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Items: 1 to 50 of 93

1.

Kinetics of trihalogenated acetic acid metabolism and isoform specificity in liver microsomes.

Saghir SA, Ghanayem BI, Schultz IR.

Int J Toxicol. 2011 Oct;30(5):551-61. doi: 10.1177/1091581811414213. Epub 2011 Sep 20.

PMID:
21933969
2.

Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity.

Ghanayem BI, Bai R, Kissling GE, Travlos G, Hoffler U.

Biol Reprod. 2010 Jan;82(1):96-104. doi: 10.1095/biolreprod.109.078915. Epub 2009 Aug 19.

3.

Diet-induced obesity is associated with hyperleptinemia, hyperinsulinemia, hepatic steatosis, and glomerulopathy in C57Bl/6J mice.

Hoffler U, Hobbie K, Wilson R, Bai R, Rahman A, Malarkey D, Travlos G, Ghanayem BI.

Endocrine. 2009 Oct;36(2):311-25. doi: 10.1007/s12020-009-9224-9. Epub 2009 Aug 11.

4.

Effect of dose volume on the toxicokinetics of acrylamide and its metabolites and 2-deoxy-D-glucose.

Ghanayem BI, Bai R, Burka LT.

Drug Metab Dispos. 2009 Feb;37(2):259-63. doi: 10.1124/dmd.108.024265. Epub 2008 Nov 20.

5.

Investigation of xenobiotics metabolism, genotoxicity, and carcinogenicity using Cyp2e1(-/-) mice.

Ghanayem BI, Hoffler U.

Curr Drug Metab. 2007 Oct;8(7):728-49. Review.

PMID:
17979661
6.

Inhibition of urethane-induced carcinogenicity in cyp2e1-/- in comparison to cyp2e1+/+ mice.

Ghanayem BI.

Toxicol Sci. 2007 Feb;95(2):331-9. Epub 2006 Nov 8.

PMID:
17093202
7.

CYP2E1-catalyzed oxidation contributes to the sperm toxicity of 1-bromopropane in mice.

Garner CE, Sloan C, Sumner SC, Burgess J, Davis J, Etheridge A, Parham A, Ghanayem BI.

Biol Reprod. 2007 Mar;76(3):496-505. Epub 2006 Nov 8.

PMID:
17093198
8.

Comparative metabolism and disposition of trichloroethylene in Cyp2e1-/-and wild-type mice.

Kim D, Ghanayem BI.

Drug Metab Dispos. 2006 Dec;34(12):2020-7. Epub 2006 Sep 7.

PMID:
16959879
9.

Pulmonary bronchiolar cytotoxicity and formation of dichloroacetyl lysine protein adducts in mice treated with trichloroethylene.

Forkert PG, Millen B, Lash LH, Putt DA, Ghanayem BI.

J Pharmacol Exp Ther. 2006 Feb;316(2):520-9. Epub 2005 Nov 3.

PMID:
16269531
10.

Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts.

Ghanayem BI, McDaniel LP, Churchwell MI, Twaddle NC, Snyder R, Fennell TR, Doerge DR.

Toxicol Sci. 2005 Dec;88(2):311-8. Epub 2005 Sep 1.

PMID:
16141435
11.

Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect.

Ghanayem BI, Witt KL, Kissling GE, Tice RR, Recio L.

Mutat Res. 2005 Oct 15;578(1-2):284-97. Epub 2005 Jun 27.

PMID:
15982677
12.

Comparative metabolism of methacrylonitrile and acrylonitrile to cyanide using cytochrome P4502E1 and microsomal epoxide hydrolase-null mice.

El Hadri L, Chanas B, Ghanayem BI.

Toxicol Appl Pharmacol. 2005 Jun 1;205(2):116-25. Epub 2004 Nov 25.

PMID:
15893539
13.

Increased bioaccumulation of urethane in CYP2E1-/- versus CYP2E1+/+ mice.

Hoffler U, Ghanayem BI.

Drug Metab Dispos. 2005 Aug;33(8):1144-50. Epub 2005 May 6.

PMID:
15879495
14.

Inhibition of urethane-induced genotoxicity and cell proliferation in CYP2E1-null mice.

Hoffler U, Dixon D, Peddada S, Ghanayem BI.

Mutat Res. 2005 May 2;572(1-2):58-72.

PMID:
15790490
15.

Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect.

Ghanayem BI, Witt KL, El-Hadri L, Hoffler U, Kissling GE, Shelby MD, Bishop JB.

Biol Reprod. 2005 Jan;72(1):157-63. Epub 2004 Sep 8.

PMID:
15355880
16.

Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.

Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.

Drug Metab Dispos. 2004 Sep;32(9):1032-9.

PMID:
15319346
17.

Bioactivation of 1,1-dichloroethylene by CYP2E1 and CYP2F2 in murine lung.

Simmonds AC, Ghanayem BI, Sharma A, Reilly CA, Millen B, Yost GS, Forkert PG.

J Pharmacol Exp Ther. 2004 Sep;310(3):855-64. Epub 2004 May 3. Erratum in: J Pharmacol Exp Ther. 2004 Nov;311(2):853.

PMID:
15123768
18.
19.

Cytochrome P450 2E1 (CYP2E1) is the principal enzyme responsible for urethane metabolism: comparative studies using CYP2E1-null and wild-type mice.

Hoffler U, El-Masri HA, Ghanayem BI.

J Pharmacol Exp Ther. 2003 May;305(2):557-64. Erratum in: J Pharmacol Exp Ther. 2003 Dec;307(3):1243.

PMID:
12704224
20.

Characterization of the toxicity, mutagenicity, and carcinogenicity of methacrylonitrile in F344 Rats and B6C3F1 mice.

Nyska A, Ghanayem BI.

Arch Toxicol. 2003 Apr;77(4):233-42. Epub 2003 Feb 14.

PMID:
12698239
21.
22.

Acrylonitrile is a multisite carcinogen in male and female B6C3F1 mice.

Ghanayem BI, Nyska A, Haseman JK, Bucher JR.

Toxicol Sci. 2002 Jul;68(1):59-68.

PMID:
12075111
23.

Effect of methacrylonitrile on cytochrome P-450 2E1 (CYP2E1) expression in male F344 rats.

Wang H, Chanas B, Ghanayem BI.

J Toxicol Environ Health A. 2002 Apr 12;65(7):523-37.

PMID:
11939710
25.

Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

Dai D, Zeldin DC, Blaisdell JA, Chanas B, Coulter SJ, Ghanayem BI, Goldstein JA.

Pharmacogenetics. 2001 Oct;11(7):597-607.

PMID:
11668219
26.

Hemolytic anemia, thrombosis, and infarction in male and female F344 rats following gavage exposure to 2-butoxyethanol.

Ghanayem BI, Long PH, Ward SM, Chanas B, Nyska M, Nyska A.

Exp Toxicol Pathol. 2001 Jun;53(2-3):97-105.

PMID:
11484844
27.

Using cytochrome P-450 gene knock-out mice to study chemical metabolism, toxicity, and carcinogenicity.

Ghanayem BI, Wang H, Sumner S.

Toxicol Pathol. 2000 Nov-Dec;28(6):839-50. Review.

PMID:
11127301
28.

Comparison of the acute hematotoxicity of 2-butoxyethanol in male and female F344 rats.

Ghanayem BI, Ward SM, Chanas B, Nyska A.

Hum Exp Toxicol. 2000 Mar;19(3):185-92.

PMID:
10889517
29.

Dental pulp infarction in female rats following inhalation exposure to 2-butoxyethanol.

Long PH, Maronpot RR, Ghanayem BI, Roycroft JH, Nyska A.

Toxicol Pathol. 2000 Mar-Apr;28(2):246-52.

PMID:
10805142
30.

Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice.

Sumner SC, Fennell TR, Moore TA, Chanas B, Gonzalez F, Ghanayem BI.

Chem Res Toxicol. 1999 Nov;12(11):1110-6.

PMID:
10563837
31.

Ocular thrombosis and retinal degeneration induced in female F344 rats by 2-butoxyethanol.

Nyska A, Maronpot RR, Ghanayem BI.

Hum Exp Toxicol. 1999 Sep;18(9):577-82.

PMID:
10523872
32.

A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin.

Ibeanu GC, Blaisdell J, Ferguson RJ, Ghanayem BI, Brosen K, Benhamou S, Bouchardy C, Wilkinson GR, Dayer P, Goldstein JA.

J Pharmacol Exp Ther. 1999 Aug;290(2):635-40.

PMID:
10411572
33.

Disseminated thrombosis and bone infarction in female rats following inhalation exposure to 2-butoxyethanol.

Nyska A, Maronpot RR, Long PH, Roycroft JH, Hailey JR, Travlos GS, Ghanayem BI.

Toxicol Pathol. 1999 May-Jun;27(3):287-94.

PMID:
10356705
34.

Role of cytochrome P-450 2E1 in methacrylonitrile metabolism and disposition.

Ghanayem BI, Sanders JM, Chanas B, Burka LT, Gonzalez FJ.

J Pharmacol Exp Ther. 1999 May;289(2):1054-9.

PMID:
10215687
35.

An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians.

Ibeanu GC, Blaisdell J, Ghanayem BI, Beyeler C, Benhamou S, Bouchardy C, Wilkinson GR, Dayer P, Daly AK, Goldstein JA.

Pharmacogenetics. 1998 Apr;8(2):129-35.

PMID:
10022751
36.

Identification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen.

Klose TS, Ibeanu GC, Ghanayem BI, Pedersen LG, Li L, Hall SD, Goldstein JA.

Arch Biochem Biophys. 1998 Sep 15;357(2):240-8.

PMID:
9735164
37.

Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin.

Ibeanu GC, Goldstein JA, Meyer U, Benhamou S, Bouchardy C, Dayer P, Ghanayem BI, Blaisdell J.

J Pharmacol Exp Ther. 1998 Sep;286(3):1490-5.

PMID:
9732415
38.

Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4.

Yan ZH, Karam WG, Staudinger JL, Medvedev A, Ghanayem BI, Jetten AM.

J Biol Chem. 1998 May 1;273(18):10948-57.

40.
41.

Disruption of the mouse cyclooxygenase 1 gene. Characteristics of the mutant and areas of future study.

Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, Mahler JF, Davis BJ, Lee CA.

Adv Exp Med Biol. 1997;407:87-92.

PMID:
9321936
42.

Nonoxidative metabolism of 2-butoxyethanol via fatty acid conjugation in Fischer 344 rats.

Kaphalia BS, Ghanayem BI, Ansari GA.

J Toxicol Environ Health. 1996 Dec 6;49(5):463-79.

PMID:
8968408
43.

Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.

Karam WG, Goldstein JA, Lasker JM, Ghanayem BI.

Drug Metab Dispos. 1996 Oct;24(10):1081-7.

PMID:
8894508
44.

Species differences in the disposition and metabolism of nalidixic acid.

Nomeir AA, Markham P, Burka LT, Griffin RJ, Ghanayem BI.

J Pharmacol Exp Ther. 1996 Oct;279(1):222-30.

PMID:
8858997
45.
46.

The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism.

Sullivan-Klose TH, Ghanayem BI, Bell DA, Zhang ZY, Kaminsky LS, Shenfield GM, Miners JO, Birkett DJ, Goldstein JA.

Pharmacogenetics. 1996 Aug;6(4):341-9.

PMID:
8873220
47.

Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity.

Ibeanu GC, Ghanayem BI, Linko P, Li L, Pederson LG, Goldstein JA.

J Biol Chem. 1996 May 24;271(21):12496-501.

48.

Excretion and identification of methacrylonitrile metabolites in the bile of male F344 rats.

Ghanayem BI, Burka LT.

Drug Metab Dispos. 1996 Apr;24(4):390-4.

PMID:
8801052
49.

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, Mahler JF, Lee CA, Goulding EH, Kluckman KD, Kim HS, Smithies O.

Cell. 1995 Nov 3;83(3):483-92.

50.

Spermatocyte toxicity of 2-methoxyethanol (ME) in rats and guinea pigs: evidence for the induction of apoptosis.

Ku WW, Wine RN, Chae BY, Ghanayem BI, Chapin RE.

Toxicol Appl Pharmacol. 1995 Sep;134(1):100-10.

PMID:
7676444

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