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Items: 29

1.

Effects of a neutral endoprotease enzyme inhibitor, thiorphan, on hemodynamics and renal excretory function in four models of experimental hypertension.

Pamnani MB, Chen S, Bryant HJ, Schooley JF, Haddy FJ, Ghai RD.

Clin Exp Hypertens. 2000 Jan;22(1):45-62.

PMID:
10685724
2.

Antihypertensive and natriuretic effects of CGS 30440, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase 24.11.

Chatelain RE, Ghai RD, Trapani AJ, Odorico LM, Dardik BN, De Lombaert S, Lappe RW, Fink CA.

J Pharmacol Exp Ther. 1998 Mar;284(3):974-82.

PMID:
9495857
3.

Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.

Ksander GM, de Jesus R, Yuan A, Ghai RD, McMartin C, Bohacek R.

J Med Chem. 1997 Feb 14;40(4):506-14.

PMID:
9046341
4.

Ortho-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.

Ksander GM, de Jesus R, Yuan A, Ghai RD, Trapani A, McMartin C, Bohacek R.

J Med Chem. 1997 Feb 14;40(4):495-505.

PMID:
9046340
5.

New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.

Fink CA, Qiao Y, Berry CJ, Sakane Y, Ghai RD, Trapani AJ.

J Med Chem. 1995 Dec 22;38(26):5023-30.

PMID:
8544178
6.

Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.

Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A.

J Med Chem. 1995 May 12;38(10):1689-700.

PMID:
7752193
7.

A rapid indirect method to determine the plasma concentrations of neutral endopeptidase inhibitors.

Ghai RD, De Lombaert S, Ksander GM, Berry C, Sakane Y, Trapani AJ.

Res Commun Mol Pathol Pharmacol. 1995 Feb;87(2):211-20.

PMID:
7749658
8.
9.

Pharmacological profile of a non-peptidic dual inhibitor of neutral endopeptidase 24.11 and endothelin-converting enzyme.

De Lombaert S, Ghai RD, Jeng AY, Trapani AJ, Webb RL.

Biochem Biophys Res Commun. 1994 Oct 14;204(1):407-12.

PMID:
7945387
10.

Pharmacologic profile of CGS 24128, a potent, long-acting inhibitor of neutral endopeptidase 24.11.

Trapani AJ, Beil ME, Coté DT, de Lombaert S, Erion MD, Gerlock TE, Ghai RD, Hopkins MF, Peppard JV, Webb RL, et al.

J Cardiovasc Pharmacol. 1994 Mar;23(3):358-64.

PMID:
7515977
11.

N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors.

De Lombaert S, Erion MD, Tan J, Blanchard L, el-Chehabi L, Ghai RD, Sakane Y, Berry C, Trapani AJ.

J Med Chem. 1994 Feb 18;37(4):498-511.

PMID:
8120868
12.

The pharmacology of CGS 25462: a potent, orally bioavailable, long-acting inhibitor of neutral endopeptidase 24.11.

Trapani AJ, De Lombaert S, Erion MD, Ghai RD, Peppard JV, Lappe RW, Worcel M.

J Hypertens Suppl. 1993 Dec;11(5):S220-1. No abstract available.

PMID:
8158354
13.

Heterocyclic lactam derivatives as dual angiotensin converting enzyme and neutral endopeptidase 24.11 inhibitors.

Stanton JL, Sperbeck DM, Trapani AJ, Cote D, Sakane Y, Berry CJ, Ghai RD.

J Med Chem. 1993 Nov 26;36(24):3829-33.

PMID:
8254612
14.

Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor.

MacPherson LJ, Bayburt EK, Capparelli MP, Bohacek RS, Clarke FH, Ghai RD, Sakane Y, Berry CJ, Peppard JV, Trapani AJ.

J Med Chem. 1993 Nov 26;36(24):3821-8.

PMID:
8254611
15.

Disposition of thiorphan in DOCA-salt and spontaneously hypertensive rats.

Sakane Y, Berry C, Hopkins MF, Singh K, Ghai RD.

Res Commun Chem Pathol Pharmacol. 1993 Aug;81(2):151-8.

PMID:
8210694
16.

The biological activity of atrial natriuretic factor cleaved by endoprotease 3.4.24.11.

Ghai RD, Webb RL, Sonnenberg JL, Sakane Y, Ghai G.

J Enzyme Inhib. 1991;4(3):267-72.

PMID:
1645400
17.

Occurrence of neutral endopeptidase activity in the cat carotid body and its significance in chemoreception.

Kumar GK, Runold M, Ghai RD, Cherniack NS, Prabhakar NR.

Brain Res. 1990 May 28;517(1-2):341-3.

PMID:
2376002
18.

Enkephalinase inhibitors. 1. 2,4-Dibenzylglutaric acid derivatives.

Ksander GM, Diefenbacher CG, Yuan AM, Clark F, Sakane Y, Ghai RD.

J Med Chem. 1989 Dec;32(12):2519-26.

PMID:
2585440
19.

Biochemical and immunocytochemical analysis of a histone H1 variant from the mouse testis.

Rasheed BK, Whisenant EC, Ghai RD, Papaioannou VE, Bhatnagar YM.

J Cell Sci. 1989 Sep;94 ( Pt 1):61-71.

20.

Role of atrial natriuretic factor in regulation of blood pressure in normotensive rats having reduced renal mass.

Pamnani MB, Mueller GP, Ghai RD, Haddy FJ.

Proc Soc Exp Biol Med. 1988 Dec;189(3):297-303.

PMID:
2974594
21.

Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney.

Sonnenberg JL, Sakane Y, Jeng AY, Koehn JA, Ansell JA, Wennogle LP, Ghai RD.

Peptides. 1988 Jan-Feb;9(1):173-80.

PMID:
2966343
22.

Degradation of atrial natriuretic factor by kidney cortex membranes. Isolation and characterization of the primary proteolytic product.

Koehn JA, Norman JA, Jones BN, LeSueur L, Sakane Y, Ghai RD.

J Biol Chem. 1987 Aug 25;262(24):11623-7.

23.

Dopaminergic mediation of the diuretic and natriuretic effects of ANF in the rat.

Webb RL, Della Puca R, Manniello J, Robson RD, Zimmerman MB, Ghai RD.

Life Sci. 1986 Jun 23;38(25):2319-27.

PMID:
2941632
24.

Atrial natriuretic factor: atrial conversion of high to low molecular weight forms.

Trippodo NC, Ghai RD, MacPhee AA, Cole FE.

Biochem Biophys Res Commun. 1984 Feb 29;119(1):282-8.

PMID:
6538413
25.

Biochemical and immunological characterization of a histone variant associated with spermatogenesis in the mouse.

Bhatnagar YM, McCullar K, Faulkner RD, Ghai RD.

Biochim Biophys Acta. 1983 Oct 4;760(1):25-33.

PMID:
6193814
26.
27.

Structure and location of the O-glycosidic carbohydrate units of human chorionic gonadotropin.

Kessler MJ, Mise T, Ghai RD, Bahl OP.

J Biol Chem. 1979 Aug 25;254(16):7909-14. No abstract available.

28.

Immunological properties of the beta-subunit of human chorionic gonadotropin.

Bahl OP, Pandian MR, Ghai RD.

Biochem Biophys Res Commun. 1976 May 17;70(2):525-32. No abstract available.

PMID:
938508
29.

Effect of glucose loading on serum glycoproteins.

Ghai RD, Pai ML, Shah CP, Srinvasan S.

J Assoc Physicians India. 1974 Aug;22(8):597-600. No abstract available.

PMID:
4443332

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