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Self-Assembly of the Cephalopod Protein Reflectin.

Naughton KL, Phan L, Leung EM, Kautz R, Lin Q, Van Dyke Y, Marmiroli B, Sartori B, Arvai A, Li S, Pique ME, Naeim M, Kerr JP, Aquino MJ, Roberts VA, Getzoff ED, Zhu C, Bernstorff S, Gorodetsky AA.

Adv Mater. 2016 Oct;28(38):8405-8412. doi: 10.1002/adma.201601666. Epub 2016 Jul 25.


Functional Conversion of CPD and (6-4) Photolyases by Mutation.

Yamada D, Dokainish HM, Iwata T, Yamamoto J, Ishikawa T, Todo T, Iwai S, Getzoff ED, Kitao A, Kandori H.

Biochemistry. 2016 Aug 2;55(30):4173-83. doi: 10.1021/acs.biochem.6b00361. Epub 2016 Jul 19.


Single Hydrogen Bond Donation from Flavin N5 to Proximal Asparagine Ensures FAD Reduction in DNA Photolyase.

Wijaya IM, Domratcheva T, Iwata T, Getzoff ED, Kandori H.

J Am Chem Soc. 2016 Apr 6;138(13):4368-76. doi: 10.1021/jacs.5b10533. Epub 2016 Mar 22.


Structural Changes of the Active Center during the Photoactivation of Xenopus (6-4) Photolyase.

Yamada D, Yamamoto J, Zhang Y, Iwata T, Hitomi K, Getzoff ED, Iwai S, Kandori H.

Biochemistry. 2016 Feb 2;55(4):715-23. doi: 10.1021/acs.biochem.5b01111. Epub 2016 Jan 19.


Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus.

Pratt AJ, DiDonato M, Shin DS, Cabelli DE, Bruns CK, Belzer CA, Gorringe AR, Langford PR, Tabatabai LB, Kroll JS, Tainer JA, Getzoff ED.

J Bacteriol. 2015 Dec;197(24):3834-47. doi: 10.1128/JB.00343-15. Epub 2015 Oct 12.


Reaction dynamics of the UV-B photosensor UVR8.

Miyamori T, Nakasone Y, Hitomi K, Christie JM, Getzoff ED, Terazima M.

Photochem Photobiol Sci. 2015 May;14(5):995-1004. doi: 10.1039/c5pp00012b.


Structural role of two histidines in the (6-4) photolyase reaction.

Yamada D, Iwata T, Yamamoto J, Hitomi K, Todo T, Iwai S, Getzoff ED, Kandori H.

Biophys Physicobiol. 2015 Dec 22;12:139-44. doi: 10.2142/biophysico.12.0_139. eCollection 2015.


FTIR study of CPD photolyase with substrate in single strand DNA.

Mahaputra Wijaya IM, Iwata T, Yamamoto J, Hitomi K, Iwai S, Getzoff ED, Kandori H.

Biophysics (Nagoya-shi). 2015 Feb 13;11:39-45. doi: 10.2142/biophysics.11.39. eCollection 2015.


Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes.

Pratt AJ, Shin DS, Merz GE, Rambo RP, Lancaster WA, Dyer KN, Borbat PP, Poole FL 2nd, Adams MW, Freed JH, Crane BR, Tainer JA, Getzoff ED.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4568-76. doi: 10.1073/pnas.1308531111. Epub 2014 Oct 14.


Copper-based pulsed dipolar ESR spectroscopy as a probe of protein conformation linked to disease states.

Merz GE, Borbat PP, Pratt AJ, Getzoff ED, Freed JH, Crane BR.

Biophys J. 2014 Oct 7;107(7):1669-74. doi: 10.1016/j.bpj.2014.07.068.


Flavin adenine dinucleotide chromophore charge controls the conformation of cyclobutane pyrimidine dimer photolyase α-helices.

Wijaya IM, Iwata T, Yamamoto J, Hitomi K, Iwai S, Getzoff ED, Kennis JT, Mathes T, Kandori H.

Biochemistry. 2014 Sep 23;53(37):5864-75. doi: 10.1021/bi500638b. Epub 2014 Sep 9.


ATP binding turns plant cryptochrome into an efficient natural photoswitch.

Müller P, Bouly JP, Hitomi K, Balland V, Getzoff ED, Ritz T, Brettel K.

Sci Rep. 2014 Jun 5;4:5175. doi: 10.1038/srep05175.


FRET-based reporters for the direct visualization of abscisic acid concentration changes and distribution in Arabidopsis.

Waadt R, Hitomi K, Nishimura N, Hitomi C, Adams SR, Getzoff ED, Schroeder JI.

Elife. 2014 Apr 15;3:e01739. doi: 10.7554/eLife.01739.


Going green: phytohormone mimetics for drought rescue.

Hitomi K, Getzoff ED, Schroeder JI.

Plant Physiol. 2013 Nov;163(3):1087-8. doi: 10.1104/pp.113.227660. No abstract available.


Variable electron transfer pathways in an amphibian cryptochrome: tryptophan versus tyrosine-based radical pairs.

Biskup T, Paulus B, Okafuji A, Hitomi K, Getzoff ED, Weber S, Schleicher E.

J Biol Chem. 2013 Mar 29;288(13):9249-60. doi: 10.1074/jbc.M112.417725. Epub 2013 Feb 19.


Detection of distinct α-helical rearrangements of cyclobutane pyrimidine dimer photolyase upon substrate binding by Fourier transform infrared spectroscopy.

Wijaya IM, Zhang Y, Iwata T, Yamamoto J, Hitomi K, Iwai S, Getzoff ED, Kandori H.

Biochemistry. 2013 Feb 12;52(6):1019-27. doi: 10.1021/bi3016179. Epub 2013 Jan 30.


Amyotrophic lateral sclerosis: update and new developments.

Pratt AJ, Getzoff ED, Perry JJ.

Degener Neurol Neuromuscul Dis. 2012 Feb;2012(2):1-14.


Fourier-transform infrared study of the photoactivation process of Xenopus (6-4) photolyase.

Yamada D, Zhang Y, Iwata T, Hitomi K, Getzoff ED, Kandori H.

Biochemistry. 2012 Jul 24;51(29):5774-83. doi: 10.1021/bi300530x. Epub 2012 Jul 13.


Structural tuning of the fluorescent protein iLOV for improved photostability.

Christie JM, Hitomi K, Arvai AS, Hartfield KA, Mettlen M, Pratt AJ, Tainer JA, Getzoff ED.

J Biol Chem. 2012 Jun 22;287(26):22295-304. doi: 10.1074/jbc.M111.318881. Epub 2012 May 9.


Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridges.

Christie JM, Arvai AS, Baxter KJ, Heilmann M, Pratt AJ, O'Hara A, Kelly SM, Hothorn M, Smith BO, Hitomi K, Jenkins GI, Getzoff ED.

Science. 2012 Mar 23;335(6075):1492-6. doi: 10.1126/science.1218091. Epub 2012 Feb 9.


Computational reconstruction of multidomain proteins using atomic force microscopy data.

Trinh MH, Odorico M, Pique ME, Teulon JM, Roberts VA, Ten Eyck LF, Getzoff ED, Parot P, Chen SW, Pellequer JL.

Structure. 2012 Jan 11;20(1):113-20. doi: 10.1016/j.str.2011.10.023.


Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants.

Hitomi K, Arvai AS, Yamamoto J, Hitomi C, Teranishi M, Hirouchi T, Yamamoto K, Iwai S, Tainer JA, Hidema J, Getzoff ED.

J Biol Chem. 2012 Apr 6;287(15):12060-9. doi: 10.1074/jbc.M111.244020. Epub 2011 Dec 14.


Unexpected electron transfer in cryptochrome identified by time-resolved EPR spectroscopy.

Biskup T, Hitomi K, Getzoff ED, Krapf S, Koslowski T, Schleicher E, Weber S.

Angew Chem Int Ed Engl. 2011 Dec 23;50(52):12647-51. doi: 10.1002/anie.201104321. Epub 2011 Nov 15.


Light-induced conformational changes in full-length Arabidopsis thaliana cryptochrome.

Kondoh M, Shiraishi C, Müller P, Ahmad M, Hitomi K, Getzoff ED, Terazima M.

J Mol Biol. 2011 Oct 14;413(1):128-37. doi: 10.1016/j.jmb.2011.08.031. Epub 2011 Aug 22.


FTIR study of light-dependent activation and DNA repair processes of (6-4) photolyase.

Zhang Y, Iwata T, Yamamoto J, Hitomi K, Iwai S, Todo T, Getzoff ED, Kandori H.

Biochemistry. 2011 May 10;50(18):3591-8. doi: 10.1021/bi1019397. Epub 2011 Apr 15.


Light-induced conformational change and product release in DNA repair by (6-4) photolyase.

Kondoh M, Hitomi K, Yamamoto J, Todo T, Iwai S, Getzoff ED, Terazima M.

J Am Chem Soc. 2011 Feb 23;133(7):2183-91. doi: 10.1021/ja107691w. Epub 2011 Jan 27.


Key dynamics of conserved asparagine in a cryptochrome/photolyase family protein by fourier transform infrared spectroscopy.

Iwata T, Zhang Y, Hitomi K, Getzoff ED, Kandori H.

Biochemistry. 2010 Oct 19;49(41):8882-91. doi: 10.1021/bi1009979.


Early abscisic acid signal transduction mechanisms: newly discovered components and newly emerging questions.

Hubbard KE, Nishimura N, Hitomi K, Getzoff ED, Schroeder JI.

Genes Dev. 2010 Aug 15;24(16):1695-708. doi: 10.1101/gad.1953910. Review.


Origin of light-induced spin-correlated radical pairs in cryptochrome.

Weber S, Biskup T, Okafuji A, Marino AR, Berthold T, Link G, Hitomi K, Getzoff ED, Schleicher E, Norris JR Jr.

J Phys Chem B. 2010 Nov 18;114(45):14745-54. doi: 10.1021/jp103401u. Epub 2010 Aug 4.


Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation.

Rosenfeld RJ, Bonaventura J, Szymczyna BR, MacCoss MJ, Arvai AS, Yates JR 3rd, Tainer JA, Getzoff ED.

J Biol Chem. 2010 Oct 8;285(41):31581-9. doi: 10.1074/jbc.M109.072496. Epub 2010 Jul 21.


Light-induced activation of class II cyclobutane pyrimidine dimer photolyases.

Okafuji A, Biskup T, Hitomi K, Getzoff ED, Kaiser G, Batschauer A, Bacher A, Hidema J, Teranishi M, Yamamoto K, Schleicher E, Weber S.

DNA Repair (Amst). 2010 May 4;9(5):495-505. doi: 10.1016/j.dnarep.2010.01.014. Epub 2010 Mar 15.


The Electronic State of Flavoproteins: Investigations with Proton Electron-Nuclear Double Resonance.

Schleicher E, Wenzel R, Ahmad M, Batschauer A, Essen LO, Hitomi K, Getzoff ED, Bittl R, Weber S, Okafuji A.

Appl Magn Reson. 2010 Jan 1;37(1-4):339-352.


Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer.

Guan ZW, Haque MM, Wei CC, Garcin ED, Getzoff ED, Stuehr DJ.

J Biol Chem. 2010 Jan 29;285(5):3064-75. doi: 10.1074/jbc.M109.000810. Epub 2009 Nov 30.


Structural mechanism of abscisic acid binding and signaling by dimeric PYR1.

Nishimura N, Hitomi K, Arvai AS, Rambo RP, Hitomi C, Cutler SR, Schroeder JI, Getzoff ED.

Science. 2009 Dec 4;326(5958):1373-9. doi: 10.1126/science.1181829. Epub 2009 Oct 22.


The structural biochemistry of the superoxide dismutases.

Perry JJ, Shin DS, Getzoff ED, Tainer JA.

Biochim Biophys Acta. 2010 Feb;1804(2):245-62. doi: 10.1016/j.bbapap.2009.11.004. Epub 2009 Nov 13. Review.


Identification of a flavin mononucleotide module residue critical for activity of inducible nitrite oxide synthase.

Liu XD, Mazumdar T, Xu Y, Getzoff ED, Eissa NT.

J Immunol. 2009 Nov 1;183(9):5977-82. doi: 10.4049/jimmunol.0902274. Epub 2009 Oct 14.


Recognition and reaction mechanisms of the (6-4) photolyase as determined by using a (6-4) photoproduct analog.

Yamamoto J, Hitomi K, Hayashi R, Getzoff ED, Iwai S.

Nucleic Acids Symp Ser (Oxf). 2009;(53):221-2. doi: 10.1093/nass/nrp111.


Role of the carbonyl group of the (6-4) photoproduct in the (6-4) photolyase reaction.

Yamamoto J, Hitomi K, Hayashi R, Getzoff ED, Iwai S.

Biochemistry. 2009 Oct 6;48(39):9306-12. doi: 10.1021/bi900956p.


Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes.

Hitomi K, DiTacchio L, Arvai AS, Yamamoto J, Kim ST, Todo T, Tainer JA, Iwai S, Panda S, Getzoff ED.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6962-7. doi: 10.1073/pnas.0809180106. Epub 2009 Apr 9.


Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis.

Shin DS, Didonato M, Barondeau DP, Hura GL, Hitomi C, Berglund JA, Getzoff ED, Cary SC, Tainer JA.

J Mol Biol. 2009 Feb 6;385(5):1534-55. doi: 10.1016/j.jmb.2008.11.031. Epub 2008 Nov 25.


Direct observation of a photoinduced radical pair in a cryptochrome blue-light photoreceptor.

Biskup T, Schleicher E, Okafuji A, Link G, Hitomi K, Getzoff ED, Weber S.

Angew Chem Int Ed Engl. 2009;48(2):404-7. doi: 10.1002/anie.200803102. No abstract available.


Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.

Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV, Tainer JA, Getzoff ED.

Nat Chem Biol. 2008 Nov;4(11):700-7. doi: 10.1038/nchembio.115. Epub 2008 Oct 12.


Spectroscopic studies on a novel intramolecular hydrogen bond within the (6-4) photoproduct.

Yamamoto J, Tanaka Y, Hitomi K, Getzoff ED, Iwai S.

Nucleic Acids Symp Ser (Oxf). 2007;(51):79-80.


Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS.

Roberts BR, Tainer JA, Getzoff ED, Malencik DA, Anderson SR, Bomben VC, Meyers KR, Karplus PA, Beckman JS.

J Mol Biol. 2007 Nov 2;373(4):877-90. Epub 2007 Aug 2.


Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death.

Rameau GA, Tukey DS, Garcin-Hosfield ED, Titcombe RF, Misra C, Khatri L, Getzoff ED, Ziff EB.

J Neurosci. 2007 Mar 28;27(13):3445-55.


The case of the missing ring: radical cleavage of a carbon-carbon bond and implications for GFP chromophore biosynthesis.

Barondeau DP, Kassmann CJ, Tainer JA, Getzoff ED.

J Am Chem Soc. 2007 Mar 21;129(11):3118-26. Epub 2007 Feb 28.


Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase.

Schleicher E, Hitomi K, Kay CW, Getzoff ED, Todo T, Weber S.

J Biol Chem. 2007 Feb 16;282(7):4738-47. Epub 2006 Dec 12.


Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase.

Panda K, Haque MM, Garcin-Hosfield ED, Durra D, Getzoff ED, Stuehr DJ.

J Biol Chem. 2006 Dec 1;281(48):36819-27. Epub 2006 Sep 25.


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