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Items: 1 to 50 of 67

1.

Corrigendum to: "Complex II phosphorylation is triggered by unbalanced redox homeostasis in cells lacking complex III." [Biochim. Biophys. Acta 2018;1859(3):182-190.].

Tropeano CV, Fiori J, Carelli V, Caporali L, Daldal F, Ghelli AM, Rugolo M.

Biochim Biophys Acta Bioenerg. 2018 Dec;1859(12):1327. doi: 10.1016/j.bbabio.2018.06.010. Epub 2018 Jun 29. No abstract available.

PMID:
29909117
2.

Manipulation of Mitochondria Dynamics Reveals Separate Roles for Form and Function in Mitochondria Distribution.

Trevisan T, Pendin D, Montagna A, Bova S, Ghelli AM, Daga A.

Cell Rep. 2018 May 8;23(6):1742-1753. doi: 10.1016/j.celrep.2018.04.017.

3.

Unravelling the Effects of the Mutation m.3571insC/MT-ND1 on Respiratory Complexes Structural Organization.

Iommarini L, Ghelli A, Tropeano CV, Kurelac I, Leone G, Vidoni S, Lombes A, Zeviani M, Gasparre G, Porcelli AM.

Int J Mol Sci. 2018 Mar 7;19(3). pii: E764. doi: 10.3390/ijms19030764.

4.

Haplogroup J mitogenomes are the most sensitive to the pesticide rotenone: Relevance for human diseases.

Strobbe D, Caporali L, Iommarini L, Maresca A, Montopoli M, Martinuzzi A, Achilli A, Olivieri A, Torroni A, Carelli V, Ghelli A.

Neurobiol Dis. 2018 Jun;114:129-139. doi: 10.1016/j.nbd.2018.02.010. Epub 2018 Feb 24.

PMID:
29486301
5.

Complex II phosphorylation is triggered by unbalanced redox homeostasis in cells lacking complex III.

Tropeano CV, Fiori J, Carelli V, Caporali L, Daldal F, Ghelli AM, Rugolo M.

Biochim Biophys Acta Bioenerg. 2018 Mar;1859(3):182-190. doi: 10.1016/j.bbabio.2017.12.003. Epub 2017 Dec 18. Erratum in: Biochim Biophys Acta Bioenerg. 2018 Dec;1859(12):1327.

6.

Mild phenotypes and proper supercomplex assembly in human cells carrying the homoplasmic m.15557G > A mutation in cytochrome b gene.

Iommarini L, Ghelli A, Leone G, Tropeano CV, Kurelac I, Amato LB, Gasparre G, Porcelli AM.

Hum Mutat. 2018 Jan;39(1):92-102. doi: 10.1002/humu.23350. Epub 2017 Oct 12.

PMID:
28967163
7.

Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always.

Georg B, Ghelli A, Giordano C, Ross-Cisneros FN, Sadun AA, Carelli V, Hannibal J, La Morgia C.

Mitochondrion. 2017 Sep;36:77-84. doi: 10.1016/j.mito.2017.04.003. Epub 2017 Apr 12. Review.

PMID:
28412540
8.

Mitochondrial metabolism and energy sensing in tumor progression.

Iommarini L, Ghelli A, Gasparre G, Porcelli AM.

Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):582-590. doi: 10.1016/j.bbabio.2017.02.006. Epub 2017 Feb 14. Review.

9.

Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways.

Giordano L, Deceglie S, d'Adamo P, Valentino ML, La Morgia C, Fracasso F, Roberti M, Cappellari M, Petrosillo G, Ciaravolo S, Parente D, Giordano C, Maresca A, Iommarini L, Del Dotto V, Ghelli AM, Salomao SR, Berezovsky A, Belfort R Jr, Sadun AA, Carelli V, Loguercio Polosa P, Cantatore P.

Cell Death Dis. 2015 Dec 17;6:e2021. doi: 10.1038/cddis.2015.364.

10.

Targeting estrogen receptor β as preventive therapeutic strategy for Leber's hereditary optic neuropathy.

Pisano A, Preziuso C, Iommarini L, Perli E, Grazioli P, Campese AF, Maresca A, Montopoli M, Masuelli L, Sadun AA, d'Amati G, Carelli V, Ghelli A, Giordano C.

Hum Mol Genet. 2015 Dec 15;24(24):6921-31. doi: 10.1093/hmg/ddv396. Epub 2015 Sep 26.

PMID:
26410888
11.

A novel in-frame 18-bp microdeletion in MT-CYB causes a multisystem disorder with prominent exercise intolerance.

Carossa V, Ghelli A, Tropeano CV, Valentino ML, Iommarini L, Maresca A, Caporali L, La Morgia C, Liguori R, Barboni P, Carbonelli M, Rizzo G, Tonon C, Lodi R, Martinuzzi A, De Nardo V, Rugolo M, Ferretti L, Gandini F, Pala M, Achilli A, Olivieri A, Torroni A, Carelli V.

Hum Mutat. 2014 Aug;35(8):954-8. doi: 10.1002/humu.22596. Epub 2014 Jun 28.

PMID:
24863938
12.

Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells.

Calabrese C, Iommarini L, Kurelac I, Calvaruso MA, Capristo M, Lollini PL, Nanni P, Bergamini C, Nicoletti G, Giovanni CD, Ghelli A, Giorgio V, Caratozzolo MF, Marzano F, Manzari C, Betts CM, Carelli V, Ceccarelli C, Attimonelli M, Romeo G, Fato R, Rugolo M, Tullo A, Gasparre G, Porcelli AM.

Cancer Metab. 2013 Mar 18;1(1):11. doi: 10.1186/2049-3002-1-11.

13.

Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment.

Iommarini L, Kurelac I, Capristo M, Calvaruso MA, Giorgio V, Bergamini C, Ghelli A, Nanni P, De Giovanni C, Carelli V, Fato R, Lollini PL, Rugolo M, Gasparre G, Porcelli AM.

Hum Mol Genet. 2014 Mar 15;23(6):1453-66. doi: 10.1093/hmg/ddt533. Epub 2013 Oct 24.

PMID:
24163135
14.

Molecular mechanisms of superoxide production by complex III: a bacterial versus human mitochondrial comparative case study.

Lanciano P, Khalfaoui-Hassani B, Selamoglu N, Ghelli A, Rugolo M, Daldal F.

Biochim Biophys Acta. 2013 Nov-Dec;1827(11-12):1332-9. doi: 10.1016/j.bbabio.2013.03.009. Epub 2013 Mar 28. Review.

15.

The cytochrome b p.278Y>C mutation causative of a multisystem disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes.

Ghelli A, Tropeano CV, Calvaruso MA, Marchesini A, Iommarini L, Porcelli AM, Zanna C, De Nardo V, Martinuzzi A, Wibrand F, Vissing J, Kurelac I, Gasparre G, Selamoglu N, Daldal F, Rugolo M.

Hum Mol Genet. 2013 Jun 1;22(11):2141-51. doi: 10.1093/hmg/ddt067. Epub 2013 Feb 14.

16.

Cybrid studies establish the causal link between the mtDNA m.3890G>A/MT-ND1 mutation and optic atrophy with bilateral brainstem lesions.

Caporali L, Ghelli AM, Iommarini L, Maresca A, Valentino ML, La Morgia C, Liguori R, Zanna C, Barboni P, De Nardo V, Martinuzzi A, Rizzo G, Tonon C, Lodi R, Calvaruso MA, Cappelletti M, Porcelli AM, Achilli A, Pala M, Torroni A, Carelli V.

Biochim Biophys Acta. 2013 Mar;1832(3):445-52. doi: 10.1016/j.bbadis.2012.12.002. Epub 2012 Dec 14.

17.

The effects of idebenone on mitochondrial bioenergetics.

Giorgio V, Petronilli V, Ghelli A, Carelli V, Rugolo M, Lenaz G, Bernardi P.

Biochim Biophys Acta. 2012 Feb;1817(2):363-9. doi: 10.1016/j.bbabio.2011.10.012. Epub 2011 Nov 4.

18.

Mitochondrial complex I and cell death: a semi-automatic shotgun model.

Gonzalez-Halphen D, Ghelli A, Iommarini L, Carelli V, Esposti MD.

Cell Death Dis. 2011 Oct 27;2:e222. doi: 10.1038/cddis.2011.107. Review.

19.

A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.

Gasparre G, Kurelac I, Capristo M, Iommarini L, Ghelli A, Ceccarelli C, Nicoletti G, Nanni P, De Giovanni C, Scotlandi K, Betts CM, Carelli V, Lollini PL, Romeo G, Rugolo M, Porcelli AM.

Cancer Res. 2011 Oct 1;71(19):6220-9. doi: 10.1158/0008-5472.CAN-11-1042. Epub 2011 Aug 18.

20.

A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16.

Carelli V, Schimpf S, Fuhrmann N, Valentino ML, Zanna C, Iommarini L, Papke M, Schaich S, Tippmann S, Baumann B, Barboni P, Longanesi L, Rugolo M, Ghelli A, Alavi MV, Youle RJ, Bucchi L, Carroccia R, Giannoccaro MP, Tonon C, Lodi R, Cenacchi G, Montagna P, Liguori R, Wissinger B.

Hum Mol Genet. 2011 May 15;20(10):1893-905. doi: 10.1093/hmg/ddr071. Epub 2011 Feb 24.

PMID:
21349918
21.

Oestrogens ameliorate mitochondrial dysfunction in Leber's hereditary optic neuropathy.

Giordano C, Montopoli M, Perli E, Orlandi M, Fantin M, Ross-Cisneros FN, Caparrotta L, Martinuzzi A, Ragazzi E, Ghelli A, Sadun AA, d'Amati G, Carelli V.

Brain. 2011 Jan;134(Pt 1):220-34. doi: 10.1093/brain/awq276. Epub 2010 Oct 13.

22.

The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization.

Porcelli AM, Ghelli A, Ceccarelli C, Lang M, Cenacchi G, Capristo M, Pennisi LF, Morra I, Ciccarelli E, Melcarne A, Bartoletti-Stella A, Salfi N, Tallini G, Martinuzzi A, Carelli V, Attimonelli M, Rugolo M, Romeo G, Gasparre G.

Hum Mol Genet. 2010 Mar 15;19(6):1019-32. doi: 10.1093/hmg/ddp566. Epub 2009 Dec 22.

PMID:
20028790
23.

The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity.

Ghelli A, Porcelli AM, Zanna C, Vidoni S, Mattioli S, Barbieri A, Iommarini L, Pala M, Achilli A, Torroni A, Rugolo M, Carelli V.

PLoS One. 2009 Nov 19;4(11):e7922. doi: 10.1371/journal.pone.0007922.

24.

An inherited mitochondrial DNA disruptive mutation shifts to homoplasmy in oncocytic tumor cells.

Gasparre G, Iommarini L, Porcelli AM, Lang M, Ferri GG, Kurelac I, Zuntini R, Mariani E, Pennisi LF, Pasquini E, Pasquinelli G, Ghelli A, Bonora E, Ceccarelli C, Rugolo M, Salfi N, Romeo G, Carelli V.

Hum Mutat. 2009 Mar;30(3):391-6. doi: 10.1002/humu.20870.

PMID:
19086058
25.

Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels.

Porcelli AM, Angelin A, Ghelli A, Mariani E, Martinuzzi A, Carelli V, Petronilli V, Bernardi P, Rugolo M.

J Biol Chem. 2009 Jan 23;284(4):2045-52. doi: 10.1074/jbc.M807321200. Epub 2008 Dec 1.

26.

The antioxidant function of Bcl-2 preserves cytoskeletal stability of cells with defective respiratory complex I.

Porcelli AM, Ghelli A, Iommarini L, Mariani E, Hoque M, Zanna C, Gasparre G, Rugolo M.

Cell Mol Life Sci. 2008 Sep;65(18):2943-51. doi: 10.1007/s00018-008-8300-2.

PMID:
18695940
27.

Protection against oxidant-induced apoptosis by exogenous glutathione in Leber hereditary optic neuropathy cybrids.

Ghelli A, Porcelli AM, Zanna C, Martinuzzi A, Carelli V, Rugolo M.

Invest Ophthalmol Vis Sci. 2008 Feb;49(2):671-6. doi: 10.1167/iovs.07-0880.

PMID:
18235013
28.

OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion.

Zanna C, Ghelli A, Porcelli AM, Karbowski M, Youle RJ, Schimpf S, Wissinger B, Pinti M, Cossarizza A, Vidoni S, Valentino ML, Rugolo M, Carelli V.

Brain. 2008 Feb;131(Pt 2):352-67. doi: 10.1093/brain/awm335.

PMID:
18222991
29.

Green tea modulates alpha(1)-adrenergic stimulated glucose transport in cultured rat cardiomyocytes.

Angeloni C, Maraldi T, Ghelli A, Rugolo M, Leoncini E, Hakim G, Hrelia S.

J Agric Food Chem. 2007 Sep 5;55(18):7553-8. Epub 2007 Aug 4.

PMID:
17676868
30.

Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.

Gasparre G, Porcelli AM, Bonora E, Pennisi LF, Toller M, Iommarini L, Ghelli A, Moretti M, Betts CM, Martinelli GN, Ceroni AR, Curcio F, Carelli V, Rugolo M, Tallini G, Romeo G.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):9001-6. Epub 2007 May 15.

31.

Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.

Bonora E, Porcelli AM, Gasparre G, Biondi A, Ghelli A, Carelli V, Baracca A, Tallini G, Martinuzzi A, Lenaz G, Rugolo M, Romeo G.

Cancer Res. 2006 Jun 15;66(12):6087-96.

32.

Caspase-independent death of Leber's hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G.

Zanna C, Ghelli A, Porcelli AM, Martinuzzi A, Carelli V, Rugolo M.

Apoptosis. 2005 Oct;10(5):997-1007.

PMID:
16151635
33.

pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant.

Porcelli AM, Ghelli A, Zanna C, Pinton P, Rizzuto R, Rugolo M.

Biochem Biophys Res Commun. 2005 Jan 28;326(4):799-804.

PMID:
15607740
34.

The ND1 gene of complex I is a mutational hot spot for Leber's hereditary optic neuropathy.

Valentino ML, Barboni P, Ghelli A, Bucchi L, Rengo C, Achilli A, Torroni A, Lugaresi A, Lodi R, Barbiroli B, Dotti M, Federico A, Baruzzi A, Carelli V.

Ann Neurol. 2004 Nov;56(5):631-41.

PMID:
15505787
35.

Bioenergetics shapes cellular death pathways in Leber's hereditary optic neuropathy: a model of mitochondrial neurodegeneration.

Carelli V, Rugolo M, Sgarbi G, Ghelli A, Zanna C, Baracca A, Lenaz G, Napoli E, Martinuzzi A, Solaini G.

Biochim Biophys Acta. 2004 Jul 23;1658(1-2):172-9. Review.

36.

Staurosporine induces apoptotic volume decrease (AVD) in ECV304 cells.

Porcelli AM, Ghelli A, Zanna C, Valente P, Ferroni S, Rugolo M.

Ann N Y Acad Sci. 2003 Dec;1010:342-6.

PMID:
15033748
37.

Apoptotic cell death of cybrid cells bearing Leber's hereditary optic neuropathy mutations is caspase independent.

Zanna C, Ghelli A, Porcelli AM, Carelli V, Martinuzzi A, Rugolo M.

Ann N Y Acad Sci. 2003 Dec;1010:213-7.

PMID:
15033723
38.

Apoptosis induced by staurosporine in ECV304 cells requires cell shrinkage and upregulation of Cl- conductance.

Porcelli AM, Ghelli A, Zanna C, Valente P, Ferroni S, Rugolo M.

Cell Death Differ. 2004 Jun;11(6):655-62.

39.

Leber's hereditary optic neuropathy (LHON) pathogenic mutations induce mitochondrial-dependent apoptotic death in transmitochondrial cells incubated with galactose medium.

Ghelli A, Zanna C, Porcelli AM, Schapira AH, Martinuzzi A, Carelli V, Rugolo M.

J Biol Chem. 2003 Feb 7;278(6):4145-50. Epub 2002 Nov 21.

40.
42.
44.

Ubiquinone and inhibitor sites in complex I: one, two or three?

Esposti MD, Ghelli A.

Biochem Soc Trans. 1999 Aug;27(4):606-9. No abstract available.

PMID:
10917651
45.

Biochemical features of mtDNA 14484 (ND6/M64V) point mutation associated with Leber's hereditary optic neuropathy.

Carelli V, Ghelli A, Bucchi L, Montagna P, De Negri A, Leuzzi V, Carducci C, Lenaz G, Lugaresi E, Degli Esposti M.

Ann Neurol. 1999 Mar;45(3):320-8.

PMID:
10072046
46.

Protonophoric activity of NADH coenzyme Q reductase and ATP synthase in coupled submitochondrial particles from horse platelets.

Baracca A, Bucchi L, Ghelli A, Lenaz G.

Biochem Biophys Res Commun. 1997 Jun 27;235(3):469-73.

PMID:
9207178
47.

Leber's hereditary optic neuropathy: biochemical effect of 11778/ND4 and 3460/ND1 mutations and correlation with the mitochondrial genotype.

Carelli V, Ghelli A, Ratta M, Bacchilega E, Sangiorgi S, Mancini R, Leuzzi V, Cortelli P, Montagna P, Lugaresi E, Degli Esposti M.

Neurology. 1997 Jun;48(6):1623-32.

PMID:
9191778
48.

Measurement of the membrane potential generated by complex I in submitochondrial particles.

Ghelli A, Benelli B, Esposti MD.

J Biochem. 1997 Apr;121(4):746-55.

49.

Proton pumping of mitochondrial complex I: differential activation by analogs of ubiquinone.

Helfenbaum L, Ngo A, Ghelli A, Linnane AW, Degli Esposti M.

J Bioenerg Biomembr. 1997 Feb;29(1):71-80.

PMID:
9067804
50.

Changes in mitochondrial complex I activity and coenzyme Q binding site in Leber's hereditary optic neuropathy (LHON).

Ghelli A, Degli Esposti M, Carelli V, Lenaz G.

Mol Aspects Med. 1997;18 Suppl:S263-7.

PMID:
9266534

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