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Items: 36

1.

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy.

Carlson P, Dasgupta A, Grzelak CA, Kim J, Barrett A, Coleman IM, Shor RE, Goddard ET, Dai J, Schweitzer EM, Lim AR, Crist SB, Cheresh DA, Nelson PS, Hansen KC, Ghajar CM.

Nat Cell Biol. 2019 Feb;21(2):238-250. doi: 10.1038/s41556-018-0267-0. Epub 2019 Jan 21.

PMID:
30664790
2.

Anti-angiogenic Therapy-Mediated Endothelial Damage: A Driver of Breast Cancer Recurrence?

Pisarsky L, Ghajar CM.

Adv Exp Med Biol. 2018;1100:19-45. doi: 10.1007/978-3-319-97746-1_2. Review.

PMID:
30411258
3.

Dormant tumour cells, their niches and the influence of immunity.

Goddard ET, Bozic I, Riddell SR, Ghajar CM.

Nat Cell Biol. 2018 Nov;20(11):1240-1249. doi: 10.1038/s41556-018-0214-0. Epub 2018 Oct 25. Review.

PMID:
30361702
4.

Friends with Benefits: Microenvironmental NRG1β and HGF Mediate HER2-Targeted Resistance in L-HER2+ and HER2E Breast Cancer.

Crist SB, Ghajar CM.

Cell Syst. 2018 Mar 28;6(3):268-270. doi: 10.1016/j.cels.2018.03.005.

5.

Illuminating MSK1's role in tumour dormancy.

Grzelak CA, Ghajar CM.

Nat Cell Biol. 2018 Feb;20(2):124-126. doi: 10.1038/s41556-018-0035-1. No abstract available.

PMID:
29371707
6.

Metastasis 'systems' biology: how are macro-environmental signals transmitted into microenvironmental cues for disseminated tumor cells?

Grzelak CA, Ghajar CM.

Curr Opin Cell Biol. 2017 Oct;48:79-86. doi: 10.1016/j.ceb.2017.06.002. Epub 2017 Jul 15. Review.

PMID:
28715713
7.

Pre-metastatic niches: organ-specific homes for metastases.

Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D.

Nat Rev Cancer. 2017 May;17(5):302-317. doi: 10.1038/nrc.2017.6. Epub 2017 Mar 17. Review.

8.

Taking inventory of metastasis effectors.

Pisarsky L, Dai J, Ghajar CM.

Nat Med. 2017 Mar 7;23(3):275-276. doi: 10.1038/nm.4301. No abstract available.

PMID:
28267712
9.

Circulating and disseminated tumor cells: harbingers or initiators of metastasis?

Dasgupta A, Lim AR, Ghajar CM.

Mol Oncol. 2017 Jan;11(1):40-61. doi: 10.1002/1878-0261.12022. Review.

10.

Metastasis: Pathways of parallel progression.

Ghajar CM, Bissell MJ.

Nature. 2016 Dec 22;540(7634):528-529. doi: 10.1038/nature21104. Epub 2016 Dec 14. No abstract available.

PMID:
27974802
11.

Corrigendum: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.

Peinado H, Alecˇković M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, García-Santos G, Ghajar CM, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D.

Nat Med. 2016 Dec 6;22(12):1502. doi: 10.1038/nm1216-1502b. No abstract available.

PMID:
27923027
12.

Tumour exosome integrins determine organotropic metastasis.

Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn AJ, Bissell MJ, Garcia BA, Kang Y, Rajasekhar VK, Ghajar CM, Matei I, Peinado H, Bromberg J, Lyden D.

Nature. 2015 Nov 19;527(7578):329-35. doi: 10.1038/nature15756. Epub 2015 Oct 28.

13.

Metastasis prevention by targeting the dormant niche.

Ghajar CM.

Nat Rev Cancer. 2015 Apr;15(4):238-47. doi: 10.1038/nrc3910. Review.

14.

A stiffness-mediated oncogenic hammer.

Ghajar CM.

Sci Transl Med. 2014 May 21;6(237):237fs21. doi: 10.1126/scitranslmed.3009154.

PMID:
24848253
15.

The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer.

Weigelt B, Ghajar CM, Bissell MJ.

Adv Drug Deliv Rev. 2014 Apr;69-70:42-51. doi: 10.1016/j.addr.2014.01.001. Epub 2014 Jan 9. Review.

16.

The perivascular niche regulates breast tumour dormancy.

Ghajar CM, Peinado H, Mori H, Matei IR, Evason KJ, Brazier H, Almeida D, Koller A, Hajjar KA, Stainier DY, Chen EI, Lyden D, Bissell MJ.

Nat Cell Biol. 2013 Jul;15(7):807-17. doi: 10.1038/ncb2767. Epub 2013 Jun 2.

17.

Regulation of adipose oestrogen output by mechanical stress.

Ghosh S, Ashcraft K, Jahid MJ, April C, Ghajar CM, Ruan J, Wang H, Foster M, Hughes DC, Ramirez AG, Huang T, Fan JB, Hu Y, Li R.

Nat Commun. 2013;4:1821. doi: 10.1038/ncomms2794.

18.

Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1.

Mori H, Lo AT, Inman JL, Alcaraz J, Ghajar CM, Mott JD, Nelson CM, Chen CS, Zhang H, Bascom JL, Seiki M, Bissell MJ.

Development. 2013 Jan 15;140(2):343-52. doi: 10.1242/dev.084236.

19.

On leukocytes in mammary development and cancer.

Ghajar CM.

Cold Spring Harb Perspect Biol. 2012 May 1;4(5). pii: a013276. doi: 10.1101/cshperspect.a013276. Review. No abstract available.

20.

Laser scanning-based tissue autofluorescence/fluorescence imaging (LS-TAFI), a new technique for analysis of microanatomy in whole-mount tissues.

Mori H, Borowsky AD, Bhat R, Ghajar CM, Seiki M, Bissell MJ.

Am J Pathol. 2012 Jun;180(6):2249-56. doi: 10.1016/j.ajpath.2012.02.032. Epub 2012 Apr 27.

21.

From single cells to biology.

Bissell MJ, Ghajar CM, Lee LP.

Integr Biol (Camb). 2012 Apr;4(4):357-9. doi: 10.1039/c2ib90010f. Epub 2012 Mar 21. No abstract available.

PMID:
22436976
22.

Caveolin-1: would-be Achilles' heel of tumor microenvironment?

Furuta S, Ghajar CM, Bissell MJ.

Cell Cycle. 2011 Oct 15;10(20):3431. doi: 10.4161/cc.10.20.17648. Epub 2011 Oct 15. No abstract available.

PMID:
22030625
23.

Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening.

Alcaraz J, Mori H, Ghajar CM, Brownfield D, Galgoczy R, Bissell MJ.

Integr Biol (Camb). 2011 Dec;3(12):1153-66. doi: 10.1039/c1ib00073j. Epub 2011 Oct 13.

24.

A TeNaCious foundation for the metastatic niche.

Matei I, Ghajar CM, Lyden D.

Cancer Cell. 2011 Aug 16;20(2):139-41. doi: 10.1016/j.ccr.2011.08.004.

25.

Recreating the perivascular niche ex vivo using a microfluidic approach.

Carrion B, Huang CP, Ghajar CM, Kachgal S, Kniazeva E, Jeon NL, Putnam AJ.

Biotechnol Bioeng. 2010 Dec 15;107(6):1020-8. doi: 10.1002/bit.22891.

26.

Tumor engineering: the other face of tissue engineering.

Ghajar CM, Bissell MJ.

Tissue Eng Part A. 2010 Jul;16(7):2153-6. doi: 10.1089/ten.TEA.2010.0135.

27.

Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms.

Ghajar CM, Kachgal S, Kniazeva E, Mori H, Costes SV, George SC, Putnam AJ.

Exp Cell Res. 2010 Mar 10;316(5):813-25. doi: 10.1016/j.yexcr.2010.01.013. Epub 2010 Jan 11.

28.

Quis custodiet ipsos custodies: who watches the watchmen?

Ghajar CM, Meier R, Bissell MJ.

Am J Pathol. 2009 Jun;174(6):1996-9. doi: 10.2353/ajpath.2009.090363.

29.

Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging.

Ghajar CM, Bissell MJ.

Histochem Cell Biol. 2008 Dec;130(6):1105-18. doi: 10.1007/s00418-008-0537-1. Epub 2008 Nov 14. Review.

30.

Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature.

Chen X, Aledia AS, Ghajar CM, Griffith CK, Putnam AJ, Hughes CC, George SC.

Tissue Eng Part A. 2009 Jun;15(6):1363-71. doi: 10.1089/ten.tea.2008.0314.

31.

Matrix metalloproteinase control of capillary morphogenesis.

Ghajar CM, George SC, Putnam AJ.

Crit Rev Eukaryot Gene Expr. 2008;18(3):251-78. Review.

32.

The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system.

Peyton SR, Kim PD, Ghajar CM, Seliktar D, Putnam AJ.

Biomaterials. 2008 Jun;29(17):2597-607. doi: 10.1016/j.biomaterials.2008.02.005. Epub 2008 Mar 14.

33.

The effect of matrix density on the regulation of 3-D capillary morphogenesis.

Ghajar CM, Chen X, Harris JW, Suresh V, Hughes CC, Jeon NL, Putnam AJ, George SC.

Biophys J. 2008 Mar 1;94(5):1930-41. Epub 2007 Nov 9.

34.

The emergence of ECM mechanics and cytoskeletal tension as important regulators of cell function.

Peyton SR, Ghajar CM, Khatiwala CB, Putnam AJ.

Cell Biochem Biophys. 2007;47(2):300-20. Review.

PMID:
17652777
35.

Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early matrix metalloproteinase upregulation.

Ghajar CM, Blevins KS, Hughes CC, George SC, Putnam AJ.

Tissue Eng. 2006 Oct;12(10):2875-88.

PMID:
17518656
36.

A novel three-dimensional model to quantify metastatic melanoma invasion.

Ghajar CM, Suresh V, Peyton SR, Raub CB, Meyskens FL Jr, George SC, Putnam AJ.

Mol Cancer Ther. 2007 Feb;6(2):552-61. Epub 2007 Jan 31.

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