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Items: 1 to 50 of 52

1.

Clinical validation of the Aptima Bacterial Vaginosis and Aptima Candida/Trichomonas Vaginitis Assays: results from a prospective multi-center clinical study.

Schwebke JR, Taylor SN, Ackerman R, Schlaberg R, Quigley NB, Gaydos CA, Chavoustie SE, Nyirjesy P, Remillard CV, Estes P, McKinney B, Getman DK, Clark C.

J Clin Microbiol. 2019 Nov 20. pii: JCM.01643-19. doi: 10.1128/JCM.01643-19. [Epub ahead of print]

2.

Molecular Testing for Mycoplasma genitalium in the United States: Results from the AMES Prospective Multicenter Clinical Study.

Gaydos CA, Manhart LE, Taylor SN, Lillis RA, Hook EW 3rd, Klausner JD, Remillard CV, Love M, McKinney B, Getman DK.

J Clin Microbiol. 2019 Oct 23;57(11). pii: e01125-19. doi: 10.1128/JCM.01125-19. Print 2019 Nov.

3.

Mycoplasma genitalium, Chlamydia trachomatis, and Neisseria gonorrhoeae Detected With Aptima Assays Performed on Self-Obtained Vaginal Swabs and Urine Collected at Home and in a Clinic.

Chernesky M, Jang D, Martin I, Arias M, Shah A, Smieja M, Ratnam S, Getman D, Schachter J.

Sex Transm Dis. 2019 Sep;46(9):e87-e89. doi: 10.1097/OLQ.0000000000001004.

PMID:
31415336
4.

Letter to the editor: Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019.

Unemo M, Getman D, Hadad R, Cole M, Thomson N, Puolakkainen M, Spiteri G.

Euro Surveill. 2019 Jun;24(24). doi: 10.2807/1560-7917.ES.2019.24.24.1900354. No abstract available.

5.

Treponema pallidum Nucleic Acid Amplification Testing To Augment Syphilis Screening among Men Who Have Sex with Men.

Golden M, O'Donnell M, Lukehart S, Swenson P, Hovey P, Godornes C, Romano S, Getman D.

J Clin Microbiol. 2019 Jul 26;57(8). pii: e00572-19. doi: 10.1128/JCM.00572-19. Print 2019 Aug.

PMID:
31189578
6.

Design and Validation of Transcription-Mediated-Amplification Nucleic Acid Amplification Tests for Mycoplasma genitalium.

Kirkconnell B, Weinbaum B, Santos K, Le Nguyen T, Vinluan B, Astete S, Wood GE, Totten PA, Getman DK.

J Clin Microbiol. 2019 Jul 26;57(8). pii: e00264-19. doi: 10.1128/JCM.00264-19. Print 2019 Aug.

PMID:
31018983
7.

Treatment of first-void urine with Aptima Transfer Solution increases detection of high-risk HPV E6/E7 mRNA.

Arias M, Jang D, Dockter J, Ratnam S, Shah A, Elit L, Smieja M, Lytwyn A, Getman D, Weinbaum B, Chernesky M.

J Virol Methods. 2019 May;267:48-52. doi: 10.1016/j.jviromet.2019.02.007. Epub 2019 Feb 21.

PMID:
30797768
8.

Screening for Trichomonas vaginalis in a Large High-Risk Population: Prevalence Among Men and Women Determined by Nucleic Acid Amplification Testing.

Schwebke J, Merriweather A, Massingale S, Scisney M, Hill C, Getman D.

Sex Transm Dis. 2018 May;45(5):e23-e24. doi: 10.1097/OLQ.0000000000000757.

9.

Detection of cervical precancerous lesions with Aptima HPV assays using SurePath preservative fluid specimens.

Chernesky M, Jang D, Escott N, Gilchrist J, Li J, Elit L, Lytwyn A, Smieja M, Ratnam S, Arias M, Getman D, Weinbaum B, Kirkconnell B, Dockter J.

Papillomavirus Res. 2017 Jun;3:155-159. doi: 10.1016/j.pvr.2017.04.005. Epub 2017 Apr 28.

10.

Urinary Meatal Swabbing Detects More Men Infected With Mycoplasma genitalium and Four Other Sexually Transmitted Infections Than First Catch Urine.

Chernesky M, Jang D, Smieja M, Arias M, Martin I, Weinbaum B, Getman D.

Sex Transm Dis. 2017 Aug;44(8):489-491. doi: 10.1097/OLQ.0000000000000618.

PMID:
28703728
11.

Mycoplasma genitalium Antibiotic Resistance-Mediating Mutations in Canadian Women With or Without Chlamydia Trachomatis Infection.

Chernesky MA, Jang D, Martin I, Hoang LMN, Naidu P, Levett PN, Wylie J, Rebbapragada A, Ratnam S, Smieja M, Weinbaum B, Getman D; Canadian MG Study Group.

Sex Transm Dis. 2017 Jul;44(7):433-435. doi: 10.1097/OLQ.0000000000000617.

PMID:
28608794
12.

Mycoplasma genitalium Prevalence, Coinfection, and Macrolide Antibiotic Resistance Frequency in a Multicenter Clinical Study Cohort in the United States.

Getman D, Jiang A, O'Donnell M, Cohen S.

J Clin Microbiol. 2016 Sep;54(9):2278-83. doi: 10.1128/JCM.01053-16. Epub 2016 Jun 15.

13.

Evaluation of a transcription mediated amplification assay for detection of herpes simplex virus types 1 and 2 mRNA in clinical specimens.

Swenson PD, El-Sabaeny A, Thomas-Moricz V, Allen M, Groskopf A, Jiang A, Getman D.

J Clin Virol. 2016 Jul;80:62-7. doi: 10.1016/j.jcv.2016.04.023. Epub 2016 May 2.

14.

Human papillomavirus oncogenic mRNA testing for cervical cancer screening: baseline and longitudinal results from the CLEAR study.

Reid JL, Wright TC Jr, Stoler MH, Cuzick J, Castle PE, Dockter J, Getman D, Giachetti C.

Am J Clin Pathol. 2015 Sep;144(3):473-83. doi: 10.1309/AJCPHVD7MIP3FYVV.

PMID:
26276778
15.

The reliability of high-risk human papillomavirus detection by Aptima HPV assay in women with ASC-US cytology.

Castle PE, Reid J, Dockter J, Getman D.

J Clin Virol. 2015 Aug;69:52-5. doi: 10.1016/j.jcv.2015.05.006. Epub 2015 May 11.

16.

Overdiagnosis of Urinary Tract Infection and Underdiagnosis of Sexually Transmitted Infection in Adult Women Presenting to an Emergency Department.

Tomas ME, Getman D, Donskey CJ, Hecker MT.

J Clin Microbiol. 2015 Aug;53(8):2686-92. doi: 10.1128/JCM.00670-15. Epub 2015 Jun 10.

17.
18.

Detection of human papillomavirus 16, 18, and 45 in women with ASC-US cytology and the risk of cervical precancer: results from the CLEAR HPV study.

Castle PE, Cuzick J, Stoler MH, Wright TC Jr, Reid JL, Dockter J, Giachetti C, Getman D.

Am J Clin Pathol. 2015 Feb;143(2):160-7. doi: 10.1309/AJCPLCD8TTOMLJTB.

PMID:
25596241
19.

Clinical characteristics associated with Mycoplasma genitalium among female sex workers in Nairobi, Kenya.

Gomih-Alakija A, Ting J, Mugo N, Kwatampora J, Getman D, Chitwa M, Patel S, Gokhale M, Kimani J, Behets FS, Smith JS.

J Clin Microbiol. 2014 Oct;52(10):3660-6. doi: 10.1128/JCM.00850-14. Epub 2014 Aug 6.

20.

Evaluation of a new APTIMA specimen collection and transportation kit for high-risk human papillomavirus E6/E7 messenger RNA in cervical and vaginal samples.

Chernesky M, Jang D, Gilchrist J, Elit L, Lytwyn A, Smieja M, Dockter J, Getman D, Reid J, Hill C.

Sex Transm Dis. 2014 Jun;41(6):365-8. doi: 10.1097/OLQ.0000000000000125.

PMID:
24825332
21.

APTIMA HPV assay performance in women with atypical squamous cells of undetermined significance cytology results.

Stoler MH, Wright TC Jr, Cuzick J, Dockter J, Reid JL, Getman D, Giachetti C.

Am J Obstet Gynecol. 2013 Feb;208(2):144.e1-8. doi: 10.1016/j.ajog.2012.12.003. Epub 2012 Dec 5.

PMID:
23220509
22.

Mycoplasma genitalium infection in women attending a sexually transmitted infection clinic: diagnostic specimen type, coinfections, and predictors.

Mobley VL, Hobbs MM, Lau K, Weinbaum BS, Getman DK, Seña AC.

Sex Transm Dis. 2012 Sep;39(9):706-9. doi: 10.1097/OLQ.0b013e318255de03.

23.

Molecular testing for Trichomonas vaginalis in women: results from a prospective U.S. clinical trial.

Schwebke JR, Hobbs MM, Taylor SN, Sena AC, Catania MG, Weinbaum BS, Johnson AD, Getman DK, Gaydos CA.

J Clin Microbiol. 2011 Dec;49(12):4106-11. doi: 10.1128/JCM.01291-11. Epub 2011 Sep 21.

24.
25.

Efficiency of the APTIMA HPV Assay for detection of HPV RNA and DNA targets.

Getman D, Aiyer A, Dockter J, Giachetti C, Zhang F, Ginocchio CC.

J Clin Virol. 2009 Jul;45 Suppl 1:S49-54. doi: 10.1016/S1386-6532(09)70008-3.

PMID:
19651369
26.

Synthesis and structure-activity relationships of beta- and alpha-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy.

Becker DP, Villamil CI, Barta TE, Bedell LJ, Boehm TL, Decrescenzo GA, Freskos JN, Getman DP, Hockerman S, Heintz R, Howard SC, Li MH, McDonald JJ, Carron CP, Funckes-Shippy CL, Mehta PP, Munie GE, Swearingen CA.

J Med Chem. 2005 Oct 20;48(21):6713-30.

PMID:
16220987
27.

Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease.

Nagarajan SR, De Crescenzo GA, Getman DP, Lu HF, Sikorski JA, Walker JL, McDonald JJ, Houseman KA, Kocan GP, Kishore N, Mehta PP, Funkes-Shippy CL, Blystone L.

Bioorg Med Chem. 2003 Nov 3;11(22):4769-77.

PMID:
14556792
28.

DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants.

Kaltenbach RF 3rd, Trainor G, Getman D, Harris G, Garber S, Cordova B, Bacheler L, Jeffrey S, Logue K, Cawood P, Klabe R, Diamond S, Davies M, Saye J, Jona J, Erickson-Viitanen S.

Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8.

29.

alpha-Alkyl-alpha-amino-beta-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1.

Becker DP, DeCrescenzo G, Freskos J, Getman DP, Hockerman SL, Li M, Mehta P, Munie GE, Swearingen C.

Bioorg Med Chem Lett. 2001 Oct 22;11(20):2723-5.

PMID:
11591510
30.

alpha-Amino-beta-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1.

Becker DP, Barta TE, Bedell L, DeCrescenzo G, Freskos J, Getman DP, Hockerman SL, Li M, Mehta P, Mischke B, Munie GE, Swearingen C, Villamil CI.

Bioorg Med Chem Lett. 2001 Oct 22;11(20):2719-22.

PMID:
11591509
31.

Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development.

Morris JK, Lin W, Hauser C, Marchuk Y, Getman D, Lee KF.

Neuron. 1999 Jun;23(2):273-83.

32.

Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols.

Freskos JN, Mischke BV, DeCrescenzo GA, Heintz R, Getman DP, Howard SC, Kishore NN, McDonald JJ, Munie GE, Rangwala S, Swearingen CA, Voliva C, Welsch DJ.

Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8.

PMID:
10230616
33.

Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.

Devadas B, Freeman SK, Zupec ME, Lu HF, Nagarajan SR, Kishore NS, Lodge JK, Kuneman DW, McWherter CA, Vinjamoori DV, Getman DP, Gordon JI, Sikorski JA.

J Med Chem. 1997 Aug 1;40(16):2609-25.

PMID:
9258368
34.

Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase.

Nagarajan SR, Devadas B, Zupec ME, Freeman SK, Brown DL, Lu HF, Mehta PP, Kishore NS, McWherter CA, Getman DP, Gordon JI, Sikorski JA.

J Med Chem. 1997 May 9;40(10):1422-38.

PMID:
9154965
35.

Scanning alanine mutagenesis and de-peptidization of a Candida albicans myristoyl-CoA:protein N-myristoyltransferase octapeptide substrate reveals three elements critical for molecular recognition.

McWherter CA, Rocque WJ, Zupec ME, Freeman SK, Brown DL, Devadas B, Getman DP, Sikorski JA, Gordon JI.

J Biol Chem. 1997 May 2;272(18):11874-80.

36.

N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase.

Lodge JK, Jackson-Machelski E, Devadas B, Zupec ME, Getman DP, Kishore N, Freeman SK, McWherter CA, Sikorski JA, Gordon JI.

Microbiology. 1997 Feb;143 ( Pt 2):357-66.

PMID:
9043113
37.

Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy.

Sikorski JA, Devadas B, Zupec ME, Freeman SK, Brown DL, Lu HF, Nagarajan S, Mehta PP, Wade AC, Kishore NS, Bryant ML, Getman DP, McWherter CA, Gordon JI.

Biopolymers. 1997;43(1):43-71. Review.

PMID:
9174411
38.

Transcription factor repression and activation of the human acetylcholinesterase gene.

Getman DK, Mutero A, Inoue K, Taylor P.

J Biol Chem. 1995 Oct 6;270(40):23511-9.

39.

SC-52151, a novel inhibitor of the human immunodeficiency virus protease.

Bryant M, Getman D, Smidt M, Marr J, Clare M, Dillard R, Lansky D, DeCrescenzo G, Heintz R, Houseman K, et al.

Antimicrob Agents Chemother. 1995 Oct;39(10):2229-34.

40.

Design and syntheses of potent and selective dipeptide inhibitors of Candida albicans myristoyl-CoA:protein N-myristoyltransferase.

Devadas B, Zupec ME, Freeman SK, Brown DL, Nagarajan S, Sikorski JA, McWherter CA, Getman DP, Gordon JI.

J Med Chem. 1995 May 26;38(11):1837-40. No abstract available.

PMID:
7783114
41.

Inhibitors of HIV-1 protease containing the novel and potent (R)-(hydroxyethyl)sulfonamide isostere.

Vazquez ML, Bryant ML, Clare M, DeCrescenzo GA, Doherty EM, Freskos JN, Getman DP, Houseman KA, Julien JA, Kocan GP, et al.

J Med Chem. 1995 Feb 17;38(4):581-4. No abstract available.

PMID:
7861404
42.
43.

Structure and regulation of expression of the acetylcholinesterase gene.

Taylor P, Li Y, Camp S, Rachinsky TL, Ekström T, Getman D, Fuentes ME, Vellom DC, Radić Z.

Chem Biol Interact. 1993 Jun;87(1-3):199-207. Review.

PMID:
8343976
44.

Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere.

Getman DP, DeCrescenzo GA, Heintz RM, Reed KL, Talley JJ, Bryant ML, Clare M, Houseman KA, Marr JJ, Mueller RA, et al.

J Med Chem. 1993 Jan 22;36(2):288-91. No abstract available.

PMID:
8423599
45.

Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2.

Zupan LA, Weiss RH, Hazen SL, Parnas BL, Aston KW, Lennon PJ, Getman DP, Gross RW.

J Med Chem. 1993 Jan 8;36(1):95-100.

PMID:
8421294
46.

Promoter elements and transcriptional regulation of the acetylcholinesterase gene.

Ekström TJ, Klump WM, Getman D, Karin M, Taylor P.

DNA Cell Biol. 1993 Jan-Feb;12(1):63-72.

PMID:
8422273
47.

The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7.

Getman DK, Eubanks JH, Camp S, Evans GA, Taylor P.

Am J Hum Genet. 1992 Jul;51(1):170-7.

48.

Gene structure of mammalian acetylcholinesterase. Alternative exons dictate tissue-specific expression.

Li Y, Camp S, Rachinsky TL, Getman D, Taylor P.

J Biol Chem. 1991 Dec 5;266(34):23083-90.

49.

Influence of polyfluorination of the phenylalanine ring of angiotensin II on conformation and biological activity.

Bovy PR, Getman DP, Matsoukas JM, Moore GJ.

Biochim Biophys Acta. 1991 Aug 9;1079(1):23-8.

PMID:
1888761
50.

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