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Items: 1 to 50 of 76

1.

Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1.

Jablonski JJ, Basu D, Engel DA, Geysen HM.

Bioorg Med Chem. 2012 Jan 1;20(1):487-97. doi: 10.1016/j.bmc.2011.10.026. Epub 2011 Oct 19.

2.

Novel inhibitor of influenza non-structural protein 1 blocks multi-cycle replication in an RNase L-dependent manner.

Walkiewicz MP, Basu D, Jablonski JJ, Geysen HM, Engel DA.

J Gen Virol. 2011 Jan;92(Pt 1):60-70. doi: 10.1099/vir.0.025015-0. Epub 2010 Sep 29.

3.

Comparison of competitive radioimmunoassays and two-site sandwich assays for the measurement and interpretation of plasma ghrelin levels.

Prudom C, Liu J, Patrie J, Gaylinn BD, Foster-Schubert KE, Cummings DE, Thorner MO, Geysen HM.

J Clin Endocrinol Metab. 2010 May;95(5):2351-8. doi: 10.1210/jc.2009-2407. Epub 2010 Mar 1.

4.

Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men.

Liu J, Prudom CE, Nass R, Pezzoli SS, Oliveri MC, Johnson ML, Veldhuis P, Gordon DA, Howard AD, Witcher DR, Geysen HM, Gaylinn BD, Thorner MO.

J Clin Endocrinol Metab. 2008 May;93(5):1980-7. doi: 10.1210/jc.2007-2235. Epub 2008 Mar 18.

5.

Evidence for acyl-ghrelin modulation of growth hormone release in the fed state.

Nass R, Farhy LS, Liu J, Prudom CE, Johnson ML, Veldhuis P, Pezzoli SS, Oliveri MC, Gaylinn BD, Geysen HM, Thorner MO.

J Clin Endocrinol Metab. 2008 May;93(5):1988-94. doi: 10.1210/jc.2007-2234. Epub 2008 Mar 11. Erratum in: J Clin Endocrinol Metab. 2008 Jul;93(7):2922.

6.

Survey of the diversity space coverage of reported combinatorial libraries.

Fitzgerald SH, Sabat M, Geysen HM.

J Comb Chem. 2007 Jul-Aug;9(4):724-34. Epub 2007 Jun 13.

PMID:
17567080
7.

Homo-cysteinyl peptide inhibitors of the L1 metallo-beta-lactamase, and SAR as determined by combinatorial library synthesis.

Sun Q, Law A, Crowder MW, Geysen HM.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5169-75. Epub 2006 Jul 27.

PMID:
16875814
8.

Diversity space and its application to library selection and design.

Fitzgerald SH, Sabat M, Geysen HM.

J Chem Inf Model. 2006 Jul-Aug;46(4):1588-97.

PMID:
16859290
9.

Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody.

Ramsland PA, Terzyan SS, Cloud G, Bourne CR, Farrugia W, Tribbick G, Geysen HM, Moomaw CR, Slaughter CA, Edmundson AB.

Biochem J. 2006 May 1;395(3):473-81.

10.

Combinatorial compound libraries for drug discovery: an ongoing challenge.

Geysen HM, Schoenen F, Wagner D, Wagner R.

Nat Rev Drug Discov. 2003 Mar;2(3):222-30. Review.

PMID:
12612648
11.

Binding of synthetic peptides by a human monoclonal IgM with an unusual combining site structure.

Edmundson AB, Tribbick G, Plompen S, Geysen HM, Yuriev E, Ramsland PA.

J Mol Recognit. 2001 Jul-Aug;14(4):229-38.

PMID:
11500969
12.

Ratio encoding combinatorial libraries with stable isotopes and their utility in pharmaceutical research.

Wagner DS, Markworth CJ, Wagner CD, Schoenen FJ, Rewerts CE, Kay BK, Geysen HM.

Comb Chem High Throughput Screen. 1998 Oct;1(3):143-53.

PMID:
10500773
13.

Isotope or mass encoding of combinatorial libraries.

Geysen HM, Wagner CD, Bodnar WM, Markworth CJ, Parke GJ, Schoenen FJ, Wagner DS, Kinder DS.

Chem Biol. 1996 Aug;3(8):679-88.

14.

Assembly and antigenicity of the Neisseria gonorrhoeae pilus mapped with antibodies.

Forest KT, Bernstein SL, Getzoff ED, So M, Tribbick G, Geysen HM, Deal CD, Tainer JA.

Infect Immun. 1996 Feb;64(2):644-52.

15.

High-throughput purity estimation and characterisation of synthetic peptides by electrospray mass spectrometry.

Smart SS, Mason TJ, Bennell PS, Maeij NJ, Geysen HM.

Int J Pept Protein Res. 1996 Jan-Feb;47(1-2):47-55.

PMID:
8907499
18.

Recognition of multiple peptide cores by a single T cell receptor.

Nanda NK, Arzoo KK, Geysen HM, Sette A, Sercarz EE.

J Exp Med. 1995 Aug 1;182(2):531-9.

19.

Immunodominant framework region 3 peptide from TCR V beta 8.2 chain controls murine experimental autoimmune encephalomyelitis.

Kumar V, Tabibiazar R, Geysen HM, Sercarz E.

J Immunol. 1995 Feb 15;154(4):1941-50.

PMID:
7530748
20.

Limited T cell response to donor MHC peptides during allograft rejection. Implications for selective immune therapy in transplantation.

Benichou G, Fedoseyeva E, Lehmann PV, Olson CA, Geysen HM, McMillan M, Sercarz EE.

J Immunol. 1994 Aug 1;153(3):938-45.

PMID:
7517977
21.

Scanning for T helper epitopes with human PBMC using pools of short synthetic peptides.

Reece JC, McGregor DL, Geysen HM, Rodda SJ.

J Immunol Methods. 1994 Jun 24;172(2):241-54.

PMID:
7518486
22.

T cell determinant structure of myelin basic protein in B10.PL, SJL/J, and their F1S.

Bhardwaj V, Kumar V, Grewal IS, Dao T, Lehmann PV, Geysen HM, Sercarz EE.

J Immunol. 1994 Apr 15;152(8):3711-9.

PMID:
7511656
23.
24.

Mapping the major human T helper epitopes of tetanus toxin. The emerging picture.

Reece JC, Geysen HM, Rodda SJ.

J Immunol. 1993 Dec 1;151(11):6175-84.

PMID:
7504014
25.
26.

Systematic study of substance P analogs. II. Rapid screening of 512 substance P stereoisomers for binding to NK1 receptor.

Wang JX, Dipasquale AJ, Bray AM, Maeji NJ, Spellmeyer DC, Geysen HM.

Int J Pept Protein Res. 1993 Oct;42(4):392-9.

PMID:
7503964
27.

Systematic study of substance P analogs. I. Evaluation of peptides synthesized by the multipin method for quantitative receptor binding assay.

Wang JX, Bray AM, Dipasquale AJ, Maeji NJ, Geysen HM.

Int J Pept Protein Res. 1993 Oct;42(4):384-91.

PMID:
7503963
28.

Multipin peptide synthesis at the micromole scale using 2-hydroxyethyl methacrylate grafted polyethylene supports.

Valerio RM, Bray AM, Campbell RA, Dipasquale A, Margellis C, Rodda SJ, Geysen HM, Maeji NJ.

Int J Pept Protein Res. 1993 Jul;42(1):1-9.

PMID:
8370636
29.

Principles and pitfalls in designing site-directed peptide ligands.

Edmundson AB, Harris DL, Fan ZC, Guddat LW, Schley BT, Hanson BL, Tribbick G, Geysen HM.

Proteins. 1993 Jul;16(3):246-67.

PMID:
8346191
30.

Monoclonal antipeptide antibodies: affinity and kinetic rate constants measured for the peptide and the cognate protein using a biosensor technology.

Zeder-Lutz G, Altschuh D, Geysen HM, Trifilieff E, Sommermeyer G, Van Regenmortel MH.

Mol Immunol. 1993 Feb;30(2):145-55.

PMID:
7679185
31.

Subjugation of dominant immunogenic determinants within a chimeric peptide.

Bhardwaj V, Kumar V, Geysen HM, Sercarz EE.

Eur J Immunol. 1992 Aug;22(8):2009-16.

PMID:
1379183
32.

Use of the multipin peptide synthesis technique for the generation of antipeptide sera.

Triantafyllou B, Tribbick G, Maeji NJ, Geysen HM.

Cell Biophys. 1992 Aug-Dec;21(1-3):33-52.

PMID:
1285329
33.

Altering the antigenicity of proteins.

Alexander H, Alexander S, Getzoff ED, Tainer JA, Geysen HM, Lerner RA.

Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3352-6.

34.

Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections.

Weiner AJ, Geysen HM, Christopherson C, Hall JE, Mason TJ, Saracco G, Bonino F, Crawford K, Marion CD, Crawford KA, et al.

Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3468-72.

35.

Simultaneous multiple synthesis of peptide-carrier conjugates.

Maeji NJ, Tribbick G, Bray AM, Geysen HM.

J Immunol Methods. 1992 Jan 21;146(1):83-90.

PMID:
1735784
36.

The specificity of recognition of a cytotoxic T lymphocyte epitope.

Burrows SR, Rodda SJ, Suhrbier A, Geysen HM, Moss DJ.

Eur J Immunol. 1992 Jan;22(1):191-5.

PMID:
1370414
37.

Extension of a minimal T cell determinant allows relaxation of the requirement for particular residues within the determinant.

Brown LE, Jackson DC, Tribbick G, White DO, Geysen HM.

Int Immunol. 1991 Dec;3(12):1307-13.

PMID:
1723295
38.

Role of single amino acids in the recognition of a T cell epitope.

Suhrbier A, Rodda SJ, Ho PC, Csurhes P, Dunckley H, Saul A, Geysen HM, Rzepczyk CM.

J Immunol. 1991 Oct 15;147(8):2507-13.

PMID:
1717563
39.

Subtype-specificity of antipeptide antibodies raised against unique sequences of human interferons-alpha.

Sattayasai N, Marzuki S, McMullen GL, Geysen HM, Mason TJ, Hibbs AR, Overall M, Hertzog PJ, Linnane AW.

Mol Immunol. 1991 Sep;28(9):975-83.

PMID:
1922111
40.

Framework peptides from kappa IIIb rheumatoid factor light chains with binding activity for aggregated IgG.

Hay FC, Soltys AJ, Tribbick G, Geysen HM.

Eur J Immunol. 1991 Aug;21(8):1837-41.

PMID:
1907918
41.

Systematic fractionation of serum antibodies using multiple antigen homologous peptides as affinity ligands.

Tribbick G, Triantafyllou B, Lauricella R, Rodda SJ, Mason TJ, Geysen HM.

J Immunol Methods. 1991 Jun 3;139(2):155-66.

PMID:
1904463
42.

Characterization of a Plasmodium falciparum epitope recognized by a monoclonal antibody with broad isolate and species specificity.

Limpaiboon T, Taylor DW, Jones G, Geysen HM, Saul A.

Southeast Asian J Trop Med Public Health. 1991 Jun;22(2):284. No abstract available.

PMID:
1719648
43.

Effects of end groups on the stimulatory capacity of minimal length T cell determinant peptides.

Mutch DA, Rodda SJ, Benstead M, Valerio RM, Geysen HM.

Pept Res. 1991 May-Jun;4(3):132-7.

PMID:
1823183
44.

Systematic screening for bioactive peptides.

Maeji NJ, Bray AM, Valerio RM, Seldon MA, Wang JX, Geysen HM.

Pept Res. 1991 May-Jun;4(3):142-6.

PMID:
1726649
45.
46.

T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes.

Gammon G, Geysen HM, Apple RJ, Pickett E, Palmer M, Ametani A, Sercarz EE.

J Exp Med. 1991 Mar 1;173(3):609-17.

47.

Universal antibodies to human interferon-alpha subtypes--the production of antipeptide antibodies to conserved regions of interferon-alpha.

Sattayasai N, McMullen GL, Marzuki S, Tribbick G, Geysen HM, Tymms MJ, Linnane AW.

J Interferon Res. 1991 Feb;11(1):41-8.

PMID:
1709418
48.

Binding of peptides to proteins: an exercise in molecular design.

Edmundson AB, Harris DL, Tribbick G, Geysen HM.

Ciba Found Symp. 1991;158:213-25; discussion 225-30. Review.

PMID:
1935422
49.

Defining antibody-antigen recognition: towards engineered antibodies and epitopes.

Tainer JA, Deal CD, Geysen HM, Roberts VA, Getzoff ED.

Int Rev Immunol. 1991;7(2):165-88. Review. No abstract available.

PMID:
1721650
50.

Molecular technology: peptide epitope mapping and the pin technology.

Geysen HM.

Southeast Asian J Trop Med Public Health. 1990 Dec;21(4):523-33. Review. No abstract available.

PMID:
2098912

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