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Items: 1 to 50 of 85

1.

Synergistic Genetic Interactions between Pkhd1 and Pkd1 Result in an ARPKD-Like Phenotype in Murine Models.

Olson RJ, Hopp K, Wells H, Smith JM, Furtado J, Constans MM, Escobar DL, Geurts AM, Torres VE, Harris PC.

J Am Soc Nephrol. 2019 Aug 19. pii: ASN.2019020150. doi: 10.1681/ASN.2019020150. [Epub ahead of print]

PMID:
31427367
2.

Fumarase Overexpression Abolishes Hypertension Attributable to endothelial NO synthase Haploinsufficiency in Dahl Salt-Sensitive Rats.

Xue H, Geurts AM, Usa K, Wang F, Lin Y, Phillips J, Henderson L, Baker MA, Tian Z, Liang M.

Hypertension. 2019 Aug;74(2):313-322. doi: 10.1161/HYPERTENSIONAHA.119.12723. Epub 2019 Jun 24.

PMID:
31230549
3.

The p52 isoform of SHC1 is a key driver of breast cancer initiation.

Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A.

Breast Cancer Res. 2019 Jun 15;21(1):74. doi: 10.1186/s13058-019-1155-7.

4.

Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency.

Yu FPS, Molino S, Sikora J, Rasmussen S, Rybova J, Tate E, Geurts AM, Turner PV, Mckillop WM, Medin JA.

Lab Invest. 2019 Oct;99(10):1572-1592. doi: 10.1038/s41374-019-0271-4. Epub 2019 Jun 11.

PMID:
31186526
5.

Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury.

Zhang C, He X, Murphy SR, Zhang H, Wang S, Ge Y, Gao W, Williams JM, Geurts AM, Roman RJ, Fan F.

J Pharmacol Exp Ther. 2019 Aug;370(2):206-217. doi: 10.1124/jpet.119.258954. Epub 2019 May 22.

PMID:
31118214
6.

CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes.

Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS.

Front Immunol. 2019 Jan 31;10:99. doi: 10.3389/fimmu.2019.00099. eCollection 2019.

7.

Effects of Hepatic Ischemia-Reperfusion Injuries and NRF2 on Transcriptional Activities of Bile Transporters in Rats.

Kim J, Martin A, Yee J, Fojut L, Geurts AM, Oshima K, Zimmerman MA, Hong JC.

J Surg Res. 2019 Mar;235:73-82. doi: 10.1016/j.jss.2018.09.057. Epub 2018 Oct 24.

PMID:
30691853
8.

MiR-192-5p in the Kidney Protects Against the Development of Hypertension.

Baker MA, Wang F, Liu Y, Kriegel AJ, Geurts AM, Usa K, Xue H, Wang D, Kong Y, Liang M.

Hypertension. 2019 Feb;73(2):399-406. doi: 10.1161/HYPERTENSIONAHA.118.11875.

PMID:
30595117
9.

A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome.

Jing R, Corbett JL, Cai J, Beeson GC, Beeson CC, Chan SS, Dimmock DP, Lazcares L, Geurts AM, Lemasters JJ, Duncan SA.

Cell Rep. 2018 Nov 6;25(6):1469-1484.e5. doi: 10.1016/j.celrep.2018.10.036.

10.

Tissue-specific effects of targeted mutation of Mir29b1 in rats.

Xue H, Zhang G, Geurts AM, Usa K, Jensen DM, Liu Y, Widlansky ME, Liang M.

EBioMedicine. 2018 Sep;35:260-269. doi: 10.1016/j.ebiom.2018.08.016. Epub 2018 Aug 14.

11.

MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension.

Liu Y, Usa K, Wang F, Liu P, Geurts AM, Li J, Williams AM, Regner KR, Kong Y, Liu H, Nie J, Liang M.

J Am Soc Nephrol. 2018 Oct;29(10):2518-2528. doi: 10.1681/ASN.2018020117. Epub 2018 Jul 26.

12.

Protective role of Trpc6 knockout in the progression of diabetic kidney disease.

Spires D, Ilatovskaya DV, Levchenko V, North PE, Geurts AM, Palygin O, Staruschenko A.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1091-F1097. doi: 10.1152/ajprenal.00155.2018. Epub 2018 Jun 20.

13.

Sdha+/- Rats Display Minimal Muscle Pathology Without Significant Behavioral or Biochemical Abnormalities.

Siebers EM, Choi MJ, Tinklenberg JA, Beatka MJ, Ayres S, Meng H, Helbling DC, Takizawa A, Bennett B, Garces AM, Dias Duarte Machado LG, Dimmock D, Dwinell MR, Geurts AM, Lawlor MW.

J Neuropathol Exp Neurol. 2018 Aug 1;77(8):665-672. doi: 10.1093/jnen/nly042.

14.

A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease.

Ilatovskaya DV, Blass G, Palygin O, Levchenko V, Pavlov TS, Grzybowski MN, Winsor K, Shuyskiy LS, Geurts AM, Cowley AW Jr, Birnbaumer L, Staruschenko A.

J Am Soc Nephrol. 2018 Jul;29(7):1917-1927. doi: 10.1681/ASN.2018030280. Epub 2018 May 23.

15.

Genome-wide map of proximity linkage to renin proximal promoter in rat.

Stodola TJ, Liu P, Liu Y, Vallejos AK, Geurts AM, Greene AS, Liang M.

Physiol Genomics. 2018 May 1;50(5):323-331. doi: 10.1152/physiolgenomics.00132.2017. Epub 2018 Mar 9.

16.

Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD.

Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J.

J Am Soc Nephrol. 2018 May;29(5):1525-1535. doi: 10.1681/ASN.2017080856. Epub 2018 Feb 23.

17.

miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders.

Widlansky ME, Jensen DM, Wang J, Liu Y, Geurts AM, Kriegel AJ, Liu P, Ying R, Zhang G, Casati M, Chu C, Malik M, Branum A, Tanner MJ, Tyagi S, Usa K, Liang M.

EMBO Mol Med. 2018 Mar;10(3). pii: e8046. doi: 10.15252/emmm.201708046.

18.

Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling.

Moehring F, Cowie AM, Menzel AD, Weyer AD, Grzybowski M, Arzua T, Geurts AM, Palygin O, Stucky CL.

Elife. 2018 Jan 16;7. pii: e31684. doi: 10.7554/eLife.31684.

19.

Determination of total plasma oxysterols by enzymatic hydrolysis, solid phase extraction and liquid chromatography coupled to mass-spectrometry.

Mendiara I, Domeño C, Nerín C, Geurts AM, Osada J, Martínez-Beamonte R.

J Pharm Biomed Anal. 2018 Feb 20;150:396-405. doi: 10.1016/j.jpba.2017.12.033. Epub 2017 Dec 21.

PMID:
29288965
20.

Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats.

Lukaszewicz KM, Durand MJ, Priestley JRC, Schmidt JR, Allen LA, Geurts AM, Lombard JH.

J Vis Exp. 2017 Dec 5;(130). doi: 10.3791/56133.

21.

Nitric oxide production by glomerular podocytes.

Palygin O, Ilatovskaya DV, Levchenko V, Endres BT, Geurts AM, Staruschenko A.

Nitric Oxide. 2018 Jan 30;72:24-31. doi: 10.1016/j.niox.2017.11.005. Epub 2017 Nov 8.

22.

In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit.

Raffa S, Scrofani C, Valente S, Micaloni A, Forte M, Bianchi F, Coluccia R, Geurts AM, Sciarretta S, Volpe M, Torrisi MR, Rubattu S.

Hum Mol Genet. 2017 Dec 1;26(23):4541-4555. doi: 10.1093/hmg/ddx333.

23.

Essential role of Kir5.1 channels in renal salt handling and blood pressure control.

Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Pochynyuk OM, Jacob HJ, Geurts AM, Hodges MR, Staruschenko A.

JCI Insight. 2017 Sep 21;2(18). pii: 92331. doi: 10.1172/jci.insight.92331. eCollection 2017 Sep 21.

24.

Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain.

Usa K, Liu Y, Geurts AM, Cheng Y, Lazar J, Baker MA, Grzybowski M, He Y, Tian Z, Liang M.

Physiol Genomics. 2017 Sep 1;49(9):496-504. doi: 10.1152/physiolgenomics.00063.2017. Epub 2017 Jul 28.

25.

Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer.

Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A.

Breast Cancer Res Treat. 2017 Aug;165(1):53-64. doi: 10.1007/s10549-017-4311-8. Epub 2017 May 31.

26.

Intravital imaging of the kidney in a rat model of salt-sensitive hypertension.

Endres BT, Sandoval RM, Rhodes GJ, Campos-Bilderback SB, Kamocka MM, McDermott-Roe C, Staruschenko A, Molitoris BA, Geurts AM, Palygin O.

Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F163-F173. doi: 10.1152/ajprenal.00466.2016. Epub 2017 Apr 12.

27.

Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia.

Densmore JC, Schaid TR, Jeziorczak PM, Medhora M, Audi S, Nayak S, Auchampach J, Dwinell MR, Geurts AM, Jacobs ER.

Exp Lung Res. 2017 Feb;43(1):38-48. doi: 10.1080/01902148.2017.1286697. Epub 2017 Mar 7.

28.

Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection.

Mitzelfelt KA, McDermott-Roe C, Grzybowski MN, Marquez M, Kuo CT, Riedel M, Lai S, Choi MJ, Kolander KD, Helbling D, Dimmock DP, Battle MA, Jou CJ, Tristani-Firouzi M, Verbsky JW, Benjamin IJ, Geurts AM.

Stem Cell Reports. 2017 Mar 14;8(3):491-499. doi: 10.1016/j.stemcr.2017.01.021. Epub 2017 Feb 24.

29.

Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function.

McDermott-Roe C, Leleu M, Rowe GC, Palygin O, Bukowy JD, Kuo J, Rech M, Hermans-Beijnsberger S, Schaefer S, Adami E, Creemers EE, Heinig M, Schroen B, Arany Z, Petretto E, Geurts AM.

PLoS One. 2017 Feb 3;12(2):e0170458. doi: 10.1371/journal.pone.0170458. eCollection 2017.

30.

A RATional choice for translational research?

Aitman T, Dhillon P, Geurts AM.

Dis Model Mech. 2016 Oct 1;9(10):1069-1072.

31.

Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats.

McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR, Williams JM.

Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.

32.

Gene Editing: Practical Application in the Lab.

Geurts AM, Ekker SC.

Hum Gene Ther. 2016 Jun;27(6):417-8. doi: 10.1089/hum.2016.29029.amg. No abstract available. Erratum in: Hum Gene Ther. 2016 Jul;27(7):559.

33.

p66Shc regulates renal vascular tone in hypertension-induced nephropathy.

Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A.

J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.

34.

The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility.

Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ.

J Biol Chem. 2016 Jul 15;291(29):14939-53. doi: 10.1074/jbc.M116.730481. Epub 2016 May 19.

35.

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure.

Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E.

Sci Rep. 2016 Feb 26;6:22154. doi: 10.1038/srep22154.

36.

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease.

Rubattu S, Di Castro S, Schulz H, Geurts AM, Cotugno M, Bianchi F, Maatz H, Hummel O, Falak S, Stanzione R, Marchitti S, Scarpino S, Giusti B, Kura A, Gensini GF, Peyvandi F, Mannucci PM, Rasura M, Sciarretta S, Dwinell MR, Hubner N, Volpe M.

J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701.

37.

Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats.

Kaplan K, Echert AE, Massat B, Puissant MM, Palygin O, Geurts AM, Hodges MR.

J Appl Physiol (1985). 2016 May 1;120(9):1070-81. doi: 10.1152/japplphysiol.01015.2015. Epub 2016 Feb 11.

38.

Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome.

Bennett B, Helbling D, Meng H, Jarzembowski J, Geurts AM, Friederich MW, Van Hove JLK, Lawlor MW, Dimmock DP.

Free Radic Biol Med. 2016 Mar;92:141-151. doi: 10.1016/j.freeradbiomed.2016.01.001. Epub 2016 Jan 8.

39.

The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction.

Priestley JR, Kautenburg KE, Casati MC, Endres BT, Geurts AM, Lombard JH.

Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4.

40.

Pappa2 is linked to salt-sensitive hypertension in Dahl S rats.

Cowley AW Jr, Yang C, Kumar V, Lazar J, Jacob H, Geurts AM, Liu P, Dayton A, Kurth T, Liang M.

Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3.

41.

Myosin Id is required for planar cell polarity in ciliated tracheal and ependymal epithelial cells.

Hegan PS, Ostertag E, Geurts AM, Mooseker MS.

Cytoskeleton (Hoboken). 2015 Oct;72(10):503-16. doi: 10.1002/cm.21259. Epub 2015 Oct 23.

42.

Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension.

Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA.

Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18.

43.

Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta.

Endres BT, Staruschenko A, Schulte M, Geurts AM, Palygin O.

J Vis Exp. 2015 Jun 10;(100):e52734. doi: 10.3791/52734.

44.

Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury.

Wang F, Zhang G, Lu Z, Geurts AM, Usa K, Jacob HJ, Cowley AW, Wang N, Liang M.

Kidney Int. 2015 Oct;88(4):796-803. doi: 10.1038/ki.2015.176. Epub 2015 Jun 24.

45.

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease.

Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H.

Genetics. 2015 Jun;200(2):423-30. doi: 10.1534/genetics.115.176594. Epub 2015 Mar 27.

46.

Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.

Rudemiller NP, Lund H, Priestley JR, Endres BT, Prokop JW, Jacob HJ, Geurts AM, Cohen EP, Mattson DL.

Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16.

47.

SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.

Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ.

Circ Cardiovasc Genet. 2015 Apr;8(2):294-304. doi: 10.1161/CIRCGENETICS.114.000527. Epub 2015 Jan 27.

PMID:
25628389
48.

Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.

Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ.

Am J Physiol Regul Integr Comp Physiol. 2015 Mar 1;308(5):R379-90. doi: 10.1152/ajpregu.00256.2014. Epub 2014 Dec 24.

49.

Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats.

Geurts AM, Mattson DL, Liu P, Cabacungan E, Skelton MM, Kurth TM, Yang C, Endres BT, Klotz J, Liang M, Cowley AW Jr.

Hypertension. 2015 Feb;65(2):447-55. doi: 10.1161/HYPERTENSIONAHA.114.04179. Epub 2014 Dec 1.

50.

Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.

Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ.

PLoS One. 2014 Nov 14;9(11):e112878. doi: 10.1371/journal.pone.0112878. eCollection 2014.

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