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Items: 1 to 50 of 134

1.

Neuropathologic basis of in vivo cortical atrophy in the aphasic variant of Alzheimer's disease.

Ohm DT, Fought AJ, Rademaker A, Kim G, Sridhar J, Coventry C, Gefen T, Weintraub S, Bigio E, Mesulam MM, Rogalski E, Geula C.

Brain Pathol. 2019 Aug 25. doi: 10.1111/bpa.12783. [Epub ahead of print]

PMID:
31446630
2.

Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories.

Gefen T, Kim G, Bolbolan K, Geoly A, Ohm D, Oboudiyat C, Shahidehpour R, Rademaker A, Weintraub S, Bigio EH, Mesulam MM, Rogalski E, Geula C.

Front Aging Neurosci. 2019 May 14;11:94. doi: 10.3389/fnagi.2019.00094. eCollection 2019.

3.

Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypes.

Nishihira Y, Gefen T, Mao Q, Appin C, Kohler M, Walker J, Rademakers R, Rademaker A, Rogalski E, Weintraub S, Geula C, Mesulam MM, Bigio EH.

Acta Neuropathol. 2019 Jul;138(1):167-169. doi: 10.1007/s00401-019-02024-w. Epub 2019 May 7. No abstract available.

PMID:
31065833
4.

Cortical cholinergic denervation in primary progressive aphasia with Alzheimer pathology.

Mesulam MM, Lalehzari N, Rahmani F, Ohm D, Shahidehpour R, Kim G, Gefen T, Weintraub S, Bigio E, Geula C.

Neurology. 2019 Apr 2;92(14):e1580-e1588. doi: 10.1212/WNL.0000000000007247. Epub 2019 Mar 6.

PMID:
30842294
5.

Morphology and Distribution of TDP-43 Pre-inclusions in Primary Progressive Aphasia.

Kim G, Bolbolan K, Shahidehpour R, Jamshidi P, Gefen T, Ayala IA, Weintraub S, Bigio EH, Mesulam MM, Geula C.

J Neuropathol Exp Neurol. 2019 Mar 1;78(3):229-237. doi: 10.1093/jnen/nlz005.

PMID:
30753613
6.

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Pottier C, Ren Y, Perkerson RB 3rd, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett B, Karydas AM, Hsiung GR, Seelaar H, Mol MO, Finger EC, Graff C, Öijerstedt L, Neumann M, Heutink P, Synofzik M, Wilke C, Prudlo J, Rizzu P, Simon-Sanchez J, Edbauer D, Roeber S, Diehl-Schmid J, Evers BM, King A, Mesulam MM, Weintraub S, Geula C, Bieniek KF, Petrucelli L, Ahern GL, Reiman EM, Woodruff BK, Caselli RJ, Huey ED, Farlow MR, Grafman J, Mead S, Grinberg LT, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Snowden J, Mann D, Ertekin-Taner N, Uitti RJ, Wszolek ZK, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Hodges JR, Piguet O, Geier EG, Yokoyama JS, Rissman RA, Rogaeva E, Keith J, Zinman L, Tartaglia MC, Cairns NJ, Cruchaga C, Ghetti B, Kofler J, Lopez OL, Beach TG, Arzberger T, Herms J, Honig LS, Vonsattel JP, Halliday GM, Kwok JB, White CL 3rd, Gearing M, Glass J, Rollinson S, Pickering-Brown S, Rohrer JD, Trojanowski JQ, Van Deerlin V, Bigio EH, Troakes C, Al-Sarraj S, Asmann Y, Miller BL, Graff-Radford NR, Boeve BF, Seeley WW, Mackenzie IRA, van Swieten JC, Dickson DW, Biernacka JM, Rademakers R.

Acta Neuropathol. 2019 Jun;137(6):879-899. doi: 10.1007/s00401-019-01962-9. Epub 2019 Feb 9.

PMID:
30739198
7.

Word comprehension in temporal cortex and Wernicke area: A PPA perspective.

Mesulam MM, Rader BM, Sridhar J, Nelson MJ, Hyun J, Rademaker A, Geula C, Bigio EH, Thompson CK, Gefen TD, Weintraub S, Rogalski EJ.

Neurology. 2019 Jan 15;92(3):e224-e233. doi: 10.1212/WNL.0000000000006788. Epub 2018 Dec 21.

PMID:
30578374
8.

Associations of MAP2K3 Gene Variants With Superior Memory in SuperAgers.

Huentelman MJ, Piras IS, Siniard AL, De Both MD, Richholt RF, Balak CD, Jamshidi P, Bigio EH, Weintraub S, Loyer ET, Mesulam MM, Geula C, Rogalski EJ.

Front Aging Neurosci. 2018 May 29;10:155. doi: 10.3389/fnagi.2018.00155. eCollection 2018.

9.

Differential Neurotoxicity Related to Tetracycline Transactivator and TDP-43 Expression in Conditional TDP-43 Mouse Model of Frontotemporal Lobar Degeneration.

Kukreja L, Shahidehpour R, Kim G, Keegan J, Sadleir KR, Russell T, Csernansky J, Mesulam M, Vassar RJ, Wang L, Dong H, Geula C.

J Neurosci. 2018 Jul 4;38(27):6045-6062. doi: 10.1523/JNEUROSCI.1836-17.2018. Epub 2018 May 28.

10.

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

Pottier C, Zhou X, Perkerson RB 3rd, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A, Lladó A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D, Graff C, Öijerstedt L, Troakes C, Al-Sarraj S, Cruchaga C, Cairns NJ, Rohrer JD, Halliday GM, Kwok JB, van Swieten JC, White CL 3rd, Ghetti B, Murell JR, Mackenzie IRA, Hsiung GR, Borroni B, Rossi G, Tagliavini F, Wszolek ZK, Petersen RC, Bigio EH, Grossman M, Van Deerlin VM, Seeley WW, Miller BL, Graff-Radford NR, Boeve BF, Dickson DW, Biernacka JM, Rademakers R.

Lancet Neurol. 2018 Jun;17(6):548-558. doi: 10.1016/S1474-4422(18)30126-1. Epub 2018 Apr 30.

11.

The cholinergic system in the basal forebrain of the Atlantic white-sided dolphin (Lagenorhynchus acutus).

Reid GA, Geula C, Darvesh S.

J Comp Neurol. 2018 Aug 15;526(12):1910-1926. doi: 10.1002/cne.24460.

PMID:
29700823
12.

Prominent microglial activation in cortical white matter is selectively associated with cortical atrophy in primary progressive aphasia.

Ohm DT, Kim G, Gefen T, Rademaker A, Weintraub S, Bigio EH, Mesulam MM, Rogalski E, Geula C.

Neuropathol Appl Neurobiol. 2019 Apr;45(3):216-229. doi: 10.1111/nan.12494. Epub 2018 May 17.

PMID:
29679378
13.

Atrophy and microglial distribution in primary progressive aphasia with transactive response DNA-binding protein-43 kDa.

Kim G, Bolbolan K, Gefen T, Weintraub S, Bigio EH, Rogalski E, Mesulam MM, Geula C.

Ann Neurol. 2018 Jun;83(6):1096-1104. doi: 10.1002/ana.25240. Epub 2018 May 24.

14.

Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes.

Gabrusiewicz K, Li X, Wei J, Hashimoto Y, Marisetty AL, Ott M, Wang F, Hawke D, Yu J, Healy LM, Hossain A, Akers JC, Maiti SN, Yamashita S, Shimizu Y, Dunner K, Zal MA, Burks JK, Gumin J, Nwajei F, Rezavanian A, Zhou S, Rao G, Sawaya R, Fuller GN, Huse JT, Antel JP, Li S, Cooper L, Sulman EP, Chen C, Geula C, Kalluri R, Zal T, Heimberger AB.

Oncoimmunology. 2018 Jan 16;7(4):e1412909. doi: 10.1080/2162402X.2017.1412909. eCollection 2018.

15.

Combined Pathologies in FTLD-TDP Types A and C.

Gefen T, Ahmadian SS, Mao Q, Kim G, Seckin M, Bonakdarpour B, Ramos EM, Coppola G, Rademakers R, Rogalski E, Rademaker A, Weintraub S, Mesulam MM, Geula C, Bigio EH.

J Neuropathol Exp Neurol. 2018 May 1;77(5):405-412. doi: 10.1093/jnen/nly018.

16.

Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases.

Rogalski E, Gefen T, Mao Q, Connelly M, Weintraub S, Geula C, Bigio EH, Mesulam MM.

Hippocampus. 2019 May;29(5):458-467. doi: 10.1002/hipo.22828. Epub 2018 Feb 5.

PMID:
29341318
17.

Asymmetric TDP pathology in primary progressive aphasia with right hemisphere language dominance.

Kim G, Vahedi S, Gefen T, Weintraub S, Bigio EH, Mesulam MM, Geula C.

Neurology. 2018 Jan 30;90(5):e396-e403. doi: 10.1212/WNL.0000000000004891. Epub 2018 Jan 5.

18.

Von Economo neurons of the anterior cingulate across the lifespan and in Alzheimer's disease.

Gefen T, Papastefan ST, Rezvanian A, Bigio EH, Weintraub S, Rogalski E, Mesulam MM, Geula C.

Cortex. 2018 Feb;99:69-77. doi: 10.1016/j.cortex.2017.10.015. Epub 2017 Nov 8.

19.

Variations in Acetylcholinesterase Activity within Human Cortical Pyramidal Neurons Across Age and Cognitive Trajectories.

Janeczek M, Gefen T, Samimi M, Kim G, Weintraub S, Bigio E, Rogalski E, Mesulam MM, Geula C.

Cereb Cortex. 2018 Apr 1;28(4):1329-1337. doi: 10.1093/cercor/bhx047.

20.

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS.

Genç B, Jara JH, Lagrimas AK, Pytel P, Roos RP, Mesulam MM, Geula C, Bigio EH, Özdinler PH.

Sci Rep. 2017 Feb 6;7:41765. doi: 10.1038/srep41765.

21.

Postmortem Adult Human Microglia Proliferate in Culture to High Passage and Maintain Their Response to Amyloid-β.

Guo L, Rezvanian A, Kukreja L, Hoveydai R, Bigio EH, Mesulam MM, El Khoury J, Geula C.

J Alzheimers Dis. 2016 Oct 4;54(3):1157-1167.

22.

Asymmetric pathology in primary progressive aphasia with progranulin mutations and TDP inclusions.

Kim G, Ahmadian SS, Peterson M, Parton Z, Memon R, Weintraub S, Rademaker A, Bigio E, Mesulam MM, Geula C.

Neurology. 2016 Feb 16;86(7):627-36. doi: 10.1212/WNL.0000000000002375. Epub 2016 Jan 20.

23.

Loss of calbindin-D28K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's disease.

Ahmadian SS, Rezvanian A, Peterson M, Weintraub S, Bigio EH, Mesulam MM, Geula C.

Neurobiol Aging. 2015 Dec;36(12):3163-3170. doi: 10.1016/j.neurobiolaging.2015.09.001. Epub 2015 Sep 6.

24.

Accumulation and age-related elevation of amyloid-β within basal forebrain cholinergic neurons in the rhesus monkey.

Norvin D, Kim G, Baker-Nigh A, Geula C.

Neuroscience. 2015 Jul 9;298:102-11. doi: 10.1016/j.neuroscience.2015.04.011. Epub 2015 Apr 11.

PMID:
25869619
25.

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease.

Baker-Nigh A, Vahedi S, Davis EG, Weintraub S, Bigio EH, Klein WL, Geula C.

Brain. 2015 Jun;138(Pt 6):1722-37. doi: 10.1093/brain/awv024. Epub 2015 Mar 1.

26.

Morphometric and histologic substrates of cingulate integrity in elders with exceptional memory capacity.

Gefen T, Peterson M, Papastefan ST, Martersteck A, Whitney K, Rademaker A, Bigio EH, Weintraub S, Rogalski E, Mesulam MM, Geula C.

J Neurosci. 2015 Jan 28;35(4):1781-91. doi: 10.1523/JNEUROSCI.2998-14.2015.

27.

Primary progressive aphasia and the evolving neurology of the language network.

Mesulam MM, Rogalski EJ, Wieneke C, Hurley RS, Geula C, Bigio EH, Thompson CK, Weintraub S.

Nat Rev Neurol. 2014 Oct;10(10):554-69. doi: 10.1038/nrneurol.2014.159. Epub 2014 Sep 2. Review.

28.

Asymmetry and heterogeneity of Alzheimer's and frontotemporal pathology in primary progressive aphasia.

Mesulam MM, Weintraub S, Rogalski EJ, Wieneke C, Geula C, Bigio EH.

Brain. 2014 Apr;137(Pt 4):1176-92. doi: 10.1093/brain/awu024. Epub 2014 Feb 25.

29.

A lifespan observation of a novel mouse model: in vivo evidence supports aβ oligomer hypothesis.

Zhang Y, Lu L, Jia J, Jia L, Geula C, Pei J, Xu Z, Qin W, Liu R, Li D, Pan N.

PLoS One. 2014 Jan 21;9(1):e85885. doi: 10.1371/journal.pone.0085885. eCollection 2014.

30.

Alterations of Ca²⁺-responsive proteins within cholinergic neurons in aging and Alzheimer's disease.

Riascos D, Nicholas A, Samaeekia R, Yukhananov R, Mesulam MM, Bigio EH, Weintraub S, Guo L, Geula C.

Neurobiol Aging. 2014 Jun;35(6):1325-33. doi: 10.1016/j.neurobiolaging.2013.12.017. Epub 2013 Dec 25.

31.

Neurodegenerative diversity in human cortical contusion: histological analysis of tissue derived from decompressive craniectomy.

Riascos D, Buriticá E, Jiménez E, Castro O, Guzmán F, Palacios M, Garcia-Cairasco N, Geula C, Escobar M, Pimienta H.

Brain Res. 2013 Nov 6;1537:86-99. doi: 10.1016/j.brainres.2013.09.016. Epub 2013 Sep 21.

PMID:
24060647
32.

Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid.

Bigio EH, Wu JY, Deng HX, Bit-Ivan EN, Mao Q, Ganti R, Peterson M, Siddique N, Geula C, Siddique T, Mesulam M.

Acta Neuropathol. 2013 Mar;125(3):463-5. doi: 10.1007/s00401-013-1089-6. Epub 2013 Feb 3. No abstract available.

33.

Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project.

Rogalski EJ, Gefen T, Shi J, Samimi M, Bigio E, Weintraub S, Geula C, Mesulam MM.

J Cogn Neurosci. 2013 Jan;25(1):29-36. doi: 10.1162/jocn_a_00300.

34.

In vivo AAV-mediated expression of calbindin-D₂₈k in rat basal forebrain cholinergic neurons.

Nagykery N, Terwilliger EF, Geula C.

J Neurosci Methods. 2013 Jan 15;212(1):106-13. doi: 10.1016/j.jneumeth.2012.09.021. Epub 2012 Sep 27.

35.

The 5th International Conference on Alzheimer's Disease and related disorders in the Middle East, 15-17 May 2009, Limassol Cyprus.

Sabbagh MN, Messis C, Friedland RP, Geula C.

J Alzheimers Dis. 2012;30(3):711-27. doi: 10.3233/JAD-2012-120116.

PMID:
22614876
36.

Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia.

Gefen T, Gasho K, Rademaker A, Lalehzari M, Weintraub S, Rogalski E, Wieneke C, Bigio E, Geula C, Mesulam MM.

Brain. 2012 May;135(Pt 5):1554-65. doi: 10.1093/brain/aws076. Epub 2012 Apr 19.

37.

Butyrylcholinesterase is associated with β-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease.

Darvesh S, Cash MK, Reid GA, Martin E, Mitnitski A, Geula C.

J Neuropathol Exp Neurol. 2012 Jan;71(1):2-14. doi: 10.1097/NEN.0b013e31823cc7a6.

38.

Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.

Perez SE, Getova DP, He B, Counts SE, Geula C, Desire L, Coutadeur S, Peillon H, Ginsberg SD, Mufson EJ.

Am J Pathol. 2012 Feb;180(2):526-40. doi: 10.1016/j.ajpath.2011.10.027. Epub 2011 Dec 3.

39.

Selective tau tyrosine nitration in non-AD tauopathies.

Reyes JF, Geula C, Vana L, Binder LI.

Acta Neuropathol. 2012 Jan;123(1):119-32. doi: 10.1007/s00401-011-0898-8. Epub 2011 Nov 6.

40.

Age-related loss of calcium buffering and selective neuronal vulnerability in Alzheimer's disease.

Riascos D, de Leon D, Baker-Nigh A, Nicholas A, Yukhananov R, Bu J, Wu CK, Geula C.

Acta Neuropathol. 2011 Nov;122(5):565-76. doi: 10.1007/s00401-011-0865-4. Epub 2011 Aug 27.

41.

Biochemical differentiation of cholinesterases from normal and Alzheimer's disease cortex.

Ciro A, Park J, Burkhard G, Yan N, Geula C.

Curr Alzheimer Res. 2012 Jan;9(1):138-43.

42.

Neuronal and axonal loss are selectively linked to fibrillar amyloid-{beta} within plaques of the aged primate cerebral cortex.

Shah P, Lal N, Leung E, Traul DE, Gonzalo-Ruiz A, Geula C.

Am J Pathol. 2010 Jul;177(1):325-33. doi: 10.2353/ajpath.2010.090937. Epub 2010 May 20.

43.

Asymmetric TDP-43 distribution in primary progressive aphasia with progranulin mutation.

Gliebus G, Bigio EH, Gasho K, Mishra M, Caplan D, Mesulam MM, Geula C.

Neurology. 2010 May 18;74(20):1607-10. doi: 10.1212/WNL.0b013e3181df0a1b.

44.

The 4th International Symposium on Alzheimer's Disease and Related Disorders in the Middle East, October 26-28, 2007, Athens, Greece.

Geula C, Efthymiopoulos S, Friedland RP.

Amyloid. 2010 Jun;17(2):86-90. doi: 10.3109/13506129.2010.483120. No abstract available.

PMID:
20462368
45.

Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex.

Leung E, Guo L, Bu J, Maloof M, El Khoury J, Geula C.

Neurobiol Aging. 2011 Mar;32(3):387-97. doi: 10.1016/j.neurobiolaging.2009.02.025. Epub 2009 Apr 5.

46.

Evolution of the aging brain transcriptome and synaptic regulation.

Loerch PM, Lu T, Dakin KA, Vann JM, Isaacs A, Geula C, Wang J, Pan Y, Gabuzda DH, Li C, Prolla TA, Yankner BA.

PLoS One. 2008 Oct 2;3(10):e3329. doi: 10.1371/journal.pone.0003329.

47.

Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease.

Geula C, Nagykery N, Nicholas A, Wu CK.

J Neuropathol Exp Neurol. 2008 Apr;67(4):309-18. doi: 10.1097/NEN.0b013e31816a1df3.

48.
49.

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD.

Nat Med. 2007 Apr;13(4):432-8. Epub 2007 Mar 11.

PMID:
17351623
50.

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