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In Silico Exploration of Aryl Halides Analogues as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and ADMET Screening.

Ghaleb A, Aouidate A, Bouachrine M, Lakhlifi T, Sbai A.

Adv Pharm Bull. 2019 Feb;9(1):84-92. doi: 10.15171/apb.2019.011. Epub 2019 Feb 21.


A new method to produce T-shaped tubular fittings with experimental and simulation results.

Ghaleb AM, Saleh MA, Ragab AE, Dabwan A, Khalaf TM, Umer U.

PLoS One. 2019 Apr 8;14(4):e0214608. doi: 10.1371/journal.pone.0214608. eCollection 2019.


Computer aided drug design based on 3D-QSAR and molecular docking studies of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amine derivatives as PIM2 inhibitors: a proposal to chemists.

Aouidate A, Ghaleb A, Ghamali M, Chtita S, Ousaa A, Choukrad M, Sbai A, Bouachrine M, Lakhlifi T.

In Silico Pharmacol. 2018 Mar 28;6(1):5. doi: 10.1007/s40203-018-0043-7. eCollection 2018.


Incidence of and Causes for Ventriculoperitoneal Shunt Failure in Children Younger Than 2 Years: A Systematic Review.

Hasanain AA, Abdullah A, Alsawy MFM, Soliman MAR, Ghaleb AA, Elwy R, Ezzat AAM, Al Menabbawy A, Marei AA, Abd El Razik B, El Hamaky MI, Schroeder HWS, Fleck S, El Damaty A, Marx S, Nowak S, Baldauf J, Zohdi A, El Refaee EA.

J Neurol Surg A Cent Eur Neurosurg. 2019 Jan;80(1):26-33. doi: 10.1055/s-0038-1669464. Epub 2018 Dec 3.


Migration of the Distal Catheter of Ventriculoperitoneal Shunts in Pediatric Age Group: Case Series.

Ezzat AAM, Soliman MAR, Hasanain AA, Thabit MA, Elshitany H, Kandel H, Abdel-Bari SH, Ghoul AMF, Abdullah A, Alsawy MFM, Ghaleb AA, Al Menabbawy A, Marei AA, El Razik BA, Schroeder HWS, Marx S, Zohdi A, El Refaee E.

World Neurosurg. 2018 Nov;119:e131-e137. doi: 10.1016/j.wneu.2018.07.073. Epub 2018 Jul 19.


Heat shock factor 1 confers resistance to lapatinib in ERBB2-positive breast cancer cells.

Yallowitz A, Ghaleb A, Garcia L, Alexandrova EM, Marchenko N.

Cell Death Dis. 2018 May 24;9(6):621. doi: 10.1038/s41419-018-0691-x.


3D QSAR studies, molecular docking and ADMET evaluation, using thiazolidine derivatives as template to obtain new inhibitors of PIM1 kinase.

Aouidate A, Ghaleb A, Ghamali M, Ousaa A, Choukrad M, Sbai A, Bouachrine M, Lakhlifi T.

Comput Biol Chem. 2018 Jun;74:201-211. doi: 10.1016/j.compbiolchem.2018.03.008. Epub 2018 Mar 12.


QSAR study and rustic ligand-based virtual screening in a search for aminooxadiazole derivatives as PIM1 inhibitors.

Aouidate A, Ghaleb A, Ghamali M, Chtita S, Ousaa A, Choukrad M, Sbai A, Bouachrine M, Lakhlifi T.

Chem Cent J. 2018 Mar 22;12(1):32. doi: 10.1186/s13065-018-0401-x.


QSAR studies on PIM1 and PIM2 inhibitors using statistical methods: a rustic strategy to screen for 5-(1H-indol-5-yl)-1,3,4-thiadiazol analogues and predict their PIM inhibitory activity.

Aouidate A, Ghaleb A, Ghamali M, Chtita S, Choukrad M, Sbai A, Bouachrine M, Lakhlifi T.

Chem Cent J. 2017 May 19;11(1):41. doi: 10.1186/s13065-017-0269-1.


Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes.

Fujikawa J, Takeuchi Y, Kanazawa S, Nomir AG, Kito A, Elkhashab E, Ghaleb AM, Yang VW, Akiyama S, Morisaki I, Yamashiro T, Wakisaka S, Abe M.

Cell Tissue Res. 2017 Dec;370(3):441-449. doi: 10.1007/s00441-017-2674-0. Epub 2017 Aug 31.


Krüppel-like factor 4 (KLF4): What we currently know.

Ghaleb AM, Yang VW.

Gene. 2017 May 5;611:27-37. doi: 10.1016/j.gene.2017.02.025. Epub 2017 Feb 22. Review.


Role of neutral ceramidase in colon cancer.

García-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA.

FASEB J. 2016 Dec;30(12):4159-4171. Epub 2016 Sep 8.


Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses.

Bialkowska AB, Ghaleb AM, Nandan MO, Yang VW.

J Vis Exp. 2016 Jul 13;(113). doi: 10.3791/54161.


Krüppel-like Factor 4 Modulates Development of BMI1(+) Intestinal Stem Cell-Derived Lineage Following γ-Radiation-Induced Gut Injury in Mice.

Kuruvilla JG, Kim CK, Ghaleb AM, Bialkowska AB, Kuo CJ, Yang VW.

Stem Cell Reports. 2016 Jun 14;6(6):815-824. doi: 10.1016/j.stemcr.2016.04.014. Epub 2016 May 26.


Murine Model for Colitis-Associated Cancer of the Colon.

Snider AJ, Bialkowska AB, Ghaleb AM, Yang VW, Obeid LM, Hannun YA.

Methods Mol Biol. 2016;1438:245-54. doi: 10.1007/978-1-4939-3661-8_14. Review.


KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.

Ghaleb AM, Elkarim EA, Bialkowska AB, Yang VW.

Mol Cancer Res. 2016 Apr;14(4):385-96. doi: 10.1158/1541-7786.MCR-15-0410. Epub 2016 Feb 2.


Technique and outcome of autotransplanting thyroid tissue after total thyroidectomy for simple multinodular goiters.

Mohsen AA, Nada AA, Ibrahim MY, Ghaleb AH, Abou-Gabal MA, Mohsen AA, Wassef AT.

Asian J Surg. 2017 Jan;40(1):17-22. doi: 10.1016/j.asjsur.2015.05.007. Epub 2015 Aug 31.


Role of Krüppel-like factor 5 in the maintenance of the stem cell niche in the intestinal crypt.

Kuruvilla JG, Ghaleb AM, Bialkowska AB, Nandan MO, Yang VW.

Stem Cell Transl Investig. 2015;2(2). pii: e839.


IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.

Ghaleb AM, Bialkowska AB, Snider AJ, Gnatenko DV, Hannun YA, Yang VW, Schmidt VA.

PLoS One. 2015 Jun 5;10(6):e0129314. doi: 10.1371/journal.pone.0129314. eCollection 2015.


Krüppel-like factor 6 regulates mitochondrial function in the kidney.

Mallipattu SK, Horne SJ, D'Agati V, Narla G, Liu R, Frohman MA, Dickman K, Chen EY, Ma'ayan A, Bialkowska AB, Ghaleb AM, Nandan MO, Jain MK, Daehn I, Chuang PY, Yang VW, He JC.

J Clin Invest. 2015 Mar 2;125(3):1347-61. doi: 10.1172/JCI77084. Epub 2015 Feb 17.


Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells.

Nandan MO, Ghaleb AM, Bialkowska AB, Yang VW.

Stem Cell Res. 2015 Jan;14(1):10-9. doi: 10.1016/j.scr.2014.10.008. Epub 2014 Nov 6.


Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease.

Snider AJ, Ali WH, Sticca JA, Coant N, Ghaleb AM, Kawamori T, Yang VW, Hannun YA, Obeid LM.

PLoS One. 2014 Dec 2;9(12):e113998. doi: 10.1371/journal.pone.0113998. eCollection 2014.


Krüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice.

Talmasov D, Xinjun Z, Yu B, Nandan MO, Bialkowska AB, Elkarim E, Kuruvilla J, Yang VW, Ghaleb AM.

Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15;308(2):G121-38. doi: 10.1152/ajpgi.00080.2014. Epub 2014 Nov 20.


Inducible intestine-specific deletion of Krüppel-like factor 5 is characterized by a regenerative response in adult mouse colon.

Nandan MO, Ghaleb AM, Liu Y, Bialkowska AB, McConnell BB, Shroyer KR, Robine S, Yang VW.

Dev Biol. 2014 Mar 15;387(2):191-202. doi: 10.1016/j.ydbio.2014.01.002. Epub 2014 Jan 15.


Cervical spinal cord stimulation for the management of pain from brachial plexus avulsion.

Abdel-Aziz S, Ghaleb AH.

Pain Med. 2014 Apr;15(4):712-4. doi: 10.1111/pme.12313. Epub 2013 Dec 5. No abstract available.


Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts.

El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW.

Mol Cancer. 2013 Aug 6;12:89. doi: 10.1186/1476-4598-12-89.


The importance of a percutaneous trial of a spinal cord stimulator in a patient with extreme scoliosis.

Dilley JD, Crabtree DE, Ghaleb A.

Pain Med. 2012 Jun;13(6):846-7. doi: 10.1111/j.1526-4637.2012.01373.x. Epub 2012 Apr 11. No abstract available.


Post-dural puncture headache.

Ghaleb A, Khorasani A, Mangar D.

Int J Gen Med. 2012;5:45-51. doi: 10.2147/IJGM.S17834. Epub 2012 Jan 12. Retraction in: Int J Gen Med. 2016;9:173.


Chemoprevention of familial adenomatous polyposis by bromo-noscapine (EM011) in the Apc(Min/+) mouse model.

Li S, Ghaleb AM, He J, Bughani U, Bialkowska AB, Yang VW, Joshi HC.

Int J Cancer. 2012 Sep 15;131(6):1435-44. doi: 10.1002/ijc.27344. Epub 2012 Feb 9.


Expression profiling and pathway analysis of Krüppel-like factor 4 in mouse embryonic fibroblasts.

Hagos EG, Ghaleb AM, Kumar A, Neish AS, Yang VW.

Am J Cancer Res. 2011 Jan 1;1(1):85-97.


Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine.

McConnell BB, Kim SS, Yu K, Ghaleb AM, Takeda N, Manabe I, Nusrat A, Nagai R, Yang VW.

Gastroenterology. 2011 Oct;141(4):1302-13, 1313.e1-6. doi: 10.1053/j.gastro.2011.06.086. Epub 2011 Jul 18.


Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice.

Garg P, Jeppsson S, Dalmasso G, Ghaleb AM, McConnell BB, Yang VW, Gewirtz AT, Merlin D, Sitaraman SV.

Gastroenterology. 2011 Oct;141(4):1381-92. doi: 10.1053/j.gastro.2011.06.056. Epub 2011 Jun 30.


Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene.

Ghaleb AM, McConnell BB, Kaestner KH, Yang VW.

Dev Biol. 2011 Jan 15;349(2):310-20. doi: 10.1016/j.ydbio.2010.11.001. Epub 2010 Nov 9.


Postdural puncture headache.

Ghaleb A.

Anesthesiol Res Pract. 2010;2010. pii: 102967. doi: 10.1155/2010/102967. Epub 2010 Aug 11.


Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer.

Patel NV, Ghaleb AM, Nandan MO, Yang VW.

Cancer Epidemiol Biomarkers Prev. 2010 Oct;19(10):2631-8. doi: 10.1158/1055-9965.EPI-10-0677. Epub 2010 Aug 10.


Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations.

Nandan MO, Ghaleb AM, McConnell BB, Patel NV, Robine S, Yang VW.

Mol Cancer. 2010 Mar 18;9:63. doi: 10.1186/1476-4598-9-63.


Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine.

McConnell BB, Bialkowska AB, Nandan MO, Ghaleb AM, Gordon FJ, Yang VW.

Cancer Res. 2009 May 15;69(10):4125-33. doi: 10.1158/0008-5472.CAN-08-4402. Epub 2009 May 12.


The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer.

Lin S, Wang D, Iyer S, Ghaleb AM, Shim H, Yang VW, Chun J, Yun CC.

Gastroenterology. 2009 May;136(5):1711-20. doi: 10.1053/j.gastro.2009.01.002. Epub 2009 Jan 9.


Mouse embryonic fibroblasts null for the Krüppel-like factor 4 gene are genetically unstable.

Hagos EG, Ghaleb AM, Dalton WB, Bialkowska AB, Yang VW.

Oncogene. 2009 Mar 5;28(9):1197-205. doi: 10.1038/onc.2008.465. Epub 2009 Jan 12.


Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium.

Ghaleb AM, Aggarwal G, Bialkowska AB, Nandan MO, Yang VW.

Mol Cancer Res. 2008 Dec;6(12):1920-7. doi: 10.1158/1541-7786.MCR-08-0224.


The Pathobiology of Krüppel-like Factors in Colorectal Cancer.

Ghaleb AM, Yang VW.

Curr Colorectal Cancer Rep. 2008 Apr;4(2):59-64.


Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis.

Nandan MO, McConnell BB, Ghaleb AM, Bialkowska AB, Sheng H, Shao J, Babbin BA, Robine S, Yang VW.

Gastroenterology. 2008 Jan;134(1):120-30. Epub 2007 Oct 17.


Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis.

Ghaleb AM, McConnell BB, Nandan MO, Katz JP, Kaestner KH, Yang VW.

Cancer Res. 2007 Aug 1;67(15):7147-54.


Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad.

Rusovici R, Ghaleb A, Shim H, Yang VW, Yun CC.

Biochim Biophys Acta. 2007 Aug;1770(8):1194-203. Epub 2007 May 3.


The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology.

McConnell BB, Ghaleb AM, Nandan MO, Yang VW.

Bioessays. 2007 Jun;29(6):549-57. Review. Erratum in: Bioessays. 2007 Sep;29(9):946.


p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells.

Aneja R, Ghaleb AM, Zhou J, Yang VW, Joshi HC.

Cancer Res. 2007 Apr 15;67(8):3862-70.


Impaired insulin signaling as a potential trigger of pain in diabetes and prediabetes.

Dobretsov M, Ghaleb AH, Romanovsky D, Pablo CS, Stimers JR.

Int Anesthesiol Clin. 2007 Spring;45(2):95-105. Review. No abstract available.


Are diagnostic lumbar facet injections influenced by pain of muscular origin?

Ackerman WE, Munir MA, Zhang JM, Ghaleb A.

Pain Pract. 2004 Dec;4(4):286-91.


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