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IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis.

Gungl A, Crnkovic S, Biasin V, Marsh LM, Odler B, Sahu-Osen A, Stacher-Priehse E, Brcic L, Schneider F, Cikes N, Ghanim B, Klepetko W, Graninger W, Allanore Y, Eferl R, Olschewski A, Olschewski H, Kwapiszewska G.

Eur Respir J. 2019 Jul 18. pii: 1900154. doi: 10.1183/13993003.00154-2019. [Epub ahead of print]


Hepatoprotective Actions of Ascorbic Acid, Alpha Lipoic Acid and Silymarin or Their Combination Against Acetaminophen-Induced Hepatotoxicity in Rats.

Abdulrazzaq AM, Badr M, Gammoh O, Abu Khalil AA, Ghanim BY, Alhussainy TM, Qinna NA.

Medicina (Kaunas). 2019 May 21;55(5). pii: E181. doi: 10.3390/medicina55050181.


Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic pulmonary arterial hypertension.

Papp R, Nagaraj C, Zabini D, Nagy BM, Lengyel M, Skofic Maurer D, Sharma N, Egemnazarov B, Kovacs G, Kwapiszewska G, Marsh LM, Hrzenjak A, Höfler G, Didiasova M, Wygrecka M, Sievers LK, Szucs P, Enyedi P, Ghanim B, Klepetko W, Olschewski H, Olschewski A.

Eur Respir J. 2019 Jun 5;53(6). pii: 1800965. doi: 10.1183/13993003.00965-2018. Print 2019 Jun.


ANN-Kriging hybrid model for predicting carbon and inorganic phosphorus recovery in hydrothermal carbonization.

Ismail HY, Shirazian S, Skoretska I, Mynko O, Ghanim B, Leahy JJ, Walker GM, Kwapinski W.

Waste Manag. 2019 Feb 15;85:242-252. doi: 10.1016/j.wasman.2018.12.044. Epub 2019 Jan 2.


Critical pharmacokinetic and pharmacodynamic drug-herb interactions in rats between warfarin and pomegranate peel or guava leaves extracts.

Alnaqeeb M, Mansor KA, Mallah EM, Ghanim BY, Idkaidek N, Qinna NA.

BMC Complement Altern Med. 2019 Jan 24;19(1):29. doi: 10.1186/s12906-019-2436-5.


Disconnect between Fibrotic Response and Right Ventricular Dysfunction.

Crnkovic S, Egemnazarov B, Damico R, Marsh LM, Nagy BM, Douschan P, Atsina K, Kolb TM, Mathai SC, Hooper JE, Ghanim B, Klepetko W, Fruhwald F, Lassner D, Olschewski A, Olschewski H, Hassoun PM, Kwapiszewska G.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1550-1560. doi: 10.1164/rccm.201809-1737OC.


Antioxidative stress effects of vitamins C, E, and B12, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats.

Abdulkhaleq FM, Alhussainy TM, Badr MM, Khalil AAA, Gammoh O, Ghanim BY, Qinna NA.

Drug Des Devel Ther. 2018 Oct 18;12:3525-3533. doi: 10.2147/DDDT.S172487. eCollection 2018.


Chemical induction of hepatic apoptosis in rodents.

Qinna NA, Ghanim BY.

J Appl Toxicol. 2019 Feb;39(2):178-190. doi: 10.1002/jat.3740. Epub 2018 Oct 23. Review.


Epworth sleepiness scale in medical residents: quality of sleep and its relationship to quality of life.

Alami YZ, Ghanim BT, Zyoud SH.

J Occup Med Toxicol. 2018 Jul 13;13:21. doi: 10.1186/s12995-018-0203-z. eCollection 2018.


Prognostic and diagnostic impact of fibrinogen, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio on thymic epithelial tumors outcome.

Janik S, Raunegger T, Hacker P, Ghanim B, Einwallner E, Müllauer L, Schiefer AI, Moser J, Klepetko W, Ankersmit HJ, Moser B.

Oncotarget. 2018 Apr 24;9(31):21861-21875. doi: 10.18632/oncotarget.25076. eCollection 2018 Apr 24.


Chylothorax in a 32-Year-Old Patient With Lymphangioleiomyomatosis After Bilateral Lung Transplant.

Boehm PM, Ghanim BD, Matilla J, Klepetko W, Taghavi S.

Ann Thorac Surg. 2018 Jun;105(6):e263-e264. doi: 10.1016/j.athoracsur.2017.12.042. Epub 2018 Feb 2.


The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension.

Marsh LM, Jandl K, Grünig G, Foris V, Bashir M, Ghanim B, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G.

Eur Respir J. 2018 Jan 25;51(1). pii: 1701214. doi: 10.1183/13993003.01214-2017. Print 2018 Jan.


Resident cell lineages are preserved in pulmonary vascular remodeling.

Crnkovic S, Marsh LM, El Agha E, Voswinckel R, Ghanim B, Klepetko W, Stacher-Priehse E, Olschewski H, Bloch W, Bellusci S, Olschewski A, Kwapiszewska G.

J Pathol. 2018 Apr;244(4):485-498. doi: 10.1002/path.5044. Epub 2018 Mar 9.


Treprostinil inhibits proliferation and extracellular matrix deposition by fibroblasts through cAMP activation.

Lambers C, Roth M, Jaksch P, Muraközy G, Tamm M, Klepetko W, Ghanim B, Zhao F.

Sci Rep. 2018 Jan 18;8(1):1087. doi: 10.1038/s41598-018-19294-1.


Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma.

Klikovits T, Stockhammer P, Laszlo V, Dong Y, Hoda MA, Ghanim B, Opitz I, Frauenfelder T, Nguyen-Kim TDL, Weder W, Berger W, Grusch M, Aigner C, Klepetko W, Dome B, Renyi-Vamos F, Oehler R, Hegedus B.

Sci Rep. 2017 Nov 28;7(1):16456. doi: 10.1038/s41598-017-16551-7.


Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.

Zabini D, Granton E, Hu Y, Miranda MZ, Weichelt U, Breuils Bonnet S, Bonnet S, Morrell NW, Connelly KA, Provencher S, Ghanim B, Klepetko W, Olschewski A, Kapus A, Kuebler WM.

Am J Respir Crit Care Med. 2018 Jan 15;197(2):244-260. doi: 10.1164/rccm.201702-0386OC. Erratum in: Am J Respir Crit Care Med. 2019 Apr 1;199(7):932.


Intrathoracic solitary fibrous tumor - an international multicenter study on clinical outcome and novel circulating biomarkers.

Ghanim B, Hess S, Bertoglio P, Celik A, Bas A, Oberndorfer F, Melfi F, Mussi A, Klepetko W, Pirker C, Berger W, Harmati I, Farkas A, Jan Ankersmit H, Dome B, Fillinger J, Aigner C, Hegedus B, Renyi-Vamos F, Lang G.

Sci Rep. 2017 Oct 2;7(1):12557. doi: 10.1038/s41598-017-12914-2.


Hypoxic vascular response and ventilation/perfusion matching in end-stage COPD may depend on p22phox.

Nagaraj C, Tabeling C, Nagy BM, Jain PP, Marsh LM, Papp R, Pienn M, Witzenrath M, Ghanim B, Klepetko W, Weir EK, Heschl S, Kwapiszewska G, Olschewski A, Olschewski H.

Eur Respir J. 2017 Jul 20;50(1). pii: 1601651. doi: 10.1183/13993003.01651-2016. Print 2017 Jul.


Importance of kynurenine in pulmonary hypertension.

Nagy BM, Nagaraj C, Meinitzer A, Sharma N, Papp R, Foris V, Ghanim B, Kwapiszewska G, Kovacs G, Klepetko W, Pieber TR, Mangge H, Olschewski H, Olschewski A.

Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L741-L751. doi: 10.1152/ajplung.00517.2016. Epub 2017 Jul 13.


Elevated CRP levels predict poor outcome and tumor recurrence in patients with thymic epithelial tumors: A pro- and retrospective analysis.

Janik S, Bekos C, Hacker P, Raunegger T, Ghanim B, Einwallner E, Beer L, Klepetko W, Müllauer L, Ankersmit HJ, Moser B.

Oncotarget. 2017 Jul 18;8(29):47090-47102. doi: 10.18632/oncotarget.17478.


Hydrothermal carbonisation of poultry litter: Effects of initial pH on yields and chemical properties of hydrochars.

Ghanim BM, Kwapinski W, Leahy JJ.

Bioresour Technol. 2017 Aug;238:78-85. doi: 10.1016/j.biortech.2017.04.025. Epub 2017 Apr 9.


Meprin β contributes to collagen deposition in lung fibrosis.

Biasin V, Wygrecka M, Marsh LM, Becker-Pauly C, Brcic L, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G.

Sci Rep. 2017 Jan 6;7:39969. doi: 10.1038/srep39969.


Docosahexaenoic acid causes rapid pulmonary arterial relaxation via KCa channel-mediated hyperpolarisation in pulmonary hypertension.

Nagaraj C, Tang B, Nagy BM, Papp R, Jain PP, Marsh LM, Meredith AL, Ghanim B, Klepetko W, Kwapiszewska G, Weir EK, Olschewski H, Olschewski A.

Eur Respir J. 2016 Oct;48(4):1127-1136. doi: 10.1183/13993003.01814-2015. Epub 2016 Aug 18.


Circulating activin A is a novel prognostic biomarker in malignant pleural mesothelioma - A multi-institutional study.

Hoda MA, Dong Y, Rozsas A, Klikovits T, Laszlo V, Ghanim B, Stockhammer P, Ozsvar J, Jakopovic M, Samarzija M, Brcic L, Bendek M, Szirtes I, Reid G, Kirschner MB, Kao SC, Opitz I, Weder W, Frauenfelder T, Nguyen-Kim TD, Aigner C, Klepetko W, van Zandwijk N, Berger W, Dome B, Grusch M, Hegedus B.

Eur J Cancer. 2016 Aug;63:64-73. doi: 10.1016/j.ejca.2016.04.018. Epub 2016 Jun 8.


Hydrothermal carbonisation of poultry litter: Effects of treatment temperature and residence time on yields and chemical properties of hydrochars.

Ghanim BM, Pandey DS, Kwapinski W, Leahy JJ.

Bioresour Technol. 2016 Sep;216:373-80. doi: 10.1016/j.biortech.2016.05.087. Epub 2016 May 24.


Lung transplantation in patients with incidental early stage lung cancer-institutional experience of a high volume center.

Klikovits T, Lambers C, Ghanim B, Dome B, Murakoezy G, Zöchbauer-Müller S, Waseda R, Aigner C, Lang G, Taghavi S, Klepetko W, Jaksch P, Hoda MA.

Clin Transplant. 2016 Aug;30(8):912-7. doi: 10.1111/ctr.12764. Epub 2016 Jun 16.


Functional and molecular factors associated with TAPSE in hypoxic pulmonary hypertension.

Crnkovic S, Schmidt A, Egemnazarov B, Wilhelm J, Marsh LM, Ghanim B, Klepetko W, Olschewski A, Olschewski H, Kwapiszewska G.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L59-73. doi: 10.1152/ajplung.00381.2015. Epub 2016 Apr 22.


CD133+ cells in pulmonary arterial hypertension.

Foris V, Kovacs G, Marsh LM, Bálint Z, Tötsch M, Avian A, Douschan P, Ghanim B, Klepetko W, Olschewski A, Olschewski H.

Eur Respir J. 2016 Aug;48(2):459-69. doi: 10.1183/13993003.01523-2015. Epub 2016 Apr 21.


Increased S100A4 expression in the vasculature of human COPD lungs and murine model of smoke-induced emphysema.

Reimann S, Fink L, Wilhelm J, Hoffmann J, Bednorz M, Seimetz M, Dessureault I, Troesser R, Ghanim B, Klepetko W, Seeger W, Weissmann N, Kwapiszewska G.

Respir Res. 2015 Oct 20;16:127. doi: 10.1186/s12931-015-0284-5.


Elevated inflammatory parameters and inflammation scores are associated with poor prognosis in patients undergoing pulmonary metastasectomy for colorectal cancer.

Ghanim B, Schweiger T, Jedamzik J, Glueck O, Glogner C, Lang G, Klepetko W, Hoetzenecker K.

Interact Cardiovasc Thorac Surg. 2015 Nov;21(5):616-23. doi: 10.1093/icvts/ivv206. Epub 2015 Aug 4.


Epigenetic down-regulation of integrin α7 increases migratory potential and confers poor prognosis in malignant pleural mesothelioma.

Laszlo V, Hoda MA, Garay T, Pirker C, Ghanim B, Klikovits T, Dong YW, Rozsas A, Kenessey I, Szirtes I, Grusch M, Jakopovic M, Samarzija M, Brcic L, Kern I, Rozman A, Popper H, Zöchbauer-Müller S, Heller G, Altenberger C, Ziegler B, Klepetko W, Berger W, Dome B, Hegedus B.

J Pathol. 2015 Oct;237(2):203-14. doi: 10.1002/path.4567. Epub 2015 Jul 14.


Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients.

Hoffmann J, Marsh LM, Pieper M, Stacher E, Ghanim B, Kovacs G, König P, Wilkens H, Haitchi HM, Hoefler G, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G.

Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1002-13. doi: 10.1152/ajplung.00383.2014. Epub 2015 Apr 3.


The prognostic significance of β-catenin, cyclin D1 and PIN1 in minor salivary gland carcinoma: β-catenin predicts overall survival.

Schneider S, Thurnher D, Seemann R, Brunner M, Kadletz L, Ghanim B, Aumayr K, Heiduschka G, Lill C.

Eur Arch Otorhinolaryngol. 2016 May;273(5):1283-92. doi: 10.1007/s00405-015-3609-6. Epub 2015 Mar 24.


High-mobility group box-1 induces vascular remodelling processes via c-Jun activation.

Zabini D, Crnkovic S, Xu H, Tscherner M, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G, Marsh LM.

J Cell Mol Med. 2015 May;19(5):1151-61. doi: 10.1111/jcmm.12519. Epub 2015 Feb 28.


Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis.

Spiegl-Kreinecker S, Lötsch D, Ghanim B, Pirker C, Mohr T, Laaber M, Weis S, Olschowski A, Webersinke G, Pichler J, Berger W.

Neuro Oncol. 2015 Sep;17(9):1231-40. doi: 10.1093/neuonc/nov010. Epub 2015 Feb 13.


Ki67 index is an independent prognostic factor in epithelioid but not in non-epithelioid malignant pleural mesothelioma: a multicenter study.

Ghanim B, Klikovits T, Hoda MA, Lang G, Szirtes I, Setinek U, Rozsas A, Renyi-Vamos F, Laszlo V, Grusch M, Filipits M, Scheed A, Jakopovic M, Samarzija M, Brcic L, Stancic-Rokotov D, Kern I, Rozman A, Dekan G, Klepetko W, Berger W, Glasz T, Dome B, Hegedus B.

Br J Cancer. 2015 Mar 3;112(5):783-92. doi: 10.1038/bjc.2015.9. Epub 2015 Jan 29.


Chondroid hamartoma of the lung presenting as cavern.

Ghanim B, Scheed A, Simonitsch-Klupp I, Klepetko W, Ankersmit HJ.

Clin Respir J. 2016 Sep;10(5):671-2. doi: 10.1111/crj.12266. Epub 2015 Mar 2. No abstract available.


Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy.

Schelch K, Hoda MA, Klikovits T, Münzker J, Ghanim B, Wagner C, Garay T, Laszlo V, Setinek U, Dome B, Filipits M, Pirker C, Heffeter P, Selzer E, Tovari J, Torok S, Kenessey I, Holzmann K, Grasl-Kraupp B, Marian B, Klepetko W, Berger W, Hegedus B, Grusch M.

Am J Respir Crit Care Med. 2014 Oct 1;190(7):763-72. doi: 10.1164/rccm.201404-0658OC.


Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent.

Biasin V, Chwalek K, Wilhelm J, Best J, Marsh LM, Ghanim B, Klepetko W, Fink L, Schermuly RT, Weissmann N, Olschewski A, Kwapiszewska G.

Int J Biochem Cell Biol. 2014 Sep;54:137-48. doi: 10.1016/j.biocel.2014.06.020. Epub 2014 Jul 10.


Differential expression of IL-33 and HMGB1 in the lungs of stable cystic fibrosis patients.

Tiringer K, Treis A, Kanolzer S, Witt C, Ghanim B, Gruber S, Schmidthaler K, Renner S, Dehlink E, Nachbaur E, Frischer T, Klepetko W, Akdis CA, Szépfalusi Z, Eiwegger T.

Eur Respir J. 2014 Sep;44(3):802-5. doi: 10.1183/09031936.00046614. Epub 2014 Jun 25. No abstract available.


Distinct differences in gene expression patterns in pulmonary arteries of patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis with pulmonary hypertension.

Hoffmann J, Wilhelm J, Marsh LM, Ghanim B, Klepetko W, Kovacs G, Olschewski H, Olschewski A, Kwapiszewska G.

Am J Respir Crit Care Med. 2014 Jul 1;190(1):98-111. doi: 10.1164/rccm.201401-0037OC.


Lobar lung transplantation--is it comparable with standard lung transplantation?

Slama A, Ghanim B, Klikovits T, Scheed A, Hoda MA, Hoetzenecker K, Jaksch P, Matilla J, Taghavi S, Klepetko W, Aigner C.

Transpl Int. 2014 Sep;27(9):909-16. doi: 10.1111/tri.12348. Epub 2014 Jun 17.


NPY/Y₁ receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension.

Crnkovic S, Egemnazarov B, Jain P, Seay U, Gattinger N, Marsh LM, Bálint Z, Kovacs G, Ghanim B, Klepetko W, Schermuly RT, Weissmann N, Olschewski A, Kwapiszewska G.

Br J Pharmacol. 2014 Aug;171(16):3895-907. doi: 10.1111/bph.12751.


Subtype-specific KRAS mutations in advanced lung adenocarcinoma: a retrospective study of patients treated with platinum-based chemotherapy.

Cserepes M, Ostoros G, Lohinai Z, Raso E, Barbai T, Timar J, Rozsas A, Moldvay J, Kovalszky I, Fabian K, Gyulai M, Ghanim B, Laszlo V, Klikovits T, Hoda MA, Grusch M, Berger W, Klepetko W, Hegedus B, Dome B.

Eur J Cancer. 2014 Jul;50(10):1819-1828. doi: 10.1016/j.ejca.2014.04.001. Epub 2014 Apr 22.


Extracorporeal membrane oxygenation support for complex tracheo-bronchial procedures†.

Lang G, Ghanim B, Hötzenecker K, Klikovits T, Matilla JR, Aigner C, Taghavi S, Klepetko W.

Eur J Cardiothorac Surg. 2015 Feb;47(2):250-5; discussion 256. doi: 10.1093/ejcts/ezu162. Epub 2014 Apr 16.


Correlation of β-catenin, but not PIN1 and cyclin D1, overexpression with disease-free and overall survival in patients with cancer of the parotid gland.

Lill C, Schneider S, Seemann R, Kadletz L, Aumayr K, Ghanim B, Thurnher D.

Head Neck. 2015 Jan;37(1):30-6. doi: 10.1002/hed.23546. Epub 2014 Feb 6.


Circulating fibrinogen is a prognostic and predictive biomarker in malignant pleural mesothelioma.

Ghanim B, Hoda MA, Klikovits T, Winter MP, Alimohammadi A, Grusch M, Dome B, Arns M, Schenk P, Jakopovic M, Samarzija M, Brcic L, Filipits M, Laszlo V, Klepetko W, Berger W, Hegedus B.

Br J Cancer. 2014 Feb 18;110(4):984-90. doi: 10.1038/bjc.2013.815. Epub 2014 Jan 16.


Meprin β, a novel mediator of vascular remodelling underlying pulmonary hypertension.

Biasin V, Marsh LM, Egemnazarov B, Wilhelm J, Ghanim B, Klepetko W, Wygrecka M, Olschewski H, Eferl R, Olschewski A, Kwapiszewska G.

J Pathol. 2014 May;233(1):7-17. doi: 10.1002/path.4303. Epub 2014 Jan 31.


Expression of β-catenin and cyclin D1 in Merkel cell carcinomas of the head and neck.

Lill C, Schneider S, Ghanim B, Brunner M, Heiduschka G, Loewe R, Thurnher D.

Wien Klin Wochenschr. 2013 Sep;125(17-18):501-7. doi: 10.1007/s00508-013-0406-3. Epub 2013 Aug 9.


Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP) and organ donors.

Korfei M, von der Beck D, Henneke I, Markart P, Ruppert C, Mahavadi P, Ghanim B, Klepetko W, Fink L, Meiners S, Krämer OH, Seeger W, Vancheri C, Guenther A.

J Proteomics. 2013 Jun 24;85:109-28. doi: 10.1016/j.jprot.2013.04.033. Epub 2013 May 6.

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