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Items: 31


Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells.

Luttrell LM, Dar MS, Gesty-Palmer D, El-Shewy HM, Robinson KM, Haycraft CJ, Barth JL.

PLoS One. 2019 Jan 4;14(1):e0204197. doi: 10.1371/journal.pone.0204197. eCollection 2019.


Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes.

Garg SK, Henry RR, Banks P, Buse JB, Davies MJ, Fulcher GR, Pozzilli P, Gesty-Palmer D, Lapuerta P, Simó R, Danne T, McGuire DK, Kushner JA, Peters A, Strumph P.

N Engl J Med. 2017 Dec 14;377(24):2337-2348. doi: 10.1056/NEJMoa1708337. Epub 2017 Sep 13.


Translating in vitro ligand bias into in vivo efficacy.

Luttrell LM, Maudsley S, Gesty-Palmer D.

Cell Signal. 2018 Jan;41:46-55. doi: 10.1016/j.cellsig.2017.05.002. Epub 2017 May 7. Review.


Informatic deconvolution of biased GPCR signaling mechanisms from in vivo pharmacological experimentation.

Maudsley S, Martin B, Janssens J, Etienne H, Jushaj A, van Gastel J, Willemsen A, Chen H, Gesty-Palmer D, Luttrell LM.

Methods. 2016 Jan 1;92:51-63. doi: 10.1016/j.ymeth.2015.05.013. Epub 2015 May 16.


Delineation of a conserved arrestin-biased signaling repertoire in vivo.

Maudsley S, Martin B, Gesty-Palmer D, Cheung H, Johnson C, Patel S, Becker KG, Wood WH 3rd, Zhang Y, Lehrmann E, Luttrell LM.

Mol Pharmacol. 2015 Apr;87(4):706-17. doi: 10.1124/mol.114.095224. Epub 2015 Jan 30.


Arrestins in bone.

Bohinc BN, Gesty-Palmer D.

Prog Mol Biol Transl Sci. 2013;118:335-58. doi: 10.1016/B978-0-12-394440-5.00013-9. Review.


β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo.

Gesty-Palmer D, Yuan L, Martin B, Wood WH 3rd, Lee MH, Janech MG, Tsoi LC, Zheng WJ, Luttrell LM, Maudsley S.

Mol Endocrinol. 2013 Feb;27(2):296-314. doi: 10.1210/me.2012-1091. Epub 2013 Jan 11.


The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.

Wang X, Liao S, Nelson ER, Schmalzigaug R, Spurney RF, Guilak F, Premont RT, Gesty-Palmer D.

Biochem Biophys Res Commun. 2012 Aug 24;425(2):407-12. doi: 10.1016/j.bbrc.2012.07.111. Epub 2012 Jul 27.


Biased agonism at the parathyroid hormone receptor: a demonstration of functional selectivity in bone metabolism.

Bohinc BN, Gesty-Palmer D.

Mini Rev Med Chem. 2012 Aug;12(9):856-65. Review.


The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors.

Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP.

Endocrinology. 2011 Dec;152(12):4691-705. doi: 10.1210/en.2011-1298. Epub 2011 Sep 20.


Refining efficacy: exploiting functional selectivity for drug discovery.

Gesty-Palmer D, Luttrell LM.

Adv Pharmacol. 2011;62:79-107. doi: 10.1016/B978-0-12-385952-5.00009-9. Review.


'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass?

Gesty-Palmer D, Luttrell LM.

Br J Pharmacol. 2011 Sep;164(1):59-67. doi: 10.1111/j.1476-5381.2011.01450.x. Review.


β-arrestin-biased agonism at the parathyroid hormone receptor uncouples bone formation from bone resorption.

Bohinc BN, Gesty-Palmer D.

Endocr Metab Immune Disord Drug Targets. 2011 Jun;11(2):112-9. Review.


Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor.

Koh J, Dar M, Untch BR, Dixit D, Shi Y, Yang Z, Adam MA, Dressman H, Wang X, Gesty-Palmer D, Marks JR, Spurney R, Druey KM, Olson JA Jr.

Mol Endocrinol. 2011 May;25(5):867-76. doi: 10.1210/me.2010-0277. Epub 2011 Mar 10.


Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates.

Chen BJ, Deoliveira D, Spasojevic I, Sempowski GD, Jiang C, Owzar K, Wang X, Gesty-Palmer D, Cline JM, Bourland JD, Dugan G, Meadows SK, Daher P, Muramoto G, Chute JP, Chao NJ.

PLoS One. 2010 Jun 16;5(6):e11056. doi: 10.1371/journal.pone.0011056.


The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.

DuSell CD, Nelson ER, Wang X, Abdo J, Mödder UI, Umetani M, Gesty-Palmer D, Javitt NB, Khosla S, McDonnell DP.

Endocrinology. 2010 Aug;151(8):3675-85. doi: 10.1210/en.2010-0080. Epub 2010 May 25.


Osteoporosis in lung transplant candidates compared to matched healthy controls.

Lakey WC, Spratt S, Vinson EN, Gesty-Palmer D, Weber T, Palmer S.

Clin Transplant. 2011 May-Jun;25(3):426-35. doi: 10.1111/j.1399-0012.2010.01263.x. Epub 2010 May 6.


Beyond desensitization: physiological relevance of arrestin-dependent signaling.

Luttrell LM, Gesty-Palmer D.

Pharmacol Rev. 2010 Jun;62(2):305-30. doi: 10.1124/pr.109.002436. Epub 2010 Apr 28. Review. Erratum in: Pharmacol Rev. 2010 Sep;62(3):564.


A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.

Gesty-Palmer D, Flannery P, Yuan L, Corsino L, Spurney R, Lefkowitz RJ, Luttrell LM.

Sci Transl Med. 2009 Oct 7;1(1):1ra1. doi: 10.1126/scitranslmed.3000071.


Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2).

Wang L, Gesty-Palmer D, Fields TA, Spurney RF.

Mol Endocrinol. 2009 Sep;23(9):1455-65. doi: 10.1210/me.2009-0084. Epub 2009 Jun 25.


Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

Shukla AK, Violin JD, Whalen EJ, Gesty-Palmer D, Shenoy SK, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9988-93. doi: 10.1073/pnas.0804246105. Epub 2008 Jul 11.


Heptahelical terpsichory. Who calls the tune?

Gesty-Palmer D, Luttrell LM.

J Recept Signal Transduct Res. 2008;28(1-2):39-58. doi: 10.1080/10799890801941921 . Review.


Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Wang S, Eckhardt AE, Cowan CL, Spurney RF, Luttrell LM, Lefkowitz RJ.

J Biol Chem. 2006 Apr 21;281(16):10856-64. Epub 2006 Feb 21.


beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.

Gesty-Palmer D, El Shewy H, Kohout TA, Luttrell LM.

J Biol Chem. 2005 Sep 16;280(37):32157-67. Epub 2005 Jul 15.


Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.

Pi M, Oakley RH, Gesty-Palmer D, Cruickshank RD, Spurney RF, Luttrell LM, Quarles LD.

Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.


The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.

Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM.

J Biol Chem. 2003 Feb 21;278(8):6258-67. Epub 2002 Dec 6.


Echocardiography for the Diagnosis of Staphylococcus aureus Infective Endocarditis.

Chamis AL, Gesty-Palmer D, Fowler VG, Corey GR.

Curr Infect Dis Rep. 1999 Jun;1(2):129-135.


Prospective analysis of Staphylococcus aureus bacteremia in nonneutropenic adults with malignancy.

Gopal AK, Fowler VG Jr, Shah M, Gesty-Palmer D, Marr KA, McClelland RS, Kong LK, Gottlieb GS, Lanclos K, Li J, Sexton DJ, Corey GR.

J Clin Oncol. 2000 Mar;18(5):1110-5.


Recurrent Staphylococcus aureus bacteremia: pulsed-field gel electrophoresis findings in 29 patients.

Fowler VG Jr, Kong LK, Corey GR, Gottlieb GS, McClelland RS, Sexton DJ, Gesty-Palmer D, Harrell LJ.

J Infect Dis. 1999 May;179(5):1157-61.


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