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FcγRIIB on liver sinusoidal endothelial cells is essential for antibody-induced GPVI ectodomain shedding in mice.

Stegner D, Popp M, Lorenz V, Wax JK, Gessner JE, Nieswandt B.

Blood. 2016 Aug 11;128(6):862-5. doi: 10.1182/blood-2016-05-714378. Epub 2016 Jun 13.


Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation.

Sogkas G, Stegner D, Syed SN, Vögtle T, Rau E, Gewecke B, Schmidt RE, Nieswandt B, Gessner JE.

Immun Inflamm Dis. 2015 Sep;3(3):154-70. doi: 10.1002/iid3.56. Epub 2015 May 12.


Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia.

Hillgruber C, Pöppelmann B, Weishaupt C, Steingräber AK, Wessel F, Berdel WE, Gessner JE, Ho-Tin-Noé B, Vestweber D, Goerge T.

J Exp Med. 2015 Jul 27;212(8):1255-66. doi: 10.1084/jem.20142076. Epub 2015 Jul 13.


Orai1 controls C5a-induced neutrophil recruitment in inflammation.

Sogkas G, Vögtle T, Rau E, Gewecke B, Stegner D, Schmidt RE, Nieswandt B, Gessner JE.

Eur J Immunol. 2015 Jul;45(7):2143-53. doi: 10.1002/eji.201445337. Epub 2015 May 15.


Basophil expansion protects against invasive pneumococcal disease in mice.

Bischof A, Brumshagen C, Ding N, Kirchhof G, Briles DE, Gessner JE, Welte T, Mack M, Maus UA.

J Infect Dis. 2014 Jul 1;210(1):14-24. Epub 2014 Jan 26.


Differential association of the Na+/H+ Exchanger Regulatory Factor (NHERF) family of adaptor proteins with the raft- and the non-raft brush border membrane fractions of NHE3.

Sultan A, Luo M, Yu Q, Riederer B, Xia W, Chen M, Lissner S, Gessner JE, Donowitz M, Yun CC, deJonge H, Lamprecht G, Seidler U.

Cell Physiol Biochem. 2013;32(5):1386-402.


The receptor for activated complement factor 5 (C5aR) conveys myocardial ischemic damage by mediating neutrophil transmigration.

Mueller M, Herzog C, Larmann J, Schmitz M, Hilfiker-Kleiner D, Gessner JE, Theilmeier G.

Immunobiology. 2013 Sep;218(9):1131-8. doi: 10.1016/j.imbio.2013.03.006. Epub 2013 Mar 28.


[Fcγ receptors].

Gessner JE, Schmidt RE.

Z Rheumatol. 2013 Feb;72(1):68-70. doi: 10.1007/s00393-012-1006-8. Review. German. No abstract available.


Gαi2 is the essential Gαi protein in immune complex-induced lung disease.

Wiege K, Ali SR, Gewecke B, Novakovic A, Konrad FM, Pexa K, Beer-Hammer S, Reutershan J, Piekorz RP, Schmidt RE, Nürnberg B, Gessner JE.

J Immunol. 2013 Jan 1;190(1):324-33. doi: 10.4049/jimmunol.1201398. Epub 2012 Dec 5.


Kinetics of IgM and IgA antibody response to 23-valent pneumococcal polysaccharide vaccination in healthy subjects.

Schütz K, Hughes RG, Parker A, Quinti I, Thon V, Cavaliere M, Würfel M, Herzog W, Gessner JE, Baumann U.

J Clin Immunol. 2013 Jan;33(1):288-96. doi: 10.1007/s10875-012-9792-y. Epub 2012 Sep 25.


Defective macrophage migration in Gαi2- but not Gαi3-deficient mice.

Wiege K, Le DD, Syed SN, Ali SR, Novakovic A, Beer-Hammer S, Piekorz RP, Schmidt RE, Nürnberg B, Gessner JE.

J Immunol. 2012 Jul 15;189(2):980-7. doi: 10.4049/jimmunol.1200891. Epub 2012 Jun 15.


Nephrotic syndrome and subepithelial deposits in a mouse model of immune-mediated anti-podocyte glomerulonephritis.

Meyer-Schwesinger C, Dehde S, Klug P, Becker JU, Mathey S, Arefi K, Balabanov S, Venz S, Endlich KH, Pekna M, Gessner JE, Thaiss F, Meyer TN.

J Immunol. 2011 Sep 15;187(6):3218-29. doi: 10.4049/jimmunol.1003451. Epub 2011 Aug 15.


C5a receptor targeting in neointima formation after arterial injury in atherosclerosis-prone mice.

Shagdarsuren E, Bidzhekov K, Mause SF, Simsekyilmaz S, Polakowski T, Hawlisch H, Gessner JE, Zernecke A, Weber C.

Circulation. 2010 Sep 7;122(10):1026-36. doi: 10.1161/CIRCULATIONAHA.110.954370. Epub 2010 Aug 23.


Protective role of complement C5a in an experimental model of Staphylococcus aureus bacteremia.

von Köckritz-Blickwede M, Konrad S, Foster S, Gessner JE, Medina E.

J Innate Immun. 2010;2(1):87-92. doi: 10.1159/000247157. Epub 2009 Oct 10.


Fcgamma receptor-mediated antigen uptake by lung DC contributes to allergic airway hyper-responsiveness and inflammation.

Hartwig C, Mazzega M, Constabel H, Krishnaswamy JK, Gessner JE, Braun A, Tschernig T, Behrens GM.

Eur J Immunol. 2010 May;40(5):1284-95. doi: 10.1002/eji.200939900.


Systemic, nasal and oral live vaccines against Pseudomonas aeruginosa: a clinical trial of immunogenicity in lower airways of human volunteers.

Bumann D, Behre C, Behre K, Herz S, Gewecke B, Gessner JE, von Specht BU, Baumann U.

Vaccine. 2010 Jan 8;28(3):707-13. doi: 10.1016/j.vaccine.2009.10.080. Epub 2009 Nov 1.


Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a.

Syed SN, Konrad S, Wiege K, Nieswandt B, Nimmerjahn F, Schmidt RE, Gessner JE.

Eur J Immunol. 2009 Dec;39(12):3343-56. doi: 10.1002/eji.200939884.


Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease.

Johswich K, Martin M, Bleich A, Kracht M, Dittrich-Breiholz O, Gessner JE, Suerbaum S, Wende E, Rheinheimer C, Klos A.

Inflamm Bowel Dis. 2009 Dec;15(12):1812-23. doi: 10.1002/ibd.21012. Epub 2009 Aug 27.


STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation.

Braun A, Gessner JE, Varga-Szabo D, Syed SN, Konrad S, Stegner D, Vögtle T, Schmidt RE, Nieswandt B.

Blood. 2009 Jan 29;113(5):1097-104. doi: 10.1182/blood-2008-05-158477. Epub 2008 Oct 21.


Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation.

Konrad S, Ali SR, Wiege K, Syed SN, Engling L, Piekorz RP, Hirsch E, Nürnberg B, Schmidt RE, Gessner JE.

J Biol Chem. 2008 Nov 28;283(48):33296-303. doi: 10.1074/jbc.M804617200. Epub 2008 Sep 11.


Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice.

Kumar V, Ali SR, Konrad S, Zwirner J, Verbeek JS, Schmidt RE, Gessner JE.

J Clin Invest. 2006 Feb;116(2):512-20.


Rapid and preferential distribution of blood-borne alphaCD3epsilonAb to the liver is followed by local stimulation of T cells and natural killer T cells.

Wingender G, Schumak B, Schurich A, Gessner JE, Endl E, Limmer A, Knolle PA.

Immunology. 2006 Jan;117(1):117-26.


Fc receptors and their interaction with complement in autoimmunity.

Schmidt RE, Gessner JE.

Immunol Lett. 2005 Aug 15;100(1):56-67. Review.


Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation.

Skokowa J, Ali SR, Felda O, Kumar V, Konrad S, Shushakova N, Schmidt RE, Piekorz RP, Nürnberg B, Spicher K, Birnbaumer L, Zwirner J, Claassens JW, Verbeek JS, van Rooijen N, Köhl J, Gessner JE.

J Immunol. 2005 Mar 1;174(5):3041-50.


Enhanced immunogenicity in the murine airway mucosa with an attenuated Salmonella live vaccine expressing OprF-OprI from Pseudomonas aeruginosa.

Arnold H, Bumann D, Felies M, Gewecke B, Sörensen M, Gessner JE, Freihorst J, von Specht BU, Baumann U.

Infect Immun. 2004 Nov;72(11):6546-53.


C5a initiates the inflammatory cascade in immune complex peritonitis.

Godau J, Heller T, Hawlisch H, Trappe M, Howells E, Best J, Zwirner J, Verbeek JS, Hogarth PM, Gerard C, Van Rooijen N, Klos A, Gessner JE, Köhl J.

J Immunol. 2004 Sep 1;173(5):3437-45.


New insights into the pathophysiology and in vivo function of IgG Fc receptors through gene deletion studies.

Baumann U, Schmidt RE, Gessner JE.

Arch Immunol Ther Exp (Warsz). 2003;51(6):399-406. Review.


Targeting of platelet integrin alphaIIbbeta3 determines systemic reaction and bleeding in murine thrombocytopenia regulated by activating and inhibitory FcgammaR.

Nieswandt B, Bergmeier W, Schulte V, Takai T, Baumann U, Schmidt RE, Zirngibl H, Bloch W, Gessner JE.

Int Immunol. 2003 Mar;15(3):341-9.


C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease.

Shushakova N, Skokowa J, Schulman J, Baumann U, Zwirner J, Schmidt RE, Gessner JE.

J Clin Invest. 2002 Dec;110(12):1823-30.


In vivo effects of a synthetic 2-kilodalton macrophage-activating lipopeptide of Mycoplasma fermentans after pulmonary application.

Lührmann A, Deiters U, Skokowa J, Hanke M, Gessner JE, Mühlradt PF, Pabst R, Tschernig T.

Infect Immun. 2002 Jul;70(7):3785-92.


Opposite regulation of type II and III receptors for immunoglobulin G in mouse glomerular mesangial cells and in the induction of anti-glomerular basement membrane (GBM) nephritis.

Radeke HH, Janssen-Graalfs I, Sowa EN, Chouchakova N, Skokowa J, Löscher F, Schmidt RE, Heeringa P, Gessner JE.

J Biol Chem. 2002 Jul 26;277(30):27535-44. Epub 2002 Apr 30.


Distinct tissue site-specific requirements of mast cells and complement components C3/C5a receptor in IgG immune complex-induced injury of skin and lung.

Baumann U, Chouchakova N, Gewecke B, Köhl J, Carroll MC, Schmidt RE, Gessner JE.

J Immunol. 2001 Jul 15;167(2):1022-7.


Fc gamma RIII-mediated production of TNF-alpha induces immune complex alveolitis independently of CXC chemokine generation.

Chouchakova N, Skokowa J, Baumann U, Tschernig T, Philippens KM, Nieswandt B, Schmidt RE, Gessner JE.

J Immunol. 2001 Apr 15;166(8):5193-200.


Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice.

Nieswandt B, Bergmeier W, Rackebrandt K, Gessner JE, Zirngibl H.

Blood. 2000 Oct 1;96(7):2520-7.


Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain.

Nieswandt B, Bergmeier W, Schulte V, Rackebrandt K, Gessner JE, Zirngibl H.

J Biol Chem. 2000 Aug 4;275(31):23998-4002.


Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III.

Fossati-Jimack L, Ioan-Facsinay A, Reininger L, Chicheportiche Y, Watanabe N, Saito T, Hofhuis FM, Gessner JE, Schiller C, Schmidt RE, Honjo T, Verbeek JS, Izui S.

J Exp Med. 2000 Apr 17;191(8):1293-302.


On the role of complement and Fc gamma-receptors in the Arthus reaction.

Köhl J, Gessner JE.

Mol Immunol. 1999 Sep-Oct;36(13-14):893-903. Review.


Mouse FcgammaRII is a negative regulator of FcgammaRIII in IgG immune complex-triggered inflammation but not in autoantibody-induced hemolysis.

Schiller C, Janssen-Graalfs I, Baumann U, Schwerter-Strumpf K, Izui S, Takai T, Schmidt RE, Gessner JE.

Eur J Immunol. 2000 Feb;30(2):481-90.


A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction.

Baumann U, Köhl J, Tschernig T, Schwerter-Strumpf K, Verbeek JS, Schmidt RE, Gessner JE.

J Immunol. 2000 Jan 15;164(2):1065-70.


Mast cells induce autoantibody-mediated vasculitis syndrome through tumor necrosis factor production upon triggering Fcgamma receptors.

Watanabe N, Akikusa B, Park SY, Ohno H, Fossati L, Vecchietti G, Gessner JE, Schmidt RE, Verbeek JS, Ryffel B, Iwamoto I, Izui S, Saito T.

Blood. 1999 Dec 1;94(11):3855-63.


Altered donor and recipient Ly49+ NK cell subsets in allogeneic H-2d --> H-2b and H-2b --> H-2d bone marrow chimeras.

Korten S, Wilk E, Gessner JE, Meyer D, Schmidt RE.

J Immunol. 1999 Dec 1;163(11):5896-905.


Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.

Nieswandt B, Echtenacher B, Wachs FP, Schröder J, Gessner JE, Schmidt RE, Grau GE, Männel DN.

Blood. 1999 Jul 15;94(2):684-93.


Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury.

Heller T, Hennecke M, Baumann U, Gessner JE, zu Vilsendorf AM, Baensch M, Boulay F, Kola A, Klos A, Bautsch W, Köhl J.

J Immunol. 1999 Jul 15;163(2):985-94.


Cutting edge: Fc receptor type I for IgG on macrophages and complement mediate the inflammatory response in immune complex peritonitis.

Heller T, Gessner JE, Schmidt RE, Klos A, Bautsch W, Köhl J.

J Immunol. 1999 May 15;162(10):5657-61.


FcgammaRIII (CD16)-deficient mice show IgG isotype-dependent protection to experimental autoimmune hemolytic anemia.

Meyer D, Schiller C, Westermann J, Izui S, Hazenbos WL, Verbeek JS, Schmidt RE, Gessner JE.

Blood. 1998 Dec 1;92(11):3997-4002.


IFN-gamma induces the high-affinity Fc receptor I for IgG (CD64) on human glomerular mesangial cells.

Uciechowski P, Schwarz M, Gessner JE, Schmidt RE, Resch K, Radeke HH.

Eur J Immunol. 1998 Sep;28(9):2928-35.


Murine IgG1 complexes trigger immune effector functions predominantly via Fc gamma RIII (CD16).

Hazenbos WL, Heijnen IA, Meyer D, Hofhuis FM, Renardel de Lavalette CR, Schmidt RE, Capel PJ, van de Winkel JG, Gessner JE, van den Berg TK, Verbeek JS.

J Immunol. 1998 Sep 15;161(6):3026-32.

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