, Disalvatore D, Bertalot G, Viale G, Noatynska A, Compagno M, Sigismund S, Montemurro F, Thelen M, Fan F, Meraldi P, Marchiò C, Pece S, Sapino A, Chiarle R, Di Fiore PP, Hirsch E.

Cancer Cell. 2017 Oct 9;32(4):444-459.e7. doi: 10.1016/j.ccell.2017.09.002.

PMID:
29017056
10.

Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension.

Federti E, Matté A, Ghigo A, Andolfo I, James C, Siciliano A, Leboeuf C, Janin A, Manna F, Choi SY, Iolascon A, Beneduce E, Melisi D, Kim DW, Levi S, De Franceschi L.

Free Radic Biol Med. 2017 Nov;112:376-386. doi: 10.1016/j.freeradbiomed.2017.08.004. Epub 2017 Aug 9.

PMID:
28801243
11.

PI3K and Calcium Signaling in Cardiovascular Disease.

Ghigo A, Laffargue M, Li M, Hirsch E.

Circ Res. 2017 Jul 21;121(3):282-292. doi: 10.1161/CIRCRESAHA.117.310183. Review.

PMID:
28729453
12.

PI3Ks in Diabetic Cardiomyopathy.

Li M, Murabito A, Ghigo A, Hirsch E.

J Cardiovasc Pharmacol. 2017 Dec;70(6):422-429. doi: 10.1097/FJC.0000000000000511.

PMID:
28654509
13.

Tregs restrain dendritic cell autophagy to ameliorate autoimmunity.

Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, Vassilopoulos D, Boumpas D, Chavakis T, Cadwell K, Verginis P.

J Clin Invest. 2017 Jun 30;127(7):2789-2804. doi: 10.1172/JCI92079. Epub 2017 Jun 5.

14.

Data demonstrating the anti-oxidant role of hemopexin in the heart.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Data Brief. 2017 May 13;13:69-76. doi: 10.1016/j.dib.2017.05.026. eCollection 2017 Aug.

15.

Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF).

Sala V, Margaria JP, Murabito A, Morello F, Ghigo A, Hirsch E.

Curr Heart Fail Rep. 2017 Jun;14(3):187-196. doi: 10.1007/s11897-017-0331-2. Review.

PMID:
28451983
16.

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Free Radic Biol Med. 2017 Jul;108:452-464. doi: 10.1016/j.freeradbiomed.2017.04.003. Epub 2017 Apr 8.

17.

A one-dimensional arterial network model for bypass graft assessment.

Ghigo AR, Abou Taam S, Wang X, Lagrée PY, Fullana JM.

Med Eng Phys. 2017 May;43:39-47. doi: 10.1016/j.medengphy.2017.02.002. Epub 2017 Mar 11.

PMID:
28292655
18.

A novel protective role for activating transcription factor 3 in the cardiac response to metabolic stress.

Ghigo A, Frati G, Sciarretta S.

Cardiovasc Res. 2017 Feb;113(2):113-114. doi: 10.1093/cvr/cvw252. Epub 2017 Jan 12. No abstract available.

PMID:
28082449
19.

Rac signal adaptation controls neutrophil mobilization from the bone marrow.

Campa CC, Germena G, Ciraolo E, Copperi F, Sapienza A, Franco I, Ghigo A, Camporeale A, Di Savino A, Martini M, Perino A, Megens RT, Kurz AR, Scheiermann C, Sperandio M, Gamba A, Hirsch E.

Sci Signal. 2016 Dec 20;9(459):ra124. doi: 10.1126/scisignal.aah5882.

PMID:
27999173
20.

Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.

Zamboni V, Armentano M, Sarò G, Ciraolo E, Ghigo A, Germena G, Umbach A, Valnegri P, Passafaro M, Carabelli V, Gavello D, Bianchi V, D'Adamo P, de Curtis I, El-Assawi N, Mauro A, Priano L, Ferri N, Hirsch E, Merlo GR.

Sci Rep. 2016 Oct 7;6:34877. doi: 10.1038/srep34877.

21.

Linear and Nonlinear Viscoelastic Arterial Wall Models: Application on Animals.

Ghigo AR, Wang XF, Armentano R, Fullana JM, Lagrée PY.

J Biomech Eng. 2017 Jan 1;139(1). doi: 10.1115/1.4034832.

PMID:
27685359
22.

Models of Heart Failure Based on the Cardiotoxicity of Anticancer Drugs.

Mercurio V, Pirozzi F, Lazzarini E, Marone G, Rizzo P, Agnetti G, Tocchetti CG, Ghigo A, Ameri P.

J Card Fail. 2016 Jun;22(6):449-58. doi: 10.1016/j.cardfail.2016.04.008. Epub 2016 Apr 18. Review.

PMID:
27103426
23.

The dicrotic notch analyzed by a numerical model.

Politi MT, Ghigo A, Fernández JM, Khelifa I, Gaudric J, Fullana JM, Lagrée PY.

Comput Biol Med. 2016 May 1;72:54-64. doi: 10.1016/j.compbiomed.2016.03.005. Epub 2016 Mar 14.

PMID:
27016670
24.

Fluid friction and wall viscosity of the 1D blood flow model.

Wang XF, Nishi S, Matsukawa M, Ghigo A, Lagrée PY, Fullana JM.

J Biomech. 2016 Feb 29;49(4):565-71. doi: 10.1016/j.jbiomech.2016.01.010. Epub 2016 Jan 28.

PMID:
26862041
25.

New signal transduction paradigms in anthracycline-induced cardiotoxicity.

Ghigo A, Li M, Hirsch E.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1916-25. doi: 10.1016/j.bbamcr.2016.01.021. Epub 2016 Jan 29. Review.

26.

Phosphoinositide 3-kinase: friend and foe in cardiovascular disease.

Ghigo A, Li M.

Front Pharmacol. 2015 Aug 13;6:169. doi: 10.3389/fphar.2015.00169. eCollection 2015. Review.

27.

Numerical simulations of a bypass repair of an iliac artery obliteration.

Ghigo AR, AbouTaam S, Wang X, Lagrée PY, Fullana JM.

Comput Methods Biomech Biomed Engin. 2015;18 Suppl 1:1944-5. doi: 10.1080/10255842.2015.1070584. Epub 2015 Aug 10. No abstract available.

PMID:
26260376
28.

Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation.

Zhang M, Prosser BL, Bamboye MA, Gondim ANS, Santos CX, Martin D, Ghigo A, Perino A, Brewer AC, Ward CW, Hirsch E, Lederer WJ, Shah AM.

J Am Coll Cardiol. 2015 Jul 21;66(3):261-272. doi: 10.1016/j.jacc.2015.05.020.

29.

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Shymanets A, Prajwal, Vadas O, Czupalla C, LoPiccolo J, Brenowitz M, Ghigo A, Hirsch E, Krause E, Wetzker R, Williams RL, Harteneck C, Nürnberg B.

Biochem J. 2015 Jul 1;469(1):59-69. doi: 10.1042/BJ20150099.

30.

Crossroads of PI3K and Rac pathways.

Campa CC, Ciraolo E, Ghigo A, Germena G, Hirsch E.

Small GTPases. 2015;6(2):71-80. doi: 10.4161/21541248.2014.989789. Epub 2015 May 5. Review.

31.

Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease.

Kalish BT, Matte A, Andolfo I, Iolascon A, Weinberg O, Ghigo A, Cimino J, Siciliano A, Hirsch E, Federti E, Puder M, Brugnara C, De Franceschi L.

Haematologica. 2015 Jul;100(7):870-80. doi: 10.3324/haematol.2015.124586. Epub 2015 May 1.

32.

Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.

D'Andrea I, Fardella V, Fardella S, Pallante F, Ghigo A, Iacobucci R, Maffei A, Hirsch E, Lembo G, Carnevale D.

EMBO Mol Med. 2015 Jul;7(7):904-17. doi: 10.15252/emmm.201404697.

33.

Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive.

Perino A, Beretta M, Kilić A, Ghigo A, Carnevale D, Repetto IE, Braccini L, Longo D, Liebig-Gonglach M, Zaglia T, Iacobucci R, Mongillo M, Wetzker R, Bauer M, Aime S, Vercelli A, Lembo G, Pfeifer A, Hirsch E.

Sci Signal. 2014 Nov 18;7(352):ra110. doi: 10.1126/scisignal.2005485.

PMID:
25406378
34.

Elastin degradation and ensuing inflammation as emerging keys to atherosclerosis.

Hirsch E, Ghigo A.

Cardiovasc Res. 2014 Apr 1;102(1):1-2. doi: 10.1093/cvr/cvu038. Epub 2014 Feb 11. No abstract available.

PMID:
24518143
35.

Myocyte signalling in leucocyte recruitment to the heart.

Ghigo A, Franco I, Morello F, Hirsch E.

Cardiovasc Res. 2014 May 1;102(2):270-80. doi: 10.1093/cvr/cvu030. Epub 2014 Feb 5. Review.

PMID:
24501328
36.

PI3K in cancer-stroma interactions: bad in seed and ugly in soil.

Hirsch E, Ciraolo E, Franco I, Ghigo A, Martini M.

Oncogene. 2014 Jun 12;33(24):3083-90. doi: 10.1038/onc.2013.265. Epub 2013 Jul 29. Review.

PMID:
23893246
37.

Therapeutic applications of PI3K inhibitors in cardiovascular diseases.

Ghigo A, Morello F, Perino A, Hirsch E.

Future Med Chem. 2013 Mar;5(4):479-92. doi: 10.4155/fmc.13.11. Review.

PMID:
23495693
38.

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.

Vinchi F, De Franceschi L, Ghigo A, Townes T, Cimino J, Silengo L, Hirsch E, Altruda F, Tolosano E.

Circulation. 2013 Mar 26;127(12):1317-29. doi: 10.1161/CIRCULATIONAHA.112.130179. Epub 2013 Feb 27.

39.

Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.

Suk HY, Zhou C, Yang TT, Zhu H, Yu RY, Olabisi O, Yang X, Brancho D, Kim JY, Scherer PE, Frank PG, Lisanti MP, Calvert JW, Lefer DJ, Molkentin JD, Ghigo A, Hirsch E, Jin J, Chow CW.

J Biol Chem. 2013 Feb 1;288(5):3477-88. doi: 10.1074/jbc.M112.419150. Epub 2012 Dec 20.

40.

Phosphoinositides and cardiovascular diseases.

Ghigo A, Perino A, Hirsch E.

Curr Top Microbiol Immunol. 2012;362:43-60. doi: 10.1007/978-94-007-5025-8_2. Review.

PMID:
23086412
41.

Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.

Ghigo A, Perino A, Mehel H, Zahradníková A Jr, Morello F, Leroy J, Nikolaev VO, Damilano F, Cimino J, De Luca E, Richter W, Westenbroek R, Catterall WA, Zhang J, Yan C, Conti M, Gomez AM, Vandecasteele G, Hirsch E, Fischmeister R.

Circulation. 2012 Oct 23;126(17):2073-83. doi: 10.1161/CIRCULATIONAHA.112.114074. Epub 2012 Sep 24.

42.

Anchoring proteins as regulators of signaling pathways.

Perino A, Ghigo A, Scott JD, Hirsch E.

Circ Res. 2012 Aug 3;111(4):482-92. doi: 10.1161/CIRCRESAHA.111.262899. Review.

43.

NADPH oxidases in heart failure: poachers or gamekeepers?

Zhang M, Perino A, Ghigo A, Hirsch E, Shah AM.

Antioxid Redox Signal. 2013 Mar 20;18(9):1024-41. doi: 10.1089/ars.2012.4550. Epub 2012 Aug 27. Review.

44.

Phosphoinositide 3-kinases in health and disease.

Ghigo A, Morello F, Perino A, Hirsch E.

Subcell Biochem. 2012;58:183-213. doi: 10.1007/978-94-007-3012-0_6. Review.

PMID:
22403077
45.

Specific PI3K isoform modulation in heart failure: lessons from transgenic mice.

Ghigo A, Morello F, Perino A, Damilano F, Hirsch E.

Curr Heart Fail Rep. 2011 Sep;8(3):168-75. doi: 10.1007/s11897-011-0059-3. Review.

PMID:
21519914
46.

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie GS, Damilano F, Dunlop AJ, Pawson C, Walser R, Levi R, Altruda F, Silengo L, Langeberg LK, Neubauer G, Heymans S, Lembo G, Wymann MP, Wetzker R, Houslay MD, Iaccarino G, Scott JD, Hirsch E.

Mol Cell. 2011 Apr 8;42(1):84-95. doi: 10.1016/j.molcel.2011.01.030.

47.

Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure.

Damilano F, Franco I, Perrino C, Schaefer K, Azzolino O, Carnevale D, Cifelli G, Carullo P, Ragona R, Ghigo A, Perino A, Lembo G, Hirsch E.

Circulation. 2011 Feb 1;123(4):391-9. doi: 10.1161/CIRCULATIONAHA.110.950543. Epub 2011 Jan 17.

48.

Leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure.

Perino A, Ghigo A, Hirsch E.

Trends Cardiovasc Med. 2010 Nov;20(8):273-6. doi: 10.1016/j.tcm.2011.12.007. Review.

PMID:
22433654
49.

Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema.

Fanelli V, Puntorieri V, Assenzio B, Martin EL, Elia V, Bosco M, Delsedime L, Del Sorbo L, Ferrari A, Italiano S, Ghigo A, Slutsky AS, Hirsch E, Ranieri VM.

Intensive Care Med. 2010 Nov;36(11):1935-45. doi: 10.1007/s00134-010-2018-y. Epub 2010 Aug 19.

PMID:
20721532
50.

Recycling nanocatalysts by tuning solvent quality.

Myakonkaya O, Deniau B, Eastoe J, Rogers SE, Ghigo A, Hollamby M, Vesperinas A, Sankar M, Taylor SH, Bartley JK, Hutchings GJ.

J Colloid Interface Sci. 2010 Oct 15;350(2):443-6. doi: 10.1016/j.jcis.2010.06.064. Epub 2010 Jul 7.

PMID:
20659734

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