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Items: 1 to 50 of 465

1.

Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter-deficient mice using the 5-choice CPT.

Young JW, Geyer MA, Halberstadt AL, van Enkhuizen J, Minassian A, Khan A, Perry W, Eyler LT.

Bipolar Disord. 2019 Apr 26. doi: 10.1111/bdi.12786. [Epub ahead of print]

PMID:
31025493
2.

Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen.

Halberstadt AL, van der Zee JVF, Chatha M, Geyer MA, Powell SB.

Psychopharmacology (Berl). 2019 Feb;236(2):821-830. doi: 10.1007/s00213-018-5118-y. Epub 2018 Nov 17.

PMID:
30448990
3.

Nicotine improves probabilistic reward learning in wildtype but not alpha7 nAChR null mutants, yet alpha7 nAChR agonists do not improve probabilistic learning.

Milienne-Petiot M, Higa KK, Grim A, Deben D, Groenink L, Twamley EW, Geyer MA, Young JW.

Eur Neuropsychopharmacol. 2018 Nov;28(11):1217-1231. doi: 10.1016/j.euroneuro.2018.08.005. Epub 2018 Sep 11.

4.

Amphetamine improves mouse and human attention in the 5-choice continuous performance test.

MacQueen DA, Minassian A, Kenton JA, Geyer MA, Perry W, Brigman JL, Young JW.

Neuropharmacology. 2018 Aug;138:87-96. doi: 10.1016/j.neuropharm.2018.05.034. Epub 2018 May 31.

5.

The COMT Val158Met Polymorphism and Exploratory Behavior in Bipolar Mania.

Minassian A, Young JW, Geyer MA, Kelsoe JR, Perry W.

Mol Neuropsychiatry. 2018 Feb;3(3):151-156. doi: 10.1159/000481822. Epub 2017 Nov 22.

6.

Overview of the Biography and Legacy of Professor Athina Markou.

Geyer MA, Semenova S, Li X, Der-Avakian A, Barnes SA, Grant I.

Biol Psychiatry. 2018 Jun 1;83(11):910-912. doi: 10.1016/j.biopsych.2017.10.009. Epub 2018 Mar 2. No abstract available.

PMID:
29501205
7.

Effective Use of Animal Models for Therapeutic Development in Psychiatric and Substance Use Disorders.

Phillips AG, Geyer MA, Robbins TW.

Biol Psychiatry. 2018 Jun 1;83(11):915-923. doi: 10.1016/j.biopsych.2018.01.014. Epub 2018 Jan 31. Review.

PMID:
29478700
8.

Individual variation in working memory is associated with fear extinction performance.

Stout DM, Acheson DT, Moore TM, Gur RC, Baker DG, Geyer MA, Risbrough VB; MRS Team.

Behav Res Ther. 2018 Mar;102:52-59. doi: 10.1016/j.brat.2018.01.002. Epub 2018 Jan 5.

9.

Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors.

Kwiatkowski MA, Hellemann G, Sugar CA, Cope ZA, Minassian A, Perry W, Geyer MA, Young JW.

Pharmacol Biochem Behav. 2019 Mar;178:42-50. doi: 10.1016/j.pbb.2017.12.007. Epub 2017 Dec 28.

PMID:
29289701
10.

Amphetamine Modestly Improves Conners' Continuous Performance Test Performance in Healthy Adults.

MacQueen DA, Minassian A, Henry BL, Geyer MA, Young JW, Perry W.

J Int Neuropsychol Soc. 2018 Mar;24(3):283-293. doi: 10.1017/S135561771700090X. Epub 2017 Oct 16.

11.

COMT val158met polymorphism links to altered fear conditioning and extinction are modulated by PTSD and childhood trauma.

Deslauriers J, Acheson DT, Maihofer AX, Nievergelt CM, Baker DG, Geyer MA, Risbrough VB; Marine Resiliency Study Team.

Depress Anxiety. 2018 Jan;35(1):32-42. doi: 10.1002/da.22678. Epub 2017 Aug 18.

12.

Modafinil improves attentional performance in healthy, non-sleep deprived humans at doses not inducing hyperarousal across species.

Cope ZA, Minassian A, Kreitner D, MacQueen DA, Milienne-Petiot M, Geyer MA, Perry W, Young JW.

Neuropharmacology. 2017 Oct;125:254-262. doi: 10.1016/j.neuropharm.2017.07.031. Epub 2017 Aug 1.

13.

Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikäinen LP, Maihofer AX, Minassian A, van der Most PJ, Müller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F, Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen I, Dietrich A, Ehret GB, Ellinor PT, Eskola M, Felix JF, Floras JS, Franco OH, Friberg P, Gademan MGJ, Geyer MA, Giedraitis V, Hartman CA, Hemerich D, Hofman A, Hottenga JJ, Huikuri H, Hutri-Kähönen N, Jouven X, Junttila J, Juonala M, Kiviniemi AM, Kors JA, Kumari M, Kuznetsova T, Laurie CC, Lefrandt JD, Li Y, Li Y, Liao D, Limacher MC, Lin HJ, Lindgren CM, Lubitz SA, Mahajan A, McKnight B, Zu Schwabedissen HM, Milaneschi Y, Mononen N, Morris AP, Nalls MA, Navis G, Neijts M, Nikus K, North KE, O'Connor DT, Ormel J, Perz S, Peters A, Psaty BM, Raitakari OT, Risbrough VB, Sinner MF, Siscovick D, Smit JH, Smith NL, Soliman EZ, Sotoodehnia N, Staessen JA, Stein PK, Stilp AM, Stolarz-Skrzypek K, Strauch K, Sundström J, Swenne CA, Syvänen AC, Tardif JC, Taylor KD, Teumer A, Thornton TA, Tinker LE, Uitterlinden AG, van Setten J, Voss A, Waldenberger M, Wilhelmsen KC, Willemsen G, Wong Q, Zhang ZM, Zonderman AB, Cusi D, Evans MK, Greiser HK, van der Harst P, Hassan M, Ingelsson E, Järvelin MR, Kääb S, Kähönen M, Kivimaki M, Kooperberg C, Kuh D, Lehtimäki T, Lind L, Nievergelt CM, O'Donnell CJ, Oldehinkel AJ, Penninx B, Reiner AP, Riese H, van Roon AM, Rioux JD, Rotter JI, Sofer T, Stricker BH, Tiemeier H, Vrijkotte TGM, Asselbergs FW, Brundel BJJM, Heckbert SR, Whitsel EA, den Hoed M, Snieder H, de Geus EJC.

Nat Commun. 2017 Aug 2;8:16140. doi: 10.1038/ncomms16140.

14.

Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikäinen LP, Maihofer AX, Minassian A, van der Most PJ, Müller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F, Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen I, Dietrich A, Ehret GB, Ellinor PT, Eskola M, Felix JF, Floras JS, Franco OH, Friberg P, Gademan MGJ, Geyer MA, Giedraitis V, Hartman CA, Hemerich D, Hofman A, Hottenga JJ, Huikuri H, Hutri-Kähönen N, Jouven X, Junttila J, Juonala M, Kiviniemi AM, Kors JA, Kumari M, Kuznetsova T, Laurie CC, Lefrandt JD, Li Y, Li Y, Liao D, Limacher MC, Lin HJ, Lindgren CM, Lubitz SA, Mahajan A, McKnight B, Zu Schwabedissen HM, Milaneschi Y, Mononen N, Morris AP, Nalls MA, Navis G, Neijts M, Nikus K, North KE, O'Connor DT, Ormel J, Perz S, Peters A, Psaty BM, Raitakari OT, Risbrough VB, Sinner MF, Siscovick D, Smit JH, Smith NL, Soliman EZ, Sotoodehnia N, Staessen JA, Stein PK, Stilp AM, Stolarz-Skrzypek K, Strauch K, Sundström J, Swenne CA, Syvänen AC, Tardif JC, Taylor KD, Teumer A, Thornton TA, Tinker LE, Uitterlinden AG, van Setten J, Voss A, Waldenberger M, Wilhelmsen KC, Willemsen G, Wong Q, Zhang ZM, Zonderman AB, Cusi D, Evans MK, Greiser HK, van der Harst P, Hassan M, Ingelsson E, Järvelin MR, Kääb S, Kähönen M, Kivimaki M, Kooperberg C, Kuh D, Lehtimäki T, Lind L, Nievergelt CM, O'Donnell CJ, Oldehinkel AJ, Penninx B, Reiner AP, Riese H, van Roon AM, Rioux JD, Rotter JI, Sofer T, Stricker BH, Tiemeier H, Vrijkotte TGM, Asselbergs FW, Brundel BJJM, Heckbert SR, Whitsel EA, den Hoed M, Snieder H, de Geus EJC.

Nat Commun. 2017 Jun 14;8:15805. doi: 10.1038/ncomms15805. Erratum in: Nat Commun. 2017 Aug 02;8:16140.

15.

Fear learning alterations after traumatic brain injury and their role in development of posttraumatic stress symptoms.

Glenn DE, Acheson DT, Geyer MA, Nievergelt CM, Baker DG, Risbrough VB; MRS-II Team.

Depress Anxiety. 2017 Aug;34(8):723-733. doi: 10.1002/da.22642. Epub 2017 May 10.

PMID:
28489272
16.

Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.

Higa KK, Grim A, Kamenski ME, van Enkhuizen J, Zhou X, Li K, Naviaux JC, Wang L, Naviaux RK, Geyer MA, Markou A, Young JW.

Psychopharmacology (Berl). 2017 May;234(9-10):1573-1586. doi: 10.1007/s00213-017-4572-2. Epub 2017 Feb 28.

17.

Effect of Hallucinogens on Unconditioned Behavior.

Halberstadt AL, Geyer MA.

Curr Top Behav Neurosci. 2018;36:159-199. doi: 10.1007/7854_2016_466. Review.

18.

Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown-a model of mania.

Milienne-Petiot M, Geyer MA, Arnt J, Young JW.

Psychopharmacology (Berl). 2017 Mar;234(6):1017-1028. doi: 10.1007/s00213-017-4543-7. Epub 2017 Feb 3.

19.

Effects of LPS-induced immune activation prior to trauma exposure on PTSD-like symptoms in mice.

Deslauriers J, van Wijngaarde M, Geyer MA, Powell S, Risbrough VB.

Behav Brain Res. 2017 Apr 14;323:117-123. doi: 10.1016/j.bbr.2017.01.048. Epub 2017 Jan 31.

PMID:
28159589
20.

Striatal dopamine D1 receptor suppression impairs reward-associative learning.

Higa KK, Young JW, Ji B, Nichols DE, Geyer MA, Zhou X.

Behav Brain Res. 2017 Apr 14;323:100-110. doi: 10.1016/j.bbr.2017.01.041. Epub 2017 Jan 29.

PMID:
28143767
21.

Prepulse Inhibition Deficits in Obsessive-Compulsive Disorder are More Pronounced in Females.

Ahmari SE, Risbrough VB, Geyer MA, Simpson HB.

Neuropsychopharmacology. 2016 Dec;41(13):2963-2964. doi: 10.1038/npp.2015.363. No abstract available.

22.

Athina Markou.

Geyer MA.

Neuropsychopharmacology. 2016 Dec;41(13):3121-3122. doi: 10.1038/npp.2016.137. No abstract available.

23.

The effects of reduced dopamine transporter function and chronic lithium on motivation, probabilistic learning, and neurochemistry in mice: Modeling bipolar mania.

Milienne-Petiot M, Kesby JP, Graves M, van Enkhuizen J, Semenova S, Minassian A, Markou A, Geyer MA, Young JW.

Neuropharmacology. 2017 Feb;113(Pt A):260-270. doi: 10.1016/j.neuropharm.2016.07.030. Epub 2016 Oct 11.

24.

Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next.

Swerdlow NR, Braff DL, Geyer MA.

J Psychopharmacol. 2016 Nov;30(11):1072-1081. Epub 2016 Aug 18. Review.

25.

Premature responses in the five-choice serial reaction time task reflect rodents' temporal strategies: evidence from no-light and pharmacological challenges.

Cope ZA, Halberstadt AL, van Enkhuizen J, Flynn AD, Breier M, Swerdlow NR, Geyer MA, Young JW.

Psychopharmacology (Berl). 2016 Oct;233(19-20):3513-25. doi: 10.1007/s00213-016-4389-4. Epub 2016 Aug 17.

26.

Locomotor Profiling from Rodents to the Clinic and Back Again.

Young JW, Minassian A, Geyer MA.

Curr Top Behav Neurosci. 2016;28:287-303. doi: 10.1007/7854_2015_5015. Review.

PMID:
27418071
27.

Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets.

Bespalov A, Steckler T, Altevogt B, Koustova E, Skolnick P, Deaver D, Millan MJ, Bastlund JF, Doller D, Witkin J, Moser P, O'Donnell P, Ebert U, Geyer MA, Prinssen E, Ballard T, Macleod M.

Nat Rev Drug Discov. 2016 Jul;15(7):516. doi: 10.1038/nrd.2016.88. Epub 2016 Jun 17. No abstract available.

PMID:
27312728
28.

Effect of 5-HT2A and 5-HT2C receptors on temporal discrimination by mice.

Halberstadt AL, Sindhunata IS, Scheffers K, Flynn AD, Sharp RF, Geyer MA, Young JW.

Neuropharmacology. 2016 Aug;107:364-375. doi: 10.1016/j.neuropharm.2016.03.038. Epub 2016 Mar 25.

29.

HIGH AND LOW THRESHOLD FOR STARTLE REACTIVITY ASSOCIATED WITH PTSD SYMPTOMS BUT NOT PTSD RISK: EVIDENCE FROM A PROSPECTIVE STUDY OF ACTIVE DUTY MARINES.

Glenn DE, Acheson DT, Geyer MA, Nievergelt CM, Baker DG, Risbrough VB; MRS Team.

Depress Anxiety. 2016 Mar;33(3):192-202. doi: 10.1002/da.22475. Epub 2016 Feb 15.

PMID:
26878585
30.

PREPULSE INHIBITION DEFICITS ONLY IN FEMALES WITH OBSESSIVE-COMPULSIVE DISORDER.

Steinman SA, Ahmari SE, Choo T, Kimeldorf MB, Feit R, Loh S, Risbrough V, Geyer MA, Steinglass JE, Wall M, Schneier FR, Fyer AJ, Simpson HB.

Depress Anxiety. 2016 Mar;33(3):238-46. doi: 10.1002/da.22474. Epub 2016 Feb 15.

31.

Wet or dry: translatable "water mazes" for mice and humans.

Higa KK, Young JW, Geyer MA.

J Clin Invest. 2016 Feb;126(2):477-9. doi: 10.1172/JCI86071. Epub 2016 Jan 19.

32.

Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood.

Toth M, Flandreau EI, Deslauriers J, Geyer MA, Mansuy IM, Merlo Pich E, Risbrough VB.

Neuropsychopharmacology. 2016 May;41(6):1681-90. doi: 10.1038/npp.2015.338. Epub 2015 Nov 5.

33.

Amphetamine increases activity but not exploration in humans and mice.

Minassian A, Young JW, Cope ZA, Henry BL, Geyer MA, Perry W.

Psychopharmacology (Berl). 2016 Jan;233(2):225-33. doi: 10.1007/s00213-015-4098-4. Epub 2015 Oct 9.

34.

Lysergic Acid Diethylamide and Psilocybin Revisited.

Geyer MA.

Biol Psychiatry. 2015 Oct 15;78(8):516-8. doi: 10.1016/j.biopsych.2015.08.003. No abstract available.

PMID:
26386624
35.

Association of Predeployment Heart Rate Variability With Risk of Postdeployment Posttraumatic Stress Disorder in Active-Duty Marines.

Minassian A, Maihofer AX, Baker DG, Nievergelt CM, Geyer MA, Risbrough VB; Marine Resiliency Study Team.

JAMA Psychiatry. 2015 Oct;72(10):979-86. doi: 10.1001/jamapsychiatry.2015.0922.

36.

Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models: Rodent and human studies.

van Enkhuizen J, Geyer MA, Minassian A, Perry W, Henry BL, Young JW.

Neurosci Biobehav Rev. 2015 Nov;58:4-18. doi: 10.1016/j.neubiorev.2015.08.008. Epub 2015 Aug 19. Review.

37.

Modeling bipolar disorder in mice by increasing acetylcholine or dopamine: chronic lithium treats most, but not all features.

van Enkhuizen J, Milienne-Petiot M, Geyer MA, Young JW.

Psychopharmacology (Berl). 2015 Sep;232(18):3455-67. doi: 10.1007/s00213-015-4000-4. Epub 2015 Jul 5.

38.

Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice.

Higa KK, Ji B, Buell MR, Risbrough VB, Powell SB, Young JW, Geyer MA, Zhou X.

Int J Neuropsychopharmacol. 2015 Jun 2;18(11):pyv063. doi: 10.1093/ijnp/pyv063.

39.

Early Adolescent Emergence of Reversal Learning Impairments in Isolation-Reared Rats.

Powell SB, Khan A, Young JW, Scott CN, Buell MR, Caldwell S, Tsan E, de Jong LA, Acheson DT, Lucero J, Geyer MA, Behrens MM.

Dev Neurosci. 2015;37(3):253-62. doi: 10.1159/000430091. Epub 2015 May 23.

40.

GlyT-1 Inhibition Attenuates Attentional But Not Learning or Motivational Deficits of the Sp4 Hypomorphic Mouse Model Relevant to Psychiatric Disorders.

Young JW, Kamenski ME, Higa KK, Light GA, Geyer MA, Zhou X.

Neuropsychopharmacology. 2015 Nov;40(12):2715-26. doi: 10.1038/npp.2015.120. Epub 2015 Apr 24.

41.

Prospective Associations Between Traumatic Brain Injury and Postdeployment Tinnitus in Active-Duty Marines.

Yurgil KA, Clifford RE, Risbrough VB, Geyer MA, Huang M, Barkauskas DA, Vasterling JJ; MRS Team, Baker DG.

J Head Trauma Rehabil. 2016 Jan-Feb;31(1):30-9. doi: 10.1097/HTR.0000000000000117.

42.

Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating.

Flandreau E, Risbrough V, Lu A, Ableitner M, Geyer MA, Holsboer F, Deussing JM.

Psychoneuroendocrinology. 2015 Mar;53:16-28. doi: 10.1016/j.psyneuen.2014.12.005. Epub 2014 Dec 11.

43.

Developing treatments for cognitive deficits in schizophrenia: the challenge of translation.

Young JW, Geyer MA.

J Psychopharmacol. 2015 Feb;29(2):178-96. doi: 10.1177/0269881114555252. Epub 2014 Dec 16. Review.

44.

Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.

Nievergelt CM, Maihofer AX, Mustapic M, Yurgil KA, Schork NJ, Miller MW, Logue MW, Geyer MA, Risbrough VB, O'Connor DT, Baker DG.

Psychoneuroendocrinology. 2015 Jan;51:459-71. doi: 10.1016/j.psyneuen.2014.10.017. Epub 2014 Oct 30.

PMID:
25456346
45.

Conditioned fear and extinction learning performance and its association with psychiatric symptoms in active duty Marines.

Acheson DT, Geyer MA, Baker DG, Nievergelt CM, Yurgil K, Risbrough VB; MRS-II Team.

Psychoneuroendocrinology. 2015 Jan;51:495-505. doi: 10.1016/j.psyneuen.2014.09.030. Epub 2014 Oct 7.

46.

Psychophysiology in the study of psychological trauma: where are we now and where do we need to be?

Acheson DT, Geyer MA, Risbrough VB.

Curr Top Behav Neurosci. 2014;21:157-83. doi: 10.1007/7854_2014_346.

PMID:
25158622
47.

The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited.

van Enkhuizen J, Janowsky DS, Olivier B, Minassian A, Perry W, Young JW, Geyer MA.

Eur J Pharmacol. 2015 Apr 15;753:114-26. doi: 10.1016/j.ejphar.2014.05.063. Epub 2014 Aug 5. Review.

48.

Reduced dopamine transporter functioning induces high-reward risk-preference consistent with bipolar disorder.

van Enkhuizen J, Henry BL, Minassian A, Perry W, Milienne-Petiot M, Higa KK, Geyer MA, Young JW.

Neuropsychopharmacology. 2014 Dec;39(13):3112-22. doi: 10.1038/npp.2014.170. Epub 2014 Jul 9.

49.

Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders.

Ji B, Higa KK, Kim M, Zhou L, Young JW, Geyer MA, Zhou X.

Hum Mol Genet. 2014 Nov 1;23(21):5683-705. doi: 10.1093/hmg/ddu285. Epub 2014 Jun 6.

50.

Heart rate variability characteristics in a large group of active-duty marines and relationship to posttraumatic stress.

Minassian A, Geyer MA, Baker DG, Nievergelt CM, O'Connor DT, Risbrough VB; Marine Resiliency Study Team.

Psychosom Med. 2014 May;76(4):292-301. doi: 10.1097/PSY.0000000000000056.

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