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Items: 1 to 50 of 173

1.

Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.

Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pierattelli R, Felli IC, Brun-Heath I, García J, Nebreda ÁR, Gestwicki JE, Lieberman AP, Salvatella X.

Nat Commun. 2019 Oct 7;10(1):4605. doi: 10.1038/s41467-019-12578-8.

2.

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.

Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M.

J Biol Chem. 2019 Oct 2. pii: jbc.RA119.009432. doi: 10.1074/jbc.RA119.009432. [Epub ahead of print]

3.

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.

Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, Gestwicki JE, Xu K, Kosik KS, Gan L.

Neuron. 2019 Sep 4. pii: S0896-6273(19)30692-0. doi: 10.1016/j.neuron.2019.08.008. [Epub ahead of print]

PMID:
31542321
4.

Individualized Management of Genetic Diversity in Niemann-Pick C1 through Modulation of the Hsp70 Chaperone System.

Wang C, Scott SM, Sun S, Zhao P, Hutt DM, Shao H, Gestwicki JE, Balch WE.

Hum Mol Genet. 2019 Sep 11. pii: ddz215. doi: 10.1093/hmg/ddz215. [Epub ahead of print]

PMID:
31509197
5.

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.

Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pierattelli R, Felli IC, Brun-Heath I, García J, Nebreda ÁR, Gestwicki JE, Lieberman AP, Salvatella X.

Nat Commun. 2019 Aug 8;10(1):3562. doi: 10.1038/s41467-019-11594-y. Erratum in: Nat Commun. 2019 Oct 7;10(1):4605.

6.

Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts.

Molnar KS, Dunyak BM, Su B, Izrayelit Y, McGlasson-Naumann B, Hamilton PD, Qian M, Covey DF, Gestwicki JE, Makley LN, Andley UP.

Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3320-3331. doi: 10.1167/iovs.18-25647.

7.

Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.

Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE.

Nat Chem Biol. 2019 Aug;15(8):786-794. doi: 10.1038/s41589-019-0322-6. Epub 2019 Jul 18.

PMID:
31320752
8.

Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20.

Lee E, Ouzounova M, Piranlioglu R, Ma MT, Guzel M, Marasco D, Chadli A, Gestwicki JE, Cowell JK, Wicha MS, Hassan KA, Korkaya H.

Oncogene. 2019 Jul;38(28):5749. doi: 10.1038/s41388-019-0838-y.

PMID:
31197211
9.

A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis.

Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S.

Cell Host Microbe. 2019 Mar 13;25(3):454-462.e6. doi: 10.1016/j.chom.2019.01.006. Epub 2019 Feb 28.

PMID:
30827827
10.

Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease.

Taguwa S, Yeh MT, Rainbolt TK, Nayak A, Shao H, Gestwicki JE, Andino R, Frydman J.

Cell Rep. 2019 Jan 22;26(4):906-920.e3. doi: 10.1016/j.celrep.2018.12.095.

11.

Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks.

Meister-Broekema M, Freilich R, Jagadeesan C, Rauch JN, Bengoechea R, Motley WW, Kuiper EFE, Minoia M, Furtado GV, van Waarde MAWH, Bird SJ, Rebelo A, Zuchner S, Pytel P, Scherer SS, Morelli FF, Carra S, Weihl CC, Bergink S, Gestwicki JE, Kampinga HH.

Nat Commun. 2018 Dec 17;9(1):5342. doi: 10.1038/s41467-018-07718-5.

12.

Predicting protein targets for drug-like compounds using transcriptomics.

Pabon NA, Xia Y, Estabrooks SK, Ye Z, Herbrand AK, Süß E, Biondi RM, Assimon VA, Gestwicki JE, Brodsky JL, Camacho CJ, Bar-Joseph Z.

PLoS Comput Biol. 2018 Dec 7;14(12):e1006651. doi: 10.1371/journal.pcbi.1006651. eCollection 2018 Dec.

13.

Designing de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery.

Zaiter SS, Huo Y, Tiew FY, Gestwicki JE, McAlpine SR.

J Med Chem. 2019 Jan 24;62(2):742-761. doi: 10.1021/acs.jmedchem.8b01436. Epub 2018 Dec 20.

PMID:
30507174
14.

Function, evolution, and structure of J-domain proteins.

Kampinga HH, Andreasson C, Barducci A, Cheetham ME, Cyr D, Emanuelsson C, Genevaux P, Gestwicki JE, Goloubinoff P, Huerta-Cepas J, Kirstein J, Liberek K, Mayer MP, Nagata K, Nillegoda NB, Pulido P, Ramos C, De Los Rios P, Rospert S, Rosenzweig R, Sahi C, Taipale M, Tomiczek B, Ushioda R, Young JC, Zimmermann R, Zylicz A, Zylicz M, Craig EA, Marszalek J.

Cell Stress Chaperones. 2019 Jan;24(1):7-15. doi: 10.1007/s12192-018-0948-4. Epub 2018 Nov 26.

15.

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau.

Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE.

Nat Commun. 2018 Nov 1;9(1):4563. doi: 10.1038/s41467-018-07012-4.

16.

A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions.

Rinaldi S, Assimon VA, Young ZT, Morra G, Shao H, Taylor IR, Gestwicki JE, Colombo G.

ACS Chem Biol. 2018 Nov 16;13(11):3142-3152. doi: 10.1021/acschembio.8b00712. Epub 2018 Nov 8.

PMID:
30372610
17.

Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration.

Opoku-Nsiah KA, Gestwicki JE.

Transl Res. 2018 Aug;198:48-57. doi: 10.1016/j.trsl.2018.05.002. Epub 2018 Jun 19. Review.

18.

Inhibitors and chemical probes for molecular chaperone networks.

Gestwicki JE, Shao H.

J Biol Chem. 2019 Feb 8;294(6):2151-2161. doi: 10.1074/jbc.TM118.002813. Epub 2018 Sep 13. Review.

19.

The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20.

Lee E, Ouzounova M, Piranlioglu R, Ma MT, Guzel M, Marasco D, Chadli A, Gestwicki JE, Cowell JK, Wicha MS, Hassan KA, Korkaya H.

Oncogene. 2019 Jan;38(4):469-482. doi: 10.1038/s41388-018-0472-0. Epub 2018 Aug 30. Erratum in: Oncogene. 2019 Jun 13;:.

20.

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.

Polson ES, Kuchler VB, Abbosh C, Ross EM, Mathew RK, Beard HA, da Silva B, Holding AN, Ballereau S, Chuntharpursat-Bon E, Williams J, Griffiths HBS, Shao H, Patel A, Davies AJ, Droop A, Chumas P, Short SC, Lorger M, Gestwicki JE, Roberts LD, Bon RS, Allison SJ, Zhu S, Markowetz F, Wurdak H.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaar2718. doi: 10.1126/scitranslmed.aar2718.

21.

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).

Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers L, Gestwicki JE.

J Med Chem. 2018 Jul 26;61(14):6163-6177. doi: 10.1021/acs.jmedchem.8b00583. Epub 2018 Jul 13.

22.

Inhibitors of protein-protein interactions (PPIs): an analysis of scaffold choices and buried surface area.

Ran X, Gestwicki JE.

Curr Opin Chem Biol. 2018 Jun;44:75-86. doi: 10.1016/j.cbpa.2018.06.004. Epub 2018 Jun 13. Review.

23.

HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C.

Glazier AA, Hafeez N, Mellacheruvu D, Basrur V, Nesvizhskii AI, Lee LM, Shao H, Tang V, Yob JM, Gestwicki JE, Helms AS, Day SM.

JCI Insight. 2018 Jun 7;3(11). pii: 99319. doi: 10.1172/jci.insight.99319. eCollection 2018 Jun 7.

24.

Revisiting the "Art of the Chemical Probe".

Schwarz DMC, Gestwicki JE.

ACS Chem Biol. 2018 May 18;13(5):1109-1110. doi: 10.1021/acschembio.8b00390. No abstract available.

PMID:
29772907
25.

The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein.

Taylor IR, Ahmad A, Wu T, Nordhues BA, Bhullar A, Gestwicki JE, Zuiderweg ERP.

J Biol Chem. 2018 Jul 6;293(27):10796-10809. doi: 10.1074/jbc.RA118.002234. Epub 2018 May 15.

26.

Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer.

Moses MA, Kim YS, Rivera-Marquez GM, Oshima N, Watson MJ, Beebe KE, Wells C, Lee S, Zuehlke AD, Shao H, Bingman WE 3rd, Kumar V, Malhotra SV, Weigel NL, Gestwicki JE, Trepel JB, Neckers LM.

Cancer Res. 2018 Jul 15;78(14):4022-4035. doi: 10.1158/0008-5472.CAN-17-3728. Epub 2018 May 15.

27.

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.

Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE.

Nat Struct Mol Biol. 2018 May;25(5):384-393. doi: 10.1038/s41594-018-0057-1. Epub 2018 Apr 30.

28.

Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1).

Ran X, Burchfiel ET, Dong B, Rettko NJ, Dunyak BM, Shao H, Thiele DJ, Gestwicki JE.

Bioorg Med Chem. 2018 Oct 15;26(19):5299-5306. doi: 10.1016/j.bmc.2018.04.018. Epub 2018 Apr 7.

PMID:
29661622
29.

Protein-Protein Interactions in the Molecular Chaperone Network.

Freilich R, Arhar T, Abrams JL, Gestwicki JE.

Acc Chem Res. 2018 Apr 17;51(4):940-949. doi: 10.1021/acs.accounts.8b00036. Epub 2018 Apr 3. Review.

30.

Protein cross-linking capillary electrophoresis at increased throughput for a range of protein-protein interactions.

Ouimet CM, Dawod M, Grinias J, Assimon VA, Lodge J, Mapp AK, Gestwicki JE, Kennedy RT.

Analyst. 2018 Apr 16;143(8):1805-1812. doi: 10.1039/C7AN02098H.

31.

SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.

Min SW, Sohn PD, Li Y, Devidze N, Johnson JR, Krogan NJ, Masliah E, Mok SA, Gestwicki JE, Gan L.

J Neurosci. 2018 Apr 11;38(15):3680-3688. doi: 10.1523/JNEUROSCI.2369-17.2018. Epub 2018 Mar 14.

32.

High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex.

Taylor IR, Dunyak BM, Komiyama T, Shao H, Ran X, Assimon VA, Kalyanaraman C, Rauch JN, Jacobson MP, Zuiderweg ERP, Gestwicki JE.

J Biol Chem. 2018 Mar 16;293(11):4014-4025. doi: 10.1074/jbc.RA117.001575. Epub 2018 Feb 2.

33.

X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.

Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE.

J Biol Chem. 2018 Feb 16;293(7):2370-2380. doi: 10.1074/jbc.RA117.000634. Epub 2017 Dec 18.

34.

Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.

Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett CS, Gestwicki JE.

Mol Cancer Res. 2018 Jan;16(1):58-68. doi: 10.1158/1541-7786.MCR-17-0408. Epub 2017 Sep 28.

35.

From Fuzzy to Function: The New Frontier of Protein-Protein Interactions.

Pricer R, Gestwicki JE, Mapp AK.

Acc Chem Res. 2017 Mar 21;50(3):584-589. doi: 10.1021/acs.accounts.6b00565.

36.

The remarkable multivalency of the Hsp70 chaperones.

Zuiderweg ER, Hightower LE, Gestwicki JE.

Cell Stress Chaperones. 2017 Mar;22(2):173-189. doi: 10.1007/s12192-017-0776-y. Epub 2017 Feb 20. Review.

37.

Therapeutic Strategies for Restoring Tau Homeostasis.

Young ZT, Mok SA, Gestwicki JE.

Cold Spring Harb Perspect Med. 2018 Jan 2;8(1). pii: a024612. doi: 10.1101/cshperspect.a024612. Review.

38.

Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules.

Rauch JN, Olson SH, Gestwicki JE.

Cold Spring Harb Perspect Med. 2017 Jul 5;7(7). pii: a024034. doi: 10.1101/cshperspect.a024034. Review.

39.

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins.

Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE.

J Mol Biol. 2017 Jan 6;429(1):128-141. doi: 10.1016/j.jmb.2016.11.013. Epub 2016 Nov 21.

40.

Backbone and methyl resonance assignments of the 42 kDa human Hsc70 nucleotide binding domain in the ADP state.

Zuiderweg ER, Gestwicki JE.

Biomol NMR Assign. 2017 Apr;11(1):11-15. doi: 10.1007/s12104-016-9711-x. Epub 2016 Oct 3.

41.

Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3.

Costa MDC, Ashraf NS, Fischer S, Yang Y, Schapka E, Joshi G, McQuade TJ, Dharia RM, Dulchavsky M, Ouyang M, Cook D, Sun D, Larsen MJ, Gestwicki JE, Todi SV, Ivanova MI, Paulson HL.

Brain. 2016 Nov 1;139(11):2891-2908. doi: 10.1093/brain/aww228.

42.

Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy.

Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE.

Cell Chem Biol. 2016 Aug 18;23(8):992-1001. doi: 10.1016/j.chembiol.2016.04.014. Epub 2016 Aug 4.

43.

Non-canonical Interactions between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release.

Rauch JN, Zuiderweg ER, Gestwicki JE.

J Biol Chem. 2016 Sep 16;291(38):19848-57. doi: 10.1074/jbc.M116.742502. Epub 2016 Jul 29.

44.

Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.

Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9015-20. doi: 10.1073/pnas.1603883113. Epub 2016 Jul 22.

45.

Protein Cross-Linking Capillary Electrophoresis for Protein-Protein Interaction Analysis.

Ouimet CM, Shao H, Rauch JN, Dawod M, Nordhues B, Dickey CA, Gestwicki JE, Kennedy RT.

Anal Chem. 2016 Aug 16;88(16):8272-8. doi: 10.1021/acs.analchem.6b02126. Epub 2016 Jul 28.

46.

Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds.

Dunyak BM, Gestwicki JE.

J Med Chem. 2016 Nov 10;59(21):9622-9644. Epub 2016 Jul 25. Review.

47.

Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy.

Morozova K, Clement CC, Kaushik S, Stiller B, Arias E, Ahmad A, Rauch JN, Chatterjee V, Melis C, Scharf B, Gestwicki JE, Cuervo AM, Zuiderweg ER, Santambrogio L.

J Biol Chem. 2016 Aug 26;291(35):18096-106. doi: 10.1074/jbc.M116.736744. Epub 2016 Jul 12.

48.

Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel.

Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO.

Cell Chem Biol. 2016 May 19;23(5):561-566. doi: 10.1016/j.chembiol.2016.04.008.

49.

Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.

Martin MD, Baker JD, Suntharalingam A, Nordhues BA, Shelton LB, Zheng D, Sabbagh JJ, Haystead TA, Gestwicki JE, Dickey CA.

ACS Chem Biol. 2016 Jul 15;11(7):2041-8. doi: 10.1021/acschembio.6b00223. Epub 2016 May 26.

50.

Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity.

Assimon VA, Shao H, Garneau-Tsodikova S, Gestwicki JE.

Medchemcomm. 2015 May 1;6(5):912-918. Epub 2015 Mar 30.

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