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Items: 25


Senescent Breast Luminal Cells Promote Carcinogenesis through Interleukin-8-Dependent Activation of Stromal Fibroblasts.

Al-Khalaf HH, Ghebeh H, Inass R, Aboussekhra A.

Mol Cell Biol. 2019 Jan 3;39(2). pii: e00359-18. doi: 10.1128/MCB.00359-18. Print 2019 Jan 15.


Novel CARMIL2 Mutations in Patients with Variable Clinical Dermatitis, Infections, and Combined Immunodeficiency.

Alazami AM, Al-Helale M, Alhissi S, Al-Saud B, Alajlan H, Monies D, Shah Z, Abouelhoda M, Arnaout R, Al-Dhekri H, Al-Numair NS, Ghebeh H, Sheikh F, Al-Mousa H.

Front Immunol. 2018 Feb 9;9:203. doi: 10.3389/fimmu.2018.00203. eCollection 2018.


PD-L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation.

Almozyan S, Colak D, Mansour F, Alaiya A, Al-Harazi O, Qattan A, Al-Mohanna F, Al-Alwan M, Ghebeh H.

Int J Cancer. 2017 Oct 1;141(7):1402-1412. doi: 10.1002/ijc.30834. Epub 2017 Jun 30.


Fascin Is Critical for the Maintenance of Breast Cancer Stem Cell Pool Predominantly via the Activation of the Notch Self-Renewal Pathway.

Barnawi R, Al-Khaldi S, Majed Sleiman G, Sarkar A, Al-Dhfyan A, Al-Mohanna F, Ghebeh H, Al-Alwan M.

Stem Cells. 2016 Dec;34(12):2799-2813. doi: 10.1002/stem.2473. Epub 2016 Aug 21.


Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: significance in claudin-low breast cancer cells.

Alsuliman A, Colak D, Al-Harazi O, Fitwi H, Tulbah A, Al-Tweigeri T, Al-Alwan M, Ghebeh H.

Mol Cancer. 2015 Aug 7;14:149. doi: 10.1186/s12943-015-0421-2.


Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.

Maayah ZH, Ghebeh H, Alhaider AA, El-Kadi AO, Soshilov AA, Denison MS, Ansari MA, Korashy HM.

Toxicol Appl Pharmacol. 2015 Apr 15;284(2):217-26. doi: 10.1016/j.taap.2015.02.007. Epub 2015 Feb 17.


Fascin is involved in the chemotherapeutic resistance of breast cancer cells predominantly via the PI3K/Akt pathway.

Ghebeh H, Al-Khaldi S, Olabi S, Al-Dhfyan A, Al-Mohanna F, Barnawi R, Tulbah A, Al-Tweigeri T, Ajarim D, Al-Alwan M.

Br J Cancer. 2014 Oct 14;111(8):1552-61. doi: 10.1038/bjc.2014.453. Epub 2014 Aug 12.


Differential marker expression by cultures rich in mesenchymal stem cells.

Wetzig A, Alaiya A, Al-Alwan M, Pradez CB, Pulicat MS, Al-Mazrou A, Shinwari Z, Sleiman GM, Ghebeh H, Al-Humaidan H, Gaafar A, Kanaan I, Adra C.

BMC Cell Biol. 2013 Dec 5;14:54. doi: 10.1186/1471-2121-14-54.


Prevalence of PIK3CA mutations and the SNP rs17849079 in Arab breast cancer patients.

Karakas B, Colak D, Kaya N, Ghebeh H, Al-Qasem A, Hendrayani F, Toulimat M, Al-Tweigeri T, Park BH, Aboussekhra A.

Cancer Biol Ther. 2013 Oct 1;14(10):888-96. doi: 10.4161/cbt.25945. Epub 2013 Aug 12.


Profiling of normal and malignant breast tissue show CD44high/CD24low phenotype as a predominant stem/progenitor marker when used in combination with Ep-CAM/CD49f markers.

Ghebeh H, Sleiman GM, Manogaran PS, Al-Mazrou A, Barhoush E, Al-Mohanna FH, Tulbah A, Al-Faqeeh K, Adra CN.

BMC Cancer. 2013 Jun 14;13:289. doi: 10.1186/1471-2407-13-289.


Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules.

Al-Alwan M, Olabi S, Ghebeh H, Barhoush E, Tulbah A, Al-Tweigeri T, Ajarim D, Adra C.

PLoS One. 2011;6(11):e27339. doi: 10.1371/journal.pone.0027339. Epub 2011 Nov 4.


Therapeutic targeting of B7-H1 in breast cancer.

Hasan A, Ghebeh H, Lehe C, Ahmad R, Dermime S.

Expert Opin Ther Targets. 2011 Oct;15(10):1211-25. doi: 10.1517/14728222.2011.613826. Epub 2011 Aug 28. Review.


Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast cancer cells: role of B7-H1 as an anti-apoptotic molecule.

Ghebeh H, Lehe C, Barhoush E, Al-Romaih K, Tulbah A, Al-Alwan M, Hendrayani SF, Manogaran P, Alaiya A, Al-Tweigeri T, Aboussekhra A, Dermime S.

Breast Cancer Res. 2010;12(4):R48. doi: 10.1186/bcr2605. Epub 2010 Jul 13.


Enhancement of lytic activity of leukemic cells by CD8+ cytotoxic T lymphocytes generated against a WT1 peptide analogue.

Al Qudaihi G, Lehe C, Negash M, Al-Alwan M, Ghebeh H, Mohamed SY, Saleh AJ, Al-Humaidan H, Tbakhi A, Dickinson A, Aljurf M, Dermime S.

Leuk Lymphoma. 2009 Feb;50(2):260-9. doi: 10.1080/10428190802578478.


The Wilms' tumor antigen is a novel target for human CD4+ regulatory T cells: implications for immunotherapy.

Lehe C, Ghebeh H, Al-Sulaiman A, Al Qudaihi G, Al-Hussein K, Almohareb F, Chaudhri N, Alsharif F, Al-Zahrani H, Tbakhi A, Aljurf M, Dermime S.

Cancer Res. 2008 Aug 1;68(15):6350-9. doi: 10.1158/0008-5472.CAN-08-0050.


Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes.

Hawsawi NM, Ghebeh H, Hendrayani SF, Tulbah A, Al-Eid M, Al-Tweigeri T, Ajarim D, Alaiya A, Dermime S, Aboussekhra A.

Cancer Res. 2008 Apr 15;68(8):2717-25. doi: 10.1158/0008-5472.CAN-08-0192.


Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: a study in baboon model.

Roberts GT, Ghebeh H, Chishti MA, Al-Mohanna F, El-Sayed R, Al-Mohanna F, Bouchama A.

Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1130-6. doi: 10.1161/ATVBAHA.107.158709. Epub 2008 Apr 3.


Pluronic enhances the robustness and reduces the cell attachment of mammalian cells.

Tharmalingam T, Ghebeh H, Wuerz T, Butler M.

Mol Biotechnol. 2008 Jun;39(2):167-77. doi: 10.1007/s12033-008-9045-8.


FOXP3+ Tregs and B7-H1+/PD-1+ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy.

Ghebeh H, Barhoush E, Tulbah A, Elkum N, Al-Tweigeri T, Dermime S.

BMC Cancer. 2008 Feb 23;8:57. doi: 10.1186/1471-2407-8-57.


Cancer stem cell immunotherapy: the right bullet for the right target.

Ghebeh H, Bakr MM, Dermime S.

Hematol Oncol Stem Cell Ther. 2008 Jan-Mar;1(1):1-2. No abstract available.


Expression of B7-H1 in breast cancer patients is strongly associated with high proliferative Ki-67-expressing tumor cells.

Ghebeh H, Tulbah A, Mohammed S, Elkum N, Bin Amer SM, Al-Tweigeri T, Dermime S.

Int J Cancer. 2007 Aug 15;121(4):751-8.


The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors.

Ghebeh H, Mohammed S, Al-Omair A, Qattan A, Lehe C, Al-Qudaihi G, Elkum N, Alshabanah M, Bin Amer S, Tulbah A, Ajarim D, Al-Tweigeri T, Dermime S.

Neoplasia. 2006 Mar;8(3):190-8.


Measurement of hydrophobic interactions of mammalian cells grown in culture.

Ghebeh H, Gillis J, Butler M.

J Biotechnol. 2002 Apr 25;95(1):39-48.


Development of an assay for the measurement of the surfactant pluronic F-68 in mammalian cell culture medium.

Ghebeh H, Handa-Corrigan A, Butler M.

Anal Biochem. 1998 Aug 15;262(1):39-44.


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