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Items: 27

1.

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.

Rosenbaum M, Gewies A, Pechloff K, Heuser C, Engleitner T, Gehring T, Hartjes L, Krebs S, Krappmann D, Kriegsmann M, Weichert W, Rad R, Kurts C, Ruland J.

Nat Commun. 2019 May 28;10(1):2352. doi: 10.1038/s41467-019-10203-2.

2.

Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy.

Kong B, Bruns P, Behler NA, Chang L, Schlitter AM, Cao J, Gewies A, Ruland J, Fritzsche S, Valkovskaya N, Jian Z, Regel I, Raulefs S, Irmler M, Beckers J, Friess H, Erkan M, Mueller NS, Roth S, Hackert T, Esposito I, Theis FJ, Kleeff J, Michalski CW.

Gut. 2018 Jan;67(1):146-156. doi: 10.1136/gutjnl-2015-310913. Epub 2016 Sep 19.

PMID:
27646934
3.

Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells.

Meininger I, Griesbach RA, Hu D, Gehring T, Seeholzer T, Bertossi A, Kranich J, Oeckinghaus A, Eitelhuber AC, Greczmiel U, Gewies A, Schmidt-Supprian M, Ruland J, Brocker T, Heissmeyer V, Heyd F, Krappmann D.

Nat Commun. 2016 Apr 12;7:11292. doi: 10.1038/ncomms11292.

4.

Loss of Ifnar1 in Pancreatic Acinar Cells Ameliorates the Disease Course of Acute Pancreatitis.

Miller KJ, Raulefs S, Kong B, Steiger K, Regel I, Gewies A, Kleeff J, Michalski CW.

PLoS One. 2015 Nov 30;10(11):e0143735. doi: 10.1371/journal.pone.0143735. eCollection 2015.

5.

Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.

Gewies A, Gorka O, Bergmann H, Pechloff K, Petermann F, Jeltsch KM, Rudelius M, Kriegsmann M, Weichert W, Horsch M, Beckers J, Wurst W, Heikenwalder M, Korn T, Heissmeyer V, Ruland J.

Cell Rep. 2014 Nov 20;9(4):1292-305. doi: 10.1016/j.celrep.2014.10.044. Epub 2014 Nov 13.

6.

The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.

Turvey SE, Durandy A, Fischer A, Fung SY, Geha RS, Gewies A, Giese T, Greil J, Keller B, McKinnon ML, Neven B, Rozmus J, Ruland J, Snow AL, Stepensky P, Warnatz K.

J Allergy Clin Immunol. 2014 Aug;134(2):276-84. doi: 10.1016/j.jaci.2014.06.015. Review.

7.

Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.

Neumann K, Castiñeiras-Vilariño M, Höckendorf U, Hannesschläger N, Lemeer S, Kupka D, Meyermann S, Lech M, Anders HJ, Kuster B, Busch DH, Gewies A, Naumann R, Groß O, Ruland J.

Immunity. 2014 Mar 20;40(3):389-99. doi: 10.1016/j.immuni.2013.12.015. Epub 2014 Mar 13.

8.

Prdm6 is essential for cardiovascular development in vivo.

Gewies A, Castineiras-Vilarino M, Ferch U, Jährling N, Heinrich K, Hoeckendorf U, Przemeck GK, Munding M, Groß O, Schroeder T, Horsch M, Karran EL, Majid A, Antonowicz S, Beckers J, Hrabé de Angelis M, Dodt HU, Peschel C, Förster I, Dyer MJ, Ruland J.

PLoS One. 2013 Nov 21;8(11):e81833. doi: 10.1371/journal.pone.0081833. eCollection 2013.

9.

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.

Jabara HH, Ohsumi T, Chou J, Massaad MJ, Benson H, Megarbane A, Chouery E, Mikhael R, Gorka O, Gewies A, Portales P, Nakayama T, Hosokawa H, Revy P, Herrod H, Le Deist F, Lefranc G, Ruland J, Geha RS.

J Allergy Clin Immunol. 2013 Jul;132(1):151-8. doi: 10.1016/j.jaci.2013.04.047. Epub 2013 May 31. Erratum in: J Allergy Clin Immunol. 2013 Sep;132(3):773. J Allergy Clin Immunol. 2013 Sep;132(3):773.

10.

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.

Pechloff K, Holch J, Ferch U, Schweneker M, Brunner K, Kremer M, Sparwasser T, Quintanilla-Martinez L, Zimber-Strobl U, Streubel B, Gewies A, Peschel C, Ruland J.

J Exp Med. 2010 May 10;207(5):1031-44. doi: 10.1084/jem.20092042. Epub 2010 May 3.

11.

Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells.

Ferch U, Kloo B, Gewies A, Pfänder V, Düwel M, Peschel C, Krappmann D, Ruland J.

J Exp Med. 2009 Oct 26;206(11):2313-20. doi: 10.1084/jem.20091167. Epub 2009 Oct 19. Erratum in: J Exp Med. 2009 Nov 23;206(12):2851.

12.

Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.

Hömig-Hölzel C, Hojer C, Rastelli J, Casola S, Strobl LJ, Müller W, Quintanilla-Martinez L, Gewies A, Ruland J, Rajewsky K, Zimber-Strobl U.

J Exp Med. 2008 Jun 9;205(6):1317-29. doi: 10.1084/jem.20080238. Epub 2008 May 19.

13.

MALT1 directs B cell receptor-induced canonical nuclear factor-kappaB signaling selectively to the c-Rel subunit.

Ferch U, zum Büschenfelde CM, Gewies A, Wegener E, Rauser S, Peschel C, Krappmann D, Ruland J.

Nat Immunol. 2007 Sep;8(9):984-91. Epub 2007 Jul 29.

PMID:
17660823
14.

Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.

Gross O, Gewies A, Finger K, Schäfer M, Sparwasser T, Peschel C, Förster I, Ruland J.

Nature. 2006 Aug 10;442(7103):651-6. Epub 2006 Jul 12.

PMID:
16862125
16.

Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum.

Mund T, Gewies A, Schoenfeld N, Bauer MK, Grimm S.

FASEB J. 2003 Apr;17(6):696-8. Epub 2003 Feb 19.

PMID:
12594175
17.

UBP41 is a proapoptotic ubiquitin-specific protease.

Gewies A, Grimm S.

Cancer Res. 2003 Feb 1;63(3):682-8.

19.

Cytochrome c is involved in Fas-mediated apoptosis of prostatic carcinoma cell lines.

Gewies A, Rokhlin OW, Cohen MB.

Cancer Res. 2000 Apr 15;60(8):2163-8.

20.

p53 is involved in tumor necrosis factor-alpha-induced apoptosis in the human prostatic carcinoma cell line LNCaP.

Rokhlin OW, Gudkov AV, Kwek S, Glover RA, Gewies AS, Cohen MB.

Oncogene. 2000 Apr 6;19(15):1959-68.

21.

Analysis of the NF1 gene by temperature gradient gel electrophoresis reveals a high incidence of mutations in exon 4b.

Toliat MR, Erdogan F, Gewies A, Fahsold R, Buske A, Tinschert S, Nürnberg P.

Electrophoresis. 2000 Feb;21(3):541-4.

PMID:
10726756
22.

Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain.

Fahsold R, Hoffmeyer S, Mischung C, Gille C, Ehlers C, Kücükceylan N, Abdel-Nour M, Gewies A, Peters H, Kaufmann D, Buske A, Tinschert S, Nürnberg P.

Am J Hum Genet. 2000 Mar;66(3):790-818.

23.

Recurrent NF1 gene mutation in a patient with oligosymptomatic neurofibromatosis type 1 (NF1).

Buske A, Gewies A, Lehmann R, Rüther K, Algermissen B, Nürnberg P, Tinschert S.

Am J Med Genet. 1999 Oct 8;86(4):328-30.

PMID:
10494088
24.

McCune-Albright syndrome: clinical and molecular evidence of mosaicism in an unusual giant patient.

Tinschert S, Gerl H, Gewies A, Jung HP, Nürnberg P.

Am J Med Genet. 1999 Mar 12;83(2):100-8. Review.

PMID:
10190480
25.

Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1.

Klose A, Ahmadian MR, Schuelke M, Scheffzek K, Hoffmeyer S, Gewies A, Schmitz F, Kaufmann D, Peters H, Wittinghofer A, Nürnberg P.

Hum Mol Genet. 1998 Aug;7(8):1261-8.

PMID:
9668168
26.

Two novel mutations in exons 19a and 20 and a BsaBI [correction of BsaI] polymorphism in a newly characterized intron of the neurofibromatosis type 1 gene.

Klose A, Robinson N, Gewies A, Kluwe L, Kaufmann D, Buske A, Tinschert S, Peters H.

Hum Genet. 1998 Mar;102(3):367-71.

PMID:
9544853
27.

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