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Items: 1 to 50 of 94

1.

LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β.

Rossi M, Bucci G, Rizzotto D, Bordo D, Marzi MJ, Puppo M, Flinois A, Spadaro D, Citi S, Emionite L, Cilli M, Nicassio F, Inga A, Briata P, Gherzi R.

Nat Commun. 2019 Apr 29;10(1):1969. doi: 10.1038/s41467-019-09754-1.

2.

Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells.

Moshiri A, Puppo M, Rossi M, Gherzi R, Briata P.

Biochim Biophys Acta Gene Regul Mech. 2017 Mar;1860(3):291-298. doi: 10.1016/j.bbagrm.2017.01.001. Epub 2017 Jan 11.

PMID:
28088441
3.

miRNA-Mediated KHSRP Silencing Rewires Distinct Post-transcriptional Programs during TGF-β-Induced Epithelial-to-Mesenchymal Transition.

Puppo M, Bucci G, Rossi M, Giovarelli M, Bordo D, Moshiri A, Gorlero F, Gherzi R, Briata P.

Cell Rep. 2016 Jul 26;16(4):967-978. doi: 10.1016/j.celrep.2016.06.055. Epub 2016 Jul 7.

4.

Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease.

Briata P, Bordo D, Puppo M, Gorlero F, Rossi M, Perrone-Bizzozero N, Gherzi R.

Wiley Interdiscip Rev RNA. 2016 Mar-Apr;7(2):227-40. doi: 10.1002/wrna.1327. Epub 2015 Dec 27. Review.

5.

Retraction: The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling.

Gherzi R, Trabucchi M, Ponassi M, Ruggiero T, Corte G, Moroni C, Chen CY, Khabar KS, Andersen JS, Briata P.

PLoS Biol. 2015 Nov 16;13(11):e1002314. doi: 10.1371/journal.pbio.1002314. eCollection 2015. No abstract available.

6.

H19 long noncoding RNA controls the mRNA decay promoting function of KSRP.

Giovarelli M, Bucci G, Ramos A, Bordo D, Wilusz CJ, Chen CY, Puppo M, Briata P, Gherzi R.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5023-8. doi: 10.1073/pnas.1415098111. Epub 2014 Nov 10.

7.

Destabilization of nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fibre formation.

Cammas A, Sanchez BJ, Lian XJ, Dormoy-Raclet V, van der Giessen K, López de Silanes I, Ma J, Wilusz C, Richardson J, Gorospe M, Millevoi S, Giovarelli M, Gherzi R, Di Marco S, Gallouzi IE.

Nat Commun. 2014 Jun 27;5:4190. doi: 10.1038/ncomms5190.

8.

KSRP controls pleiotropic cellular functions.

Gherzi R, Chen CY, Ramos A, Briata P.

Semin Cell Dev Biol. 2014 Oct;34:2-8. doi: 10.1016/j.semcdb.2014.05.004. Epub 2014 May 17. Review.

PMID:
24845017
9.

KSRP and MicroRNA 145 are negative regulators of lipolysis in white adipose tissue.

Lin YY, Chou CF, Giovarelli M, Briata P, Gherzi R, Chen CY.

Mol Cell Biol. 2014 Jun;34(12):2339-49. doi: 10.1128/MCB.00042-14. Epub 2014 Apr 14.

10.

KSRP ablation enhances brown fat gene program in white adipose tissue through reduced miR-150 expression.

Chou CF, Lin YY, Wang HK, Zhu X, Giovarelli M, Briata P, Gherzi R, Garvey WT, Chen CY.

Diabetes. 2014 Sep;63(9):2949-61. doi: 10.2337/db13-1901. Epub 2014 Apr 10.

11.

KSRP silencing favors neural differentiation of P19 teratocarcinoma cells.

Giovarelli M, Bucci G, Pasero M, Gherzi R, Briata P.

Biochim Biophys Acta. 2013 May;1829(5):469-79. doi: 10.1016/j.bbagrm.2013.02.008. Epub 2013 Feb 24.

PMID:
23462617
12.

Functional and molecular insights into KSRP function in mRNA decay.

Briata P, Chen CY, Ramos A, Gherzi R.

Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):689-94. doi: 10.1016/j.bbagrm.2012.11.003. Epub 2012 Nov 22. Review.

PMID:
23178464
13.

Bone morphogenetic protein/SMAD signaling orients cell fate decision by impairing KSRP-dependent microRNA maturation.

Pasero M, Giovarelli M, Bucci G, Gherzi R, Briata P.

Cell Rep. 2012 Nov 29;2(5):1159-68. doi: 10.1016/j.celrep.2012.10.020. Epub 2012 Nov 21.

14.

Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis.

Nicastro G, García-Mayoral MF, Hollingworth D, Kelly G, Martin SR, Briata P, Gherzi R, Ramos A.

Nat Struct Mol Biol. 2012 Dec;19(12):1282-6. doi: 10.1038/nsmb.2427. Epub 2012 Nov 11.

15.

Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP.

Repetto E, Briata P, Kuziner N, Harfe BD, McManus MT, Gherzi R, Rosenfeld MG, Trabucchi M.

PLoS Genet. 2012;8(7):e1002823. doi: 10.1371/journal.pgen.1002823. Epub 2012 Jul 26. Erratum in: PLoS Genet. 2012 Sep;8(9). doi:10.1371/annotation/c93e4b67-d237-48fb-aec7-0db398407bb4.

16.

KH domains with impaired nucleic acid binding as a tool for functional analysis.

Hollingworth D, Candel AM, Nicastro G, Martin SR, Briata P, Gherzi R, Ramos A.

Nucleic Acids Res. 2012 Aug;40(14):6873-86. doi: 10.1093/nar/gks368. Epub 2012 Apr 29.

17.

[Human papillomavirus infection and cervical intraepithelial neoplasia in dialyzed patients].

David P, Tarrano E, De Mauri A, Navino C, Brustia M, Chiarinotti D, Gherzi R, De Leo M.

G Ital Nefrol. 2012 Mar-Apr;29(2):205-9. Italian.

PMID:
22538949
18.

The role of KSRP in mRNA decay and microRNA precursor maturation.

Gherzi R, Chen CY, Trabucchi M, Ramos A, Briata P.

Wiley Interdiscip Rev RNA. 2010 Sep-Oct;1(2):230-9. doi: 10.1002/wrna.2. Epub 2010 May 6. Review.

PMID:
21935887
19.

PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis.

Briata P, Lin WJ, Giovarelli M, Pasero M, Chou CF, Trabucchi M, Rosenfeld MG, Chen CY, Gherzi R.

Cell Death Differ. 2012 Mar;19(3):478-87. doi: 10.1038/cdd.2011.117. Epub 2011 Sep 2.

20.

KSRP Promotes the Maturation of a Group of miRNA Precuresors.

Trabucchi M, Briata P, Filipowicz W, Ramos A, Gherzi R, Rosenfeld MG.

Adv Exp Med Biol. 2011;700:36-42. doi: 10.1007/978-1-4419-7823-3_4.

PMID:
21755471
21.

Posttranscriptional control of type I interferon genes by KSRP in the innate immune response against viral infection.

Lin WJ, Zheng X, Lin CC, Tsao J, Zhu X, Cody JJ, Coleman JM, Gherzi R, Luo M, Townes TM, Parker JN, Chen CY.

Mol Cell Biol. 2011 Aug;31(16):3196-207. doi: 10.1128/MCB.05073-11. Epub 2011 Jun 20.

22.

KSRP, many functions for a single protein.

Briata P, Chen CY, Giovarelli M, Pasero M, Trabucchi M, Ramos A, Gherzi R.

Front Biosci (Landmark Ed). 2011 Jan 1;16:1787-96. Review.

PMID:
21196264
23.

Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets.

Díaz-Moreno I, Hollingworth D, Kelly G, Martin S, García-Mayoral M, Briata P, Gherzi R, Ramos A.

Nucleic Acids Res. 2010 Aug;38(15):5193-205. doi: 10.1093/nar/gkq216. Epub 2010 Apr 12.

24.

KSRP promotes the maturation of a group of miRNA precursors.

Trabucchi M, Briata P, Filipowicz W, Ramos A, Gherzi R, Rosenfeld MG.

Adv Exp Med Biol. 2010;700:36-42.

25.

Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation.

Gherzi R, Trabucchi M, Ponassi M, Gallouzi IE, Rosenfeld MG, Briata P.

Cell Death Differ. 2010 Jun;17(6):975-83. doi: 10.1038/cdd.2009.194. Epub 2009 Dec 18.

26.

How to control miRNA maturation?

Trabucchi M, Briata P, Filipowicz W, Rosenfeld MG, Ramos A, Gherzi R.

RNA Biol. 2009 Nov-Dec;6(5):536-40. Review.

PMID:
19875945
27.

KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells.

Nechama M, Peng Y, Bell O, Briata P, Gherzi R, Schoenberg DR, Naveh-Many T.

BMC Cell Biol. 2009 Sep 23;10:70. doi: 10.1186/1471-2121-10-70.

28.

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.

Trabucchi M, Briata P, Garcia-Mayoral M, Haase AD, Filipowicz W, Ramos A, Gherzi R, Rosenfeld MG.

Nature. 2009 Jun 18;459(7249):1010-4. doi: 10.1038/nature08025. Epub 2009 May 20.

29.

LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages.

Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe BD, McManus MT, Rosenfeld MG, Briata P, Gherzi R.

FASEB J. 2009 Sep;23(9):2898-908. doi: 10.1096/fj.09-131342. Epub 2009 May 7.

PMID:
19423639
30.

Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding.

Díaz-Moreno I, Hollingworth D, Frenkiel TA, Kelly G, Martin S, Howell S, García-Mayoral M, Gherzi R, Briata P, Ramos A.

Nat Struct Mol Biol. 2009 Mar;16(3):238-46. doi: 10.1038/nsmb.1558. Epub 2009 Feb 8.

31.

The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels.

Nechama M, Ben-Dov IZ, Briata P, Gherzi R, Naveh-Many T.

FASEB J. 2008 Oct;22(10):3458-68. doi: 10.1096/fj.08-107250. Epub 2008 Jun 26.

PMID:
18583400
32.

The structure of the C-terminal KH domains of KSRP reveals a noncanonical motif important for mRNA degradation.

García-Mayoral MF, Hollingworth D, Masino L, Díaz-Moreno I, Kelly G, Gherzi R, Chou CF, Chen CY, Ramos A.

Structure. 2007 Apr;15(4):485-98.

33.

Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling.

Ruggiero T, Trabucchi M, Ponassi M, Corte G, Chen CY, al-Haj L, Khabar KS, Briata P, Gherzi R.

BMC Mol Biol. 2007 Apr 16;8:28.

34.
35.

Stabilization of cellular mRNAs and up-regulation of proteins by oligoribonucleotides homologous to the Bcl2 adenine-uridine rich element motif.

Bevilacqua A, Ghisolfi L, Franzi S, Maresca G, Gherzi R, Capaccioli S, Nicolin A, Canti G.

Mol Pharmacol. 2007 Feb;71(2):531-8. Epub 2006 Oct 31.

PMID:
17077270
36.

Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay.

Chou CF, Mulky A, Maitra S, Lin WJ, Gherzi R, Kappes J, Chen CY.

Mol Cell Biol. 2006 May;26(10):3695-706.

37.

p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts.

Briata P, Forcales SV, Ponassi M, Corte G, Chen CY, Karin M, Puri PL, Gherzi R.

Mol Cell. 2005 Dec 22;20(6):891-903.

38.

The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B.

Schmidlin M, Lu M, Leuenberger SA, Stoecklin G, Mallaun M, Gross B, Gherzi R, Hess D, Hemmings BA, Moroni C.

EMBO J. 2004 Dec 8;23(24):4760-9. Epub 2004 Nov 11.

39.

A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.

Gherzi R, Lee KY, Briata P, Wegmüller D, Moroni C, Karin M, Chen CY.

Mol Cell. 2004 Jun 4;14(5):571-83.

40.

The Wnt/beta-catenin-->Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs.

Briata P, Ilengo C, Corte G, Moroni C, Rosenfeld MG, Chen CY, Gherzi R.

Mol Cell. 2003 Nov;12(5):1201-11.

41.

Bcl-2 protein is required for the adenine/uridine-rich element (ARE)-dependent degradation of its own messenger.

Bevilacqua A, Ceriani MC, Canti G, Asnaghi L, Gherzi R, Brewer G, Papucci L, Schiavone N, Capaccioli S, Nicolin A.

J Biol Chem. 2003 Jun 27;278(26):23451-9. Epub 2003 Apr 17.

42.

AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.

Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M.

Cell. 2001 Nov 16;107(4):451-64.

43.

Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation.

Chen CY, Gherzi R, Andersen JS, Gaietta G, Jürchott K, Royer HD, Mann M, Karin M.

Genes Dev. 2000 May 15;14(10):1236-48.

44.

Rat tenascin-R gene: structure, chromosome location and transcriptional activity of promoter and exon 1.

Leprini A, Gherzi R, Vecchi E, Borsi L, Zardi L, Siri A.

Cytogenet Cell Genet. 1998;83(1-2):115-23.

PMID:
9925948
45.
46.

Structure of 5' region of human tenascin-R gene and characterization of its promoter.

Gherzi R, Leprini A, Siri A, Zardi L.

DNA Cell Biol. 1998 Mar;17(3):275-82.

PMID:
9539107
47.

The c-Jun-induced transformation process involves complex regulation of tenascin-C expression.

Mettouchi A, Cabon F, Montreau N, Dejong V, Vernier P, Gherzi R, Mercier G, Binétruy B.

Mol Cell Biol. 1997 Jun;17(6):3202-9.

48.

The human homeodomain protein OTX2 binds to the human tenascin-C promoter and trans-represses its activity in transfected cells.

Gherzi R, Briata P, Boncinelli E, Ponassi M, Querzè G, Viti F, Corte G, Zardi L.

DNA Cell Biol. 1997 May;16(5):559-67.

PMID:
9174161
49.

Assignment of the tenascin-R gene (Tnr) to mouse chromosome 4 band E2 by fluorescence in situ hybridization; refinement of the human TNR location to chromosome 1q24.

Arrigo G, Gherzi R, Bonaglia MC, Leprini A, Zuffardi O, Zardi L.

Cytogenet Cell Genet. 1997;78(2):145-6. No abstract available.

PMID:
9371410
50.

The human tenascin-R gene.

Leprini A, Gherzi R, Siri A, Querzé G, Viti F, Zardi L.

J Biol Chem. 1996 Dec 6;271(49):31251-4.

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