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Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer.

Flebbe H, Hamdan FH, Kari V, Kitz J, Gaedcke J, Ghadimi BM, Johnsen SA, Grade M.

Cancers (Basel). 2019 Aug 9;11(8). pii: E1142. doi: 10.3390/cancers11081142.


[Evidence-based surgery of rectal cancer].

Grade M, Flebbe H, Ghadimi BM.

Chirurg. 2019 May;90(5):387-397. doi: 10.1007/s00104-019-0802-y. Review. German.


[Is acute appendicitis a surgical emergency?]

Kujath C, Kollmar O, Ghadimi BM.

Chirurg. 2019 Mar;90(3):183-185. doi: 10.1007/s00104-018-0757-4. Review. German.


Enhancer-driven transcriptional regulation is a potential key determinant for human visceral and subcutaneous adipocytes.

Liefke R, Bokelmann K, Ghadimi BM, Dango S.

Biochim Biophys Acta Gene Regul Mech. 2018 Jun 30. pii: S1874-9399(18)30095-6. doi: 10.1016/j.bbagrm.2018.06.007. [Epub ahead of print]


Stellenwert des intraoperativen Neuromonitorings in der roboterassistierten Rektumchirurgie.

Flebbe H, Beham AW, Schüler P, Kneist W, Ghadimi BM, Grade M.

Zentralbl Chir. 2018 Jun;143(3):215-219. doi: 10.1055/a-0573-3203. Epub 2018 Jun 22. German. No abstract available.


Individual endoscopic management of anastomotic insufficiency after esophagectomy for esophageal squamous cell carcinoma and creation of a neostomach.

Wedi E, Schüler P, Kunsch S, Ghadimi BM, Seif Amir Hosseini A, Ellenrieder V, Jung C.

Endoscopy. 2018 Mar;50(3):E69-E71. doi: 10.1055/s-0043-124180. Epub 2018 Jan 12. No abstract available.


Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery.

Hu Y, Gaedcke J, Emons G, Beissbarth T, Grade M, Jo P, Yeager M, Chanock SJ, Wolff H, Camps J, Ghadimi BM, Ried T.

Genes Chromosomes Cancer. 2018 Mar;57(3):140-149. doi: 10.1002/gcc.22512. Epub 2017 Nov 28.


Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.

Emons G, Spitzner M, Reineke S, Möller J, Auslander N, Kramer F, Hu Y, Beissbarth T, Wolff HA, Rave-Fränk M, Heßmann E, Gaedcke J, Ghadimi BM, Johnsen SA, Ried T, Grade M.

Mol Cancer Res. 2017 Nov;15(11):1481-1490. doi: 10.1158/1541-7786.MCR-17-0205. Epub 2017 Aug 15.


The Prognostic Value of Tyrosine Kinase SRC Expression in Locally Advanced Rectal Cancer.

Rühlmann F, Nietert M, Sprenger T, Wolff HA, Homayounfar K, Middel P, Bohnenberger H, Beissbarth T, Ghadimi BM, Liersch T, Conradi LC.

J Cancer. 2017 Apr 10;8(7):1229-1237. doi: 10.7150/jca.16980. eCollection 2017.


Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy.

Jo P, Azizian A, Salendo J, Kramer F, Bernhardt M, Wolff HA, Gruber J, Grade M, Beißbarth T, Ghadimi BM, Gaedcke J.

Int J Mol Sci. 2017 May 27;18(6). pii: E1140. doi: 10.3390/ijms18061140.


Relevance of surgery in patients with non-variceal upper gastrointestinal bleeding.

Dango S, Beißbarth T, Weiss E, Seif Amir Hosseini A, Raddatz D, Ellenrieder V, Lotz J, Ghadimi BM, Beham A.

Langenbecks Arch Surg. 2017 May;402(3):509-519. doi: 10.1007/s00423-017-1552-2. Epub 2017 Jan 14.


[Intraoperative multidimensional visualization].

Sperling J, Kauffels A, Grade M, Alves F, Kühn P, Ghadimi BM.

Chirurg. 2016 Dec;87(12):1015-1024. German.


Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer.

Wang J, Yang S, He P, Schetter AJ, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Gaida MM, Hanna N, Alexander HR, Hussain SP.

Clin Cancer Res. 2016 Dec 15;22(24):5992-6001. Epub 2016 Jul 8.


Repeated adjuvant anti-CEA radioimmunotherapy after resection of colorectal liver metastases: Safety, feasibility, and long-term efficacy results of a prospective phase 2 study.

Sahlmann CO, Homayounfar K, Niessner M, Dyczkowski J, Conradi LC, Braulke F, Meller B, Beißbarth T, Ghadimi BM, Meller J, Goldenberg DM, Liersch T.

Cancer. 2017 Feb 15;123(4):638-649. doi: 10.1002/cncr.30390. Epub 2016 Oct 20.


Inducible nitric oxide synthase enhances disease aggressiveness in pancreatic cancer.

Wang J, He P, Gaida M, Yang S, Schetter AJ, Gaedcke J, Ghadimi BM, Ried T, Yfantis H, Lee D, Weiss JM, Stauffer J, Hanna N, Alexander HR, Hussain SP.

Oncotarget. 2016 Aug 16;7(33):52993-53004. doi: 10.18632/oncotarget.10323.


A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2.

Yang S, He P, Wang J, Schetter A, Tang W, Funamizu N, Yanaga K, Uwagawa T, Satoskar AR, Gaedcke J, Bernhardt M, Ghadimi BM, Gaida MM, Bergmann F, Werner J, Ried T, Hanna N, Alexander HR, Hussain SP.

Cancer Res. 2016 Jul 1;76(13):3838-50. doi: 10.1158/0008-5472.CAN-15-2841. Epub 2016 Apr 20.


MicroRNA in rectal cancer.

Azizian A, Gruber J, Ghadimi BM, Gaedcke J.

World J Gastrointest Oncol. 2016 May 15;8(5):416-26. doi: 10.4251/wjgo.v8.i5.416. Review.


Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer.

Azizian A, Epping I, Kramer F, Jo P, Bernhardt M, Kitz J, Salinas G, Wolff HA, Grade M, Beißbarth T, Ghadimi BM, Gaedcke J.

Int J Mol Sci. 2016 Apr 15;17(4):568. doi: 10.3390/ijms17040568.


[Robotic Rectal Cancer Surgery].

Grade M, Ridwelski K, Voigt I, Ghadimi BM, Mann B.

Zentralbl Chir. 2016 Apr;141(2):165-9. doi: 10.1055/s-0042-101960. Epub 2016 Apr 13. German.


Relevance of Sp Binding Site Polymorphism in WWOX for Treatment Outcome in Pancreatic Cancer.

Schirmer MA, Lüske CM, Roppel S, Schaudinn A, Zimmer C, Pflüger R, Haubrock M, Rapp J, Güngör C, Bockhorn M, Hackert T, Hank T, Strobel O, Werner J, Izbicki JR, Johnsen SA, Gaedcke J, Brockmöller J, Ghadimi BM.

J Natl Cancer Inst. 2016 Feb 8;108(5). doi: 10.1093/jnci/djv387. Print 2016 May.


Pelvic intraoperative neuromonitoring during robotic-assisted low anterior resection for rectal cancer.

Grade M, Beham AW, Schüler P, Kneist W, Ghadimi BM.

J Robot Surg. 2016 Jun;10(2):157-60. doi: 10.1007/s11701-015-0556-6. Epub 2015 Dec 24.


Cancer Gene Profiling for Response Prediction.

Ghadimi BM, Jo P.

Methods Mol Biol. 2016;1381:163-79. doi: 10.1007/978-1-4939-3204-7_9.


[Management of delayed complications after esophagectomy].

Beham A, Dango S, Ghadimi BM.

Chirurg. 2015 Nov;86(11):1029-33. doi: 10.1007/s00104-015-0086-9. Review. German.


Hepatocellular carcinoma: Surgeon's view on latest findings and future perspectives.

Slotta JE, Kollmar O, Ellenrieder V, Ghadimi BM, Homayounfar K.

World J Hepatol. 2015 May 28;7(9):1168-83. doi: 10.4254/wjh.v7.i9.1168. Review.


Preoperative Prediction of Lymph Node Status by Circulating Mir-18b and Mir-20a During Chemoradiotherapy in Patients with Rectal Cancer.

Azizian A, Kramer F, Jo P, Wolff HA, Beißbarth T, Skarupke R, Bernhardt M, Grade M, Ghadimi BM, Gaedcke J.

World J Surg. 2015 Sep;39(9):2329-35. doi: 10.1007/s00268-015-3083-8.


HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer.

Styczen H, Nagelmeier I, Beissbarth T, Nietert M, Homayounfar K, Sprenger T, Boczek U, Stanek K, Kitz J, Wolff HA, Ghadimi BM, Middel P, Liersch T, Rüschoff J, Conradi LC.

Oncotarget. 2015 Jun 20;6(17):15065-76.


Comprehensive lymph node morphometry in rectal cancer using acetone compression.

Scheel AH, Reineke RA, Sprenger T, Lokka S, Kitz J, Ghadimi BM, Rüschoff J, Liersch T, Middel P.

J Clin Pathol. 2015 Jun;68(6):458-64. doi: 10.1136/jclinpath-2014-202555. Epub 2015 Mar 16.


STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy.

Spitzner M, Ebner R, Wolff HA, Ghadimi BM, Wienands J, Grade M.

Cancers (Basel). 2014 Sep 29;6(4):1986-2011. doi: 10.3390/cancers6041986. Review.


Combined DNA methylation and gene expression profiling in gastrointestinal stromal tumors reveals hypomethylation of SPP1 as an independent prognostic factor.

Haller F, Zhang JD, Moskalev EA, Braun A, Otto C, Geddert H, Riazalhosseini Y, Ward A, Balwierz A, Schaefer IM, Cameron S, Ghadimi BM, Agaimy A, Fletcher JA, Hoheisel J, Hartmann A, Werner M, Wiemann S, Sahin O.

Int J Cancer. 2015 Mar 1;136(5):1013-23. doi: 10.1002/ijc.29088. Epub 2014 Aug 1.


STED super-resolution microscopy of clinical paraffin-embedded human rectal cancer tissue.

Ilgen P, Stoldt S, Conradi LC, Wurm CA, Rüschoff J, Ghadimi BM, Liersch T, Jakobs S.

PLoS One. 2014 Jul 15;9(7):e101563. doi: 10.1371/journal.pone.0101563. eCollection 2014.


Standardized and quality-assured video-recorded examination in undergraduate education: informed consent prior to surgery.

Kiehl C, Simmenroth-Nayda A, Goerlich Y, Entwistle A, Schiekirka S, Ghadimi BM, Raupach T, Koenig S.

J Surg Res. 2014 Sep;191(1):64-73. doi: 10.1016/j.jss.2014.01.048. Epub 2014 Jan 30.


Oxaliplatin-Induced Leukocytoclastic Vasculitis under Adjuvant Chemotherapy for Colorectal Cancer: Two Cases of a Rare Adverse Event.

Quack H, Erpenbeck L, Wolff HA, Sprenger T, Seitz CS, Schön MP, Neumann S, Stanek K, Ghadimi BM, Michels B, Middel P, Schaefer IM, Liersch T, Conradi LC.

Case Rep Oncol. 2013 Dec 11;6(3):609-15. doi: 10.1159/000357166. eCollection 2013 Sep.


Preoperative chemoradiation therapy with capecitabine/oxaliplatin and cetuximab in rectal cancer: long-term results of a prospective phase 1/2 study.

Fokas E, Conradi L, Weiss C, Sprenger T, Middel P, Rau T, Dellas K, Kitz J, Rödel F, Sauer R, Rüschoff J, Beissbarth T, Arnold D, Ghadimi BM, Rödel C, Liersch T.

Int J Radiat Oncol Biol Phys. 2013 Dec 1;87(5):992-9. doi: 10.1016/j.ijrobp.2013.09.011. Epub 2013 Oct 24.


Chromosomal aberrations in primary PDGFRA-mutated gastrointestinal stromal tumors.

Schaefer IM, Delfs C, Cameron S, Gunawan B, Agaimy A, Ghadimi BM, Haller F.

Hum Pathol. 2014 Jan;45(1):85-97. doi: 10.1016/j.humpath.2013.05.027. Epub 2013 Oct 21.


STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.

Spitzner M, Roesler B, Bielfeld C, Emons G, Gaedcke J, Wolff HA, Rave-Fränk M, Kramer F, Beissbarth T, Kitz J, Wienands J, Ghadimi BM, Ebner R, Ried T, Grade M.

Int J Cancer. 2014 Feb 15;134(4):997-1007. doi: 10.1002/ijc.28429. Epub 2013 Sep 3.


Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer.

Zhang G, He P, Tan H, Budhu A, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Maitra A, Hanna N, Alexander HR, Hussain SP.

Clin Cancer Res. 2013 Sep 15;19(18):4983-93. doi: 10.1158/1078-0432.CCR-13-0209. Epub 2013 Aug 5.


FOXL1, a novel candidate tumor suppressor, inhibits tumor aggressiveness and predicts outcome in human pancreatic cancer.

Zhang G, He P, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Hanna N, Alexander HR, Hussain SP.

Cancer Res. 2013 Sep 1;73(17):5416-25. doi: 10.1158/0008-5472.CAN-13-0362. Epub 2013 Jun 25.


Increased growth of colorectal liver metastasis following partial hepatectomy.

Krause P, Flikweert H, Monin M, Seif Amir Hosseini A, Helms G, Cantanhede G, Ghadimi BM, Koenig S.

Clin Exp Metastasis. 2013 Jun;30(5):681-93. doi: 10.1007/s10585-013-9572-y. Epub 2013 Feb 6.


Massive intrafollicular and arterial hyalinosis of the spleen following rituximab and methylprednisolone therapy in a patient with splenic marginal zone lymphoma.

Schaefer IM, Marx A, Sauer C, Hohloch K, Ghadimi BM, Trümper L, Ströbel P.

Histopathology. 2013 Mar;62(4):664-7. doi: 10.1111/his.12051. Epub 2013 Feb 5. No abstract available.


Metastatic recurrence after complete resection of colorectal liver metastases: impact of surgery and chemotherapy on survival.

Homayounfar K, Bleckmann A, Conradi LC, Sprenger T, Lorf T, Niessner M, Sahlmann CO, Meller J, Liersch T, Ghadimi BM.

Int J Colorectal Dis. 2013 Jul;28(7):1009-17. doi: 10.1007/s00384-013-1648-2. Epub 2013 Feb 1.


Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer.

Camps J, Pitt JJ, Emons G, Hummon AB, Case CM, Grade M, Jones TL, Nguyen QT, Ghadimi BM, Beissbarth T, Difilippantonio MJ, Caplen NJ, Ried T.

Cancer Res. 2013 Mar 15;73(6):2003-13. doi: 10.1158/0008-5472.CAN-12-3159. Epub 2013 Jan 14.


PAM4 enzyme immunoassay alone and in combination with CA 19-9 for the detection of pancreatic adenocarcinoma.

Gold DV, Gaedcke J, Ghadimi BM, Goggins M, Hruban RH, Liu M, Newsome G, Goldenberg DM.

Cancer. 2013 Feb 1;119(3):522-8. doi: 10.1002/cncr.27762. Epub 2012 Aug 16.


The rectal cancer microRNAome--microRNA expression in rectal cancer and matched normal mucosa.

Gaedcke J, Grade M, Camps J, Søkilde R, Kaczkowski B, Schetter AJ, Difilippantonio MJ, Harris CC, Ghadimi BM, Møller S, Beissbarth T, Ried T, Litman T.

Clin Cancer Res. 2012 Sep 15;18(18):4919-30. Epub 2012 Jul 31.


Enrichment of CD133-expressing cells in rectal cancers treated with preoperative radiochemotherapy is an independent marker for metastasis and survival.

Sprenger T, Conradi LC, Beissbarth T, Ermert H, Homayounfar K, Middel P, Rüschoff J, Wolff HA, Schüler P, Ghadimi BM, Rödel C, Becker H, Rödel F, Liersch T.

Cancer. 2013 Jan 1;119(1):26-35. doi: 10.1002/cncr.27703. Epub 2012 Jun 26.


Bilobar spreading of colorectal liver metastases does not significantly affect survival after R0 resection in the era of interdisciplinary multimodal treatment.

Homayounfar K, Bleckmann A, Conradi LC, Sprenger T, Beissbarth T, Lorf T, Niessner M, Sahlmann CO, Meller J, Becker H, Liersch T, Ghadimi BM.

Int J Colorectal Dis. 2012 Oct;27(10):1359-67. Epub 2012 Mar 21.


The consequences of chromosomal aneuploidy on the transcriptome of cancer cells.

Ried T, Hu Y, Difilippantonio MJ, Ghadimi BM, Grade M, Camps J.

Biochim Biophys Acta. 2012 Jul;1819(7):784-93. doi: 10.1016/j.bbagrm.2012.02.020. Epub 2012 Mar 6. Review.


The molecular basis of chemoradiosensitivity in rectal cancer: implications for personalized therapies.

Grade M, Wolff HA, Gaedcke J, Ghadimi BM.

Langenbecks Arch Surg. 2012 Apr;397(4):543-55. doi: 10.1007/s00423-012-0929-5. Epub 2012 Mar 2. Review.


DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma.

Zhang G, Schetter A, He P, Funamizu N, Gaedcke J, Ghadimi BM, Ried T, Hassan R, Yfantis HG, Lee DH, Lacy C, Maitra A, Hanna N, Alexander HR, Hussain SP.

PLoS One. 2012;7(2):e31507. doi: 10.1371/journal.pone.0031507. Epub 2012 Feb 20.


Optimal lymph node harvest in rectal cancer (UICC stages II and III) after preoperative 5-FU-based radiochemotherapy. Acetone compression is a new and highly efficient method.

Gehoff A, Basten O, Sprenger T, Conradi LC, Bismarck C, Bandorski D, Merkelbach-Bruse S, Schneider-Stock R, Stoehr R, Wirtz RM, Kitz J, Müller A, Hartmann A, Becker H, Ghadimi BM, Liersch T, Rüschoff J.

Am J Surg Pathol. 2012 Feb;36(2):202-13. doi: 10.1097/PAS.0b013e31823fa35b.


Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers.

Sharon E, Zhang J, Hollevoet K, Steinberg SM, Pastan I, Onda M, Gaedcke J, Ghadimi BM, Ried T, Hassan R.

Clin Chem Lab Med. 2012 Apr;50(4):721-5. doi: 10.1515/CCLM.2011.816.

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