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Items: 1 to 50 of 178

1.

PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis.

Jensen KL, Sørensen G, Dencker D, Owens WA, Rahbek-Clemmensen T, Brett Lever M, Runegaard AH, Riis Christensen N, Weikop P, Wörtwein G, Fink-Jensen A, Madsen KL, Daws L, Gether U, Rickhag M.

eNeuro. 2018 Jun 11;5(3). pii: ENEURO.0422-17.2018. doi: 10.1523/ENEURO.0422-17.2018. eCollection 2018 May-Jun.

2.

An unsuspected role for organic cation transporter 3 in the actions of amphetamine.

Mayer FP, Schmid D, Owens WA, Gould GG, Apuschkin M, Kudlacek O, Salzer I, Boehm S, Chiba P, Williams PH, Wu HH, Gether U, Koek W, Daws LC, Sitte HH.

Neuropsychopharmacology. 2018 Apr 6. doi: 10.1038/s41386-018-0053-5. [Epub ahead of print]

PMID:
29773909
3.

An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1.

Herlo R, Lund VK, Lycas MD, Jansen AM, Khelashvili G, Andersen RC, Bhatia V, Pedersen TS, Albornoz PBC, Johner N, Ammendrup-Johnsen I, Christensen NR, Erlendsson S, Stoklund M, Larsen JB, Weinstein H, Kjærulff O, Stamou D, Gether U, Madsen KL.

Cell Rep. 2018 May 15;23(7):2056-2069. doi: 10.1016/j.celrep.2018.04.074.

4.

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT.

Merkle PS, Gotfryd K, Cuendet MA, Leth-Espensen KZ, Gether U, Loland CJ, Rand KD.

Sci Adv. 2018 May 11;4(5):eaar6179. doi: 10.1126/sciadv.aar6179. eCollection 2018 May.

5.

Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes.

Herborg F, Andreassen TF, Berlin F, Loland CJ, Gether U.

J Biol Chem. 2018 May 11;293(19):7250-7262. doi: 10.1074/jbc.RA118.001753. Epub 2018 Mar 20.

PMID:
29559554
6.

Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake.

Jensen KL, Runegaard AH, Weikop P, Gether U, Rickhag M.

J Vis Exp. 2017 Sep 21;(127). doi: 10.3791/56093.

PMID:
28994779
7.

Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains.

Rahbek-Clemmensen T, Lycas MD, Erlendsson S, Eriksen J, Apuschkin M, Vilhardt F, Jørgensen TN, Hansen FH, Gether U.

Nat Commun. 2017 Sep 29;8(1):740. doi: 10.1038/s41467-017-00790-3.

8.

Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm.

Runegaard AH, Jensen KL, Dencker D, Wörtwein G, Gether U.

J Neurosci Methods. 2017 Sep 1;289:85-92. doi: 10.1016/j.jneumeth.2017.07.010. Epub 2017 Jul 12.

PMID:
28711378
9.

Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research.

Jørgensen SH, Fitzpatrick CM, Gether U, Woldbye DPD, Sørensen AT.

Basic Clin Pharmacol Toxicol. 2017 Nov;121(5):373-381. doi: 10.1111/bcpt.12819. Epub 2017 Jul 10. Review.

PMID:
28609587
10.

Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer.

Jacobsen SE, Gether U, Bräuner-Osborne H.

Sci Rep. 2017 Apr 18;7:46355. doi: 10.1038/srep46355.

11.

The GPRC6A receptor displays constitutive internalization and sorting to the slow recycling pathway.

Jacobsen SE, Ammendrup-Johnsen I, Jansen AM, Gether U, Madsen KL, Bräuner-Osborne H.

J Biol Chem. 2017 Apr 28;292(17):6910-6926. doi: 10.1074/jbc.M116.762385. Epub 2017 Mar 9.

12.

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR.

Erlendsson S, Gotfryd K, Larsen FH, Mortensen JS, Geiger MA, van Rossum BJ, Oschkinat H, Gether U, Teilum K, Loland CJ.

Elife. 2017 Jan 24;6. pii: e19314. doi: 10.7554/eLife.19314.

13.

Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task.

Fitzpatrick CM, Caballero-Puntiverio M, Gether U, Habekost T, Bundesen C, Vangkilde S, Woldbye DP, Andreasen JT, Petersen A.

Psychopharmacology (Berl). 2017 Mar;234(5):845-855. doi: 10.1007/s00213-016-4520-6. Epub 2017 Jan 9.

PMID:
28070619
14.

The Environment Shapes the Inner Vestibule of LeuT.

Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T.

PLoS Comput Biol. 2016 Nov 11;12(11):e1005197. doi: 10.1371/journal.pcbi.1005197. eCollection 2016 Nov.

15.

Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter.

Billesbølle CB, Mortensen JS, Sohail A, Schmidt SG, Shi L, Sitte HH, Gether U, Loland CJ.

Nat Commun. 2016 Sep 28;7:12755. doi: 10.1038/ncomms12755.

16.

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290.

Khelashvili G, Schmidt SG, Shi L, Javitch JA, Gether U, Loland CJ, Weinstein H.

J Biol Chem. 2016 Sep 16;291(38):19786-99. doi: 10.1074/jbc.M116.731455. Epub 2016 Jul 29.

17.

Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice.

Runegaard AH, Jensen KL, Fitzpatrick CM, Dencker D, Weikop P, Gether U, Rickhag M.

Eur J Neurosci. 2017 Jan;45(1):121-128. doi: 10.1111/ejn.13347. Epub 2016 Aug 22.

18.

Structural biology: Antidepressants at work.

Caron MG, Gether U.

Nature. 2016 Apr 21;532(7599):320-1. doi: 10.1038/nature17883. Epub 2016 Apr 6. No abstract available.

PMID:
27049942
19.

A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function.

Vuorenpää A, Ammendrup-Johnsen I, Jørgensen TN, Gether U.

Neurochem Int. 2016 Sep;98:103-14. doi: 10.1016/j.neuint.2016.03.013. Epub 2016 Mar 26.

PMID:
27020406
20.

Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini.

Vuorenpää A, Jørgensen TN, Newman AH, Madsen KL, Scheinin M, Gether U.

J Biol Chem. 2016 Mar 11;291(11):5634-51. doi: 10.1074/jbc.M115.702050. Epub 2016 Jan 19.

21.

Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial.

Knorr U, Koefoed P, Gluud C, Wetterslev J, Winkel P, Gether U, Vinberg M, Kessing LV.

Nord J Psychiatry. 2016;70(4):297-302. doi: 10.3109/08039488.2015.1109138. Epub 2016 Jan 11.

PMID:
26752119
22.

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter.

Larsen MA, Plenge P, Andersen J, Eildal JN, Kristensen AS, Bøgesø KP, Gether U, Strømgaard K, Bang-Andersen B, Loland CJ.

Br J Pharmacol. 2016 Mar;173(5):925-36. doi: 10.1111/bph.13411. Epub 2016 Feb 8.

23.

No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial.

Knorr U, Koefoed P, Soendergaard MH, Vinberg M, Gether U, Gluud C, Wetterslev J, Winkel P, Kessing LV.

Acta Neuropsychiatr. 2016 Apr;28(2):101-9. doi: 10.1017/neu.2015.55. Epub 2015 Nov 17.

PMID:
26573431
24.

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

Billesbølle CB, Krüger MB, Shi L, Quick M, Li Z, Stolzenberg S, Kniazeff J, Gotfryd K, Mortensen JS, Javitch JA, Weinstein H, Loland CJ, Gether U.

J Biol Chem. 2015 Oct 30;290(44):26725-38. doi: 10.1074/jbc.M115.677658. Epub 2015 Sep 11.

25.

[Optogenetics brings hidden neural mechanisms into the light and could become a future therapy].

Axelsen TM, Navntoft CA, Christiansen SH, Dreyer JK, Sørensen JB, Gether U, Woldbye DP.

Ugeskr Laeger. 2015 Aug 17;177(34). pii: V06150501. Review. Danish.

PMID:
26320592
26.

A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity.

Apuschkin M, Stilling S, Rahbek-Clemmensen T, Sørensen G, Fortin G, Herborg Hansen F, Eriksen J, Trudeau LE, Egerod K, Gether U, Rickhag M.

Eur J Neurosci. 2015 Oct;42(7):2438-54. doi: 10.1111/ejn.13046. Epub 2015 Sep 30.

27.

Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering.

Karlsen ML, Thorsen TS, Johner N, Ammendrup-Johnsen I, Erlendsson S, Tian X, Simonsen JB, Høiberg-Nielsen R, Christensen NM, Khelashvili G, Streicher W, Teilum K, Vestergaard B, Weinstein H, Gether U, Arleth L, Madsen KL.

Structure. 2015 Jul 7;23(7):1258-1270. doi: 10.1016/j.str.2015.04.020. Epub 2015 Jun 11.

28.

Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII.

Steinkellner T, Montgomery TR, Hofmaier T, Kudlacek O, Yang JW, Rickhag M, Jung G, Lubec G, Gether U, Freissmuth M, Sitte HH.

J Neurosci. 2015 May 27;35(21):8258-71. doi: 10.1523/JNEUROSCI.4034-14.2015. Erratum in: J Neurosci. 2015 Aug 19;35(33):11762.

29.

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.

Stolzenberg S, Quick M, Zhao C, Gotfryd K, Khelashvili G, Gether U, Loland CJ, Javitch JA, Noskov S, Weinstein H, Shi L.

J Biol Chem. 2015 May 29;290(22):13992-4003. doi: 10.1074/jbc.M114.625343. Epub 2015 Apr 13.

30.

Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors.

Cartier E, Hamilton PJ, Belovich AN, Shekar A, Campbell NG, Saunders C, Andreassen TF, Gether U, Veenstra-Vanderweele J, Sutcliffe JS, Ulery-Reynolds PG, Erreger K, Matthies HJ, Galli A.

EBioMedicine. 2015 Feb;2(2):135-146.

31.

Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation.

Rajamanickam J, Annamalai B, Rahbek-Clemmensen T, Sundaramurthy S, Gether U, Jayanthi LD, Ramamoorthy S.

Biochem J. 2015 May 15;468(1):177-90. doi: 10.1042/BJ20140826.

PMID:
25761794
32.

The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells.

Pinheiro PS, Jansen AM, de Wit H, Tawfik B, Madsen KL, Verhage M, Gether U, Sørensen JB.

J Neurosci. 2014 Aug 6;34(32):10688-700. doi: 10.1523/JNEUROSCI.5132-13.2014.

33.

The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride.

Borre L, Andreassen TF, Shi L, Weinstein H, Gether U.

J Biol Chem. 2014 Sep 12;289(37):25764-73. doi: 10.1074/jbc.M114.574269. Epub 2014 Jul 25.

34.

Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.

Erlendsson S, Rathje M, Heidarsson PO, Poulsen FM, Madsen KL, Teilum K, Gether U.

J Biol Chem. 2014 Sep 5;289(36):25327-40. doi: 10.1074/jbc.M114.548743. Epub 2014 Jul 13.

35.

The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation.

Rahbek-Clemmensen T, Bay T, Eriksen J, Gether U, Jørgensen TN.

J Biol Chem. 2014 Aug 15;289(33):23004-19. doi: 10.1074/jbc.M113.495754. Epub 2014 Jun 27.

36.

Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram.

Kumar V, Rahbek-Clemmensen T, Billesbølle CB, Jorgensen TN, Gether U, Newman AH.

ACS Med Chem Lett. 2014 Mar 27;5(6):696-9. doi: 10.1021/ml5000806. eCollection 2014 Jun 12.

37.

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJ, Friberg L, Law I, Pinborg LH, Sitte HH, Loland C, Shi L, Weinstein H, Galli A, Hjermind LE, Møller LB, Gether U.

J Clin Invest. 2014 Jul;124(7):3107-20. doi: 10.1172/JCI73778. Epub 2014 Jun 9.

38.

In vivo amphetamine action is contingent on αCaMKII.

Steinkellner T, Mus L, Eisenrauch B, Constantinescu A, Leo D, Konrad L, Rickhag M, Sørensen G, Efimova EV, Kong E, Willeit M, Sotnikova TD, Kudlacek O, Gether U, Freissmuth M, Pollak DD, Gainetdinov RR, Sitte HH.

Neuropsychopharmacology. 2014 Oct;39(11):2681-93. doi: 10.1038/npp.2014.124. Epub 2014 May 29.

39.

Reply to Wilkinson et al.: Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling.

Rathje M, Fang H, Bachman JL, Gether U, Huganir RL, Madsen KL.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E305. No abstract available.

40.

Serotonin-induced down-regulation of cell surface serotonin transporter.

Jørgensen TN, Christensen PM, Gether U.

Neurochem Int. 2014 Jul;73:107-12. doi: 10.1016/j.neuint.2014.01.005. Epub 2014 Jan 22.

41.

Drosophila melanogaster: a novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter gene.

Hamilton PJ, Campbell NG, Sharma S, Erreger K, Hansen FH, Saunders C, Belovich AN, Sahai MA, Cook EH, Gether U, McHaourab HS, Matthies HJ, Sutcliffe JS, Galli A.

Mol Psychiatry. 2013 Dec;18(12):1235. doi: 10.1038/mp.2013.157. No abstract available.

PMID:
24253181
42.

Novel tripod amphiphiles for membrane protein analysis.

Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SG, Bae HE, Chandra R, Gether U, Guan L, Kobilka BK, Loland CJ, Byrne B, Gellman SH.

Chemistry. 2013 Nov 11;19(46):15645-51. doi: 10.1002/chem.201301423. Epub 2013 Oct 2.

43.

De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder.

Hamilton PJ, Campbell NG, Sharma S, Erreger K, Herborg Hansen F, Saunders C, Belovich AN; NIH ARRA Autism Sequencing Consortium, Sahai MA, Cook EH, Gether U, McHaourab HS, Matthies HJ, Sutcliffe JS, Galli A.

Mol Psychiatry. 2013 Dec;18(12):1315-23. doi: 10.1038/mp.2013.102. Epub 2013 Aug 27.

44.

AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons.

Rathje M, Fang H, Bachman JL, Anggono V, Gether U, Huganir RL, Madsen KL.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14426-31. doi: 10.1073/pnas.1312982110. Epub 2013 Aug 12.

45.

Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.

Rickhag M, Owens WA, Winkler MT, Strandfelt KN, Rathje M, Sørensen G, Andresen B, Madsen KL, Jørgensen TN, Wörtwein G, Woldbye DP, Sitte H, Daws LC, Gether U.

J Biol Chem. 2013 Sep 20;288(38):27534-44. doi: 10.1074/jbc.M112.441295. Epub 2013 Jul 24.

46.

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort.

Larsen MH, Albrechtsen A, Thørner LW, Werge T, Hansen T, Gether U, Haastrup E, Ullum H.

PLoS One. 2013 Jun 18;8(6):e66262. doi: 10.1371/journal.pone.0066262. Print 2013.

47.

PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.

Holst B, Madsen KL, Jansen AM, Jin C, Rickhag M, Lund VK, Jensen M, Bhatia V, Sørensen G, Madsen AN, Xue Z, Møller SK, Woldbye D, Qvortrup K, Huganir R, Stamou D, Kjærulff O, Gether U.

PLoS Biol. 2013;11(4):e1001542. doi: 10.1371/journal.pbio.1001542. Epub 2013 Apr 23.

48.

A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter.

Rickhag M, Hansen FH, Sørensen G, Strandfelt KN, Andresen B, Gotfryd K, Madsen KL, Vestergaard-Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, Füchtbauer EM, Gomeza J, Woldbye DP, Wörtwein G, Gether U.

Nat Commun. 2013;4:1580. doi: 10.1038/ncomms2568. Erratum in: Nat Commun. 2013;4:2589.

49.

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study.

Chae PS, Rana RR, Gotfryd K, Rasmussen SG, Kruse AC, Cho KH, Capaldi S, Carlsson E, Kobilka B, Loland CJ, Gether U, Banerjee S, Byrne B, Lee JK, Gellman SH.

Chem Commun (Camb). 2013 Mar 21;49(23):2287-9. doi: 10.1039/c2cc36844g. Erratum in: Chem Commun (Camb). 2013 Dec 28;49(100):11821-2.

50.

Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter.

Plenge P, Shi L, Beuming T, Te J, Newman AH, Weinstein H, Gether U, Loland CJ.

J Biol Chem. 2012 Nov 16;287(47):39316-26. doi: 10.1074/jbc.M112.371765. Epub 2012 Sep 24.

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