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Items: 46

1.

Kupffer cell function during the erythocytic stage of malaria.

Murthi P, Kalionis B, Ghabrial H, Dunlop ME, Smallwood RA, Sewell RB.

J Gastroenterol Hepatol. 2006 Jan;21(1 Pt 2):313-8.

PMID:
16460493
2.

Differential bidirectional transfer of indinavir in the isolated perfused human placenta.

Sudhakaran S, Ghabrial H, Nation RL, Kong DC, Gude NM, Angus PW, Rayner CR.

Antimicrob Agents Chemother. 2005 Mar;49(3):1023-8.

3.

Reduced tubular cation transport in diabetes: prevented by ACE inhibition.

Thomas MC, Tikellis C, Burns WC, Thallas V, Forbes JM, Cao Z, Osicka TM, Russo LM, Jerums G, Ghabrial H, Cooper ME, Kantharidis P.

Kidney Int. 2003 Jun;63(6):2152-61.

4.

A novel method for determining hepatic sinusoidal oxygen permeability in the isolated perfused rat liver using [15O]O2.

Froomes PR, Sachinidis J, Ghabrial H, Tochon-Danguy H, Scott A, Ching MS, Morgan DJ, Angus PW.

Nucl Med Biol. 2003 Feb;30(2):93-100.

PMID:
12623107
5.

The effect of oxygen supplementation on the arterial ketone body ratio in human cirrhosis.

Froomes PR, Ghabrial H, Morgan DJ, Angus PW.

Digestion. 2002;66(4):257-61.

PMID:
12592102
6.

Hepatic Kupffer cell phagocytotic function in rats with erythrocytic-stage malaria.

Nobes MS, Ghabrial H, Simms KM, Smallwood RB, Morgan DJ, Sewell RB.

J Gastroenterol Hepatol. 2002 May;17(5):598-605.

PMID:
12084035
7.

Differential inhibition of human CYP1A1 and CYP1A2 by quinidine and quinine.

Ching MS, Blake CL, Malek NA, Angus PW, Ghabrial H.

Xenobiotica. 2001 Nov;31(11):757-67.

PMID:
11765139
8.

Neonatal hepatic drug elimination.

Gow PJ, Ghabrial H, Smallwood RA, Morgan DJ, Ching MS.

Pharmacol Toxicol. 2001 Jan;88(1):3-15. Review.

PMID:
11169155
9.

Right heart failure impairs hepatic elimination of p-nitrophenol without inducing changes in content or latency of hepatic UDP-glucuronosyltransferases.

Ng CY, Ghabrial H, Morgan DJ, Ching MS, Smallwood RA, Angus PW.

J Pharmacol Exp Ther. 2000 Nov;295(2):830-5.

PMID:
11046125
10.

Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin.

Haritos VS, Ghabrial H, Ahokas JT, Ching MS.

Pharmacogenetics. 2000 Oct;10(7):591-603.

PMID:
11037801
11.

Impaired elimination of propranolol due to right heart failure: drug clearance in the isolated liver and its relationship to intrinsic metabolic capacity.

Ng CY, Ghabrial H, Morgan DJ, Ching MS, Smallwood RA, Angus PW.

Drug Metab Dispos. 2000 Oct;28(10):1217-21.

PMID:
10997943
12.

Neonatal hepatic propranolol elimination: studies in the isolated perfused neonatal sheep liver.

Gow PJ, Treepongkaruna S, Ghabrial H, Shulkes A, Smallwood RA, Morgan DJ, Ching MS.

J Pharm Sci. 2000 May;89(5):586-93.

PMID:
10756324
13.

Stereoselective measurement of E- and Z-doxepin and its N-desmethyl and hydroxylated metabolites by gas chromatography-mass spectrometry.

Haritos VS, Ghabrial H, Ahokas JT, Ching MS.

J Chromatogr B Biomed Sci Appl. 1999 Dec 24;736(1-2):201-8.

PMID:
10677000
14.

Fetal hepatic drug elimination.

Ring JA, Ghabrial H, Ching MS, Smallwood RA, Morgan DJ.

Pharmacol Ther. 1999 Dec;84(3):429-45. Review.

PMID:
10665839
15.

Conjugation of para-nitrophenol by the isolated perfused neonatal sheep liver.

Gow PJ, Ghabrial H, Treepongkaruna S, Shulkes A, Smallwood RA, Morgan DJ, Ching MS.

J Pharm Sci. 2000 Jan;89(1):36-44.

PMID:
10664536
16.

Uptake and excretion of sodium taurocholate by the isolated perfused neonatal sheep liver.

Gow PJ, Treepongkaruna S, Ching MS, Ghabrial H, Shulkes A, Smallwood RA, Jin CJ, Morgan DJ.

J Pharm Sci. 1999 Apr;88(4):445-9.

PMID:
10187755
17.

Metabolism of dexfenfluramine in human liver microsomes and by recombinant enzymes: role of CYP2D6 and 1A2.

Haritos VS, Ching MS, Ghabrial H, Gross AS, Taavitsainen P, Pelkonen O, Battaglia SE, Smallwood RA, Ahokas JT.

Pharmacogenetics. 1998 Oct;8(5):423-32.

PMID:
9825834
18.

A priming dose of propranolol reduces the availability of a subsequent dose in the isolated perfused rat liver preparation.

Ghabrial H, Sewell RB, Smallwood RA, Morgan DJ.

Clin Exp Pharmacol Physiol. 1998 Feb;25(2):110-3.

PMID:
9493498
19.

Propranolol elimination by right and left fetal liver: studies in the intact isolated perfused fetal sheep liver.

Ring JA, Ghabrial H, Ching MS, Shulkes A, Smallwood RA, Morgan DJ.

J Pharmacol Exp Ther. 1998 Feb;284(2):535-41.

PMID:
9454794
20.

Measurement of dexfenfluramine metabolism in rat liver microsomes by gas chromatography-mass spectrometry.

Haritos VS, Ching MS, Ghabrial H, Ahokas JT.

J Chromatogr B Biomed Sci Appl. 1997 Jun 6;693(2):327-36.

PMID:
9210436
21.

Effects of acute myocardial infarction on theophylline elimination in rats.

Ng CY, Ghabrial H, Morgan DJ, Smallwood RA, Angus PW.

Drug Metab Dispos. 1997 Jan;25(1):61-5.

PMID:
9010631
23.

Conjugation of para-nitrophenol by isolated perfused fetal sheep liver.

Ring JA, Ghabrial H, Ching MS, Shulkes A, Smallwood RA, Morgan DJ.

Drug Metab Dispos. 1996 Dec;24(12):1378-84.

PMID:
8971145
24.

Propranolol 4- and 5-hydroxylation and N-desisopropylation by cloned human cytochrome P4501A1 and P4501A2.

Ching MS, Bichara N, Blake CL, Ghabrial H, Tukey RH, Smallwood RA.

Drug Metab Dispos. 1996 Jun;24(6):692-4. No abstract available.

PMID:
8781788
25.

Effect of erythrocyte binding on elimination of harmol by the isolated perfused rat liver.

Morgan DJ, Guttmann A, Watson RG, Ghabrial H, Elliott SL, Smallwood RA.

J Pharm Sci. 1996 Jan;85(1):40-4.

PMID:
8926581
26.
27.

Potent inhibition of yeast-expressed CYP2D6 by dihydroquinidine, quinidine, and its metabolites.

Ching MS, Blake CL, Ghabrial H, Ellis SW, Lennard MS, Tucker GT, Smallwood RA.

Biochem Pharmacol. 1995 Sep 7;50(6):833-7.

PMID:
7575645
28.

Determinants of placental drug transfer: studies in the isolated perfused human placenta.

Bassily M, Ghabrial H, Smallwood RA, Morgan DJ.

J Pharm Sci. 1995 Sep;84(9):1054-60.

PMID:
8537881
29.

Right heart failure impairs hepatic oxygenation and theophylline clearance in rats.

Ng CY, Angus PW, Ghabrial H, Chou ST, Arnolda L, Morgan DJ, Smallwood RA.

J Pharmacol Exp Ther. 1995 Jun;273(3):1332-6.

PMID:
7791105
30.

Effects of chronic left ventricular failure on hepatic oxygenation and theophylline elimination in the rat.

Angus PW, Ng CY, Ghabrial H, Morgan DJ, Smallwood RA.

Drug Metab Dispos. 1995 Apr;23(4):485-9.

PMID:
7600916
31.

Fetal hepatic propranolol metabolism. Studies in the isolated perfused fetal sheep liver.

Ring JA, Ghabrial H, Ching MS, Shulkes A, Smallwood RA, Morgan DJ.

Drug Metab Dispos. 1995 Feb;23(2):190-6.

PMID:
7736910
32.

Hepatic uptake and excretion of [14C]sodium taurocholate by the isolated perfused fetal sheep liver.

Ring JA, Ghabrial H, Ching MS, Potocnik S, Shulkes A, Smallwood RA, Morgan DJ.

Biochem Pharmacol. 1994 Aug 17;48(4):667-74.

PMID:
8080439
33.

Product inhibition and dose-dependent bioavailability of propranolol in the isolated perfused rat liver preparation.

Ghabrial H, Nand R, Stead CK, Smallwood RA, Morgan DJ.

J Pharm Sci. 1994 Jul;83(7):931-6.

PMID:
7965671
34.

The effect of hypoxia and acidosis on propranolol clearance in the isolated perfused rat liver preparation.

Elliott SL, Morgan DJ, Angus PW, Ghabrial H, Smallwood RA.

Biochem Pharmacol. 1993 Feb 9;45(3):763-5.

PMID:
8442773
35.

The effect of hypoxia on propranolol clearance during antegrade and retrograde flow in the isolated perfused rat liver preparation.

Elliott SL, Morgan DJ, Angus PW, Ghabrial H, Watson RG, Smallwood RA.

Biochem Pharmacol. 1993 Feb 9;45(3):573-8.

PMID:
8442756
36.

Sensitivity of propranolol elimination to hypoxia in the isolated perfused rat liver preparation.

Elliott SL, Morgan DJ, Angus PW, Ghabrial H, Smallwood RA.

Clin Exp Pharmacol Physiol. 1993 Jan;20(1):27-33.

PMID:
8432038
37.

Effect of malaria on phenol conjugation pathways in perfused rat liver.

Murdoch RT, Ghabrial H, Smallwood RA, Morgan DJ.

Biochem Pharmacol. 1992 Mar 17;43(6):1229-34.

PMID:
1562275
38.
39.

Malaria infection impairs glucuronidation and biliary excretion by the isolated perfused rat liver.

Murdoch RT, Ghabrial H, Mihaly GW, Morgan DJ, Smallwood RA.

Xenobiotica. 1991 Dec;21(12):1571-82.

PMID:
1785204
40.

Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans.

Schellens JH, Ghabrial H, van der Wart HH, Bakker EN, Wilkinson GR, Breimer DD.

Clin Pharmacol Ther. 1991 Nov;50(5 Pt 1):520-8.

PMID:
1934865
41.

Transfer of acipimox across the isolated perfused human placenta.

Ghabrial H, Czuba MA, Stead CK, Smallwood RA, Morgan DJ.

Placenta. 1991 Nov-Dec;12(6):653-61.

PMID:
1805205
42.

Disposition of the diastereoisomers quinine and quinidine in the ovine fetus.

Czuba MA, Morgan DJ, Ching MS, Mihaly GW, Ghabrial H, Hardy KJ, Smallwood RA.

J Pharm Sci. 1991 May;80(5):445-8.

PMID:
1880724
43.

Geometric isomerization of doxepin during its N-demethylation in humans.

Ghabrial H, Prakash C, Tacke UG, Blair IA, Wilkinson GR.

Drug Metab Dispos. 1991 May-Jun;19(3):596-9.

PMID:
1680624
44.

Studies on the mechanisms of action of activated charcoal on theophylline pharmacokinetics.

Mckinnon RS, Desmond PV, Harman PJ, Kamm M, Ghabrial H, Martin CJ, Mashford ML.

J Pharm Pharmacol. 1987 Jul;39(7):522-5.

PMID:
2886620
45.

The effects of age and chronic liver disease on the elimination of temazepam.

Ghabrial H, Desmond PV, Watson KJ, Gijsbers AJ, Harman PJ, Breen KJ, Mashford ML.

Eur J Clin Pharmacol. 1986;30(1):93-7.

PMID:
2872062
46.

Use of single doses and rapid sampling to detect interactions with cimetidine.

Ghabrial H, Harman PJ, Desmond PV, Mashford ML, Breen KJ.

Eur J Clin Pharmacol. 1984;27(5):603-6.

PMID:
6519166

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