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Items: 1 to 50 of 164

1.

Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development.

Mastellos DC, Blom AM, Connolly ES, Daha MR, Geisbrecht BV, Ghebrehiwet B, Gros P, Hajishengallis G, Holers VM, Huber-Lang M, Kinoshita T, Mollnes TE, Montgomery RA, Morgan BP, Nilsson B, Pio R, Ricklin D, Risitano AM, Taylor RP, Mantovani A, Ioannidis JPA, Lambris JD.

Nat Immunol. 2019 Oct 11. doi: 10.1038/s41590-019-0531-x. [Epub ahead of print]

PMID:
31605100
2.

'Stealth' corporate innovation: an emerging threat for therapeutic drug development.

Mastellos DC, Blom AM, Connolly ES, Daha MR, Geisbrecht BV, Ghebrehiwet B, Gros P, Hajishengallis G, Holers VM, Huber-Lang M, Kinoshita T, Mollnes TE, Montgomery RA, Morgan BP, Nilsson B, Pio R, Ricklin D, Risitano AM, Taylor RP, Mantovani A, Ioannidis JPA, Lambris JD.

Nat Immunol. 2019 Sep 27. doi: 10.1038/s41590-019-0503-1. [Epub ahead of print] No abstract available. Erratum in: Nat Immunol. 2019 Oct 11;:.

PMID:
31562490
3.

Is the A-Chain the Engine That Drives the Diversity of C1q Functions? Revisiting Its Unique Structure.

Ghebrehiwet B, Kandov E, Kishore U, Peerschke EIB.

Front Immunol. 2018 Feb 5;9:162. doi: 10.3389/fimmu.2018.00162. eCollection 2018.

4.

Complement Protein C1q Interacts with DC-SIGN via Its Globular Domain and Thus May Interfere with HIV-1 Transmission.

Pednekar L, Pandit H, Paudyal B, Kaur A, Al-Mozaini MA, Kouser L, Ghebrehiwet B, Mitchell DA, Madan T, Kishore U.

Front Immunol. 2016 Dec 22;7:600. doi: 10.3389/fimmu.2016.00600. eCollection 2016.

5.

Analysis of the Interaction between Globular Head Modules of Human C1q and Its Candidate Receptor gC1qR.

Pednekar L, Pathan AA, Paudyal B, Tsolaki AG, Kaur A, Abozaid SM, Kouser L, Khan HA, Peerschke EI, Shamji MH, Stenbeck G, Ghebrehiwet B, Kishore U.

Front Immunol. 2016 Dec 13;7:567. doi: 10.3389/fimmu.2016.00567. eCollection 2016.

6.

The complement system: an evolution in progress.

Ghebrehiwet B.

F1000Res. 2016 Dec 12;5:2840. eCollection 2016. Review.

7.

C1q as an autocrine and paracrine regulator of cellular functions.

Ghebrehiwet B, Hosszu KH, Peerschke EI.

Mol Immunol. 2017 Apr;84:26-33. doi: 10.1016/j.molimm.2016.11.003. Epub 2016 Nov 30. Review.

8.

Platelet activation, adhesion, inflammation, and aggregation potential are altered in the presence of electronic cigarette extracts of variable nicotine concentrations.

Hom S, Chen L, Wang T, Ghebrehiwet B, Yin W, Rubenstein DA.

Platelets. 2016 Nov;27(7):694-702. Epub 2016 Apr 20.

PMID:
27096416
9.

The complement and contact activation systems: partnership in pathogenesis beyond angioedema.

Ghebrehiwet B, Kaplan AP, Joseph K, Peerschke EI.

Immunol Rev. 2016 Nov;274(1):281-289. doi: 10.1111/imr.12469. Review.

PMID:
27782339
10.

Identification of the gC1qR sites for the HIV-1 viral envelope protein gp41 and the HCV core protein: Implications in viral-specific pathogenesis and therapy.

Pednekar L, Valentino A, Ji Y, Tumma N, Valentino C, Kadoor A, Hosszu KK, Ramadass M, Kew RR, Kishore U, Peerschke EI, Ghebrehiwet B.

Mol Immunol. 2016 Jun;74:18-26. doi: 10.1016/j.molimm.2016.03.016. Epub 2016 Apr 23.

11.

Soluble gC1qR in Blood and Body Fluids: Examination in a Pancreatic Cancer Patient Cohort.

Peerschke EI, Brandwijk RJ, Dembitzer FR, Kinoshita Y, Ghebrehiwet B.

Int J Cancer Res Mol Mech. 2015 Oct;1(3). doi: 10.16966/ijcrmm.110. Epub 2015 Sep 3.

12.

Structural and Functional Characterization of a Single-Chain Form of the Recognition Domain of Complement Protein C1q.

Moreau C, Bally I, Chouquet A, Bottazzi B, Ghebrehiwet B, Gaboriaud C, Thielens N.

Front Immunol. 2016 Mar 2;7:79. doi: 10.3389/fimmu.2016.00079. eCollection 2016.

13.

Tobacco and e-cigarette products initiate Kupffer cell inflammatory responses.

Rubenstein DA, Hom S, Ghebrehiwet B, Yin W.

Mol Immunol. 2015 Oct;67(2 Pt B):652-60. doi: 10.1016/j.molimm.2015.05.020. Epub 2015 Jun 11.

PMID:
26072673
14.

The combined effect of sidestream smoke and dynamic shear stress on endothelial cell inflammatory responses.

Yin W, Ngwe EC, Ghebrehiwet B, Rubenstein DA.

Thromb Res. 2015 Feb;135(2):362-7. doi: 10.1016/j.thromres.2014.11.018. Epub 2014 Nov 22.

PMID:
25467082
15.

Enhanced recognition of plasma proteins in a non-native state by complement C3b. A possible clearance mechanism for damaged proteins in blood.

Ramadass M, Ghebrehiwet B, Kew RR.

Mol Immunol. 2015 Mar;64(1):55-62. doi: 10.1016/j.molimm.2014.10.022. Epub 2014 Nov 15.

16.

A novel assay to diagnose hereditary angioedema utilizing inhibition of bradykinin-forming enzymes.

Joseph K, Bains S, Tholanikunnel BG, Bygum A, Aabom A, Koch C, Farkas H, Varga L, Ghebrehiwet B, Kaplan AP.

Allergy. 2015 Jan;70(1):115-9. doi: 10.1111/all.12520. Epub 2014 Oct 15.

PMID:
25186184
17.

cC1qR/CR and gC1qR/p33: observations in cancer.

Peerschke EI, Ghebrehiwet B.

Mol Immunol. 2014 Oct;61(2):100-9. doi: 10.1016/j.molimm.2014.06.011. Epub 2014 Jul 16. Review.

PMID:
25044096
18.

Monocyte Expressed Macromolecular C1 and C1q Receptors as Molecular Sensors of Danger: Implications in SLE.

Ghebrehiwet B, Hosszu KK, Valentino A, Ji Y, Peerschke EI.

Front Immunol. 2014 Jun 26;5:278. doi: 10.3389/fimmu.2014.00278. eCollection 2014. Review.

19.

C1q as a unique player in angiogenesis with therapeutic implication in wound healing.

Bossi F, Tripodo C, Rizzi L, Bulla R, Agostinis C, Guarnotta C, Munaut C, Baldassarre G, Papa G, Zorzet S, Ghebrehiwet B, Ling GS, Botto M, Tedesco F.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4209-14. doi: 10.1073/pnas.1311968111. Epub 2014 Mar 3.

20.

Generation of multiple fluid-phase C3b:plasma protein complexes during complement activation: possible implications in C3 glomerulopathies.

Ramadass M, Ghebrehiwet B, Smith RJ, Kew RR.

J Immunol. 2014 Feb 1;192(3):1220-30. doi: 10.4049/jimmunol.1302288. Epub 2013 Dec 23.

21.

Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells.

Ghebrehiwet B, Ji Y, Valentino A, Pednekar L, Ramadass M, Habiel D, Kew RR, Hosszu KH, Galanakis DK, Kishore U, Peerschke EI.

J Immunol. 2014 Jan 1;192(1):377-84. doi: 10.4049/jimmunol.1302031. Epub 2013 Dec 6.

22.

Purification of C1q receptors and functional analysis.

Ghebrehiwet B, Peerschke EI.

Methods Mol Biol. 2014;1100:319-27. doi: 10.1007/978-1-62703-724-2_26.

PMID:
24218271
23.

Factor XII-independent activation of the bradykinin-forming cascade: Implications for the pathogenesis of hereditary angioedema types I and II.

Joseph K, Tholanikunnel BG, Bygum A, Ghebrehiwet B, Kaplan AP.

J Allergy Clin Immunol. 2013 Aug;132(2):470-5. doi: 10.1016/j.jaci.2013.03.026. Epub 2013 May 11.

PMID:
23672780
24.

Targeting gC1qR domains for therapy against infection and inflammation.

Ghebrehiwet B, Jesty J, Vinayagasundaram R, Vinayagasundaram U, Ji Y, Valentino A, Tumma N, Hosszu KH, Peerschke EI.

Adv Exp Med Biol. 2013;735:97-110. Review.

PMID:
23402021
25.

DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.

Hosszu KK, Valentino A, Vinayagasundaram U, Vinayagasundaram R, Joyce MG, Ji Y, Peerschke EI, Ghebrehiwet B.

Blood. 2012 Aug 9;120(6):1228-36. doi: 10.1182/blood-2011-07-369728. Epub 2012 Jun 13.

26.

gC1qR expression in normal and pathologic human tissues: differential expression in tissues of epithelial and mesenchymal origin.

Dembitzer FR, Kinoshita Y, Burstein D, Phelps RG, Beasley MB, Garcia R, Harpaz N, Jaffer S, Thung SN, Unger PD, Ghebrehiwet B, Peerschke EI.

J Histochem Cytochem. 2012 Jun;60(6):467-74. doi: 10.1369/0022155412440882.

27.

Cell surface expression and function of the macromolecular c1 complex on the surface of human monocytes.

Hosszu KK, Valentino A, Ji Y, Matkovic M, Pednekar L, Rehage N, Tumma N, Peerschke EI, Ghebrehiwet B.

Front Immunol. 2012 Mar 5;3:38. doi: 10.3389/fimmu.2012.00038. eCollection 2012.

28.

The C1q family of proteins: insights into the emerging non-traditional functions.

Ghebrehiwet B, Hosszu KK, Valentino A, Peerschke EI.

Front Immunol. 2012 Apr 5;3. pii: 52.

29.

Structure-function studies using deletion mutants identify domains of gC1qR/p33 as potential therapeutic targets for vascular permeability and inflammation.

Ghebrehiwet B, Jesty J, Xu S, Vinayagasundaram R, Vinayagasundaram U, Ji Y, Valentino A, Hosszu KK, Mathew S, Joseph K, Kaplan AP, Peerschke EI.

Front Immunol. 2011 Nov 1;2. pii: 58.

30.

Cofactor regulation of C5a chemotactic activity in physiological fluids. Requirement for the vitamin D binding protein, thrombospondin-1 and its receptors.

Trujillo G, Zhang J, Habiel DM, Ge L, Ramadass M, Ghebrehiwet B, Kew RR.

Mol Immunol. 2011 Dec;49(3):495-503. doi: 10.1016/j.molimm.2011.09.024. Epub 2011 Oct 19.

31.

Cross-talk between the complement and the kinin system in vascular permeability.

Bossi F, Peerschke EI, Ghebrehiwet B, Tedesco F.

Immunol Lett. 2011 Oct 30;140(1-2):7-13. doi: 10.1016/j.imlet.2011.06.006. Epub 2011 Jul 6. Review.

32.

Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by surface plasmon resonance (BiaCore).

Pixley RA, Espinola RG, Ghebrehiwet B, Joseph K, Kao A, Bdeir K, Cines DB, Colman RW.

Thromb Haemost. 2011 Jun;105(6):1053-9. doi: 10.1160/TH10-09-0591. Epub 2011 May 5.

33.

Blockade of gC1qR/p33, a receptor for C1q, inhibits adherence of Staphylococcus aureus to the microvascular endothelium.

Sethi S, Herrmann M, Roller J, von Müller L, Peerschke EI, Ghebrehiwet B, Bajric I, Menger MD, Laschke MW.

Microvasc Res. 2011 Jul;82(1):66-72. doi: 10.1016/j.mvr.2011.04.007. Epub 2011 Apr 22.

34.

An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development.

Agostinis C, Bulla R, Tripodo C, Gismondi A, Stabile H, Bossi F, Guarnotta C, Garlanda C, De Seta F, Spessotto P, Santoni A, Ghebrehiwet B, Girardi G, Tedesco F.

J Immunol. 2010 Oct 1;185(7):4420-9. doi: 10.4049/jimmunol.0903215. Epub 2010 Sep 1.

35.

Complement activation on platelets: implications for vascular inflammation and thrombosis.

Peerschke EI, Yin W, Ghebrehiwet B.

Mol Immunol. 2010 Aug;47(13):2170-5. doi: 10.1016/j.molimm.2010.05.009. Epub 2010 Jun 1. Review.

36.

The plasma bradykinin-forming pathways and its interrelationships with complement.

Kaplan AP, Ghebrehiwet B.

Mol Immunol. 2010 Aug;47(13):2161-9. doi: 10.1016/j.molimm.2010.05.010. Review.

PMID:
20580091
37.

Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damage.

Sansonno D, Tucci FA, Ghebrehiwet B, Lauletta G, Peerschke EI, Conteduca V, Russi S, Gatti P, Sansonno L, Dammacco F.

J Immunol. 2009 Nov 1;183(9):6013-20. doi: 10.4049/jimmunol.0902038. Epub 2009 Oct 14.

38.

Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency.

Bossi F, Fischetti F, Regoli D, Durigutto P, Frossi B, Gobeil F Jr, Ghebrehiwet B, Peerschke EI, Cicardi M, Tedesco F.

J Allergy Clin Immunol. 2009 Dec;124(6):1303-10.e4. doi: 10.1016/j.jaci.2009.08.007.

39.

Evidence that a C1q/C1qR system regulates monocyte-derived dendritic cell differentiation at the interface of innate and acquired immunity.

Hosszu KK, Santiago-Schwarz F, Peerschke EI, Ghebrehiwet B.

Innate Immun. 2010 Apr;16(2):115-27. doi: 10.1177/1753425909339815. Epub 2009 Aug 26.

40.

Serum complement activation on heterologous platelets is associated with arterial thrombosis in patients with systemic lupus erythematosus and antiphospholipid antibodies.

Peerschke EI, Yin W, Alpert DR, Roubey RA, Salmon JE, Ghebrehiwet B.

Lupus. 2009 May;18(6):530-8. doi: 10.1177/0961203308099974.

41.

Platelet mediated complement activation.

Peerschke EI, Yin W, Ghebrehiwet B.

Adv Exp Med Biol. 2008;632:81-91. Review.

42.

Expression of complement components and inhibitors on platelet microparticles.

Yin W, Ghebrehiwet B, Peerschke EI.

Platelets. 2008 May;19(3):225-33. doi: 10.1080/09537100701777311.

43.

Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium.

Bulla R, Agostinis C, Bossi F, Rizzi L, Debeus A, Tripodo C, Radillo O, De Seta F, Ghebrehiwet B, Tedesco F.

Mol Immunol. 2008 May;45(9):2629-40. doi: 10.1016/j.molimm.2007.12.025. Epub 2008 Mar 4.

44.

C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition.

Païdassi H, Tacnet-Delorme P, Garlatti V, Darnault C, Ghebrehiwet B, Gaboriaud C, Arlaud GJ, Frachet P.

J Immunol. 2008 Feb 15;180(4):2329-38.

45.

Trimeric reassembly of the globular domain of human C1q.

Tacnet P, Cheong EC, Goeltz P, Ghebrehiwet B, Arlaud GJ, Liu XY, Lesieur C.

Biochim Biophys Acta. 2008 Mar;1784(3):518-29. doi: 10.1016/j.bbapap.2007.12.005. Epub 2007 Dec 15.

46.

Regulated complement deposition on the surface of human endothelial cells: effect of tobacco smoke and shear stress.

Yin W, Ghebrehiwet B, Weksler B, Peerschke EI.

Thromb Res. 2008;122(2):221-8. doi: 10.1016/j.thromres.2007.11.005. Epub 2007 Dec 31.

47.

The exosporium of B. cereus contains a binding site for gC1qR/p33: implication in spore attachment and/or entry.

Ghebrehiwet B, Tantral L, Titmus MA, Panessa-Warren BJ, Tortora GT, Wong SS, Warren JB.

Adv Exp Med Biol. 2007;598:181-97.

48.

The contribution of gC1qR/p33 in infection and inflammation.

Peerschke EI, Ghebrehiwet B.

Immunobiology. 2007;212(4-5):333-42. Epub 2007 Jan 3.

49.

Classical pathway complement activation on human endothelial cells.

Yin W, Ghebrehiwet B, Weksler B, Peerschke EI.

Mol Immunol. 2007 Mar;44(9):2228-34. Epub 2006 Dec 14.

50.

Blood platelets activate the classical pathway of human complement.

Peerschke EI, Yin W, Grigg SE, Ghebrehiwet B.

J Thromb Haemost. 2006 Sep;4(9):2035-42.

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